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Your Science Matters™. > Learn more about Olympus microscopes | | | | | | | | | Advertisement | | Princeton University, Princeton Institute for the Science and Technology of Materials (PRISM), Nature Communications, Nature Materials, Nature Structural & Molecular Biology present: Princeton — Nature Conference: Frontiers in Electron Microscopy for the Physical and Life Sciences July 11-13, 2018, Princeton University, Princeton, NJ, USA Register now to secure your place. | | | | | | Advertisement | | nature.com webcasts Nature Research Custom Media presents a webcast on: Ultra-Sensitive Immunoassays: Beyond Biomarkers and into PK and Immunogenicity Date: Thursday, June 21, 2018 Dr. Daniel Sikkema, Vice President of Quanterix will present the latest advances in biomarker testing and how to solve drug tolerance and characterization issues for immunogenicity. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: Quanterix | | | | | | | Nature Communications - fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | Latest Articles | View all Articles | | | Hot-electron transfer in quantum-dot heterojunction films OPEN | | Gianluca Grimaldi, Ryan W. Crisp, Stephanie ten Brinck, Felipe Zapata, Michiko van Ouwendorp, Nicolas Renaud, Nicholas Kirkwood, Wiel H. Evers, Sachin Kinge, Ivan Infante, Laurens D. A. Siebbeles & Arjan J. Houtepen | | Efficient use of high-energy, or “hot”, carriers could increase the efficiency of solar cells, provided efficient extraction of electrons at a specific energy. Here, the authors show the presence of hot-electron transfer between two quantum dot species, allowing facile optimization of the extraction energy. | | 13 June 2018 | doi: 10.1038/s41467-018-04623-9 | | Electronic properties and materials Quantum dots Solar cells | A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes OPEN | | Evangelia K. Papachristou, Kamal Kishore, Andrew N. Holding, Kate Harvey, Theodoros I. Roumeliotis, Chandra Sekhar Reddy Chilamakuri, Soleilmane Omarjee, Kee Ming Chia, Alex Swarbrick, Elgene Lim, Florian Markowetz, Matthew Eldridge, Rasmus Siersbaek, Clive S. D’Santos & Jason S. Carroll | | Chromatin-associated protein complexes play a critical role in the regulation of gene expression in health and disease. Here, the authors describe a sensitive mass spectrometry-based method to monitor the dynamic interactions of endogenous chromatin-associated protein complexes in clinical samples. | | 13 June 2018 | doi: 10.1038/s41467-018-04619-5 | | Breast cancer Immunoprecipitation Mass spectrometry Protein–protein interaction networks | Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels OPEN | | Wang Zheng, Xiaoyong Yang, Ruikun Hu, Ruiqi Cai, Laura Hofmann, Zhifei Wang, Qiaolin Hu, Xiong Liu, David Bulkey, Yong Yu, Jingfeng Tang, Veit Flockerzi, Ying Cao, Erhu Cao & Xing-Zhen Chen | | Mutations in the cation channel PKD2 cause human autosomal dominant polycystic kidney disease but its channel function and gating mechanism are poorly understood. Here authors study PKD2 using electrophysiology and cryo-EM, which identifies hydrophobic gates and proposes a gating mechanism for PKD2. | | 13 June 2018 | doi: 10.1038/s41467-018-04586-x | | Cryoelectron microscopy Molecular conformation Polycystic kidney disease | Controlled synthesis of highly-branched plasmonic gold nanoparticles through peptoid engineering OPEN | | Feng Yan, Lili Liu, Tiffany R. Walsh, Yu Gong, Patrick Z. El-Khoury, Yanyan Zhang, Zihua Zhu, James J. De Yoreo, Mark H. Engelhard, Xin Zhang & Chun-Long Chen | | Peptoids are promising crystallization agents, as they offer the molecular recognition capabilities of proteins and peptides but with higher stability and synthetic tunability. Here, the authors show that sequence-defined peptoids can controllably template the formation and shape evolution of gold nanostructures with defined morphologies. | | 13 June 2018 | doi: 10.1038/s41467-018-04789-2 | | Bioinspired materials Biomimetic synthesis Biomineralization Nanophotonics and plasmonics | Crossover from lattice to plasmonic polarons of a spin-polarised electron gas in ferromagnetic EuO OPEN | | J. M. Riley, F. Caruso, C. Verdi, L. B. Duffy, M. D. Watson, L. Bawden, K. Volckaert, G. van der Laan, T. Hesjedal, M. Hoesch, F. Giustino & P. D. C. King | | Many-body interactions in solids offer opportunities to realize striking physical properties. Here the authors demonstrate the formation of plasmonic polarons in Eu1-xGd x O and their tunability with charge carrier doping, providing a route to tailoring quantum many-body interactions in solid. | | 13 June 2018 | doi: 10.1038/s41467-018-04749-w | | Electronic properties and materials Magnetic properties and materials Surfaces, interfaces and thin films | High energy-density and reversibility of iron fluoride cathode enabled via an intercalation-extrusion reaction OPEN | | Xiulin Fan, Enyuan Hu, Xiao Ji, Yizhou Zhu, Fudong Han, Sooyeon Hwang, Jue Liu, Seongmin Bak, Zhaohui Ma, Tao Gao, Sz-Chian Liou, Jianming Bai, Xiao-Qing Yang, Yifei Mo, Kang Xu, Dong Su & Chunsheng Wang | | Poor electrochemical reversibility of the conversion-type cathode materials remains an important challenge for their practical applications. Here, the authors report a highly reversible fluoride cathode material with low hysteresis through concerted doping of cobalt and oxygen into iron fluoride. | | 13 June 2018 | doi: 10.1038/s41467-018-04476-2 | | Batteries | UBXN3B positively regulates STING-mediated antiviral