Tuesday, June 26, 2018

Nature Reviews Immunology Contents June 2018 Volume 18 Number 7 pp 417-478

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Nature Reviews Immunology

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July 2018 Volume 18, Issue 7

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Calming the cytokine storm    p417
Lucy Bird

Two papers show that combining IL-1 blockade with chimeric antigen receptor T cell therapy for cancer can prevent the induction of a potentially lethal ‘cytokine storm’.


LC3 anchors TLR9 signalling    pp418 - 419
Kirsty Minton

TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKK╬▒ to a signalling platform anchored by the autophagy protein LC3.


Cheating cell death    pp418 - 419
Kirsty Minton

AHR ensures cells rest in peace    p419
Yvonne Bordon

Activation of aryl hydrocarbon receptor in phago cytes during apoptotic cell uptake induces an anti-inflammatory response.


T cell balancing act in TB    pp420 - 421
Grant Otto

CYPD regulates the host response to tuberculosis infection through modulating T cell metabolism.


High-fibre diet beats flu    pp420 - 421
Lucy Bird

A high-fibre diet protects against influenza virus infection by limiting lung immunopathology and enhancing antiviral T cell responses.


Starvation suppresses T cell appetite    p421
Gabrielle Belz

Gabrielle Belz describes a 2002 paper by Iyer et al. that linked cellular nutrient levels in cytotoxic T cells with their ability to mount a vigorous response.


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Clocking in to immunity    pp423 - 437
Christoph Scheiermann, Julie Gibbs, Louise Ince & Andrew Loudon

This Review considers the importance of the core circadian clock for regulating both innate and adaptive immune cell responses. The authors consider the implications for vaccination and other clinical strategies, highlighting the emerging field of chrono-immunotherapy.


A cold-blooded view of adaptive immunity    pp438 - 453
Martin F. Flajnik

Adaptive immunity arose 500 million years ago in cold-blooded vertebrates. Here, Martin Flajnik discusses how recent discoveries in fish, amphibians and reptiles have improved our understanding of the origins and functions of adaptive immune systems.


Targeting cytokines to treat asthma and chronic obstructive pulmonary disease    pp454 - 466
Peter J. Barnes

Drugs that target the cytokines that drive asthma and chronic obstructive pulmonary disease offer relief to some people with these diseases. However, as discussed here, further success will require a better understanding of the disease mechanisms and selection of the right drug for the right patient.


Understanding the drivers of MHC restriction of T cell receptors    pp467 - 478
Nicole L. La Gruta, Stephanie Gras, Stephen R. Daley, Paul G. Thomas & Jamie Rossjohn

Jamie Rossjohn and colleagues review the structural and functional data that provide insight into the MHC restriction of T cell receptors. They discuss the non-mutually exclusive contributions of intrinsic germline-encoded motifs and developmental selection to MHC restriction.


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