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| | 23 May 2018 | | | | Advertisement | Who are the future leading women in science? The Nature Research Awards for Inspiring Science and Innovating Science are now open for nominations. In partnership with The Estée Lauder Companies. | | | | | | Advertisement | | Al-Sumait Prize Call for Nominations Nominations are now open for the $1Million 2018 Health Category of Al-Sumait Prize for African Development. Nominations are accepted for Institutions or Individuals advancing Health in Africa. The nominations period closes on June 30 2018. Conditions, requirements and a link to the nomination form can be found below. Nominate here | | | | | | Advertisement | | nature.com webcasts Nature Research Custom presents a webcast on: Saving an Enzymatic HTS Assay with Sound Date: Wednesday, June 13, 2018 Labcyte and Servier will present a recent experiment about Echo technology. Learn about the solutions for a robust enzymatic HTS assay and absorption issue. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: Labcyte | | | | | | Latest Editorial | | | | | | | | Latest Comment | | | | | | | | | Latest Articles | View all Articles | | | A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation OPEN | | Sofie Voet , Conor Mc Guire, Nora Hagemeyer, Arne Martens, Anna Schroeder, Peter Wieghofer, Carmen Daems, Ori Staszewski, Lieselotte Vande Walle, Marta Joana Costa Jordao, Mozes Sze, Hanna-Kaisa Vikkula, Delphine Demeestere, Griet Van Imschoot, Charlotte L. Scott, Esther Hoste, Amanda Gonçalves, Martin Guilliams, Saskia Lippens, Claude Libert et al. | | As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system. | | 23 May 2018 | doi: 10.1038/s41467-018-04376-5 | | Interleukins Multiple sclerosis Neuroimmunology | Silicon-oriented regio- and enantioselective rhodium-catalyzed hydroformylation OPEN | | Cai You, Xiuxiu Li, Yuhong Yang, Yu-Sheng Yang, Xuefeng Tan, Shuailong Li, Biao Wei, Hui Lv, Lung-Wa Chung & Xumu Zhang | | Hydroformylation of 1,2-disubstituted alkenes usually occurs at the α position of the directing heteroatom. Here, the authors report the asymmetric rhodium-catalyzed hydroformylation of 1,2-disubstituted alkenylsilanes with excellent regioselectivity at the β position (relative to the silicon heteroatom) and enantioselectivity. | | 23 May 2018 | doi: 10.1038/s41467-018-04277-7 | | Asymmetric catalysis Asymmetric synthesis Stereochemistry | Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair OPEN | | Ja-Hwan Seol, Cory Holland, Xiaolei Li, Christopher Kim, Fuyang Li, Melisa Medina-Rivera, Robin Eichmiller, Ignacio F. Gallardo, Ilya J. Finkelstein, Paul Hasty, Eun Yong Shim, Jennifer A. Surtees & Sang Eun Lee | | The yeast Rad1–Rad10 complex has multiple roles in DNA damage repair. Here the authors uncover mutants that uncouple the roles in UV excision repair and non-NER functions. | | 23 May 2018 | doi: 10.1038/s41467-018-04327-0 | | DNA damage and repair Genomic instability | Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity OPEN | | Quy H. Nguyen, Nicholas Pervolarakis, Kerrigan Blake, Dennis Ma, Ryan Tevia Davis, Nathan James, Anh T. Phung, Elizabeth Willey, Raj Kumar, Eric Jabart, Ian Driver, Jason Rock, Andrei Goga, Seema A. Khan, Devon A. Lawson, Zena Werb & Kai Kessenbrock | | Epithelial subpopulations are present in the human breast but how these differentiate or form is unclear. Here, the authors use single-cell RNA sequencing of primary human breast epithelial cells to define previously undescribed luminal, basal epithelial subpopulations and ZEB1-positive basal cells. | | 23 May 2018 | doi: 10.1038/s41467-018-04334-1 | | Breast cancer Cells High-throughput screening RNA sequencing | Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes OPEN | | Amparo Garcia-Lopez , Francesca Tessaro, Hendrik R. A. Jonker, Anna Wacker, Christian