immune responses OPEN | | Long Yang, Leilei Wang, Harshada Ketkar, Jinzhu Ma, Guang Yang, Shuang Cui, Tingting Geng, Dana G. Mordue, Toyoshi Fujimoto, Gong Cheng, Fuping You, Rongtuan Lin, Erol Fikrig & Penghua Wang | | The UBXN proteins are likely involved in a diverse range of biological processes, but their physiological functions remain largely unknown. Here the authors show that UBXN3B positively regulates STING-mediated immune responses in the context of viral infections. | | 13 June 2018 | doi: 10.1038/s41467-018-04759-8 | | Infection Innate immunity Viral host response Viral infection | On-surface synthesis of poly(p-phenylene ethynylene) molecular wires via in situ formation of carbon-carbon triple bond OPEN | | Chen-Hui Shu, Meng-Xi Liu, Ze-Qi Zha, Jin-Liang Pan, Shao-Ze Zhang, Yu-Li Xie, Jian-Le Chen, Ding-Wang Yuan, Xiao-Hui Qiu & Pei-Nian Liu | | Incorporating carbon-carbon triple bonds into conjugated chains typically requires acetylenic precursors. Here, the authors synthesize poly(p-phenylene ethynylene) molecular wires on Cu(111) by directly coupling trichloromethyl-containing precursors, forming C-C triple bonds in situ | | 13 June 2018 | doi: 10.1038/s41467-018-04681-z | | Materials chemistry Nanoscale materials Chemical synthesis | FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells OPEN | | Minh Binh Nguyen, Idan Cohen, Vinod Kumar, Zijian Xu, Carmit Bar, Katherine L. Dauber-Decker, Pai-Chi Tsai, Pauline Marangoni, Ophir D. Klein, Ya-Chieh Hsu, Ting Chen, Marja L. Mikkola & Elena Ezhkova | | Merkel cells are mechanoreceptors located in the epidermis whose developmental origin is unclear. Here the authors show that Merkel cells originate from SOX9 positive cells inside hair follicles and that FGFR2-mediated epithelial signalling is required for their specification. | | 13 June 2018 | doi: 10.1038/s41467-018-04399-y | | Differentiation Skin stem cells Stem-cell differentiation | Tuneable near white-emissive two-dimensional covalent organic frameworks OPEN | | Xing Li, Qiang Gao, Juefan Wang, Yifeng Chen, Zhi-Hui Chen, Hai-Sen Xu, Wei Tang, Kai Leng, Guo-Hong Ning, Jishan Wu, Qing-Hua Xu, Su Ying Quek, Yixin Lu & Kian Ping Loh | | Encoding functionalities in covalent organic frameworks (COFs) is important for widening their application field but the development of fluorescent COFs is hampered by a lack of guiding design principles. Here the authors demonstrate tuning and switching of the photoluminescence in 2D COFs made of non-emissive building blocks. | | 13 June 2018 | doi: 10.1038/s41467-018-04769-6 | | Organic molecules in materials science Structural properties Supramolecular polymers | Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes OPEN | | Viktoria Gusarova , Colm O’Dushlaine, Tanya M. Teslovich, Peter N. Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V. Van Hout, Michael F. Murray, Anubha Mahajan, Jonas B. Nielsen, Lars Fritsche, Anders Berg Wulff, Daniel F. Gudbjartsson, Marketa Sjögren, Connor A. Emdin, Robert A. Scott, Wen-Jane Lee, Aeron Small, Lydia C. Kwee, Om Prakash Dwivedi et al. | | Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4−/− mice on a high-fat diet show improved insulin sensitivity. | | 13 June 2018 | doi: 10.1038/s41467-018-04611-z | | Diabetes Genetic association study Genetics research Type 2 diabetes | Near infrared light induced plasmonic hot hole transfer at a nano-heterointerface OPEN | | Zichao Lian, Masanori Sakamoto, Hironori Matsunaga, Junie Jhon M. Vequizo, Akira Yamakata, Mitsutaka Haruta, Hiroki Kurata, Wataru Ota, Tohru Sato & Toshiharu Teranishi | | Hot hole transfer has applications in plasmonics, photocatalysis, and light harvesting, but is often limited by low quantum yields and short-lived charge separation times. Here, Lian et al. overcome these limitations in heterostructured nanocrystals and proposed a new hot hole transfer mechanism. | | 13 June 2018 | doi: 10.1038/s41467-018-04630-w | | Energy transfer Light harvesting Nanoparticles Nanophotonics and plasmonics | Soft transparent graphene contact lens electrodes for conformal full-cornea recording of electroretinogram OPEN | | Rongkang Yin, Zheng Xu, Ming Mei, Zhaolong Chen, Kai Wang, Yanlin Liu, Tao Tang, Manish Kr. Priydarshi, Xuejuan Meng, Siyuan Zhao, Bing Deng, Hailin Peng, Zhongfan Liu & Xiaojie Duan | | The electrical response of the eye to optical stimulus is important in disease diagnosis but current electrodes used have limitations. Here, the authors report on the development of soft transparent graphene-based contact lens electrodes for electroretinogram recording and test the device in vivo. | | 13 June 2018 | doi: 10.1038/s41467-018-04781-w | | Biomedical engineering Electrophysiology Sensors and biosensors | A surface-modified antiperovskite as an electrocatalyst for water oxidation OPEN | | Yanping Zhu, Gao Chen, Yijun Zhong, Yubo Chen, Nana Ma, Wei Zhou & Zongping Shao | | Splitting water into its component elements, oxygen and hydrogen gas, provides a carbon-neutral fuel source, although the availability of cheap, earth-abundant catalysts is lacking. Here, the authors demonstrate antiperovskite-derived materials as high-performance water oxidation electrocatalysts. | | 13 June 2018 | doi: 10.1038/s41467-018-04682-y | | Electrocatalysis Nanoscale materials Solid-state chemistry | Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies OPEN | | Mariangela Russo, Simona Lamba, Annalisa Lorenzato, Alberto Sogari, Giorgio Corti, Giuseppe Rospo, Benedetta Mussolin, Monica Montone, Luca Lazzari, Sabrina Arena, Daniele Oddo, Michael Linnebacher, Andrea Sartore-Bianchi, Filippo Pietrantonio, Salvatore Siena, Federica Di Nicolantonio & Alberto Bardelli | | The emergence of sub-clones that are resistant to targeted agents is a major therapeutic obstacle in oncology. Here, using colorectal cancer as a model system, the authors show that interfering with ancestral oncogenic events present in all subclones-like APC-WNT pathway alterations—can restrain the emergence of drug-resistant populations. | | 12 June 2018 | doi: 10.1038/s41467-018-04506-z | | Cancer genomics Cancer therapeutic resistance Colorectal cancer Targeted therapies Tumour heterogeneity | α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease OPEN | | Marthe H. R. Ludtmann , Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, Artyom Y. Baev, Alexey V. Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J. Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V. Pavlov et al. | | How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parkinson’s disease. | | 12 June 2018 | doi: 10.1038/s41467-018-04422-2 | | Cellular neuroscience Mechanisms of disease Neurological disorders | Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner OPEN | | Yoonmi Lee, Nam Hee Kim, Eunae Sandra Cho, Ji Hye Yang, Yong Hoon Cha, Hee Eun Kang, Jun Seop Yun, Sue Bean Cho, Seon-Hyeong Lee, Petra Paclikova, Tomasz W. Radaszkiewicz, Vitezslav Bryja, Chi Gu Kang, Young Soo Yuk, So Young Cha, Soo-Youl Kim, Hyun Sil Kim & Jong In Yook | | Hippo and Wnt pathways are important for cancer development, and they can cross talk; however, the mechanisms behind this connection are unknown. Here the authors show that DVL (a scaffold protein in the Wnt pathway) regulates the shuttling of YAP (a key component of the Hippo pathway) between cytoplasm and nucleus in specific tumor suppressor contexts. | | 12 June 2018 | doi: 10.1038/s41467-018-04757-w | | Growth factor signalling Morphogen signalling Oncogenes | Caspr1 is a host receptor for meningitis-causing Escherichia coli OPEN | | Wei-Dong Zhao, Dong-Xin Liu, Jia-Yi Wei, Zi-Wei Miao, Ke Zhang, Zheng-Kang Su, Xue-Wei Zhang, Qiang Li, Wen-Gang Fang, Xiao-Xue Qin, De-Shu Shang, Bo Li, Qing-Chang Li, Liu Cao, Kwang Sik Kim & Yu-Hua Chen | | Penetration of the blood–brain barrier (BBB) is crucial for development of E. coli-caused meningitis. Here, the authors show that a host membrane protein, Caspr1, acts as a receptor for a bacterial virulence factor to facilitate BBB penetration and entry of E. coli into brain neurons. | | 12 June 2018 | doi: 10.1038/s41467-018-04637-3 | | Mechanisms of disease Pathogens | Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes OPEN | | Yue-xiao Shen, Woochul C. Song, D. Ryan Barden, Tingwei Ren, Chao Lang, Hasin Feroz, Codey B. Henderson, Patrick O. Saboe, Daniel Tsai, Hengjing Yan, Peter J. Butler, Guillermo C. Bazan, William A. Phillip, Robert J. Hickey, Paul S. Cremer, Harish Vashisth & Manish Kumar | | Synthetic polymeric membranes used for separations suffer from permeability-selectivity trade-offs. Here the authors demonstrate how a bioinspired pillar[5]arene artificial water channel embedded in a copolymer membrane can improve selectivity while still achieving high permeability. | | 12 June 2018 | doi: 10.1038/s41467-018-04604-y | | Molecular self-assembly Self-assembly Two-dimensional materials | Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells OPEN | | Juliane Hitzel , Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork et al. | | During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism towards production of purines and thus compensates for their loss. | | 12 June 2018 | doi: 10.1038/s41467-018-04602-0 | | Atherosclerosis Bayesian inference Phospholipids Regulatory networks | Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood OPEN | | Ting Qi, Yang Wu, Jian Zeng, Futao Zhang, Angli Xue, Longda Jiang, Zhihong Zhu, Kathryn Kemper, Loic Yengo, Zhili Zheng, Riccardo E. Marioni, Grant W. Montgomery, Ian J. Deary, Naomi R. Wray, Peter M. Visscher, Allan F. McRae & Jian Yang | | To comprehend the genetic regulatory mechanisms underlying brain-related traits in humans, Qi et al. estimate the correlation of expression and DNA methylation QTL effects in cis between blood and brain and show that using blood eQTL/mQTL data of large sample size can increase power in gene discovery for brain-related traits and diseases. | | 11 June 2018 | doi: 10.1038/s41467-018-04558-1 | | DNA methylation Gene regulation Genetics of the nervous system Genome-wide association studies | Ependymal cilia beating induces an actin network to protect centrioles against shear stress OPEN | | Alexia Mahuzier, Asm Shihavuddin, Clémence Fournier, Pauline Lansade, Marion Faucourt, Nikita Menezes, Alice Meunier, Meriem Garfa-Traoré, Marie-France Carlier, Raphael Voituriez, Auguste Genovesio, Nathalie Spassky & Nathalie Delgehyr | | Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to protect centrioles against the shear stress generated by ciliary motility. | | 11 June 2018 | doi: 10.1038/s41467-018-04676-w | | Actin Centrosome Cilia | Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment OPEN | | Diego Scheggia , Rosa Mastrogiacomo, Maddalena Mereu, Sara Sannino, Richard E. Straub, Marco Armando, Francesca Managò, Simone Guadagna, Fabrizio Piras, Fengyu Zhang, Joel E. Kleinman, Thomas M. Hyde, Sanne S. Kaalund, Maria Pontillo, Genny Orso, Carlo Caltagirone, Emiliana Borrelli, Maria A. De Luca, Stefano Vicari, Daniel R. Weinberger et al. | | Patients