Thursday, June 7, 2018

Nature Medicine Contents: June 2018 Volume 24 Number 6 pp 691-880

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Nature Medicine

Nature Outlook: Huntington's Disease

There is fresh hope for treating Huntington's disease, an inherited neurodegenerative condition. But biological mysteries remain.

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Produced with support from
F.Hoffmann-La Roche

June 2018 Volume 24, Issue 6

News Feature
Research Highlights
News & Views
Review Articles
Brief Communications
Innovations In: The Biggest Questions in Science

Read our new special report on the nature of spacetime, the origin of life, the source of consciousness, and other fundamental questions in science. 

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Produced with support from
The Kavli Prize


Al-Sumait Prize Call for Nominations 

Nominations are now open for the $1Million 2018 Health Category of Al-Sumait Prize for African Development. Nominations are accepted for Institutions or Individuals advancing Health in Africa. The nominations period closes on June 30 2018. Conditions, requirements and a link to the nomination form can be found below. 

Nominate here 
Key Advances in Medicine eBook from Nature Reviews - FREE to download!
This essential resource summarizes the ground-breaking clinical and biomedical discoveries of 2017 and highlights the trends to watch out for in 2018, making it a must read eBook for anyone with an interest in medical science.

Download for free

One of the most important ingredients in breast milk you've never heard of

Nutrition matters, and early diet has life-long effects. So how are indigestible molecules in breast milk helping ensure the healthiest start for both breast-fed and formula-fed babies? 

Read now 

Produced for Abbott by Nature Research Custom Media

Content intended for healthcare professionals.



Potential and ethics    p691

News Feature


What models eat    pp692 - 695
Daniel Engber

About time    pp696 - 698
Shraddha Chakradhar

Do you have a career question? 

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today! 



Impact of neutralizing antibodies against AAV is a key consideration in gene transfer to nonhuman primates    p699
Weidong Xiao, Guangping Gao, Chen Ling, Roland W. Herzog, Xiao Xiao et al.

Wang et al. reply    pp700 - 701
Pi-Xiao Wang, Guang-Nian Zhao, Yan-Xiao Ji, Peng Zhang, Xiao-Jing Zhang et al.

Searching for a new career? 

At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you.

Visit our research editorial and publishing careers website to discover more about what we do

Research Highlights


CRISPR-based diagnostics    p702
Hannah Stower

Tracing clear cell renal carcinoma evolution    p702
Hannah Stower

Zika virus shedding in semen    p702
Hannah Stower

Training neuropathology    p702
Hannah Stower

In utero correction of a genetic disorder    p702
Hannah Stower

JOBS of the week
Academic Position in Cancer Research
Cedars Sinai Medical Center
Post Doctoral Associate
Weill Cornell Medicine
Postdoctoral Research Associate-Stem Cell and Cancer Biology
University of North Texas Health Science Center
PhD Position in Health / Biomedical Sciences
University of Auckland
Postdoctoral Fellow
Johns Hopkins University
More Science jobs from
International Conference on Surgery and Medicine
Bangkok, Thailand
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News & Views


Targeting the cancer mutanome of breast cancer    pp703 - 704
Laszlo G. Radvanyi

Modeling cytokine release syndrome    pp705 - 706
Cliona Rooney & Tim Sauer

Intersection of schizophrenia genetics and placental complications    pp707 - 708
Margaret M. McCarthy

Reducing diabetes risk at an early age    pp708 - 710
Daniel S. Hsia & Steven B. Heymsfield

Review Articles


Myeloid cell contributions to cardiovascular health and disease    pp711 - 720
Matthias Nahrendorf

The precise link between macrophages and cardiovascular disease is emerging from mouse studies and clinical trials, providing new therapeutic avenues.


Brief Communications


Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys    pp721 - 723
Peter Abbink, Rafael A. Larocca, Wanwisa Dejnirattisai, Rebecca Peterson, Joseph P. Nkolola et al.

A single monoclonal antibody is therapeutic and has prophylactic activity against Zika virus in monkeys.




Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer    pp724 - 730
Nikolaos Zacharakis, Harshini Chinnasamy, Mary Black, Hui Xu, Yong-Chen Lu et al.

Adoptive T cell therapy induced complete and durable remission in a patient with refractory metastatic breast cancer, providing proof of principle for this approach in breast cancer therapy.


CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade    pp731 - 738
Theodoros Giavridis, Sjoukje J. C. van der Stegen, Justin Eyquem, Mohamad Hamieh, Alessandra Piersigilli et al.

