Nature Reviews Drug Discovery contents July 2018 Volume 17 Number 7 pp 455-527

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Advertisement On the Pathway to Discovery, All Signals Are Clear What if you could get high quality results without the hassle? Our wide range of assay solutions makes it easier to take an orthogonal approach to your cell-based assays, glean more biologically relevant information, and get to breakthroughs faster. Learn More TABLE OF CONTENTS July 2018 Volume 17, Issue 7 Comment News and Analysis Research Highlights Reviews   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Submit your abstract for the RNA at the Bench and Bedside conference by July 30. This conference will cover the numerous roles of RNAs and the efforts to translate advances in the basic science into new therapies. It will address the opportunities, current status, and the future of this exciting field. View the draft program for more details. Remember to register before submitting your abstract.   Comment   Translating translation    pp455 - 456 Christopher P. Austin doi:10.1038/nrd.2018.27 The term 'translation' has emerged as a dominant concept in biomedical science over the last decade, but confusion around what the term means, and how it differs from translational research and translational science, is common. This article aims to help address this issue by clarifying the distinctions. News and Analysis   First GPCR-directed antibody passes approval milestone    pp457 - 459 Elie Dolgin doi:10.1038/nrd.2018.103 News in Brief FDA approves Eli Lilly's baricitinib    p460 Asher Mullard doi:10.1038/nrd.2018.112 mRNA vaccines get another booster    p460 Asher Mullard doi:10.1038/nrd.2018.113 Ebola outbreak prompts experimental drug rollout    p460 Asher Mullard doi:10.1038/nrd.2018.114 Biobusiness Briefs Market watch: Upcoming catalysts in Q3 2018    p461 Karen Nguyen doi:10.1038/nrd.2018.108 An Audience With Amy Abernethy    pp462 - 464 doi:10.1038/nrd.2018.101 Amy Abernethy, CSO at Flatiron Health, talks about how cleaned up and curated real-world data stands to transform clinical trials, drug regulation, competition in the health-care market and drug prices. From the analyst's couch The global landscape of cancer cell therapy    pp465 - 466 Jun Tang, Vanessa M. Hubbard-Lucey, Laura Pearce, Jill O'Donnell-Tormey & Aiman Shalabi doi:10.1038/nrd.2018.74 How many cancer cell therapies are being developed? To harmonize efforts in this arena, the Cancer Research Institute has curated a database that includes all cell therapies in development. Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Research Highlights   Stroke: Opening the therapeutic window    p467 Sarah Crunkhorn doi:10.1038/nrd.2018.98 Cancer: Re-educating tumour-associated macrophages with nanoparticles    p468 Megan Cully doi:10.1038/nrd.2018.102 Infectious diseases: The painful path to avoiding the immune system    p469 M. Teresa Villanueva doi:10.1038/nrd.2018.100 Lead identification: The importance of residual complexity    p470 Rebecca Kelsey doi:10.1038/nrd.2018.104 In Brief Cancer: Minimizing metastasis    p470 Sarah Crunkhorn doi:10.1038/nrd.2018.105 Infectious disease: Alphavirus receptor identified    p470 Sarah Crunkhorn doi:10.1038/nrd.2018.106 Autoimmune disease: Aryl hydrocarbon receptor suppresses inflammation    p470 Sarah Crunkhorn doi:10.1038/nrd.2018.107 Drug Discovery JOBS of the week In Vivo Scientist / Sr Research Associate, PDX Model- Oncology AstraZeneca Postdoctoral Research Fellowship- Drug Addiction / Cognitive Neuroscience National Institute on Drug Abuse (NIDA) Postdoctoral Research Scientist Johns Hopkins University Postdoctoral Research Associate Stowers Institute for Medical Research Postdoctoral Fellow Position Vanderbilt University Medical Center More Science jobs from Drug Discovery EVENT Keystone Symposia: 21st Century Drug Discovery and Development for Global Health 17.10.18 Berlin, Germany More science events from Reviews   Cryo-EM in drug discovery: achievements, limitations and prospects    pp471 - 492 Jean-Paul Renaud, Ashwin Chari, Claudio Ciferri, Wen-ti Liu, Hervé-William Rémigy et al. doi:10.1038/nrd.2018.77 Recent technological advances with cryo-electron microscopy (cryo-EM) — a biophysical technique that can be used to determine the structure of biological macromolecules and assemblies — have raised hopes that it might soon become an important tool for drug discovery, particularly for 'intractable' targets that are still not accessible to analysis by X-ray crystallography. This article describes these advances and critically assesses their relevance for drug discovery. Advances and innovations in haemophilia treatment    pp493 - 508 Rob Peters & Tim Harris doi:10.1038/nrd.2018.70 New therapies in development for haemophilia — including gene therapies, proteins with extended half-lives and inhibitors of natural anticoagulants — look poised to change the management of this disease. In this Review, Peters and Harris discuss recent progress, including the hurdles that still need to be overcome in order to translate these advances into routine clinical use. The promise and challenges of immune agonist antibody development in cancer    pp509 - 527 Patrick A. Mayes, Kenneth W. Hance & Axel Hoos doi:10.1038/nrd.2018.75 Co-stimulatory receptors mediate the anticancer immune response. This Review discusses the current efforts in targeting co-stimulatory receptors with agonist antibodies and the landscape of agonist antibodies in clinical development for cancer treatment. Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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