with schizophrenia show varied response to antipsychotics. Here, the authors demonstrate in patients under antipsychotics treatment that a haplotype associated with lower dysbindin-1 expression correlated with better executive functions, providing further mechanistic support from mouse models. | | 11 June 2018 | doi: 10.1038/s41467-018-04711-w | | Molecular medicine Psychiatric disorders Schizophrenia | Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition OPEN | | D. Sean Froese, Jolanta Kopec, Elzbieta Rembeza, Gustavo Arruda Bezerra, Anselm Erich Oberholzer, Terttu Suormala, Seraina Lutz, Rod Chalk, Oktawia Borkowska, Matthias R. Baumgartner & Wyatt W. Yue | | The human enzyme MTHFR links the folate and methionine cycles, which are essential for the biosynthesis of nucleotides and proteins. Here, the authors present the crystal structure and biochemical analysis of human MTHFR, providing molecular insights into its function and regulation in higher eukaryotes. | | 11 June 2018 | doi: 10.1038/s41467-018-04735-2 | | Mass spectrometry Oxidoreductases SAXS X-ray crystallography | In situ atomistic insight into the growth mechanisms of single layer 2D transition metal carbides OPEN | | Xiahan Sang, Yu Xie, Dundar E. Yilmaz, Roghayyeh Lotfi, Mohamed Alhabeb, Alireza Ostadhossein, Babak Anasori, Weiwei Sun, Xufan Li, Kai Xiao, Paul R. C. Kent, Adri C. T. van Duin, Yury Gogotsi & Raymond R. Unocic | | Understanding bottom-up growth mechanisms of 2D transition metal carbides (MXenes) may enable new synthetic routes to tailor functional properties. Here, the authors use in situ electron microscopy, density functional theory and molecular dynamics simulations to reveal the homoepitaxial growth mechanisms of a single TiC adlayer from a Ti3C2 monolayer substrate. | | 11 June 2018 | doi: 10.1038/s41467-018-04610-0 | | Synthesis and processing Transmission electron microscopy Two-dimensional materials | Expansion of a superconducting vortex core into a diffusive metal OPEN | | Vasily S. Stolyarov, Tristan Cren, Christophe Brun, Igor A. Golovchanskiy, Olga V. Skryabina, Daniil I. Kasatonov, Mikhail M. Khapaev, Mikhail Yu. Kupriyanov, Alexander A. Golubov & Dimitri Roditchev | | Quantum condensates may penetrate from one material to another due to the proximity effect. Here, Stolyarov et al. report the spatial evolution of quantum vortices from a superconducting Nb layer to a 50 nanometer thick diffusive metallic Cu-film, which is quite thick away from the interface. | | 11 June 2018 | doi: 10.1038/s41467-018-04582-1 | | Superconducting properties and materials Surfaces, interfaces and thin films | Diversity and evolution of the emerging Pandoraviridae family OPEN | | Matthieu Legendre, Elisabeth Fabre, Olivier Poirot, Sandra Jeudy, Audrey Lartigue, Jean-Marie Alempic, Laure Beucher, Nadège Philippe, Lionel Bertaux, Eugène Christo-Foroux, Karine Labadie, Yohann Couté, Chantal Abergel & Jean-Michel Claverie | | Giant viruses are visible by light microscopy and have unusually long genomes. Here, the authors report three new members of the Pandoraviridae family and investigate their evolution and diversity. | | 11 June 2018 | doi: 10.1038/s41467-018-04698-4 | | Comparative genomics Genome evolution Molecular evolution Viral evolution | Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons OPEN | | Jiejie Wang, Xinyou Lv, Yu Wu, Tao Xu, Mingfei Jiao, Risheng Yang, Xia Li, Ming Chen, Yinggang Yan, Changwan Chen, Weifan Dong, Wei Yang, Min Zhuo, Tao Chen, Jianhong Luo & Shuang Qiu | | Rab3-interacting molecules (RIMs) are a key component of the presynaptic active zone that regulate neurotransmitter release. Here, the authors show that RIM1 also has postsynaptic function to organize NMDA receptors and synaptic response. | | 11 June 2018 | doi: 10.1038/s41467-018-04672-0 | | Exocytosis Molecular neuroscience Synaptic transmission | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants OPEN | | Tokhir Dadaev , Edward J. Saunders, Paul J. Newcombe, Ezequiel Anokian, Daniel A. Leongamornlert, Mark N. Brook, Clara Cieza-Borrella, Martina Mijuskovic, Sarah Wakerell, Ali Amin Al Olama, Fredrick R. Schumacher, Sonja I. Berndt, Sara Benlloch, Mahbubl Ahmed, Chee Goh, Xin Sheng, Zhuo Zhang, Kenneth Muir, Koveela Govindasami, Artitaya Lophatananon et al. | | Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling. | | 11 June 2018 | doi: 10.1038/s41467-018-04109-8 | | Genetics research Prostate cancer | SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity OPEN | | Fan Yao, Zhicheng Zhou, Jongchan Kim, Qinglei Hang, Zhenna Xiao, Baochau N. Ton, Liang Chang, Na Liu, Liyong Zeng, Wenqi Wang, Yumeng Wang, Peijing Zhang, Xiaoyu Hu, Xiaohua Su, Han Liang, Yutong Sun & Li Ma | | Regulation of Yes-associated protein (YAP) through the Hippo pathway is well established, but its Hippo-independent regulation remains to be elucidated. Here, the authors show that non-proteolytic ubiquitination presents another means of YAP regulation, promoting its nuclear localization and activity. | | 11 June 2018 | doi: 10.1038/s41467-018-04620-y | | Protein translocation Ubiquitylated proteins Ubiquitylation | An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex OPEN | | Keiko Kawauchi, Wataru Sugimoto, Takatoshi Yasui, Kohei Murata, Katsuhiko Itoh, Kazuki Takagi, Takaaki Tsuruoka, Kensuke Akamatsu, Hisae Tateishi-Karimata, Naoki Sugimoto & Daisuke Miyoshi | | Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn2+ in combination with photo-irradiation. | | 11 June 2018 | doi: 10.1038/s41467-018-04771-y | | Nucleic acids RNA | Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48 OPEN | | Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter W. Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Brin Rosenthal, Kathleen M. Fisch, Jason Moffat, Jörg Menche, Haico van Attikum, Stephen P. Jackson & Joanna I. Loizou | | Fanconi anemia is a rare disease caused by defective DNA interstrand crosslink repair. Here the authors observe that USP48 deficiencies reduce chromosomal instability in FA-defective cells, suggesting it might be a potential therapeutic target. | | 11 June 2018 | doi: 10.1038/s41467-018-04649-z | | Cell signalling DNA damage and repair Genetic interaction | Rice actin binding protein RMD controls crown root angle in response to external phosphate OPEN | | Guoqiang Huang, Wanqi Liang, Craig J. Sturrock, Bipin K. Pandey, Jitender Giri, Stefan Mairhofer, Daoyang Wang, Lukas Muller, Hexin Tan, Larry M. York, Jing Yang, Yu Song, Yu-Jin Kim, Yang Qiao, Jian Xu, Stefan Kepinski, Malcolm J. Bennett & Dabing Zhang | | The orientation of plant roots responds to gravity and influences nutrient acquisition. Here the authors show that the formin RMD buffers movement of specialized gravity-sensing organelles and report enhanced RMD expression during phosphate deficiency that could alter root angle to improve phosphate uptake. | | 11 June 2018 | doi: 10.1038/s41467-018-04710-x | | Abiotic Cytoskeleton | A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci OPEN | | Hélène Choquet, Seyyedhassan Paylakhi, Stephen C. Kneeland, Khanh K. Thai, Thomas J. Hoffmann, Jie Yin, Mark N. Kvale, Yambazi Banda, Nicholas G. Tolman, Pete A. Williams, Catherine Schaefer, Ronald B. Melles, Neil Risch, Simon W. M. John, K. Saidas Nair & Eric Jorgenson | | Primary open-angle glaucoma (POAG) leads to progressive vision loss. Here, Choquet et al. perform genome-wide association analysis for POAG in a multi-ethnic cohort, identify a total of nine novel genetic loci and show relevant function of FMNL2 and LMX1B using cell line and mouse experiments. | | 11 June 2018 | doi: 10.1038/s41467-018-04555-4 | | Genetics research Genome-wide association studies Glaucoma Risk factors | Scaling law for excitons in 2D perovskite quantum wells OPEN | | J.-C. Blancon, A. V. Stier, H. Tsai, W. Nie, C. C. Stoumpos, B. Traoré, L. Pedesseau, M. Kepenekian, F. Katsutani, G. T. Noe, J. Kono, S. Tretiak, S. A. Crooker, C. Katan, M. G. Kanatzidis, J. J. Crochet, J. Even & A. D. Mohite | | Hybrid 2D layered perovskites are solution-processed quantum wells whose optoelectronic properties are tunable by varying the thickness of the inorganic slab. Here Blancon et al. work out a general behavior for dependence of the excitonic properties in layered 2D perovskites. | | 08 June 2018 | doi: 10.1038/s41467-018-04659-x | | Organic–inorganic nanostructures Semiconductors Two-dimensional materials | Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation OPEN | | Tali Lang, Jacinta P. W. Lee, Kirstin Elgass, Anita A. Pinar, Michelle D. Tate, Elizabeth H. Aitken, Huapeng Fan, Sarah J. Creed, Nadia S. Deen, Daouda A. K. Traore, Ivo Mueller, Danielle Stanisic, Francesca S. Baiwog, Colin Skene, Matthew C. J. Wilce, Ashley Mansell, Eric F. Morand & James Harris | | MIF is a cytokine best known for its modulatory effect on expression of proinflammatory cytokines. Here the authors show that MIF facilitates the NLRP3–vimentin interaction, resulting in Nlrp3 inflammasome activation. | | 08 June 2018 | doi: 10.1038/s41467-018-04581-2 | | Cell biology Cytokines Inflammasome Innate immunity | Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague OPEN | | Maria A. Spyrou, Rezeda I. Tukhbatova, Chuan-Chao Wang, Aida Andrades Valtueña, Aditya K. Lankapalli, Vitaly V. Kondrashin, Victor A. Tsybin, Aleksandr Khokhlov, Denise Kühnert, Alexander Herbig, Kirsten I. Bos & Johannes Krause | | Yersinia pestis has caused infections (plague) in humans since the Early Bronze Age (5000 years ago). Here, Spyrou et al. reconstruct Y. pestis genomes from Late Bronze Age individuals, and find genomic evidence compatible with flea-mediated transmission causing bubonic plague. | | 08 June 2018 | doi: 10.1038/s41467-018-04550-9 | | Bacterial genetics Bacterial infection | Globally asynchronous sulphur isotope signals require re-definition of the Great Oxidation Event OPEN | | Pascal Philippot, Janaína N. Ávila, Bryan A. Killingsworth, Svetlana Tessalina, Franck Baton, Tom Caquineau, Elodie Muller, Ernesto Pecoits, Pierre Cartigny, Stefan V. Lalonde, Trevor R. Ireland, Christophe Thomazo, Martin J. van Kranendonk & Vincent Busigny | | The Great Oxidation Event (GOE) is considered to have occurred at 2.33–2.32 Ga based on the last occurrence of MIF-S in South Africa. Here, based on sulphur isotope analysis of samples from Western Australia, the authors show preservation of MIF-S beyond 2.31 Ga and call for a re-evaluation of GOE timing. | | 08 June 2018 | doi: 10.1038/s41467-018-04621-x | | Element cycles Geochemistry | Dynamically prognosticating patients with hepatocellular carcinoma through survival paths mapping based on time-series data OPEN | | Lujun Shen, Qi Zeng, Pi Guo, Jingjun Huang, Chaofeng Li, Tao Pan, Boyang Chang, Nan Wu, Lewei Yang, Qifeng Chen, Tao Huang, Wang Li & Peihong Wu | | Patients with hepatocellular carcinoma require regular follow-up. Here, using Cox-based feature selection to identify key prognostic features, the authors convert time-series follow-up data into a cascading survival map, and