TABLE OF CONTENTS
|  |  |  | | Volume 32, Issue 4 (April 2018) |  | In this issue Original Articles Letters to the Editor Correspondence Corrigendum Also new AOP | |  |  |  | Original Articles |  |  |  | | Acute myeloid leukemia |  | Dual inhibition of EZH1/2 breaks the quiescence of leukemia stem cells in acute myeloid leukemia S Fujita, D Honma, N Adachi, K Araki, E Takamatsu et al. Leukemia 2017 32 :855 - 864; September 27, 2017; 10.1038/leu.2017.300 Abstract | Full Text |  |  |  |  | A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target F Yan, N Shen, J X Pang, N Zhao, Y W Zhang et al. Leukemia 2017 32 :865 - 873; October 10, 2017; 10.1038/leu.2017.307 Abstract | Full Text |  |  |  |  | Automated database-guided expert-supervised orientation for immunophenotypic diagnosis and classification of acute leukemia L Lhermitte, E Mejstrikova, A J van der Sluijs-Gelling, G E Grigore, L Sedek et al. Leukemia 2017 32 :874 - 881; November 01, 2017; 10.1038/leu.2017.313 Abstract | Full Text |  |  |  |  | Targeting acute myeloid leukemia by drug-induced c-MYB degradation V Walf-Vorderwülbecke, K Pearce, T Brooks, M Hubank, M M van den Heuvel-Eibrink et al. Leukemia 2017 32 :882 - 889; November 01, 2017; 10.1038/leu.2017.317 Abstract | Full Text |  |  |  |  | SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia J Bu, A Chen, X Yan, F He, Y Dong et al. Leukemia 2017 32 :890 - 899; November 29, 2017; 10.1038/leu.2017.339 Abstract | Full Text |  |  |  |  | AZA-MS: a novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo A Unnikrishnan, A N Q Vo, R Pickford, M J Raftery, A C Nunez et al. Leukemia 2017 32 :900 - 910; November 29, 2017; 10.1038/leu.2017.340 Abstract | Full Text |  |  |  |  | The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia A G Sanarico, C Ronchini, A Croce, E M Memmi, U A Cammarata et al. Leukemia 2017 32 :911 - 919; December 06, 2017; 10.1038/leu.2017.342 Abstract | Full Text |  | | Molecular targets for therapy |  | Pharmacodynamics and proteomic analysis of acalabrutinib therapy: similarity of on-target effects to ibrutinib and rationale for combination therapy V K Patel, B Lamothe, M L Ayres, J Gay, J P Cheung et al. Leukemia 2017 32 :920 - 930; November 03, 2017; 10.1038/leu.2017.321 Abstract | Full Text |  | | Acute lymphoblastic leukemia |  | RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia I S Jerchel, A Q Hoogkamer, I M Ariës, E M P Steeghs, J M Boer et al. Leukemia 2017 32 :931 - 940; October 03, 2017; 10.1038/leu.2017.303 Abstract | Full Text |  |  |  |  | Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system S Bornschein, S Demeyer, R Stirparo, O Gielen, C Vicente et al. Leukemia 2017 32 :941 - 951; November 20, 2017; 10.1038/leu.2017.328 Abstract | Full Text |  | | Chronic myelogenous leukemia |  | Risk of developing chronic myeloid neoplasms in well-differentiated thyroid cancer patients treated with radioactive iodine R J Molenaar, C Pleyer, T Radivoyevitch, S Sidana, A Godley et al. Leukemia 2017 32 :952 - 959; November 06, 2017; 10.1038/leu.2017.323 Abstract | Full Text |  | | Chronic lymphocytic leukemia |  | Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway K Kondo, H Shaim, P A Thompson, J A Burger, M Keating et al. Leukemia 2017 32 :960 - 970; October 03, 2017; 10.1038/leu.2017.304 Abstract | Full Text |  | | Multiple myeloma, gammopathies |  | Prognostic value of antigen expression in multiple myeloma: a PETHEMA/GEM study on 1265 patients enrolled in four consecutive clinical trials P Arana, B Paiva, M-T Cedena, N Puig, L Cordon et al. Leukemia 2017 32 :971 - 