| | | | | Table of ContentsOpinion News & Views Science & Society Scientific Reports Articles | Volume 19, Number 6 | Opinion | Science bears some hallmarks of religion. But, unlike many organized religions, there is no central authority and no tenet remains unchallenged. Brooke Morriswood and Oliver Hoeller Published online 16.05.2018 | | Scientists and commercial scientific instrument makers have a shared incentive against discloseing an instrument maker's contributions to research. Stricter rules to encourage reporting of such collaboration would help to improve transparency and reproducibility. Carsten Bergenholtz, Samuel C MacAulay, Christos Kolympiris and Inge Seim | | The reproducibility crisis in biomedical research has spurred much debate about the causes of the failure to validate experimental results. But the discussion may be overlooking one crucial factor that is inherent to research with low sample sizes: random variation. Thiago FA França and José Maria Monserrat Published online 25.04.2018 | News & Views | Two recent studies independently show that loss of the mitochondrial protease ClpP protects mice from insulin resistance and diet‐induced obesity. Marc Liesa and Orian S Shirihai Published online 22.05.2018 | Science & Society | The deluge of sequencing and other data has spurred a growing demand for qualified bioinformaticians. Training the next generation of students to acquire the necessary skills is a major challenge for biology. David R Smith Published online 03.05.2018 | | Our project to engage members of the public with metagenomics of microbiota in their households yielded interesting results about their perception of health and hygiene. These findings could direct health‐oriented research and help scientists to navigate the social contexts or microbiome research. Timothy Hodgetts, Richard Grenyer, Beth Greenhough, Carmen McLeod, Andrew Dwyer and Jamie Lorimer Published online 18.05.2018 | | The German DEAL project negotiates full open access publishing with the major publishers for many academic institutions in Germany. If successful, it could have a global impact on funders’ publishing policies. Philip Hunter Published online 15.05.2018 | Scientific Reports | Yes‐associated protein (YAP) is a transcriptional co‐activator and major effector of the Hippo pathway, promoting cell proliferation and stemness. YAP interacts with PRDM4, thereby promoting transendothelial invasion of cancer cells by inducing expression of the leukocyte‐specific integrin ITGB2. Huan Liu, Xiaoming Dai, Xiaolei Cao, Huan Yan, Xinyan Ji, Haitao Zhang, Shuying Shen, Yuan Si, Hailong Zhang, Jianfeng Chen, Li Li, Jonathan C Zhao, Jindan Yu, Xin‐Hua Feng and Bin Zhao Published online 17.04.2018 | | Elevated levels of the transcriptional regulators TAZ/YAP, key effectors of Hippo pathway signalling, mediate breast cancer cell growth dependence on exogenous glutamine. Cancer cells with high TAZ/YAP activity are sensitive to transaminase inhibition. Chih‐Sheng Yang, Eleni Stampouloglou, Nathan M Kingston, Liye Zhang, Stefano Monti and Xaralabos Varelas Published online 16.04.2018 | | The scavenger receptor CD36 and its ligand amyloid beta trigger NF‐κB pathway activation and the acquisition of a senescence‐associated secretory phenotype (SASP) in response to various senescence‐inducing stimuli. Mengyang Chong, Tao Yin, Rui Chen, Handan Xiang, Lifeng Yuan, Yi Ding, Christopher C Pan, Zhen Tang, Peter B Alexander, Qi‐Jing Li and Xiao‐Fan Wang Published online 18.05.2018 | Articles | The GTPase Mitofusin mediates mitochondrial fusion, but the underlying mechanism of membrane fusion remains unclear. This study shows that the amphipathic nature of the heptad repeat domain 1 (HR1) of Mitofusin perturbs the lipid bilayer structure to drive mitochondrial fusion. Frédéric Daste, Cécile Sauvanet, Andrej Bavdek, James Baye, Fabienne Pierre, Rémi Le Borgne, Claudine David, Manuel Rojo, Patrick Fuchs and David Tareste Published online 16.04.2018 | | The Raf‐1 kinase inhibitor protein participates in the pathogenesis of IL‐17‐mediated autoimmune diseases and inflammation by promoting the formation of the IL‐17RA‐Act1 complex, required for downstream signaling and cytokine production. Wenlong Lin, Ning Wang, Kangxing Zhou, Fasheng Su, Yu Jiang, Jianan Shou, Huan Liu, Chunmei Ma, Youchun Qian, Kai Wang and Xiaojian Wang Published online 19.04.2018 | | The innate immune RNA sensor LGP2 is a negative regulator of antiviral signal transduction. LGP2 interferes with TRAF ubiquitin ligase activity, thereby suppressing TRAF‐dependent signaling to prevent activation of IRF3 and NFκB. Jean‐Patrick Parisien, Jessica J Lenoir, Roli Mandhana, Kenny R Rodriguez, Kenin Qian, Annie M Bruns and Curt M Horvath Published online 16.04.2018 | | Extensive crosstalk between microRNAs and alternative splicing programs shapes the transcriptome of ESCs. The miR‐290/302 family and Mbnl1/2 proteins opposingly regulate alternative splicing and gene expression, thereby influencing cell fate determination. Da‐Ren Wu, Kai‐Li Gu, Jian‐Cheng Yu, Xing Fu, Xi‐Wen Wang, Wen‐Ting Guo, Le‐Qi Liao, Hong Zhu, Xiao‐Shan Zhang, Jingyi Hui and Yangming Wang Published online 07.05.2018 | | eIF5A is required for lipidation of ATG8 proteins and autophagosome formation. This results from eIF5A‐mediated translation of the E2‐like ATG3 protein, which contains an amino acid motif causing eIF5A dependency for its efficient translation. Michal Lubas, Lea M Harder, Caroline Kumsta, Imke Tiessen, Malene Hansen, Jens S Andersen, Anders H Lund and Lisa B Frankel Published online 30.04.2018 | | | | Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation. | | | |
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