Richter, Arnaud Comte, Nikolaos Berntenis, Roland Schmucki, Klas Hatje, Olivier Petermann, Gianpaolo Chiriano, Remo Perozzo, Daniel Sciarra, Piotr Konieczny, Ignacio Faustino, Guy Fournet, Modesto Orozco, Ruben Artero, Friedrich Metzger, Martin Ebeling et al. | | Spinal muscular atrophy (SMA) is an autosomal recessive disorder with no present cure. Here the authors perform an in vitro screening leading to the identification of a small molecule that alters the conformational dynamics of the TSL2 RNA structure and acts as a modulator of SMN exon 7 splicing. | | 23 May 2018 | doi: 10.1038/s41467-018-04110-1 | | High-throughput screening Molecular modelling RNA Solution-state NMR Target validation | Synthetic cytokine receptors transmit biological signals using artificial ligands OPEN | | Erika Engelowski, Artur Schneider, Manuel Franke, Haifeng Xu, Ramona Clemen, Alexander Lang, Paul Baran, Christian Binsch, Birgit Knebel, Hadi Al-Hasani, Jens M. Moll, Doreen M. Floß, Philipp A. Lang & Jürgen Scheller | | Cytokine-induced signaling acts as an ON/OFF switch dependent on the presence of ligands. Here the authors construct synthetic cytokine receptors responsive to synthetic ligands able to activate canonical signaling pathways. | | 23 May 2018 | doi: 10.1038/s41467-018-04454-8 | | Interleukins Molecular engineering Signal transduction Synthetic biology | Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation OPEN | | Zakaria Ezzoukhry, Elodie Henriet, Fabrice P. Cordelières, Jean-William Dupuy, Marlène Maître, Nathan Gay, Sylvaine Di-Tommaso, Luc Mercier, Jacky G. Goetz, Marion Peter, Frédéric Bard, Violaine Moreau, Anne-Aurélie Raymond & Frédéric Saltel | | Invadosomes degrade extracellular matrix and facilitate cell invasion but their molecular composition is not fully understood. Here, the authors combine laser capture and mass spectrometry to map the proteome of invadosomes, showing that they rely on internal translational activity to maintain their structure. | | 23 May 2018 | doi: 10.1038/s41467-018-04461-9 | | Invadopodia Isolation, separation and purification Podosomes Proteomics | Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays OPEN | | Martin Thunemann, Yichen Lu, Xin Liu, Kıvılcım Kılıç, Michèle Desjardins, Matthieu Vandenberghe, Sanaz Sadegh, Payam A. Saisan, Qun Cheng, Kimberly L. Weldy, Hongming Lyu, Srdjan Djurovic, Ole A. Andreassen, Anders M. Dale, Anna Devor & Duygu Kuzum | | Optical imaging and manipulation technologies cannot be easily integrated with electrical recordings due to generation of light-induced artifacts. Here the authors report the optimization of transparent graphene microelectrode fabrication to achieve artifact-free electrical recordings along with deep 2-photon imaging in vivo. | | 23 May 2018 | doi: 10.1038/s41467-018-04457-5 | | Biomedical engineering Neuroscience | Structural resolution of inorganic nanotubes with complex stoichiometry OPEN | | Geoffrey Monet, Mohamed S. Amara, Stéphan Rouzière, Erwan Paineau, Ziwei Chai, Joshua D. Elliott, Emiliano Poli, Li-Min Liu, Gilberto Teobaldi & Pascale Launois | | Structural determination of inorganic nanotubes has lagged far behind that of their carbon-based counterparts. Here, the authors present a transferable methodology, combining wide angle X-ray scattering and computation, to quantitatively resolve the atomic structure of inorganic nanotubes with complex stoichiometry. | | 23 May 2018 | doi: 10.1038/s41467-018-04360-z | | Characterization and analytical techniques Inorganic chemistry Organic–inorganic nanostructures | Extremely stable graphene electrodes doped with macromolecular acid OPEN | | Sung-Joo Kwon, Tae-Hee Han, Taeg Yeoung Ko, Nannan Li, Youngsoo Kim, Dong Jin Kim, Sang-Hoon Bae, Yang Yang, Byung Hee Hong, Kwang S. Kim, Sunmin Ryu & Tae-Woo Lee | | Chemical doping is a viable strategy to tune the