EMBO reports Table of Contents for April 2018; Vol. 19, No. 4

April 2018 | Volume 19, Number 4 Submit Table of Contents Opinion News & Views Correspondence Science & Society Scientific Reports Articles Volume 19, Number 4 Opinion Monkey see, Humans Won't Do—the misguided reaction to the first cloning of primates Notwithstanding the media hype and scaremongering, the recent cloning of two macaques by Chinese researchers is not a harbinger of human clones. Instead, scientists and ethicists should discuss the much more realistic scenario of enhancement through gene editing. Arthur L Caplan Published online 21.02.2018 If the papers don't come to the journal… What if the roles between journals and scientists were reversed: if journals had to chase papers instead of authors chasing journals? Such a role reversal would have benefits for authors and might create more healthy competition among journals. Shai Berlin Published online 22.02.2018 News & Views From white to beige: a new hypothalamic pathway A study in this issue shows that the adaptor protein APPL2 induces activation of RIP‐Cre neurons in the VMH, which enhances sympathetic outflow to sWAT, sWAT beiging and cold tolerance. Maria Consolata Miletta and Tamas L Horvath Published online 26.03.2018 Heterochromatin and cohesion protection at human centromeres: the final say of a long controversy? The role of heterochromatin in the protection of mammalian centromere cohesion has long been controversial. A study in this issue now shows that HP1 isoforms interact with Haspin to promote mitotic centromere cohesion. Jean‐Paul Javerzat Published online 23.03.2018 Correspondence Comment on “Why are NGOs sceptical of genome editing?” Comment on “Why are NGOs sceptical of genome editing?” by Helliwell et al. Giovanni Tagliabue Published online 07.03.2018 Reply to Tagliabue The response by the authors. Warren Pearce, Sarah Hartley, Richard Helliwell and Liz O'Neill Published online 07.03.2018 Science & Society The power of synthetic biology for bioproduction, remediation and pollution control: The UN's Sustainable Development Goals will inevitably require the application of molecular biology and biotechnology on a global scale The UN's Sustainable Development Goals present a challenge for biotechnology to develop new environmentally‐friendly and sustainable products and production processes. Víctor de Lorenzo, Kristala LJ Prather, Guo‐Qiang Chen, Elizabeth O'Day, Conrad von Kameke, Diego A Oyarzún, Leticia Hosta‐Rigau, Habiba Alsafar, Cong Cao, Weizhi Ji, Hideyuki Okano, Richard J Roberts, Mostafa Ronaghi, Karen Yeung, Feng Zhang and Sang Yup Lee Published online 26.03.2018 Personalized medicine and proper dosage: Over‐ and undertreatment of chronic diseases endanger patients’ health and strain public health systems Improper treatment of common diseases and conditions endangers patients’ health and wastes enormous public resources. Better clinical trial data and more personalized treatment of these conditions could greatly improve health and health care. Anthi Trasta Published online 27.02.2018 The genesis of a conspiracy theory: Why do people believe in scientific conspiracy theories and how do they spread? Conspiracy theories about science can do real damage if they affect matters of health and disease. Understanding the psychology of a conspiracy theorist along with openness about how scientists come to conclusions could help to combat harmful theories. Katrin Weigmann Published online 28.02.2018 No place to run: Plants have evolved a dazzling array of chemical defences and regulatory networks that matches the mammalian immune system for complexity Plants have evolved an astounding armory of chemical defenses and communication to fend of pests and predators. Understanding this complex network would benefit architecture and biotechnology. Philip Hunter Published online 23.03.2018 Scientific Reports HP1 links centromeric heterochromatin to centromere cohesion in mammals Sister‐chromatid cohesion must be properly regulated to prevent chromosome mis‐segregation and chromosomal instability. HP1 proteins bind to the cohesin protector Haspin and promote its centromeric localization, thereby protecting cohesion at mitotic centromeres. Qi Yi, Qinfu Chen, Cai Liang, Haiyan Yan, Zhenlei Zhang, Xingfeng Xiang, Miao Zhang, Feifei Qi, Linli Zhou and Fangwei Wang Published online 28.02.2018 SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin‐2 SNX18 recruits Dynamin‐2 to transport ATG9A and ATG16L1 from juxtanuclear recycling endosomes to pre‐autophagic structures. Kristiane Søreng, Michael J Munson, Christopher A Lamb, Gunnveig T Bjørndal, Serhiy Pankiv, Sven R Carlsson, Sharon A Tooze and Anne Simonsen Published online 07.02.2018 ZBTB2 reads unmethylated CpG island promoters and regulates embryonic stem cell differentiation