The EMBO Journal Table of Contents for 03 April 2018; Vol. 37, No. 7

03 April 2018 | Volume 37, Number 7 Submit Table of Contents News & Views Articles Volume 37, Number 7 News & Views Paligenosis: prepare to regenerate! Differentiated cells in stomach and pancreas return to proliferation in an autophagy‐ and mTORC1‐dependent manner to enable efficient tissue renewal. Hendrik A Messal, Catherine A Cremona, Linxiang Lan and Axel Behrens Published online 22.03.2018 Differentiate and switch, a tale of two heads of a lipid Intricate mechanisms govern glycosphingolipid switching during neurodevelopment to regulate neuronal differentiation. Yusuf A Hannun Published online 23.03.2018 Metastasis inside‐out: dissemination of cancer cell clusters with inverted polarity A novel cellular mechanism for metastasis in colorectal cancer highlights collective invasion of the peritoneum led by apical cell membranes. Andrew J Ewald Published online 09.03.2018 Articles Non‐cell‐autonomous function of DR6 in Schwann cell proliferation Metalloprotease ADAM10 sheds a soluble ectodomain of the orphan TNFR‐family death receptor 6, which regulates myelination in the peripheral nervous system in a paracrine fashion. Alessio Colombo, Hung‐En Hsia, Mengzhe Wang, Peer‐Hendrik Kuhn, Monika S Brill, Paolo Canevazzi, Regina Feederle, Carla Taveggia, Thomas Misgeld and Stefan F Lichtenthaler Published online 19.02.2018 Regenerative proliferation of differentiated cells by mTORC1‐dependent paligenosis Acute injury elicits proliferation of differentiated cells in diverse organs via a shared program involving upregulation of autodegradative pathways, metaplastic genes and cell cycle re‐entry. Spencer G Willet, Mark A Lewis, Zhi‐Feng Miao, Dengqun Liu, Megan D Radyk, Rebecca L Cunningham, Joseph Burclaff, Greg Sibbel, Hei‐Yong G Lo, Valerie Blanc, Nicholas O Davidson, Zhen‐Ning Wang and Jason C Mills Published online 21.02.2018 Glycosphingolipid metabolic reprogramming drives neural differentiation The switch from globo‐ to ganglio‐series glycophospholipids during neurodevelopment involves a self‐contained regulatory circuit controlling expression of both neuronal and ganglioside‐producing genes. Domenico Russo, Floriana Della Ragione, Riccardo Rizzo, Eiji Sugiyama, Francesco Scalabrì, Kei Hori, Serena Capasso, Lucia Sticco, Salvatore Fioriniello, Roberto De Gregorio, Ilaria Granata, Mario R Guarracino, Vittorio Maglione, Ludger Johannes, Gian Carlo Bellenchi, Mikio Hoshino, Mitsutoshi Setou, Maurizio D'Esposito, Alberto Luini and Giovanni D'Angelo Published online 27.12.2017 Tau protein liquid–liquid phase separation can initiate tau aggregation An Alzheimer's Disease‐associated tau phase transition from soluble to droplet may exemplify a biophysical mechanism underlying several neurodegenerative diseases. Susanne Wegmann, Bahareh Eftekharzadeh, Katharina Tepper, Katarzyna M Zoltowska, Rachel E Bennett, Simon Dujardin, Pawel R Laskowski, Danny MacKenzie, Tarun Kamath, Caitlin Commins, Charles Vanderburg, Allyson D Roe, Zhanyun Fan, Amandine M Molliex, Amayra Hernandez‐Vega, Daniel Muller, Anthony A Hyman, Eckhard Mandelkow, J Paul Taylor and Bradley T Hyman Published online 22.02.2018 Two distinct conformational states define the interaction of human RAD51‐ATP with single‐stranded DNA Single‐molecule studies of RAD51 DNA binding and a new crystal structure of the hRAD51 filament suggest that different conformations of ATP‐bound RAD51 may be involved in DNA homology recognition and strand exchange. Ineke Brouwer, Tommaso Moschetti, Andrea Candelli, Edwige B Garcin, Mauro Modesti, Luca Pellegrini, Gijs JL Wuite and Erwin JG Peterman Published online 05.03.2018 Regulation of Hed1 and Rad54 binding during maturation of the meiosis‐specific presynaptic complex Single‐molecule imaging of recombinase dynamics on DNA identify kinetic competition by a meiosis‐specific factor as basis for the switch from mitotic to meiotic double‐strand break repair. J Brooks Crickard, Kyle Kaniecki, YoungHo Kwon, Patrick Sung, Michael Lisby and Eric C Greene Published online 14.02.2018 Structure of a eukaryotic cytoplasmic pre‐40S ribosomal subunit A high‐resolution cryo‐EM structure of the yeast ribosome's immature 40S subunit shows how assembly factors interact with the 20S rRNA, check the integrity of important regions, and prevent premature binding of mRNAs and tRNAs. Alain Scaiola, Cohue Peña, Melanie Weisser, Daniel Böhringer, Marc Leibundgut, Purnima Klingauf‐Nerurkar, Stefan Gerhardy, Vikram Govind Panse and Nenad Ban Published online 19.02.2018 Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes Crystal structures of translational repressor LSM14 bound to its co‐factors 4E‐T and DDX6 show how short linear interacting motifs (SLiMs) help organize multiprotein complexes in mRNA metabolism. Tobias Brandmann, Hana Fakim, Zoya Padamsi, Ji‐Young Youn, Anne‐Claude Gingras, Marc R Fabian and Martin Jinek Published online 06.03.2018 Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases A conserved phenylalanine residue in the flap region of apicomplexan aspartyl proteases TgASP3, PfPMIX and PfPMX confers selective sensitivity to the peptidomimetic inhibitor 49c. Budhaditya Mukherjee, Francesca Tessaro, Juha Vahokoski, Inari Kursula, Jean‐Baptiste Marq, Leonardo Scapozza and Dominique Soldati‐Favre Published online 08.03.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.