Nature Reviews Molecular Cell Biology contents July 2018 Volume 19 Number 7

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TABLE OF CONTENTS July 2018 Volume 19, Issue 7 Comment Research Highlights Reviews Amendments & Corrections   Advertisement nature.com webcasts Nature Research Custom Media presents a webcast on: Rspondin3 from stromal myofibroblasts orchestrates gastric epithelial stem cells Date: Wednesday, July 11, 2018 Join our webcast to learn how the RNAscope® Dual ISH technology was utilized to thoroughly characterize the gastric antral gland stem cell niche. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE  Sponsored by: ACD   Advertisement Nature Ecology & Evolution publishes the best research from across the fields of ecology and evolutionary biology. Need access to content at your work place or institution?  Recommend institutional license access to your librarian.   Comment   (More) women in science    pp413 - 414 Fiona M. Watt doi:10.1038/s41580-018-0006-1 Fiona M. Watt at King’s College London Centre for Stem Cells and Regenerative Medicine (UK) discusses how gender balance in the scientific community is evolving.   Research Highlights   Overcoming obstacles to progression    p415 Eytan Zlotorynski doi:10.1038/s41580-018-0027-9 The spindle checkpoint complex BUB3–BUB1 facilitates telomere replication through recruitment of the helicase BLM, and the telomere capping protein TRF2 promotes replication at pericentromeres by recruiting the helicase RTEL1; both helicases resolve G-quadruplex structures.   A self-made quiescent niche    pp416 - 417 Kim Baumann doi:10.1038/s41580-018-0031-0 Muscle stem cells produce collagen V, which becomes a component of the niche that promotes their quiescence.   EpiTOFing ageing    pp416 - 417 Grant Otto doi:10.1038/s41580-018-0026-x EpiTOF characterized the epigenetic landscape of various types of single immune cells and revealed that their heterogeneity increases with age.   The beginning of totipotency    p417 Kikuë Tachibana doi:10.1038/s41580-018-0017-y Kikuë Tachibana discusses some of the key findings of the seminal works of Sir John Gurdon on nuclear reprogramming and how, by being examples of scientific rigour, they have inspired her own research.   Nature Reviews Molecular Cell Biology JOBS of the week PhD Candidate position University Medical Center Göttingen Clinic for Cardiology and Pneumology Postdoctoral Fellow University of Colorado Anschutz Medical Campus Head of School of Biosciences Birmingham University More Science jobs from Nature Reviews Molecular Cell Biology EVENT 15th International Symposium "Horizons in Molecular Biology" 10.09.18 Goettingen, Germany More science events from Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    Reviews   Contextual determinants of TGFβ action in development, immunity and cancer    pp419 - 435 Charles J. David & Joan Massagué doi:10.1038/s41580-018-0007-0 Transforming growth factor-β (TGFβ) family cytokines are important regulators of cell fate with pleiotropic roles in development, tissue homeostasis, regeneration and tumorigenesis. Recent studies revealed that this context dependency relies on the convergence between TGFβ signals and other contextual inputs, whereby transcription factors downstream of these pathways collaboratively act to regulate gene expression.   Dynamics of the epigenetic landscape during the maternal-to-zygotic transition    pp436 - 450 Melanie A. Eckersley-Maslin, Celia Alda-Catalinas & Wolf Reik doi:10.1038/s41580-018-0008-z The maternal-to-zygotic transition (MZT) is defined as the transition from maternal gene expression in the oocyte to zygotic genome activation and embryonic-driven development. Recent studies have improved our understanding of the dynamics of the MZT, which is characterized by global DNA demethylation, chromatin remodelling, genome reorganization and substantial transcriptional changes.   Microtubule dynamics: an interplay of biochemistry and mechanics    pp451 - 463 Gary J. Brouhard & Luke M. Rice doi:10.1038/s41580-018-0009-y Microtubules are highly dynamic tubulin polymers, and their dynamics are associated with a conformational cycle of individual tubulin subunits in the lattice. Recent evidence suggests that fine-tuning microtubule dynamics is enabled by the allosteric coupling of tubulin subunits, which propagates conformational changes through the lattice.   Born to run: control of transcription elongation by RNA polymerase II    pp464 - 478 Fei Xavier Chen, Edwin R. Smith & Ali Shilatifard doi:10.1038/s41580-018-0010-5 Transcription elongation by RNA polymerase II (Pol II) involves pausing of Pol II at promoter-proximal regions. Pol II release into gene bodies (productive elongation) is controlled by many transcription-specific factors, enhancers and factors that are canonically associated with genome maintenance.   Amendments & Corrections   Publisher Correction: Contextual determinants of TGFβ action in development, immunity and cancer    p479 Charles J. David & Joan Massagué doi:10.1038/s41580-018-0018-x Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes    p479 Samara L. Reck-Peterson, William B. Redwine, Ronald D. Vale & Andrew P. Carter doi:10.1038/s41580-018-0021-2 Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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