| Differential tuning of excitation and inhibition shapes direction selectivity in ferret visual cortex Inhibition to the null direction of motion has a critical role in the direction selectivity of neurons in ferret primary visual cortex. Daniel E. Wilson, Benjamin Scholl, David Fitzpatrick | Drug candidate and target for leishmaniasis Better treatments are needed for the neglected tropical disease leishmaniasis. The development of a compound that tackles the disease in mice, and the identification of the protein it targets, offer a way forward. Carolina M. C. Catta-Preta, Jeremy C. Mottram | Hurricane-induced selection on the morphology of an island lizard Two populations of Anolis lizards that survived Hurricanes Irma and Maria had larger toepads, longer forelimbs and shorter hindlimbs relative to the pre-hurricane populations, which suggests hurricane-induced natural selection. Colin M. Donihue, Anthony Herrel, Anne-Claire Fabre et al. | Room-temperature electrical control of exciton flux in a van der Waals heterostructure Heterobilayer excitonic devices consisting of two different van der Waals materials, in which excitons are shared between the layers, exhibit electrically controlled switching actions at room temperature. Dmitrii Unuchek, Alberto Ciarrocchi, Ahmet Avsar et al. | A lymphatic waste-disposal system implicated in Alzheimer’s disease The discovery that a set of lymphatic vessels interacts with blood vessels to remove toxic waste products from the brain has implications for cognition, ageing and disorders such as Alzheimer’s disease. Melanie D. Sweeney, Berislav V. Zlokovic | 53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ The specificity of 53BP1 and its co-factors for particular DNA substrates during non-homologous end joining (NHEJ) derives from REV7–shieldin, a four-subunit DNA-binding complex that is required for REV7-dependent NHEJ but not for REV7-dependent DNA interstrand cross-link repair. Hind Ghezraoui, Catarina Oliveira, Jordan R. Becker et al. | Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease Meningeal lymphatic dysfunction promotes amyloid-β deposition in the meninges and worsens brain amyloid-β pathology, acting as an aggravating factor in Alzheimer’s disease and in age-associated cognitive decline; improving meningeal lymphatic function could help to prevent or delay age-associated neurological diseases. Sandro Da Mesquita, Antoine Louveau, Andrea Vaccari et al. | Ecosystem restructuring along the Great Barrier Reef following mass coral bleaching Fish and invertebrate communities transformed across the span of the Great Barrier Reef following the 2016 bleaching event due to a decline in coral-feeding fishes resulting from coral loss, and because of different regional responses of key trophic groups to the direct effect of temperature. Rick D. Stuart-Smith, Christopher J. Brown, Daniela M. Ceccarelli et al. | Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination Many small molecules that stimulate oligodendrocyte formation act not through their canonical pathways but by inhibiting enzymes within the cholesterol biosynthesis pathway and thereby inducing the accumulation of 8,9-unsaturated sterols. Zita Hubler, Dharmaraja Allimuthu, Ilya Bederman et al. | Coherent spin–photon coupling using a resonant exchange qubit Coherent coupling between a three-electron spin qubit and single photons in a microwave resonator is demonstrated, which, unlike previous demonstrations, does not require ferromagnetic components near the qubit. A. J. Landig, J. V. Koski, P. Scarlino et al. | New mitochondrial DNA synthesis enables NLRP3 inflammasome activation New mitochondrial DNA synthesis links the priming and activation of the NLRP3 inflammasome. Zhenyu Zhong, Shuang Liang, Elsa Sanchez-Lopez et al. | Mitochondrial double-stranded RNA triggers antiviral signalling in humans Mitochondrial double-stranded RNA can induce an interferon response if released into the cytoplasm, but self-recognition is prevented by SUV3 helicase and PNPase exoribonuclease. Ashish Dhir, Somdutta Dhir, Lukasz S. Borowski et al. | Newly made mitochondrial DNA drives inflammation Activation of the inflammasome protein complex in immune cells is a key step that triggers an innate immune response. It emerges that the synthesis and oxidation of mitochondrial DNA drives this activation step. Michael P. Murphy | Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis A series of compounds are discovered for the treatment of visceral leishmaniasis, and cdc2-related kinase 12 (CRK12) is identified as the probable primary drug target. Susan Wyllie, Michael Thomas, Stephen Patterson et al. | Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability Nahid Iglesias, Mark A. Currie, Gloria Jih et al. | Developing neurons are innately inclined to learn on the job How genetic and environmental factors contribute to the generation of various subtypes of inhibitory neurons called interneurons in the brain is unclear. A study in mice provides new insight into this process. Christian Mayer, Gord Fishell | Ferroelectric switching of a two-dimensional metal Two- and three-layer WTe2 exhibits spontaneous out-of-plane electric polarization that can be switched electrically at room temperature and is sufficiently robust for use in applications with other two-dimensional materials. Zaiyao Fei, Wenjin Zhao, Tauno A. Palomaki et al. | | | Tropics Anna Armstrong, I-han Chou, Juliane Mossinger et al. | | | The future of hyperdiverse tropical ecosystems The immense biodiversity of tropical ecosystems is threatened by multiple interacting local and global stressors that can only be addressed by the concerted efforts of grassroots organizations, researchers, national governments and the international community. Jos Barlow, Filipe França, Toby A. Gardner et al. | | El Niño–Southern Oscillation complexity Our current understanding of the spatio-temporal complexity of the El Niño–Southern Oscillation phenomenon is reviewed and a unifying framework that identifies the key factors for this complexity is proposed. Axel Timmermann, Soon-Il An, Jong-Seong Kug et al. | | | Evolution of a central neural circuit underlies Drosophila mate preferences A female Drosophila melanogaster pheromone is recognized by males from both the same and a closely related species through conserved peripheral sensory neurons; the signal is then differentially propagated to promote conspecific and suppress interspecies courtship. Laura F. Seeholzer, Max Seppo, David L. Stern et al. | | | Atmosphere–soil carbon transfer as a function of soil depth This study of whole-soil carbon dynamics finds that, of the atmospheric carbon that is incorporated into the topmost metre of soil over 50 years, just 19 per cent reaches the subsoil, in a manner that depends on land use and aridity. Jérôme Balesdent, Isabelle Basile-Doelsch, Joël Chadoeuf et al. | | | | | |
| Alzheimer’s disease Alzheimer’s disease is the most common form of dementia. For decades, researchers have sought a treatment to no avail, and our understanding of the condition is now being questioned. | | Tropics The tropics are home to a dizzying array of species, store vast quantities of carbon, drive year-to-year climate variability, and will soon be home to half the world’s population. This Insight gathers together Reviews that explore some of the most important scientific and societal challenges posed by the tropics, and some of the solutions being devised. | | | | | | | | naturejobs.com Science jobs of the week | | | | | | | | | | | | | | | No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter. | | | | | | | | | natureevents directory featured events | | | | | | | Natureevents Directory is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide. | | | | | | | Your email address is in the Nature mailing list. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). | | | | | For further technical assistance, please contact our registration department at registration@nature.com For print subscription enquiries, please contact our subscription department at subscriptions@nature.com For other enquiries, please contact feedback@nature.com Nature Research | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Nature Research's offices: Principal offices: London - New York - Tokyo Worldwide offices: Basingstoke - Beijing - Boston - Buenos Aires - Delhi - Heidelberg - Hong Kong - Madrid - Melbourne - Munich - Paris - San Francisco - Seoul - Shanghai - Washington DC - Sydney Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2018 Macmillan Publishers Limited. All Rights Reserved. | | | | |
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