electrical properties of pristine graphene, but suffers from stability issues. Here, the authors develop a macromolecular chemical doping approach that makes use of polymeric acid and provides high stability. | | 23 May 2018 | doi: 10.1038/s41467-018-04385-4 | | Electronic devices Electronic properties and devices | The rice blast resistance gene Ptr encodes an atypical protein required for broad-spectrum disease resistance OPEN | | Haijun Zhao, Xueyan Wang, Yulin Jia, Bastian Minkenberg, Matthew Wheatley, Jiangbo Fan, Melissa H. Jia, Adam Famoso, Jeremy D. Edwards, Yeshi Wamishe, Barbara Valent, Guo-Liang Wang & Yinong Yang | | Genes that confer resistance to plant pathogens such as rice blast disease typically encode NLR-type receptor proteins. Here, Zhao et al. describe a new resistance locus that encodes a non-NLR Armadillo repeat protein required for broad-spectrum resistance in rice. | | 23 May 2018 | doi: 10.1038/s41467-018-04369-4 | | Agricultural genetics Biotic Plant genetics Plant immunity | Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors OPEN | | Yibing Wang , Liqin Cao, Chia-Ying Lee, Tomohiko Matsuo, Kejia Wu, Greg Asher, Lijun Tang, Tsuyoshi Saitoh, Jamie Russell, Daniela Klewe-Nebenius, Li Wang, Shingo Soya, Emi Hasegawa, Yoan Chérasse, Jiamin Zhou, Yuwenbin Li, Tao Wang, Xiaowei Zhan, Chika Miyoshi, Yoko Irukayama et al. | | TMT is a chemical that evokes innate defensive behaviors yet the molecular mechanisms are not well understood. Here the authors perform a large-scale forward genetics screen in mice and identify Trpa1, a pungency/irritancy receptor, as a chemosensor for predator odor-evoked innate fear and defensive behaviors. | | 23 May 2018 | doi: 10.1038/s41467-018-04324-3 | | Genetics of the nervous system Molecular neuroscience | Postnatal DNA demethylation and its role in tissue maturation OPEN | | Yitzhak Reizel, Ofra Sabag, Yael Skversky, Adam Spiro, Benjamin Steinberg, Diana Bernstein, Amber Wang, Julia Kieckhaefer, Catherine Li, Eli Pikarsky, Rena Levin-Klein, Alon Goren, Klaus Rajewsky, Klaus H. Kaestner & Howard Cedar | | Here the authors show that. large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play. major role in the regulation of gene expression and tissue maturation in the liver. | | 23 May 2018 | doi: 10.1038/s41467-018-04456-6 | | Epigenetics Transcriptional regulatory elements | Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods OPEN | | Wei Liu, Zhouqing Luo, Yun Wang, Nhan T. Pham, Laura Tuck, Irene Pérez-Pi, Longying Liu, Yue Shen, Chris French, Manfred Auer, Jon Marles-Wright, Junbiao Dai & Yizhi Cai | | Pathway optimization and chassis engineering are usually carried out in a step-wise and trial-and-error manner. Here the authors present ’SCRaMbLE-in’ that combines in-vitro pathway rapid prototyping with in-vivo genome integration and optimization. | | 22 May 2018 | doi: 10.1038/s41467-018-04254-0 | | Genomic engineering Metabolic engineering Synthetic biology | Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES OPEN | | Zhouqing Luo, Lihui Wang, Yun Wang, Weimin Zhang, Yakun Guo, Yue Shen, Linghuo Jiang, Qingyu Wu, Chong Zhang, Yizhi Cai & Junbiao Dai | | The use of synthetic chromosomes and the recombinase-based SCRaMbLE system could enable rapid strain evolution through massive chromosome rearrangements. Here the authors present ReSCuES, which uses auxotrophic markers to rapidly identify yeast with rearrangements for strain engineering. | | 22 May 2018 | doi: 10.1038/s41467-017-00806-y | | Genome evolution Synthetic biology | Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components OPEN | | T. Tony Yang, Weng Man Chong, Won-Jing Wang, Gregory Mazo, Barbara Tanos, Zhengmin Chen, Thi Minh Nguyet Tran, Yi-De Chen, Rueyhung Roc Weng, Chia-En Huang, Wann-Neng Jane, Meng-Fu Bryan Tsou & Jung-Chi Liao | | Distal appendages (DAPs) at