show that the approach improves dynamic prognosis prediction for patients. | | 08 June 2018 | doi: 10.1038/s41467-018-04633-7 | | Cancer models Liver cancer | Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit OPEN | | Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens & Renate König | | SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 phase of primary CD4+ T cells. | | 08 June 2018 | doi: 10.1038/s41467-018-04671-1 | | Cell-cycle exit HIV infections Innate immunity Restriction factors | A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis OPEN | | Andrew Schrepf, Chelsea M. Kaplan, Eric Ichesco, Tony Larkin, Steven E. Harte, Richard E. Harris, Alison D. Murray, Gordon D. Waiter, Daniel J. Clauw & Neil Basu | | Many diseases, such as rheumatoid arthritis, are characterized by a chronic inflammatory state, but it is not clear whether or how this affects the brain. Here, the authors show that the severity of on-going inflammation predicts altered functional brain connectivity in people with rheumatoid arthritis. | | 08 June 2018 | doi: 10.1038/s41467-018-04648-0 | | Chronic inflammation Neural circuits Neuroimmunology Rheumatoid arthritis | Gene flow contributes to diversification of the major fungal pathogen Candida albicans OPEN | | Jeanne Ropars , Corinne Maufrais, Dorothée Diogo, Marina Marcet-Houben, Aurélie Perin, Natacha Sertour, Kevin Mosca, Emmanuelle Permal, Guillaume Laval, Christiane Bouchier, Laurence Ma, Katja Schwartz, Kerstin Voelz, Robin C. May, Julie Poulain, Christophe Battail, Patrick Wincker, Andrew M. Borman, Anuradha Chowdhary, Shangrong Fan et al. | | The fungal pathogen Candida albicans can undergo a parasexual process that may contribute to genetic diversity, but its actual relevance is unclear. Here, Ropars et al. analyse the genomic sequences of 182 C. albicans isolates collected worldwide and find evidence of gene flow and thus parasexuality in nature. | | 08 June 2018 | doi: 10.1038/s41467-018-04787-4 | | Microbial genetics Pathogens Population genetics | CREB controls cortical circuit plasticity and functional recovery after stroke OPEN | | L. Caracciolo, M. Marosi, J. Mazzitelli, S. Latifi, Y. Sano, L. Galvan, R. Kawaguchi, S. Holley, M. S. Levine, G. Coppola, C. Portera-Cailliau, A. J. Silva & S. T. Carmichael | | Increasing excitability in the peri-infarct area enhances motor recovery after stroke. Here the authors show that expressing CREB, a transcription factor known for its role in synaptic plasticity, or increasing activity of CREB-expressing cells near the stroke site improves recovery in an effect that is strong enough that it can be used to turn on and off motor recovery after stroke. | | 08 June 2018 | doi: 10.1038/s41467-018-04445-9 | | Stroke | Ultrafast perturbation maps as a quantitative tool for testing of multi-port photonic devices OPEN | | Kevin Vynck, Nicholas J. Dinsdale, Bigeng Chen, Roman Bruck, Ali Z. Khokhar, Scott A. Reynolds, Lee Crudgington, David J. Thomson, Graham T. Reed, Philippe Lalanne & Otto L. Muskens | | Advanced photonic probes are important for the development of non-contact wafer-scale testing of photonic chips. Here, Vynck et al. develop a quantitative technique based on mapping of transmittance variations by ultrafast perturbations to analyze arbitrary linear multi-port photonic devices. | | 08 June 2018 | doi: 10.1038/s41467-018-04662-2 | | Imaging and sensing Integrated optics Silicon photonics Optical spectroscopy | Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells OPEN | | Christophe Chopard, Phuoc Bao Viet Tong, Petra Tóth, Malvina Schatz, Hocine Yezid, Solène Debaisieux, Clément Mettling, Antoine Gross, Martine Pugnière, Annie Tu, Jean-Marc Strub, Jean-Michel Mesnard, Nicolas Vitale & Bruno Beaumelle | | It is not clear whether and how incoming HIV-1 Tat accumulates in uninfected cells. Here, Chopard et al. show that, in uninfected cells, incoming Tat is palmitoylated on Cys31 by DHHC-20, which increases its affinity for PI(4,5)P2 and results in its accumulation at the plasma membrane. | | 08 June 2018 | doi: 10.1038/s41467-018-04674-y | | HIV infections Mechanisms of disease Protein translocation Virus–host interactions | Mitochondrial reactive oxygen species regulate the induction of CD8+ T cells by plasmacytoid dendritic cells OPEN | | Marine Oberkampf, Camille Guillerey, Juliette Mouriès, Pierre Rosenbaum, Catherine Fayolle, Alexandre Bobard, Ariel Savina, Eric Ogier-Denis, Jost Enninga, Sebastian Amigorena, Claude Leclerc & Gilles Dadaglio | | Cross-presentation allows exogenous antigens to be presented by the major histocompatibility I pathway. Here the authors show that the inducible cross-presentation by plasmacytoid dendritic cells is modulated by mitochondria-originated reactive oxygen species. | | 08 June 2018 | doi: 10.1038/s41467-018-04686-8 | | Antigen presentation Cytotoxic T cells Plasmacytoid dendritic cells Toll-like receptors | Strong sesquiterpene emissions from Amazonian soils OPEN | | E. Bourtsoukidis, T. Behrendt, A. M. Yañez-Serrano, H. Hellén, E. Diamantopoulos, E. Catão, K. Ashworth, A. Pozzer, C. A. Quesada, D. L. Martins, M. Sá, A. Araujo, J. Brito, P. Artaxo, J. Kesselmeier, J. Lelieveld & J. Williams | | Recent measurements in the Amazon rainforest indicate missing sources of volatile organic compounds (VOCs). Here the authors show that soil microorganisms are a strong, unaccounted source of highly reactive sesquiterpenes, a class of VOCs that can regulate ozone chemistry within the forest canopy. | | 08 June 2018 | doi: 