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nature.com webcasts Nature Research Custom Media presents a webcast on: Combining scRNA-seq and Flow Analyses Date: Tuesday, July 24, 2018 Join our webcast to learn how fluorescence intensity information from flow parameters can be merged into a single-cell RNA expression matrix and analysed. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: SeqGeq | | | |
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TABLE OF CONTENTS
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July 2018 Volume 18, Issue 7 |
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| Research Highlights Reviews | | Advertisement | | | | One of the most important ingredients in breast milk you've never heard of Nutrition matters, and early diet has life-long effects. So how are indigestible molecules in breast milk helping ensure the healthiest start for both breast-fed and formula-fed babies? Read now Produced for Abbott by Nature Research Custom Media Content intended for healthcare professionals. | | | | |
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Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! | | | |
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Research Highlights | |
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| | Calming the cytokine storm p417 Lucy Bird doi:10.1038/s41577-018-0030-6 Two papers show that combining IL-1 blockade with chimeric antigen receptor T cell therapy for cancer can prevent the induction of a potentially lethal ‘cytokine storm’. | | | | LC3 anchors TLR9 signalling pp418 - 419 Kirsty Minton doi:10.1038/s41577-018-0019-1 TLR9-mediated signalling induces type I IFN production through the direct recruitment of IKKα to a signalling platform anchored by the autophagy protein LC3. | | | | Cheating cell death pp418 - 419 Kirsty Minton doi:10.1038/s41577-018-0026-2 | | | | AHR ensures cells rest in peace p419 Yvonne Bordon doi:10.1038/s41577-018-0022-6 Activation of aryl hydrocarbon receptor in phago cytes during apoptotic cell uptake induces an anti-inflammatory response. | | | | T cell balancing act in TB pp420 - 421 Grant Otto doi:10.1038/s41577-018-0023-5 CYPD regulates the host response to tuberculosis infection through modulating T cell metabolism. | | | | High-fibre diet beats flu pp420 - 421 Lucy Bird doi:10.1038/s41577-018-0024-4 A high-fibre diet protects against influenza virus infection by limiting lung immunopathology and enhancing antiviral T cell responses. | | | | Starvation suppresses T cell appetite p421 Gabrielle Belz doi:10.1038/s41577-018-0021-7 Gabrielle Belz describes a 2002 paper by Iyer et al. that linked cellular nutrient levels in cytotoxic T cells with their ability to mount a vigorous response. | | | | | |
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nature.com webcasts Nature Research Custom Media presents a webcast on: Practical Considerations for T Cell Receptor (TCR) Therapies Targeting Solid Tumors Date: Tuesday, July 17, 2018 Join the webcast to learn about the advantages of automated cell cloning and methods for rapid cloning and validation of functional TCRs. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: Berkeley Lights Inc | | |
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Reviews | |
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Clocking in to immunity pp423 - 437 Christoph Scheiermann, Julie Gibbs, Louise Ince & Andrew Loudon doi:10.1038/s41577-018-0008-4 This Review considers the importance of the core circadian clock for regulating both innate and adaptive immune cell responses. The authors consider the implications for vaccination and other clinical strategies, highlighting the emerging field of chrono-immunotherapy. |
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A cold-blooded view of adaptive immunity pp438 - 453 Martin F. Flajnik doi:10.1038/s41577-018-0003-9 Adaptive immunity arose 500 million years ago in cold-blooded vertebrates. Here, Martin Flajnik discusses how recent discoveries in fish, amphibians and reptiles have improved our understanding of the origins and functions of adaptive immune systems. |
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Targeting cytokines to treat asthma and chronic obstructive pulmonary disease pp454 - 466 Peter J. Barnes doi:10.1038/s41577-018-0006-6 Drugs that target the cytokines that drive asthma and chronic obstructive pulmonary disease offer relief to some people with these diseases. However, as discussed here, further success will require a better understanding of the disease mechanisms and selection of the right drug for the right patient. |
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Understanding the drivers of MHC restriction of T cell receptors pp467 - 478 Nicole L. La Gruta, Stephanie Gras, Stephen R. Daley, Paul G. Thomas & Jamie Rossjohn doi:10.1038/s41577-018-0007-5 Jamie Rossjohn and colleagues review the structural and functional data that provide insight into the MHC restriction of T cell receptors. They discuss the non-mutually exclusive contributions of intrinsic germline-encoded motifs and developmental selection to MHC restriction. |
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| | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | |
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