the cilia base mediate membrane docking during ciliogenesis. Here the authors use super-resolution microscopy to map 16 centriole distal end components, revealing the structure of the backbone of the DAP, as well as a previously undescribed distal appendage matrix. | | 22 May 2018 | doi: 10.1038/s41467-018-04469-1 | | Centrosome Cilia Ciliogenesis | Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models OPEN | | Samuel Y. Ng , Noriaki Yoshida, Amanda L. Christie, Mahmoud Ghandi, Neekesh V. Dharia, Joshua Dempster, Mark Murakami, Kay Shigemori, Sara N. Morrow, Alexandria Van Scoyk, Nicolas A. Cordero, Kristen E. Stevenson, Maneka Puligandla, Brian Haas, Christopher Lo, Robin Meyers, Galen Gao, Andrew Cherniack, Abner Louissaint Jr, Valentina Nardi et al. | | T- and NK-cell lymphomas (TCL) are a group of lymphoid malignancies characterized by poor prognosis, but the absence of appropriate pre-clinical models has hampered the development of effective therapies. Here the authors establish several pre-clinical models and identify vulnerabilities that could be further exploited to treat patients afflicted by these diseases. | | 22 May 2018 | doi: 10.1038/s41467-018-04356-9 | | Cancer genomics Molecular medicine Preclinical research | In vitro DNA SCRaMbLE OPEN | | Yi Wu, Rui-Ying Zhu, Leslie A. Mitchell, Lu Ma, Rui Liu, Meng Zhao, Bin Jia, Hui Xu, Yun-Xiang Li, Zu-Ming Yang, Yuan Ma, Xia Li, Hong Liu, Duo Liu, Wen-Hai Xiao, Xiao Zhou, Bing-Zhi Li, Ying-Jin Yuan & Jef D. Boeke | | SCRaMbLE allows for the rapid and large scale rearrangement of genetic data in yeast carrying synthetic chromosomes. Here the authors demonstrate an in vitro use of the method to generate DNA libraries for optimization of biochemical reactions. | | 22 May 2018 | doi: 10.1038/s41467-018-03743-6 | | Metabolic engineering Synthetic biology | Controlling the coherence of a diamond spin qubit through its strain environment OPEN | | Young-Ik Sohn, Srujan Meesala, Benjamin Pingault, Haig A. Atikian, Jeffrey Holzgrafe, Mustafa Gündoğan, Camille Stavrakas, Megan J. Stanley, Alp Sipahigil, Joonhee Choi, Mian Zhang, Jose L. Pacheco, John Abraham, Edward Bielejec, Mikhail D. Lukin, Mete Atatüre & Marko Lončar | | Silicon-vacancy centres in diamond are promising candidates as emitters in photonic quantum networks, but their coherence is degraded by large electron-phonon interactions. Sohn et al. demonstrate the use of strain to tune a silicon vacancy’s electronic structure and suppress phonon-mediated decoherence. | | 22 May 2018 | doi: 10.1038/s41467-018-04340-3 | | Optical properties of diamond Mechanical engineering Quantum information Qubits | Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS OPEN | | Raphaelle Luisier, Giulia E. Tyzack, Claire E. Hall, Jamie S. Mitchell, Helen Devine, Doaa M. Taha, Bilal Malik, Ione Meyer, Linda Greensmith, Jia Newcombe, Jernej Ule, Nicholas M. Luscombe & Rickie Patani | | Intron retention (IR) can increase protein diversity and function, and yet unregulated IR may be detrimental to cellular health. This study shows that aberrant IR occurs in ALS and finds nuclear loss of an RNA-binding protein called SFPQ as a new molecular hallmark in this devastating condition. | | 22 May 2018 | doi: 10.1038/s41467-018-04373-8 | | Alternative splicing Induced pluripotent stem cells Neural stem cells Neurology Pathogenesis | Heterozygous diploid and interspecies SCRaMbLEing OPEN | | Michael J. Shen, Yi Wu, Kun Yang, Yunxiang Li, Hui Xu, Haoran Zhang, Bing-Zhi Li, Xia Li, Wen-Hai Xiao, Xiao Zhou, Leslie A. Mitchell, Joel S. Bader, Yingjin Yuan & Jef D. Boeke | | SCRaMbLE has been used to rearrange synthetic chromosomes that have been introduced into host yeast. Here the authors produce semi-synthetic heterozygous diploid strains for rapid selection of phenotypes and map the rearrangements underlying selected phenotypes