10.1038/s41467-018-04658-y | | Atmospheric chemistry Carbon cycle Forest ecology | Interplay between spherical confinement and particle shape on the self-assembly of rounded cubes OPEN | | Da Wang, Michiel Hermes, Ramakrishna Kotni, Yaoting Wu, Nikos Tasios, Yang Liu, Bart de Nijs, Ernest B. van der Wee, Christopher B. Murray, Marjolein Dijkstra & Alfons van Blaaderen | | Colloidal nanoparticles self-assembled under spherical confinement can form a rich variety of structures. Here, the authors study the self-assembly of sharp and rounded nanocubes under such confinement, revealing the influence of particle and face geometry on positional and orientational behavior. | | 08 June 2018 | doi: 10.1038/s41467-018-04644-4 | | Colloids Nanoparticles Self-assembly Statistical physics | CRISPR-FRT targets shared sites in a knock-out collection for off-the-shelf genome editing OPEN | | Toon Swings, David C. Marciano, Benu Atri, Rachel E. Bosserman, Chen Wang, Marlies Leysen, Camille Bonte, Thomas Schalck, Ian Furey, Bram Van den Bergh, Natalie Verstraeten, Peter J. Christie, Christophe Herman, Olivier Lichtarge & Jan Michiels | | Genome editing requires precise targeting of loci with specific gRNAs. Here the authors introduce CRISPR-FRT, which targets flippase recognition sites, common in bacterial genetic collections, for fast off-the-shelf genome engineering. | | 08 June 2018 | doi: 10.1038/s41467-018-04651-5 | | Biotechnology CRISPR-Cas9 genome editing Microbial genetics Mutation | Diverse populations of local interneurons integrate into the Drosophila adult olfactory circuit OPEN | | Nan-Fu Liou, Shih-Han Lin, Ying-Jun Chen, Kuo-Ting Tsai, Chi-Jen Yang, Tzi-Yang Lin, Ting-Han Wu, Hsin-Ju Lin, Yuh-Tarng Chen, Daryl M. Gohl, Marion Silies & Ya-Hui Chou | | Local interneurons (LNs) in the Drosophila olfactory system are highly diverse. Here, the authors labeled different LN types and described how different LN subtypes are integrated into the developing circuit. | | 08 June 2018 | doi: 10.1038/s41467-018-04675-x | | Developmental biology Neuroscience | Engineering triangular carbon quantum dots with unprecedented narrow bandwidth emission for multicolored LEDs OPEN | | Fanglong Yuan, Ting Yuan, Laizhi Sui, Zhibin Wang, Zifan Xi, Yunchao Li, Xiaohong Li, Louzhen Fan, Zhan’ao Tan, Anmin Chen, Mingxing Jin & Shihe Yang | | Carbon quantum dots have promising advantages such as high stability, low cost and environment-friendliness, but their broad emission band limits their application in displays. Here Yuan et al. synthesize these dots showing tunable emission color, high fluorescence and a narrow FWHM of only 30 nanometers. | | 08 June 2018 | doi: 10.1038/s41467-018-04635-5 | | Lasers, LEDs and light sources Materials for devices Nanoscale materials | Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations OPEN | | Aran Singanayagam , Nicholas Glanville, Jason L. Girkin, Yee Man Ching, Andrea Marcellini, James D. Porter, Marie Toussaint, Ross P. Walton, Lydia J. Finney, Julia Aniscenko, Jie Zhu, Maria-Belen Trujillo-Torralbo, Maria Adelaide Calderazzo, Chris Grainge, Su-Ling Loo, Punnam Chander Veerati, Prabuddha S. Pathinayake, Kristy S. Nichol, Andrew T. Reid, Phillip L. James et al. | | Corticosteroid therapy is frequently used for chronic obstructive pulmonary disease (COPD) but its use is associated with increased risk of pneumonia. Here the authors show that corticosteroid use impairs innate and adaptive immunity to rhinovirus infection, which is restored by exogenous IFNβ. | | 08 June 2018 | doi: 10.1038/s41467-018-04574-1 | | Antimicrobial responses Immunology Innate immunity Translational immunology | Semen inhibits Zika virus infection of cells and tissues from the anogenital region OPEN | | Janis A. Müller , Mirja Harms, Franziska Krüger, Rüdiger Groß, Simone Joas, Manuel Hayn, Andrea N. Dietz, Sina Lippold, Jens von Einem, Axel Schubert, Manuela Michel, Benjamin Mayer, Mirko Cortese, Karen S. Jang, Nathallie Sandi-Monroy, Miriam Deniz, Florian Ebner, Olli Vapalahti, Markus Otto, Ralf Bartenschlager et al. | | Semen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses. | | 07 June 2018 | doi: 10.1038/s41467-018-04442-y | | Pathogens Viral transmission | Nature of the metal-insulator transition in few-unit-cell-thick LaNiO3 films OPEN | | M. Golalikhani, Q. Lei, R. U. Chandrasena, L. Kasaei, H. Park, J. Bai, P. Orgiani, J. Ciston, G. E. Sterbinsky, D. A. Arena, P. Shafer, E. Arenholz, B. A. Davidson, A. J. Millis, A. X. Gray & X. X. Xi | | The electronic behaviour of complex oxides such as LaNiO3 depends on many intrinsic and extrinsic factors, making it challenging to identify microscopic mechanisms. Here the authors demonstrate the influence of oxygen vacancies on the thickness-dependent metal-insulator transition of LaNiO3 films. | | 07 June 2018 | doi: 10.1038/s41467-018-04546-5 | | Electronic properties and materials Phase transitions and critical phenomena Surfaces, interfaces and thin films | A novel atypical sperm centriole is functional during human fertilization OPEN | | Emily L. Fishman, Kyoung Jo, Quynh P. H. Nguyen, Dong Kong, Rachel Royfman, Anthony R. Cekic, Sushil Khanal, Ann L. Miller, Calvin Simerly, Gerald Schatten, Jadranka Loncarek, Vito Mennella & Tomer Avidor-Reiss | | The two zygote centrioles are paternally inherited; however, their development is incompletely understood. Here, the authors show that the distal centriole is remodeled into an atypical centriole which functions as the zygote’s second centriole. | | 07 June 2018 | doi: 10.1038/s41467-018-04678-8 | | Centrosome Spermatogenesis | Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen OPEN | | Daniel Heine, Neil A. Holmes, Sarah F. Worsley, Ana Carolina A. Santos, Tabitha M. Innocent, Kirstin Scherlach, Elaine H. Patrick, Douglas W. Yu, J. Colin Murrell, Paulo C. Vieria, Jacobus J. Boomsma, Christian Hertweck, Matthew I. Hutchings & Barrie Wilkinson | | Acromyrmex ants cultivate fungus gardens that can be parasitized by Escovopsis sp., leading to colony collapse. Here, Heine et al. identify two secondary metabolites produced by Escovopsis that accumulate in Acromyrmex tissue, reduce behavioural defenses and suppress symbiotic Pseudonocardia bacteria. | | 07 June 2018 | doi: 10.1038/s41467-018-04520-1 | | Chemical biology Chemical ecology Ecology Symbiosis | Parasitic insect-derived miRNAs modulate host development OPEN | | Zhi-zhi Wang , Xi-qian Ye, Min Shi, Fei Li, Ze-hua Wang, Yue-nan Zhou, Qi-juan Gu, Xiao-tong Wu, Chuan-lin Yin, Dian-hao Guo, Rong-min Hu, Na-na Hu, Ting Chen, Bo-ying Zheng, Jia-ni Zou, Le-qing Zhan, Shu-jun Wei, Yan-ping Wang, Jian-hua Huang, Xiao-dong Fang et al. | | The moth Plutella xylostella during its larval stage is the host of the endoparasitic wasp Cotesia vestalis. Here the authors show that the parasitoids deliver microRNAs to their hosts through their symbiotic virus and specialized cells leading to induced developmental delay. | | 07 June 2018 | doi: 10.1038/s41467-018-04504-1 | | miRNAs Post-translational modifications | HuR regulates telomerase activity through TERC methylation OPEN | | Hao Tang , Hu Wang, Xiaolei Cheng, Xiuqin Fan, Fan Yang, Mengmeng Zhang, Yanlian Chen, Yuyang Tian, Cihang Liu, Dongxing Shao, Bin Jiang, Yali Dou, Yusheng Cong, Junyue Xing, Xiaotian Zhang, Xia Yi, Zhou Songyang, Wenbin Ma, Yong Zhao, Xian Wang et al. | | Mutations in the RNA component TERC can cause telomerase dysfunction but the underlying mechanisms are largely unknown. Here, the authors show that RNA-binding protein HuR regulates telomerase function by enhancing the methylation of TERC, which is impaired by several disease-relevant TERC mutations. | | 07 June 2018 | doi: 10.1038/s41467-018-04617-7 | | Non-coding RNAs RNA-binding proteins RNA modification Telomeres | Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints OPEN | | Ayenachew Bezawork-Geleta , He Wen, LanFeng Dong, Bing Yan, Jelena Vider, Stepana Boukalova, Linda Krobova, Katerina Vanova, Renata Zobalova, Margarita Sobol, Pavel Hozak, Silvia Magalhaes Novais, Veronika Caisova, Pavel Abaffy, Ravindra Naraine, Ying Pang, Thiri Zaw, Ping Zhang, Radek Sindelka, Mikael Kubista et al. | | Mitochondrial complex II is normally composed of four subunits. Here the authors show that bioenergetic stress conditions give rise to a partially assembled variant of complex II, which shifts the anabolic pathways to less energy demanding processes. | | 07 June 2018 | doi: 10.1038/s41467-018-04603-z | | Energy metabolism Metabolic pathways Mitochondrial proteins Stress signalling | Quantum limit transport and destruction of the Weyl nodes in TaAs OPEN | | B. J. Ramshaw, K. A. Modic, Arkady Shekhter, Yi Zhang, Eun-Ah Kim, Philip J. W. Moll, Maja D. Bachmann, M. K. Chan, J. B. Betts, F. Balakirev, A. Migliori, N. J. Ghimire, E. D. Bauer, F. Ronning & R. D. McDonald | | Weyl semimetals should exhibit unusual electronic behaviour but conditions where these effects dominate are difficult to achieve. Ramshaw et al. use high magnetic fields to drive TaAs into the quantum limit, finding evidence for the predicted chiral anomaly and an unanticipated increase in resistivity at the highest fields. | | 07 June 2018 | doi: 10.1038/s41467-018-04542-9 | | Electronic properties and materials Phase transitions and critical phenomena Topological matter | | | | | | Latest Author Corrections | | | | Author Correction: A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum OPEN | | Alison Roth , Steven P. Maher, Amy J. Conway, Ratawan Ubalee, Victor Chaumeau, Chiara Andolina, Stephen A. Kaba, Amélie Vantaux, Malina A. Bakowski, Richard Thomson-Luque, Swamy Rakesh Adapa, Naresh Singh, Samantha J. Barnes, Caitlin A. Cooper, Mélanie Rouillier, Case W. McNamara, Sebastian A. Mikolajczak, Noah Sather, Benoît Witkowski, Brice Campo et al. | | 08 June 2018 | doi: 10.1038/s41467-018-04817-1 | | Drug screening High-throughput screening Malaria Vaccines | | | | | Latest Publisher Corrections | | | | Publisher Correction: Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing OPEN | | Soon Hee Kim, Yeung Kyu Yeon, Jung Min Lee, Janet Ren Chao, Young Jin Lee, Ye Been Seo, Md. Tipu Sultan, Ok Joo Lee, Ji Seung Lee, Sung-il Yoon, In-Sun Hong, Gilson Khang, Sang Jin Lee, James J. Yoo & Chan Hum Park | | 11 June 2018 | doi: 10.1038/s41467-018-04517-w | | Biomaterials – cells Tissue engineering | Publisher Correction: Studying light-harvesting models with superconducting circuits OPEN | | Anton Potočnik, Arno Bargerbos, Florian A. Y. N. Schröder, Saeed A. Khan, Michele C. Collodo, Simone Gasparinetti, Yves Salathé, Celestino Creatore, Christopher Eichler, Hakan E. Türeci, Alex W. Chin & Andreas Wallraff | | 08 June 2018 | doi: 10.1038/s41467-018-04655-1 | | Biological physics Quantum simulation | | | | | Advertisement | | Calls for nominations 2018 John Maddox Prize for Standing up for Science Recognising the work of individuals who promote science in the face of hostility | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. 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