The EMBO Journal Table of Contents for 13 April 2018; Vol. 37, No. 8

13 April 2018 | Volume 37, Number 8 Submit Table of Contents Editorial News & Views Articles Volume 37, Number 8 Editorial Publication catalysis—lowering activation energy Life Science Alliance, a new peer reviewed open access platform for and by the research community to increase the efficacy of publishing high quality research findings. Bernd Pulverer Published online 03.04.2018 News & Views Waking up muscle stem cells: PI3K signalling is ringing Mouse genetics combined with cell culture and transcriptome analyses highlight dependence of satellite cell activation on PI3K–mTORC1–Jun signalling. Frederic Relaix and Léo Machado Published online 26.03.2018 Fat nerves keep pain at bay New work reveals a striking role for cholesterol in controlling an inflammatory pain‐mediating sodium channel via lipid rafts. Shihab Shah and Nikita Gamper Published online 23.03.2018 Articles Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1 Stimulation of the cGAS‐STING innate immunity pathway by cytosolic DNA leads to TBK1‐mediated phosphorylation of the selective autophagy receptor p62, directing ubiquitinated STING to autophagosomes and degradation. Thaneas Prabakaran, Chiranjeevi Bodda, Christian Krapp, Bao‐cun Zhang, Maria H Christensen, Chenglong Sun, Line Reinert, Yujia Cai, Søren B Jensen, Morten K Skouboe, Jens R Nyengaard, Craig B Thompson, Robert Jan Lebbink, Ganes C Sen, Geert van Loo, Rikke Nielsen, Masaaki Komatsu, Lene N Nejsum, Martin R Jakobsen, Mads Gyrd‐Hansen and Søren R Paludan Published online 01.03.2018 p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells Phosphatidylinositol 3‐kinase (PI3K)–mTORC1–c‐Jun signaling is essential for muscle stem cell quiescence exit and tissue repair upon injury. Gang Wang, Han Zhu, Chenghao Situ, Lifang Han, Youqian Yu, Tom H Cheung, Kai Liu and Zhenguo Wu Published online 26.03.2018 Membrane cholesterol depletion as a trigger of Nav1.9 channel‐mediated inflammatory pain An unexpected pain transmission function of cholesterol in skin tissue and sensory neurons expands its pathophysiological roles beyond metabolism and vascular diseases. Muriel Amsalem, Corinne Poilbout, Géraldine Ferracci, Patrick Delmas and Francoise Padilla Published online 19.02.2018 Transmembrane redox control and proteolysis of PdeC, a novel type of c‐di‐GMP phosphodiesterase A new class of c‐di‐GMP phosphodiesterases in Escherichia coli are regulated by posttranslational modifications in the periplasm to reduce biofilm formation. Susanne Herbst, Martin Lorkowski, Olga Sarenko, Thi Kim Loan Nguyen, Tina Jaenicke and Regine Hengge Published online 07.03.2018 Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix Regulated TACC3 recruitment by clathrin involves phosphorylation‐mediated conformational changes rather than direct phosphate group recognition, exemplifying a flexible alternative mechanism of phospho‐regulation. Selena G Burgess, Manjeet Mukherjee, Sarah Sabir, Nimesh Joseph, Cristina Gutiérrez‐Caballero, Mark W Richards, Nicolas Huguenin‐Dezot, Jason W Chin, Eileen J Kennedy, Mark Pfuhl, Stephen J Royle, Fanni Gergely and Richard Bayliss Published online 06.03.2018 OST1‐mediated BTF3L phosphorylation positively regulates CBFs during plant cold responses The cold‐induced kinase OST1 phosphorylates components of the nascent polypeptide associated complex, leading to stabilisation of cold response factors CBFs and increased plant freezing tolerance. Yanglin Ding, Yuxin Jia, Yiting Shi, Xiaoyan Zhang, Chunpeng Song, Zhizhong Gong and Shuhua Yang Published online 05.03.2018 Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation In contrast to its global role in RNA polymerase II pausing and elongation in yeast, Spt5 depletion in mouse triggers dissociation of Pol II at a specific region 15–20 kb downstream from the promoter. Johanna Fitz, Tobias Neumann and Rushad Pavri Published online 07.03.2018 LncKdm2b controls self‐renewal of embryonic stem cells via activating expression of transcription factor Zbtb3 The long noncoding RNA lncKdm2b promotes activity of the chromatin remodeling complex SRCAP, thereby promoting Zbtb3 expression and Nanog‐dependent embryonic stem cell (ESC) renewal and embryonic development. Buqing Ye, Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Dongdong Zhang, Wei Wu, Pingping Zhu, Yanying Wang, Shuo Wang, Pengyan Xia, Ying Du, Shu Meng, Guanling Huang, Jiayi Wu, Runsheng Chen, Yong Tian and Zusen Fan Published online 13.03.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.