such as thermoresistance and caffeine resistance. | | 22 May 2018 | doi: 10.1038/s41467-018-04157-0 | | Experimental evolution Genome evolution Genomic engineering Synthetic biology | High-throughput screening of prostate cancer risk loci by single nucleotide polymorphisms sequencing OPEN | | Peng Zhang, Ji-Han Xia, Jing Zhu, Ping Gao, Yi-Jun Tian, Meijun Du, Yong-Chen Guo, Sufyan Suleman, Qin Zhang, Manish Kohli, Lori S. Tillmans, Stephen N. Thibodeau, Amy J. French, James R. Cerhan, Li-Dong Wang, Gong-Hong Wei & Liang Wang | | Functional characterization of disease-causing variants at risk loci in cancer is challenging. Here, in prostate cancer the authors report a pipeline for high-throughput single-nucleotide polymorphisms sequencing (SNPs-seq) for large scale screening of functional SNPs at disease risk loci. | | 22 May 2018 | doi: 10.1038/s41467-018-04451-x | | Genetic variation Genetics research Genomic analysis Genomics Sequencing | Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders OPEN | | Yao Xiao , Can Wang, Jia-Yu Chen, Fujian Lu, Jue Wang, Ning Hou, Xiaomin Hu, Fanxin Zeng, Dongwei Ma, Xueting Sun, Yi Ding, Yan Zhang, Wen Zheng, Yuli Liu, Haibao Shang, Wenzhen Zhu, Chensheng Han, Yulin Zhang, Kunfu Ouyang, Liangyi Chen et al. | | Hyperinsulinemia can precede the development of insulin resistance. Here the authors identify a PKD2 mutation that leads to hyperinsulinemia and insulin resistance in Rhesus monkey and show that PKD2 deficiency promotes beta cell insulin secretion by activating L-type Ca2+ channels. | | 22 May 2018 | doi: 10.1038/s41467-018-04352-z | | Islets of Langerhans Metabolic syndrome Type 2 diabetes | Precise control of SCRaMbLE in synthetic haploid and diploid yeast OPEN | | Bin Jia, Yi Wu, Bing-Zhi Li, Leslie A. Mitchell, Hong Liu, Shuo Pan, Juan Wang, Hao-Ran Zhang, Nan Jia, Bo Li, Michael Shen, Ze-Xiong Xie, Duo Liu, Ying-Xiu Cao, Xia Li, Xiao Zhou, Hao Qi, Jef D. Boeke & Ying-Jin Yuan | | The SCRaMbLE system integrated into Sc2.0’s synthetic yeast chromosome project allows rapid strain evolution. Here the authors use a genetic logic gate to control induction of recombination in a haploid and diploid yeast carrying synthetic chromosomes. | | 22 May 2018 | doi: 10.1038/s41467-018-03084-4 | | Genome evolution Mutagenesis Synthetic biology | Taxon-specific aerosolization of bacteria and viruses in an experimental ocean-atmosphere mesocosm OPEN | | Jennifer M. Michaud, Luke R. Thompson, Drishti Kaul, Josh L. Espinoza, R. Alexander Richter, Zhenjiang Zech Xu, Christopher Lee, Kevin M. Pham, Charlotte M. Beall, Francesca Malfatti, Farooq Azam, Rob Knight, Michael D. Burkart, Christopher L. Dupont & Kimberly A. Prather | | Factors controlling the transfer of microbes from the ocean to the atmosphere are unclear. Here, Michaud et al. study this process in an enclosed ocean-atmosphere facility, and show that the degree of aerosolization of bacteria and viruses is taxon-specific. | | 22 May 2018 | doi: 10.1038/s41467-018-04409-z | | Air microbiology Atmospheric chemistry | Polarization insensitive frequency conversion for an atom-photon entanglement distribution via a telecom network OPEN | | Rikizo Ikuta, Toshiki Kobayashi, Tetsuo Kawakami, Shigehito Miki, Masahiro Yabuno, Taro Yamashita, Hirotaka Terai, Masato Koashi, Tetsuya Mukai, Takashi Yamamoto & Nobuyuki Imoto | | Quantum repeater-based communication requires the ability to interface good quantum memories to telecom photons. Here, the authors report polarization-insensitive frequency conversion to telecom wavelength of a photon entangled with a Rb ensemble, preserving the entanglement in the process. | | 21 May 2018 | doi: 10.1038/s41467-018-04338-x | | Atomic and molecular interactions with photons Quantum information Quantum optics Single photons and quantum effects | Multiple convergent supergene evolution events