Thursday, June 21, 2018

Nature Reviews Molecular Cell Biology contents July 2018 Volume 19 Number 7

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Nature Reviews Molecular Cell Biology

July 2018 Volume 19, Issue 7

Research Highlights
Amendments & Corrections
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(More) women in science    pp413 - 414
Fiona M. Watt

Fiona M. Watt at King’s College London Centre for Stem Cells and Regenerative Medicine (UK) discusses how gender balance in the scientific community is evolving.


Research Highlights


Overcoming obstacles to progression    p415
Eytan Zlotorynski

The spindle checkpoint complex BUB3–BUB1 facilitates telomere replication through recruitment of the helicase BLM, and the telomere capping protein TRF2 promotes replication at pericentromeres by recruiting the helicase RTEL1; both helicases resolve G-quadruplex structures.


A self-made quiescent niche    pp416 - 417
Kim Baumann

Muscle stem cells produce collagen V, which becomes a component of the niche that promotes their quiescence.


EpiTOFing ageing    pp416 - 417
Grant Otto

EpiTOF characterized the epigenetic landscape of various types of single immune cells and revealed that their heterogeneity increases with age.


The beginning of totipotency    p417
Kikuë Tachibana

Kikuë Tachibana discusses some of the key findings of the seminal works of Sir John Gurdon on nuclear reprogramming and how, by being examples of scientific rigour, they have inspired her own research.


Nature Reviews Molecular Cell Biology
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Contextual determinants of TGFβ action in development, immunity and cancer    pp419 - 435
Charles J. David & Joan Massagué

Transforming growth factor-β (TGFβ) family cytokines are important regulators of cell fate with pleiotropic roles in development, tissue homeostasis, regeneration and tumorigenesis. Recent studies revealed that this context dependency relies on the convergence between TGFβ signals and other contextual inputs, whereby transcription factors downstream of these pathways collaboratively act to regulate gene expression.


Dynamics of the epigenetic landscape during the maternal-to-zygotic transition    pp436 - 450
Melanie A. Eckersley-Maslin, Celia Alda-Catalinas & Wolf Reik

The maternal-to-zygotic transition (MZT) is defined as the transition from maternal gene expression in the oocyte to zygotic genome activation and embryonic-driven development. Recent studies have improved our understanding of the dynamics of the MZT, which is characterized by global DNA demethylation, chromatin remodelling, genome reorganization and substantial transcriptional changes.


Microtubule dynamics: an interplay of biochemistry and mechanics    pp451 - 463
Gary J. Brouhard & Luke M. Rice

Microtubules are highly dynamic tubulin polymers, and their dynamics are associated with a conformational cycle of individual tubulin subunits in the lattice. Recent evidence suggests that fine-tuning microtubule dynamics is enabled by the allosteric coupling of tubulin subunits, which propagates conformational changes through the lattice.


Born to run: control of transcription elongation by RNA polymerase II    pp464 - 478
Fei Xavier Chen, Edwin R. Smith & Ali Shilatifard

Transcription elongation by RNA polymerase II (Pol II) involves pausing of Pol II at promoter-proximal regions. Pol II release into gene bodies (productive elongation) is controlled by many transcription-specific factors, enhancers and factors that are canonically associated with genome maintenance.


Amendments & Corrections


Publisher Correction: Contextual determinants of TGFβ action in development, immunity and cancer    p479
Charles J. David & Joan Massagué

Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes    p479
Samara L. Reck-Peterson, William B. Redwine, Ronald D. Vale & Andrew P. Carter

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