Many transcriptional regulators bind to DNA depending on its methylation status. ZBTB2 is a novel reader of unmethylated DNA in mouse embryonic stem cells, and regulates cellular differentiation as an activator at CpG island promoters. Ino D Karemaker and Michiel Vermeulen Published online 01.02.2018 Articles PINK1 autophosphorylation is required for ubiquitin recognition The mitochondrial kinase PINK1 autophosphorylates rapidly in trans at a single conserved serine. This phosphorylation step is required for PINK1 to interact with its substrates ubiquitin and Parkin. Shafqat Rasool, Naoto Soya, Luc Truong, Nathalie Croteau, Gergely L Lukacs and Jean‐François Trempe Published online 23.02.2018 Activation of hypothalamic RIP‐Cre neurons promotes beiging of WAT via sympathetic nervous system The adaptor protein APPL2 induces activation of RIP‐Cre neurons in the VMH, which enhances sympathetic outflow to sWAT, sWAT beiging and cold tolerance. Baile Wang, Ang Li, Xiaomu Li, Philip WL Ho, Donghai Wu, Xiaoqi Wang, Zhuohao Liu, Kelvin KL Wu, Sonata SY Yau, Aimin Xu and Kenneth KY Cheng Published online 21.02.2018 Mouse GTSF1 is an essential factor for secondary piRNA biogenesis Mouse GTSF1 is essential for MILI‐directed secondary piRNA biogenesis in prospermatogonia and associates with the MIWI2 complex probably to transcriptionally silence its targets. Takuji Yoshimura, Toshiaki Watanabe, Satomi Kuramochi‐Miyagawa, Noriaki Takemoto, Yusuke Shiromoto, Akihiko Kudo, Masami Kanai‐Azuma, Fumi Tashiro, Satsuki Miyazaki, Ami Katanaya, Shinichiro Chuma and Jun‐ichi Miyazaki Published online 07.02.2018 The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation The deubiquitinating enzyme USP20 acts as a positive regulator of autophagy initiation through the deubiquitination of ULK1. USP20 interferes with the lysosome‐dependent degradation of ULK1 and thereby maintains ULK1 stability at basal state. Jun Hwan Kim, Dongyeob Seo, Sun‐Jick Kim, Dong Wook Choi, Jin Seok Park, Jihoon Ha, Jungwon Choi, Ji‐Hyung Lee, Su Myung Jung, Kyoung‐Wan Seo, Eun‐Woo Lee, Youn Sook Lee, Heesun Cheong, Cheol Yong Choi and Seok Hee Park Published online 27.02.2018 Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function Mass spectrometry‐based proteomics identifies putative substrates of the ubiquitin‐dependent remodeler VCP in human cells and reveals its role in the regulation of the c‐Myc level and activity. Chemical inhibition of VCP increases cellular K6‐linked ubiquitylation that is dependent on the HECT‐type ubiquitin ligase HUWE1. Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner and Petra Beli Published online 21.02.2018 PAWS1 controls Wnt signalling through association with casein kinase 1α PAWS1 is a novel mediator of the Wnt signalling pathway through its interaction with and regulation of CK1α. Polyxeni Bozatzi, Kevin S Dingwell, Kevin ZL Wu, Fay Cooper, Timothy D Cummins, Luke D Hutchinson, Janis Vogt, Nicola T Wood, Thomas J Macartney, Joby Varghese, Robert Gourlay, David G Campbell, James C Smith and Gopal P Sapkota Published online 07.03.2018 SORCS1 and SORCS3 control energy balance and orexigenic peptide production Diabetes‐associated sorting receptors SORCS1 and SORCS3 play a role in central control of metabolism. In mice, loss of the proteins increases production of orexigenic agouti‐related peptide, possibly via enhancement of neurotrophin signaling in AgRP neurons. Aygul Subkhangulova, Anna R Malik, Guido Hermey, Oliver Popp, Gunnar Dittmar, Thomas Rathjen, Matthew N Poy, Alexander Stumpf, Prateep Sanker Beed, Dietmar Schmitz, Tilman Breiderhoff and Thomas E Willnow Published online 12.02.2018 The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics The unconventional myosin MYO6 interacts with its cargoes through distinct adaptor proteins. Here, the MYO6 interactome is identified using proximity labelling‐based proteomics, highlighting the role of MYO6 in coordinating endosome dynamics and cytoskeletal architecture. Thomas O'Loughlin, Thomas A Masters and Folma Buss Published online 21.02.2018 Zc3h10 is a novel mitochondrial regulator Genome‐wide functional screens coupled to integrated omic approaches identify Zinc finger CCCH‐type containing 10 (Zc3h10) as a new regulator of mitochondrial biology. Zc3h10 silencing in vitro and mutation in vivo are associated with impaired mitochondrial function. Matteo Audano, Silvia Pedretti, Gaia Cermenati, Elisabetta Brioschi, Giuseppe Riccardo Diaferia, Serena Ghisletti, Alessandro Cuomo, Tiziana Bonaldi, Franco Salerno, Marina Mora, Liliana Grigore, Katia Garlaschelli, Andrea Baragetti, Fabrizia Bonacina, Alberico Luigi Catapano, Giuseppe Danilo Norata, Maurizio Crestani, Donatella Caruso, Enrique Saez, Emma De Fabiani and Nico Mitro Published online 05.03.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.