in mating-type chromosomes OPEN | | Sara Branco, Fantin Carpentier, Ricardo C. Rodríguez de la Vega, Hélène Badouin, Alodie Snirc, Stéphanie Le Prieur, Marco A. Coelho, Damien M. de Vienne, Fanny E. Hartmann, Dominik Begerow, Michael E. Hood & Tatiana Giraud | | Supergenes result from beneficial linkage and recombination suppression between two or more genes. Giraud and colleagues use whole genome sequencing data to show convergent evolution of supergenes on mating-type chromosomes in multiple closely-related fungal lineages. | | 21 May 2018 | doi: 10.1038/s41467-018-04380-9 | | Evolutionary biology Evolutionary genetics | Factor XIIIA—expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking OPEN | | Alessandro Porrello , Patrick L. Leslie, Emily B. Harrison, Balachandra K. Gorentla, Sravya Kattula, Subrata K. Ghosh, Salma H. Azam, Alisha Holtzhausen, Yvonne L. Chao, Michele C. Hayward, Trent A. Waugh, Sanggyu Bae, Virginia Godfrey, Scott H. Randell, Cecilia Oderup, Liza Makowski, Jared Weiss, Matthew D. Wilkerson, D. Neil Hayes, H. Shelton Earp et al. | | Lung squamous carcinomas (LUSC) are poorly molecularly characterized, but sub-populations show promising response to immune checkpoint inhibitors. Here, the authors identify a subset of LUSC characterized by infiltration of inflammatory monocytes, where metastasis is linked to Factor XIIIA promoting fibrin cross-linking. | | 18 May 2018 | doi: 10.1038/s41467-018-04355-w | | Monocytes and macrophages Non-small-cell lung cancer | Phenotypic diversification by enhanced genome restructuring after induction of multiple DNA double-strand breaks OPEN | | Nobuhiko Muramoto, Arisa Oda, Hidenori Tanaka, Takahiro Nakamura, Kazuto Kugou, Kazuki Suda, Aki Kobayashi, Shiori Yoneda, Akinori Ikeuchi, Hiroki Sugimoto, Satoshi Kondo, Chikara Ohto, Takehiko Shibata, Norihiro Mitsukawa & Kunihiro Ohta | | DNA double-strand break (DSB) leads to genome rearrangements with various genetic and phenotypic effects. Here, the authors develop a tool to induce large-scale genome restructuring by introducing conditional multiple DNA breaks, and produce various traits in yeast and Arabidopsis thaliana. | | 18 May 2018 | doi: 10.1038/s41467-018-04256-y | | DNA recombination Evolutionary biology Genetic engineering | Bacterial encapsulins as orthogonal compartments for mammalian cell engineering OPEN | | Felix Sigmund, Christoph Massner, Philipp Erdmann, Anja Stelzl, Hannes Rolbieski, Mitul Desai, Sarah Bricault, Tobias P. Wörner, Joost Snijder, Arie Geerlof, Helmut Fuchs, Martin Hrabĕ de Angelis, Albert J. R. Heck, Alan Jasanoff, Vasilis Ntziachristos, Jürgen Plitzko & Gil G. Westmeyer | | Artificial compartments have been expressed in prokaryotes and yeast, but similar capabilities have been missing for mammalian cell engineering. Here the authors use bacterial encapsulins to engineer genetically controlled multifunctional orthogonal compartments in mammalian cells. | | 18 May 2018 | doi: 10.1038/s41467-018-04227-3 | | Biomaterials – proteins Biomineralization Cellular imaging Metalloproteins Nanostructures | Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor OPEN | | Sahil Gulati, Hui Jin, Ikuo Masuho, Tivadar Orban, Yuan Cai, Els Pardon, Kirill A. Martemyanov, Philip D. Kiser, Phoebe L. Stewart, Christopher P. Ford, Jan Steyaert & Krzysztof Palczewski | | G protein-coupled receptors (GPCRs) activate and dissociate the G protein heterotrimer into Gα-GTP and Gβγ dimer, which facilitate distinct signalling events. Here authors develop a nanobody, Nb5 that modulates Gβγ-mediated signaling without affecting GTP-bound Gαq and Gαs-mediated signaling events. | | 18 May 2018 | doi: 10.1038/s41467-018-04432-0 | | Biochemistry G protein-coupled receptors Membrane proteins Structural biology | Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection OPEN | | Julian A. Rycroft, Bridget