Nature Medicine Contents: June 2018 Volume 24 Number 6 pp 691-880

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Advertisement Nature Outlook: Huntington's Disease There is fresh hope for treating Huntington's disease, an inherited neurodegenerative condition. But biological mysteries remain. Access free online Produced with support from F.Hoffmann-La Roche   TABLE OF CONTENTS June 2018 Volume 24, Issue 6 Editorial News Feature Correspondence Research Highlights News & Views Review Articles Brief Communications Letters Articles Resources   Advertisement Innovations In: The Biggest Questions in Science Read our new special report on the nature of spacetime, the origin of life, the source of consciousness, and other fundamental questions in science.  Access free online Produced with support from The Kavli Prize   Advertisement Al-Sumait Prize Call for Nominations  Nominations are now open for the $1Million 2018 Health Category of Al-Sumait Prize for African Development. Nominations are accepted for Institutions or Individuals advancing Health in Africa. The nominations period closes on June 30 2018. Conditions, requirements and a link to the nomination form can be found below.  Nominate here    Advertisement Key Advances in Medicine eBook from Nature Reviews - FREE to download!   This essential resource summarizes the ground-breaking clinical and biomedical discoveries of 2017 and highlights the trends to watch out for in 2018, making it a must read eBook for anyone with an interest in medical science. Download for free     Advertisement One of the most important ingredients in breast milk you've never heard of Nutrition matters, and early diet has life-long effects. So how are indigestible molecules in breast milk helping ensure the healthiest start for both breast-fed and formula-fed babies?  Read now  Produced for Abbott by Nature Research Custom Media Content intended for healthcare professionals.   Editorial   Potential and ethics    p691 doi:10.1038/s41591-018-0072-0 News Feature   What models eat    pp692 - 695 Daniel Engber doi:10.1038/s41591-018-0055-1 About time    pp696 - 698 Shraddha Chakradhar doi:10.1038/s41591-018-0069-8 Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    Correspondence   Impact of neutralizing antibodies against AAV is a key consideration in gene transfer to nonhuman primates    p699 Weidong Xiao, Guangping Gao, Chen Ling, Roland W. Herzog, Xiao Xiao et al. doi:10.1038/s41591-018-0062-2 Wang et al. reply    pp700 - 701 Pi-Xiao Wang, Guang-Nian Zhao, Yan-Xiao Ji, Peng Zhang, Xiao-Jing Zhang et al. doi:10.1038/s41591-018-0063-1 Advertisement Searching for a new career?  At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do   Research Highlights   CRISPR-based diagnostics    p702 Hannah Stower doi:10.1038/s41591-018-0073-z Tracing clear cell renal carcinoma evolution    p702 Hannah Stower doi:10.1038/s41591-018-0074-y Zika virus shedding in semen    p702 Hannah Stower doi:10.1038/s41591-018-0075-x Training neuropathology    p702 Hannah Stower doi:10.1038/s41591-018-0076-9 In utero correction of a genetic disorder    p702 Hannah Stower doi:10.1038/s41591-018-0077-8 Medicine JOBS of the week Academic Position in Cancer Research Cedars Sinai Medical Center Post Doctoral Associate Weill Cornell Medicine Postdoctoral Research Associate-Stem Cell and Cancer Biology University of North Texas Health Science Center PhD Position in Health / Biomedical Sciences University of Auckland Postdoctoral Fellow Johns Hopkins University More Science jobs from Medicine EVENT International Conference on Surgery and Medicine 16.07.18 Bangkok, Thailand More science events from News & Views   Targeting the cancer mutanome of breast cancer    pp703 - 704 Laszlo G. Radvanyi doi:10.1038/s41591-018-0065-z Modeling cytokine release syndrome    pp705 - 706 Cliona Rooney & Tim Sauer doi:10.1038/s41591-018-0068-9 Intersection of schizophrenia genetics and placental complications    pp707 - 708 Margaret M. McCarthy doi:10.1038/s41591-018-0066-y Reducing diabetes risk at an early age    pp708 - 710 Daniel S. Hsia & Steven B. Heymsfield doi:10.1038/s41591-018-0067-x Review Articles   Myeloid cell contributions to cardiovascular health and disease    pp711 - 720 Matthias Nahrendorf doi:10.1038/s41591-018-0064-0 The precise link between macrophages and cardiovascular disease is emerging from mouse studies and clinical trials, providing new therapeutic avenues.   Brief Communications   Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys    pp721 - 723 Peter Abbink, Rafael A. Larocca, Wanwisa Dejnirattisai, Rebecca Peterson, Joseph P. Nkolola et al. doi:10.1038/s41591-018-0056-0 A single monoclonal antibody is therapeutic and has prophylactic activity against Zika virus in monkeys.   Letters   Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer    pp724 - 730 Nikolaos Zacharakis, Harshini Chinnasamy, Mary Black, Hui Xu, Yong-Chen Lu et al. doi:10.1038/s41591-018-0040-8 Adoptive T cell therapy induced complete and durable remission in a patient with refractory metastatic breast cancer, providing proof of principle for this approach in breast cancer therapy.   CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade    pp731 - 738 Theodoros Giavridis, Sjoukje J. C. van der Stegen, Justin Eyquem, Mohamad Hamieh, Alessandra Piersigilli et al. doi:10.1038/s41591-018-0041-7 Blocking IL-1 and iNOS prevents CAR T cell–induced cytokine release syndrome.   Articles   Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells    pp739 - 748 Margherita Norelli, Barbara Camisa, Giulia Barbiera, Laura Falcone, Ayurzana Purevdorj et al. doi:10.1038/s41591-018-0036-4 IL-1 blockade prevents cytokine-release syndrome and neurotoxicity by CAR T cells.   Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma    pp749 - 757 David F. McDermott, Mahrukh A. Huseni, Michael B. Atkins, Robert J. Motzer, Brian I. Rini et al. doi:10.1038/s41591-018-0053-3 An exploratory randomized controlled clinical trial of renal cell carcinoma identifies molecular patterns distinguishing responders to immune checkpoint blockade alone or combined with angiogenesis inhibitor versus angiogenesis inhibitor alone.   Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy    pp758 - 769 Lu Wang, Zibo Zhao, Patrick A. Ozark, Damiano Fantini, Stacy A. Marshall et al. doi:10.1038/s41591-018-0034-6 Interactions between the MLL3 histone methyltransferase and the BAP1–UTX complex set the level of histone H3K27 methylation and suggest a new therapy for MLL3-mutant cancer.   Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle    pp770 - 781 Gang Wang, Anup K. Biswas, Wanchao Ma, Manoj Kandpal, Courtney Coker et al. doi:10.1038/s41591-018-0054-2 Accumulation of zinc in muscle cells resulting from transcriptional upregulation of metal transporter ZIP14 causes muscle atrophy and promotes cachexia in metastatic cancer.   Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche    pp782 - 791 Maria Maryanovich, Ali H. Zahalka, Halley Pierce, Sandra Pinho, Fumio Nakahara et al. doi:10.1038/s41591-018-0030-x Loss of sympathetic nerve innervention of the bone marrow contributes to the aging of hematopoietic stem cells, which can be rejuvenated using an adrenergic receptor agonist.   Convergence of placenta biology and genetic risk for schizophrenia    pp792 - 801 Gianluca Ursini, Giovanna Punzi, Qiang Chen, Stefano Marenco, Joshua F. Robinson et al. doi:10.1038/s41591-018-0021-y Early-life complications modulate the association of genomic risk and schizophrenia.   Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome    pp802 - 813 Norifumi Shioda, Yasushi Yabuki, Kouya Yamaguchi, Misaki Onozato, Yue Li et al. doi:10.1038/s41591-018-0018-6 In a mouse model of intellectual disability, the chromatin remodeling protein ATR-X is shown to bind to G-quadruplex DNA structures and modulate target gene expression, which can be pharmacologically targeted to restore neuronal and cognitive phenotypes in these animals.   An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling    pp814 - 822 Heejin Jun, Hui Yu, Jianke Gong, Juan Jiang, Xiaona Qiao et al. doi:10.1038/s41591-018-0032-8 Inhibition of immune cell–derived acetylcholine synthesis or of its signaling via CHRNA2 in beige adipocytes reduces thermogenesis and exacerbates diet-induced obesity, suggesting a new mode of immuno–fat communication in energy metabolism.   Targeting skeletal endothelium to ameliorate bone loss    pp823 - 833 Ren Xu, Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin et al. doi:10.1038/s41591-018-0020-z Recombinant SLIT3 represents a new mechanistic approach to treating osteoporosis by increasing skeletal CD31hiEMCNhi vascular endothelium.   Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood    pp834 - 846 Brooke Tata, Nour El Houda Mimouni, Anne-Laure Barbotin, Samuel A. Malone, Anne Loyens et al. doi:10.1038/s41591-018-0035-5 Excess anti-Müllerian hormone during pregnancy results in polycystic ovary syndrome-like phenotypes in female offspring, possibly explaining its pathogenesis as well as suggesting a possible therapy.   HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition    pp847 - 856 Monica Vaccari, Slim Fourati, Shari N. Gordon, Dallas R. Brown, Massimilano Bissa et al. doi:10.1038/s41591-018-0025-7 Distinct monocyte subsets associate with different outcomes of SIV vaccines.   Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1    pp857 - 867 Kai Xu, Priyamvada Acharya, Rui Kong, Cheng Cheng, Gwo-Yu Chuang et al. doi:10.1038/s41591-018-0042-6 An alternative HIV vaccine design facilitates generation of HIV-1-antibodies, with promising neutralization breadth in rodents and nonhuman primates.   Resources   The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia    pp868 - 880 Renée Beekman, Vicente Chapaprieta, Núria Russiñol, Roser Vilarrasa-Blasi, Núria Verdaguer-Dot et al. doi:10.1038/s41591-018-0028-4 An integrated resource of (epi)genomic features in annotated chronic lymphocytic leukemia (CLL) primary samples uncovers subgroup-specific regulatory alterations associated with clinical behavior.   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. 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