Nature Reviews Microbiology contents April 2018 Volume 16 Number 4 pp 183-255

 

TABLE OF CONTENTS
April 2018 Volume 16 Number 4
2016 2-year Impact Factor 26.819 Journal Metrics 2-year Median 18	In this issue News and Analysis Research Highlights Reviews   Also this month Article series: New technologies: methods and applications  Featured article: Prokaryotic cytoskeletons: protein filaments organizing small cells James Wagstaff & Jan Löwe
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Nature Collection: Gut-brain axis  This Nature Collection brings together Research, Reviews and News from across the Nature Research journals and presents a selection of articles covering key aspects of the gut-brain axis including the gut microbiota and immune, neuroendocrine and neural factors.  Access this collection >>  Produced with support from:  Abbott
RESEARCH HIGHLIGHTS   Top Cellular microbiology: Lysozyme protects bacteria from β-lactams p183 | doi:10.1038/nrmicro.2018.26 A recent study reports that host lysozyme counteracts β-lactam-mediated killing of some bacteria by promoting efficient L-form switching. PDF Bacterial pathogenesis: Channelling the host epigenome p184 | doi:10.1038/nrmicro.2018.25 This study reports that the P. aeruginosa type III secretion system translocon functions as a pore-forming toxin that triggers the modification of histones in eukaryotic cells. PDF Bacterial physiology: Bridging the gap for lipopolysaccharides p184 | doi:10.1038/nrmicro.2018.30 This study provides evidence that lipopolysaccharides are pushed from the inner membrane to the outer membrane of the bacterial cell envelope over a protein bridge. PDF IN THE NEWS Resurrection of a poxvirus causes alarm p184 | doi:10.1038/nrmicro.2018.31 A controversial study in which researchers generated an infectious horsepox virus using synthetic DNA and reverse genetics was recently reported. PDF
NEWS AND ANALYSIS		Top
GENOME WATCH A new piece in the microbiome puzzle Lindsay J. Pike & Samuel C. Forster p186 | doi:10.1038/nrmicro.2018.24 This month's Genome Watch discusses the detailed analysis of the human 'archaeome' from various body sites and highlights how current sequencing methods underestimate archaeal diversity and abundance. PDF
RESEARCH HIGHLIGHTS		Top
IN BRIEF
Antimicrobials: Breaking ground for new antibiotics | Viral infection: CRISPR–Cas enhances HGT by transduction | Microbiome: Principles of microbiota engraftment PDF
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Poster on: The expanding CRISPR toolbox The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR.  Available to download free online >>  Produced with support from:  Dharmacon
REVIEWS		Top
Prokaryotic cytoskeletons: protein filaments organizing small cells James Wagstaff & Jan Löwe p187 | doi:10.1038/nrmicro.2017.153 Bacteria and archaea have intracellular cytoskeletons built from dynamic protein filaments. In this Review, Wagstaff and Lowe discuss how these linear protein polymers are used to organize other molecules in prokaryotic cells. Abstract | Full Text | PDF
Ecology and evolution of Mycobacterium tuberculosis Sebastien Gagneux p202 | doi:10.1038/nrmicro.2018.8 The causative agents of tuberculosis are a group of closely related bacteria known as the Mycobacterium tuberculosis complex (MTBC). In this Review, Gagneux discusses recent insights into the origin of the MTBC, its molecular evolution and population genetic characteristics, and the evolution of antibiotic resistance. Abstract | Full Text | PDF
Article series: New technologies: methods and applications Engineering bacteria for diagnostic and therapeutic applications David T. Riglar & Pamela A. Silver p214 | doi:10.1038/nrmicro.2017.172 Advances in synthetic biology allow the generation of ever more sophisticated engineered bacteria. In this Review, Riglar and Silver showcase recent highlights in engineered bacterial therapeutics and diagnostics and discuss how best to develop them for clinical application. Abstract | Full Text | PDF | Supplementary information
Neisseria gonorrhoeae host adaptation and pathogenesis Sarah Jane Quillin & H Steven Seifert p226 | doi:10.1038/nrmicro.2017.169 The host-adapted human pathogen Neisseria gonorrhoeae is the causative agent of gonorrhoea. In this Review, Quillin and Seifert provide an overview of the bacterial factors that are important for the different stages of pathogenesis, including transmission, colonization and immune evasion, and discuss the problem of antibiotic resistance. Abstract | Full Text | PDF
The spread and evolution of rabies virus: conquering new frontiers Christine R. Fisher, Daniel G. Streicker & Matthias J. Schnell p241 | doi:10.1038/nrmicro.2018.11 Much of the molecular virology of rabies virus has been well characterized, and we are gaining a better understanding of how infection dynamics and immune status relate to transmission. In this Review, Schnell and colleagues explore rabies virus transmission, enzootic maintenance and epizootic spread, as well as molecular evolutionary dynamics, host adaptation and the origins of rabies virus. Abstract | Full Text | PDF
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