Gollan, Grzegorz J. Grabe, Alexander Hall, Angela M. Cheverton, Gerald Larrouy-Maumus, Stephen A. Hare & Sophie Helaine | | The recalcitrance of many infections to antibiotic treatment may be due to the presence of ‘persisters’, or non-growing, antibiotic-tolerant bacteria. Here, the authors study the structures and functions of aminoacyl-tRNA acetyltransferase toxins, and their roles in persister formation in Salmonella. | | 18 May 2018 | doi: 10.1038/s41467-018-04472-6 | | Antibiotics Bacteriology | Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes OPEN | | Gwen Lomberk , Yuna Blum, Rémy Nicolle, Asha Nair, Krutika Satish Gaonkar, Laetitia Marisa, Angela Mathison, Zhifu Sun, Huihuang Yan, Nabila Elarouci, Lucile Armenoult, Mira Ayadi, Tamas Ordog, Jeong-Heon Lee, Gavin Oliver, Eric Klee, Vincent Moutardier, Odile Gayet, Benjamin Bian, Pauline Duconseil et al. | | Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival. | | 17 May 2018 | doi: 10.1038/s41467-018-04383-6 | | Cancer Epigenomics | MxB is an interferon-induced restriction factor of human herpesviruses OPEN | | Michel Crameri, Michael Bauer, Nicole Caduff, Raphael Walker, Fiona Steiner, Francesca D. Franzoso, Cornelia Gujer, Karin Boucke, Talissa Kucera, Andrea Zbinden, Christian Münz, Cornel Fraefel, Urs F. Greber & Jovan Pavlovic | | MxB is an interferon-induced GTPase that inhibits HIV replication. Here, Crameri et al. show that MxB restricts replication of herpesviruses by inhibiting delivery of incoming viral DNA into the nucleus, and this antiviral activity depends on MxB’s GTPase activity. | | 17 May 2018 | doi: 10.1038/s41467-018-04379-2 | | Herpes virus Interferons Nuclear transport Restriction factors | A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration OPEN | | Yuanyuan Chen, Yu Chen, Beata Jastrzebska, Marcin Golczak, Sahil Gulati, Hong Tang, William Seibel, Xiaoyu Li, Hui Jin, Yong Han, Songqi Gao, Jianye Zhang, Xujie Liu, Hossein Heidari-Torkabadi, Phoebe L. Stewart, William E. Harte, Gregory P. Tochtrop & Krzysztof Palczewski | | Mutations that lead to misfolding of rhodopsin can cause retinitis pigmentosa. Here, the authors carry out a high throughput screen to identify a small molecule chaperone of rod opsin, and show that it protects mouse models of retinitis pigmentosa from retinal degeneration. | | 17 May 2018 | doi: 10.1038/s41467-018-04261-1 | | Protein transport Receptor pharmacology Retinal diseases | Elucidating the genetic architecture of reproductive ageing in the Japanese population OPEN | | Momoko Horikoshi, Felix R. Day, Masato Akiyama, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kazuyoshi Ishigaki, Masahiro Kanai, Hollis Wright, Carlos A. Toro, Sergio R. Ojeda, Alejandro Lomniczi, Michiaki Kubo, Ken K. Ong & John. R. B. Perry | | The timing of female reproductive capacity is influenced by genetic and environmental factors. Here, in genome-wide association studies, the authors identify genetic loci for age at menarche and onset of menopause in Japanese women, and highlight differences with European populations. | | 17 May 2018 | doi: 10.1038/s41467-018-04398-z | | Endocrine reproductive disorders Genome-wide association studies | Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment OPEN | | Shazia Ashraf , Hiroki Kudo, Jia Rao, Atsuo Kikuchi, Eugen Widmeier, Jennifer A. Lawson, Weizhen Tan, Tobias Hermle, Jillian K. Warejko, Shirlee Shril, Merlin Airik, Tilman Jobst-Schwan, Svjetlana Lovric, Daniela A. Braun, Heon Yung Gee, David Schapiro, Amar J. Majmundar, Carolin E. Sadowski, Werner L. Pabst, Ankana Daga et al. | | Nephrotic syndrome is the second most common chronic kidney disease but there are no targeted treatment strategies available. Here the authors identify mutations of six genes codifying for proteins involved in cytoskeleton remodelling and modulation of small GTPases in 17 families with nephrotic syndrome. | | 17 May 2018 | doi: 10.1038/s41467-018-04193-w | | Genetics Medical genetics | Coulombic-enhanced hetero radical pairing interactions OPEN | | Xujun Zheng, Yang Zhang, Ning Cao, Xin Li, Shuoqing Zhang, Renfeng Du, Haiying Wang, Zhenni Ye, Yan Wang, Fahe Cao, Haoran Li, Xin Hong, Andrew C.