Blocking IL-1 and iNOS prevents CAR T cell–induced cytokine release syndrome.




Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells    pp739 - 748
Margherita Norelli, Barbara Camisa, Giulia Barbiera, Laura Falcone, Ayurzana Purevdorj et al.

IL-1 blockade prevents cytokine-release syndrome and neurotoxicity by CAR T cells.


Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma    pp749 - 757
David F. McDermott, Mahrukh A. Huseni, Michael B. Atkins, Robert J. Motzer, Brian I. Rini et al.

An exploratory randomized controlled clinical trial of renal cell carcinoma identifies molecular patterns distinguishing responders to immune checkpoint blockade alone or combined with angiogenesis inhibitor versus angiogenesis inhibitor alone.


Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy    pp758 - 769
Lu Wang, Zibo Zhao, Patrick A. Ozark, Damiano Fantini, Stacy A. Marshall et al.

Interactions between the MLL3 histone methyltransferase and the BAP1–UTX complex set the level of histone H3K27 methylation and suggest a new therapy for MLL3-mutant cancer.


Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle    pp770 - 781
Gang Wang, Anup K. Biswas, Wanchao Ma, Manoj Kandpal, Courtney Coker et al.

Accumulation of zinc in muscle cells resulting from transcriptional upregulation of metal transporter ZIP14 causes muscle atrophy and promotes cachexia in metastatic cancer.


Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche    pp782 - 791
Maria Maryanovich, Ali H. Zahalka, Halley Pierce, Sandra Pinho, Fumio Nakahara et al.

Loss of sympathetic nerve innervention of the bone marrow contributes to the aging of hematopoietic stem cells, which can be rejuvenated using an adrenergic receptor agonist.


Convergence of placenta biology and genetic risk for schizophrenia    pp792 - 801
Gianluca Ursini, Giovanna Punzi, Qiang Chen, Stefano Marenco, Joshua F. Robinson et al.

Early-life complications modulate the association of genomic risk and schizophrenia.


Targeting G-quadruplex DNA as cognitive function therapy for ATR-X syndrome    pp802 - 813
Norifumi Shioda, Yasushi Yabuki, Kouya Yamaguchi, Misaki Onozato, Yue Li et al.

In a mouse model of intellectual disability, the chromatin remodeling protein ATR-X is shown to bind to G-quadruplex DNA structures and modulate target gene expression, which can be pharmacologically targeted to restore neuronal and cognitive phenotypes in these animals.


An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling    pp814 - 822
Heejin Jun, Hui Yu, Jianke Gong, Juan Jiang, Xiaona Qiao et al.

Inhibition of immune cell–derived acetylcholine synthesis or of its signaling via CHRNA2 in beige adipocytes reduces thermogenesis and exacerbates diet-induced obesity, suggesting a new mode of immuno–fat communication in energy metabolism.


Targeting skeletal endothelium to ameliorate bone loss    pp823 - 833
Ren Xu, Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin et al.

Recombinant SLIT3 represents a new mechanistic approach to treating osteoporosis by increasing skeletal CD31hiEMCNhi vascular endothelium.


Elevated prenatal anti-Müllerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood    pp834 - 846
Brooke Tata, Nour El Houda Mimouni, Anne-Laure Barbotin, Samuel A. Malone, Anne Loyens et al.

Excess anti-Müllerian hormone during pregnancy results in polycystic ovary syndrome-like phenotypes in female offspring, possibly explaining its pathogenesis as well as suggesting a possible therapy.


HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition    pp847 - 856
Monica Vaccari, Slim Fourati, Shari N. Gordon, Dallas R. Brown, Massimilano Bissa et al.

Distinct monocyte subsets associate with different outcomes of SIV vaccines.


Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1    pp857 - 867
Kai Xu, Priyamvada Acharya, Rui Kong, Cheng Cheng, Gwo-Yu Chuang et al.

An alternative HIV vaccine design facilitates generation of HIV-1-antibodies, with promising neutralization breadth in rodents and nonhuman primates.




The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia    pp868 - 880
Renée Beekman, Vicente Chapaprieta, Núria Russiñol, Roser Vilarrasa-Blasi, Núria Verdaguer-Dot et al.

An integrated resource of (epi)genomic features in annotated chronic lymphocytic leukemia (CLL) primary samples uncovers subgroup-specific regulatory alterations associated with clinical behavior.


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