Nature Reviews Immunology Contents June 2018 Volume 18 Number 6 pp 357-415

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Advertisement Real time detection of neutrophil activation Discover a new method to assess neutrophil activation and oxidative burst with Agilent Seahorse XF technology. Simultaneous glycolytic (PER) and oxygen consumption (OCR) rate detection can dissect the interdependency of the two pathways that are required for neutrophil activation. Download the app note to learn more. TABLE OF CONTENTS June 2018 Volume 18, Issue 6 Research Highlights Reviews Perspectives   Advertisement   Live-cell assays for Immunology research: Characterization of the role of the immune system in health and disease requires quantitative data from dynamic experimental models of the cells that comprise both the innate and adaptive responses. Maximize your immunological research insights with image-based, real-time analysis of living immune cells. Get more info   Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Research Highlights   Reigning in RIG-I    p357 Lucy Bird doi:10.1038/s41577-018-0018-2 Specificity for HCMV strains    pp358 - 359 Kirsty Minton doi:10.1038/s41577-018-0010-x Strain-specific recognition of different UL40 peptides determines the proliferation and activation of NKG2C+ NK cells during HCMV infection.   Microglial memory    pp358 - 359 Lucy Bird doi:10.1038/s41577-018-0015-5 Microglial cells show innate immune memory of peripheral inflammatory stimuli that influences neurological disease pathology.   γδ T cells turn up the heat    p359 Grant Otto doi:10.1038/s41577-018-0017-3 γδ T cells have a crucial role in immune homeostasis and thermogenesis in adipose tissues through their production of IL-17A and TNF.   Viral tropism for tuft cells    pp360 - 361 Kirsty Minton doi:10.1038/s41577-018-0011-9 Norovirus infection of tuft cells in the intestinal epithelium can be promoted by type 2 cytokines.   Itaconate charges down inflammation    pp360 - 361 Yvonne Bordon doi:10.1038/s41577-018-0016-4 The metabolite itaconate induces electrophilic stress that induces an antioxidant response and regulates secondary TLR transcriptional responses and IL-17-driven pathology.   The IFN road not taken    p361 Yvonne Bordon doi:10.1038/s41577-018-0012-8 SAMHD1 promotes the degradation of nascent DNA strands to protect against aberrant activation of the pro-inflammatory cGAS–STING pathway by self DNA.   Nature Reviews Immunology JOBS of the week Research Fellow Birmingham University Postdoctoral Fellow University of Colorado Anschutz Medical Campus Two Postdoctoral Fellows – immunology University of Oslo Post Doctoral Associate Weill Cornell Medicine Assistant Editor (f / m) WILEY-VCH Verlag GmbH & Co. KGaA More Science jobs from Nature Reviews Immunology EVENT World Conference on Vaccine and Immunology 13.09.18 București, Romania More science events from Reviews   The full spectrum of human naive T cells    pp363 - 373 Theo van den Broek, José A. M. Borghans & Femke van Wijk doi:10.1038/s41577-018-0001-y Evidence is increasing that naive T cells are heterogeneous in phenotype, function, dynamics and differentiation status. Here, van den Broek et al. provide a revised view of the naive T cell compartment and then discuss the implications for ageing, neonatal immunity and T cell reconstitution following haematopoietic stem cell transplantation.   C-type lectins in immunity and homeostasis    pp374 - 389 Gordon D. Brown, Janet A. Willment & Lauren Whitehead doi:10.1038/s41577-018-0004-8 Recently discovered roles for C-type lectins in development, homeostasis, cell death, cancer and autoimmune and inflammatory diseases extend the functions of this superfamily beyond their well-recognized involvement in antimicrobial responses.   Nonhuman primate models of human viral infections    pp390 - 404 Jacob D. Estes, Scott W. Wong & Jason M. Brenchley doi:10.1038/s41577-018-0005-7 Nonhuman primates (NHPs) are increasingly used as models of human viral infections. Here, Estes and colleagues introduce different NHP models, summarize the similarities and differences between human and NHP immune systems and discuss important examples of human viruses that can be modelled in NHPs.   Perspectives   To respond or not to respond — a personal perspective of intestinal tolerance    pp405 - 415 Allan McI. Mowat doi:10.1038/s41577-018-0002-x In this Timeline, Allan Mowat reflects on some of the key discoveries that have shaped our understanding of how immune tolerance towards environmental antigens, such as commensal bacteria and food proteins, develops and is maintained in the intestine.   Advertisement nature.com webcasts Nature Research Custom presents a webcast on: Saving an Enzymatic HTS Assay with Sound Date: Wednesday, June 13, 2018 Labcyte and Servier will present a recent experiment about Echo technology. Learn about the solutions for a robust enzymatic HTS assay and absorption issue. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: Labcyte     Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. 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