-H. Sue, Chuluo Yang, Wei-Guang Liu & Hao Li | | Homo radical spin-pairing interactions between two identical aromatic radicals are common in supramolecular chemistry, but hetero interactions between two different aromatic radicals are seldom observed. Here, the authors find that hetero radical pairing between a radical cation and a radical anion, together with Coulombic attraction, can drive host-guest recognition, representing a new supramolecular recognition motif. | | 17 May 2018 | doi: 10.1038/s41467-018-04335-0 | | Interlocked molecules Self-assembly | CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema OPEN | | Gabriela D. García Nores, Catherine L. Ly, Daniel A. Cuzzone, Raghu P. Kataru, Geoffrey E. Hespe, Jeremy S. Torrisi, Jung Ju Huang, Jason C. Gardenier, Ira L. Savetsky, Matthew D. Nitti, Jessie Z. Yu, Sonia Rehal & Babak J. Mehrara | | CD4+ T cells are critical for the development of lymphedema. Here the authors show how these cells contribute to lymphedema and identify that the sphingosine-1-phosphate receptor modulator FTY720 can prevent lymphedema in a mouse tail injury model by blocking the release of CD4+ T cells from the lymph nodes to the skin. | | 17 May 2018 | doi: 10.1038/s41467-018-04418-y | | CD4-positive T cells Skin diseases | Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease OPEN | | Masayoshi Ohkuro , Jun-Dal Kim, Yoshikazu Kuboi, Yuki Hayashi, Hayase Mizukami, Hiroko Kobayashi-Kuramochi, Kenzo Muramoto, Manabu Shirato, Fumiko Michikawa-Tanaka, Jun Moriya, Teruya Kozaki, Kazuma Takase, Kenichi Chiba, Kishan Lal Agarwala, Takayuki Kimura, Makoto Kotake, Tetsuya Kawahara, Naoki Yoneda, Shinsuke Hirota, Hiroshi Azuma et al. | | Inflammatory bowel disease (IBD) is initiated by integrins-mediated leukocyte adhesion to the activated colonic microvascular endothelium. Here, the authors show that inhibition of the calreticulin binding to integrin α subunits ameliorates the severity of IBD in animal models. | | 17 May 2018 | doi: 10.1038/s41467-018-04420-4 | | Inflammatory bowel disease Target validation | | | | | Latest Correspondence | | | | | | | | Latest Author Corrections | | | | Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration OPEN | | Salvatore Corallino, Chiara Malinverno, Beate Neumann, Christian Tischer, Andrea Palamidessi, Emanuela Frittoli, Magdalini Panagiotakopoulou, Andrea Disanza, Gema Malet-Engra, Paulina Nastaly, Camilla Galli, Chiara Luise, Giovanni Bertalot, Salvatore Pece, Pier Paolo Di Fiore, Nils Gauthier, Aldo Ferrari, Paolo Maiuri & Giorgio Scita | | 22 May 2018 | doi: 10.1038/s41467-018-04515-y | | Chemotaxis Growth factor signalling Mesenchymal migration | | | | | Latest Publisher Corrections | | | | Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage OPEN | | Marcus J. G. W. Ladds , Ingeborg M. M. van Leeuwen, Catherine J. Drummond, Su Chu, Alan R. Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K. Sedimbi, Marta Nekulova, Marijke C. C. Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M. Thompson et al. | | 22 May 2018 | doi: 10.1038/s41467-018-04198-5 | | Drug development Mechanism of action Small molecules Target identification | | | | | Advertisement | | nature.com webcasts Nature Research Custom presents a webcast on: Multicolour Digital PCR for ctDNA detection in breast cancer Date: 12 June 2018 Dr. Isaac Garcia-Murillas from ICR will address the technical challenges for clinical utility of liquid biopsy and ctDNA as a biomarker in breast cancer. 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