978; November 03, 2017; 10.1038/leu.2017.320 Abstract | Full Text |  |  |  |  | Phase 1/2 study of weekly carfilzomib, cyclophosphamide, dexamethasone in newly diagnosed transplant-ineligible myeloma S Bringhen, M D'Agostino, L De Paoli, V Montefusco, A M Liberati et al. Leukemia 2017 32 :979 - 985; November 16, 2017; 10.1038/leu.2017.327 Abstract | Full Text |  |  |  |  | Early relapse after autologous hematopoietic cell transplantation remains a poor prognostic factor in multiple myeloma but outcomes have improved over time S K Kumar, A Dispenzieri, R Fraser, F Mingwei, G Akpek et al. Leukemia 2017 32 :986 - 995; November 16, 2017; 10.1038/leu.2017.331 Abstract | Full Text |  |  |  |  | Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma A Gullà, T Hideshima, G Bianchi, M Fulciniti, M Kemal Samur et al. Leukemia 2017 32 :996 - 1002; November 21, 2017; 10.1038/leu.2017.334 Abstract | Full Text |  |  |  |  | MiR-29b antagonizes the pro-inflammatory tumor-promoting activity of multiple myeloma-educated dendritic cells C Botta, M Cucè, M R Pitari, D Caracciolo, A Gullà et al. Leukemia 2017 32 :1003 - 1015; November 21, 2017; 10.1038/leu.2017.336 Abstract | Full Text |  | | Chronic myeloproliferative neoplasms |  | Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells B Peter, S Bibi, G Eisenwort, B Wingelhofer, D Berger et al. Leukemia 2017 32 :1016 - 1022; November 29, 2017; 10.1038/leu.2017.338 Abstract | Full Text |  | | Stem cell biology |  | Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS Y Mei, B Zhao, A A Basiorka, J Yang, L Cao et al. Leukemia 2017 32 :1023 - 1033; November 16, 2017; 10.1038/leu.2017.326 Abstract | Full Text |  | Letters to the Editor |  |  | Long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis A Pardanani, J Gotlib, A W Roberts, M Wadleigh, S Sirhan et al. Leukemia 2017 32 :1034 - 1037; November 16, 2017; 10.1038/leu.2017.330 Abstract | Full Text |  |  |  |  | Towards ‘off-the-shelf’ genetically modified T cells: prolonging functional engraftment in mice by CD8 veto T cells N Or-Geva, R Gidron-Budovsky, L Radomir, Y Edelstein, A K Singh et al. Leukemia 2017 32 :1038 - 1040; November 20, 2017; 10.1038/leu.2017.332 Abstract | Full Text |  |  |  |  | Somatic CLL mutations occur at multiple distinct hematopoietic maturation stages: documentation and cautionary note regarding cell fraction purity S Marsilio, H Khiabanian, G Fabbri, S Vergani, C Scuoppo et al. Leukemia 2017 32 :1040 - 1043; December 05, 2017; 10.1038/leu.2017.343 Abstract | Full Text |  |  |  |  | Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines F Maura, M Petljak, M Lionetti, I Cifola, W Liang et al. Leukemia 2017 32 :1043 - 1047; December 06, 2017; 10.1038/leu.2017.345 Abstract | Full Text |  |  |  |  | CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC I Tirado-Gonzalez, E Czlonka, A Nevmerzhitskaya, D Soetopo, E Bergonzani et al. Leukemia 2017 32 :1048 - 1051; December 06, 2017; 10.1038/leu.2017.346 Abstract | Full Text |  | Correspondence |  |  | The role of bone marrow morphology in the diagnosis of relapsed acute myeloid leukemia B Said, S Gilles, D Weisdorf & A Rashidi Leukemia 2017 32 :1052 - 1052; October 31, 2017; 10.1038/leu.2017.308 Abstract | Full Text |  | Corrigendum |  |  | Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML C Schütz, S Inselmann, S Saussele, C T Dietz, M C Müller et al. Leukemia 2018 32 :1053 - 1053; January 30, 2018; 10.1038/leu.2017.348 Abstract | Full Text |  |  |  |  |  |  |  | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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