Nature Immunology Contents: June 2018 Volume 19 Issue 6

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TABLE OF CONTENTS June 2018 Volume 19, Issue 6 Obituary Research Highlights News & Views Meeting Reports Review Articles Articles Resources Technical Reports Amendments & Corrections   Obituary   Bruno Kyewski 1950–2018    p509 Ludger Klein doi:10.1038/s41590-018-0095-1 Research Highlights   B cells on the brain    p510 Ioana Visan doi:10.1038/s41590-018-0096-0 Mitochondria–ER hubs    p510 Ioana Visan doi:10.1038/s41590-018-0097-z PP2A in B cells    p510 Laurie A. Dempsey doi:10.1038/s41590-018-0098-y RORα in Treg cells    p510 Laurie A. Dempsey doi:10.1038/s41590-018-0099-x Synthetic benefits    p510 Zoltan Fehervari doi:10.1038/s41590-018-0100-8 Crisis management    p510 Zoltan Fehervari doi:10.1038/s41590-018-0101-7 A more natural response    p511 Zoltan Fehervari doi:10.1038/s41590-018-0122-2 Immunoregulatory itaconate    p511 Laurie A. Dempsey doi:10.1038/s41590-018-0123-1 IgD’s role in vivo    p511 Laurie A. Dempsey doi:10.1038/s41590-018-0124-0 Flowing mechanics    p511 Zoltan Fehervari doi:10.1038/s41590-018-0125-z Mn potentiates cGAS    p511 Ioana Visan doi:10.1038/s41590-018-0126-y Training and tolerance    p511 Ioana Visan doi:10.1038/s41590-018-0127-x Immunology JOBS of the week Research Fellow Birmingham University Postdoctoral Fellow University of Colorado Anschutz Medical Campus Two Postdoctoral Fellows – immunology University of Oslo Post Doctoral Associate Weill Cornell Medicine Assistant Editor (f / m) WILEY-VCH Verlag GmbH & Co. KGaA More Science jobs from Immunology EVENT World Conference on Vaccine and Immunology 13.09.18 București, Romania More science events from Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    News & Views   TORching a semaphore for alternative macrophage activation    pp512 - 514 Jayne Louise Wilson & Thomas Weichhart doi:10.1038/s41590-018-0117-z High-affinity IgA against microbial glycans    pp514 - 515 Jiwon Lee & George Georgiou doi:10.1038/s41590-018-0116-0 CCR7 fuels and LFA-1 grips    pp516 - 518 Patrick W. Oakes & Deborah J. Fowell doi:10.1038/s41590-018-0118-y Influenza’s signature move    pp518 - 520 David F. Tough doi:10.1038/s41590-018-0115-1 Meeting Reports   Tuberculous meningitis: a roadmap for advancing basic and translational research    pp521 - 525 Sanjay K. Jain, David M. Tobin, Elizabeth W. Tucker, Vishwanath Venketaraman, Alvaro A. Ordonez et al. doi:10.1038/s41590-018-0119-x Review Articles   Regulation of macrophage immunometabolism in atherosclerosis    pp526 - 537 Graeme J. Koelwyn, Emma M. Corr, Ebru Erbay & Kathryn J. Moore doi:10.1038/s41590-018-0113-3 In this Review, Moore and colleagues discuss regulation of macrophage immunometabolism in atherosclerosis.   Tissue-resident memory T cells at the center of immunity to solid tumors    pp538 - 546 Derk Amsen, Klaas P. J. M. van Gisbergen, Pleun Hombrink & Rene A. W. van Lier doi:10.1038/s41590-018-0114-2 Articles   CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses    pp547 - 560 Xia Xu, Jin-Fu Xu, Guoxing Zheng, Hai-Wen Lu, Jie-Lin Duan et al. doi:10.1038/s41590-018-0112-4 CARD9 serves as an adaptor for C-type lectin receptor signaling. Xin Lin and colleagues show that CARD9 inhibits RelB-mediated IL-5 expression. The CARD9S12N mutant, prevalent in humans, cannot interact with RelB and promotes enhanced allergic responses to fungal pathogens.   Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization    pp561 - 570 Sujin Kang, Yoshimitsu Nakanishi, Yoshiyuki Kioi, Daisuke Okuzaki, Tetsuya Kimura et al. doi:10.1038/s41590-018-0108-0 Semaphorins play well-known roles in axon guidance. Kumanogoh and colleagues demonstrate that Semaphorin 6D cell-intrinsically activates anti-inflammatory macrophage polarization.   Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans    pp571 - 582 Rahul Shinde, Kebria Hezaveh, Marie Jo Halaby, Andreas Kloetgen, Ankur Chakravarthy et al. doi:10.1038/s41590-018-0107-1 McGaha and colleagues show that phagocytosis of apoptotic cells leads to activation of the transcription factor AhR and production of the cytokine IL-10 in phagocytes, in a manner dependent on the recognition of DNA.   Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27    pp583 - 593 Heeju Ryu, Hoyong Lim, Garam Choi, Young-Jun Park, Minkyoung Cho et al. doi:10.1038/s41590-018-0102-6 Dyslipidemia and autoimmune disease are often associated. Chung and colleagues demonstrate a mechanistic pathway by which dyslipidemia leads to the induction of pathogenic autoantibodies.   Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis    pp594 - 605 Joana Borlido, Stephen Sakuma, Marcela Raices, Florent Carrette, Roberto Tinoco et al. doi:10.1038/s41590-018-0103-5 D’Angelo and colleagues show that the nucleoporin Nup210 plays a specific role in naïve CD4+ T cell homeostasis by regulating expression of Caveolin-2, which is required for tonic TCR signaling.   Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells    pp606 - 616 Miroslav Hons, Aglaja Kopf, Robert Hauschild, Alexander Leithner, Florian Gaertner et al. doi:10.1038/s41590-018-0109-z Sixt, Stein and colleagues show that during T cell migration within lymphatic organs, the chemokine receptor CCR7 quantitatively controls the speed of a continuous actin flow, which is coupled to the environment by the integrin LFA-1.   Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen    pp617 - 624 Tim Rollenske, Valeria Szijarto, Jolanta Lukasiewicz, Luis M. Guachalla, Katarina Stojkovic et al. doi:10.1038/s41590-018-0106-2 Carbohydrate-specific antibodies are typically thought to be of low affinity and produced by T cell–independent pathways. Wardemann and colleagues identify human memory B cells that can produce specific ‘affinity-matured’ antibodies to the O antigen of Klebsiella lipopolysaccharides.   Resources   Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza    pp625 - 635 Jake Dunning, Simon Blankley, Long T. Hoang, Mike Cox, Christine M. Graham et al. doi:10.1038/s41590-018-0111-5 Influenza can occasionally result in life-threatening sequelae. Openshaw and colleagues describe the functional and transcriptional response to natural infection with influenza virus and find that a transition to an ‘anti-bacterial response’ is associated with more-severe symptoms.   Technical Reports   Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies    pp636 - 644 Zhana Haimon, Alon Volaski, Johannes Orthgiess, Sigalit Boura-Halfon, Diana Varol et al. doi:10.1038/s41590-018-0110-6 Isolating tissue-resident cells runs the risk of altering their expression profile. Jung and colleagues use a RiboTagging approach to describe the microglial translatome and demonstrate that macrophage extraction from their tissue environment results in significant transcriptional alterations.   Amendments & Corrections   Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR    p645 David Zemmour, Rapolas Zilionis, Evgeny Kiner, Allon M Klein, Diane Mathis et al. doi:10.1038/s41590-018-0104-4 Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors    p645 Etienne Patin, Milena Hasan, Jacob Bergstedt, Vincent Rouilly, Valentina Libri et al. doi:10.1038/s41590-018-0105-3 Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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