Nature Reviews Cancer contents April 2018 Volume 18 Number 4 203-263

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TABLE OF CONTENTS
April 2018 Volume 18 Number 4		Advertisement
2016 2-year Impact Factor 37.147 Journal Metrics 2-year Median 28	In this issue Comment Research Highlights Reviews Perspectives   Also this month Article series: Clinical insights  Featured article: Genetic insights into the morass of metastatic heterogeneity Kent W. Hunter, Ruhul Amin, Sarah Deasy, Ngoc-Han Ha & Lalage Wakefield	AACR Special Conferences Special Conferences are held each year that focus on emerging areas of cancer research and specific disease sites. Similar conferences are held overseas in conjunction with international cancer research organizations.  Learn more
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Breast Cancer Now Catalyst Programme Grants  Apply now We are inviting Expressions of Interest from researchers who are interested in using Pfizer drugs for preclinical or clinical breast cancer research from teams based at a single site or multiple sites in the UK and Europe. To apply please visit our website.
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Nature Outlook: Cancer immunotherapy  Drugs that mobilize our immune systems against cancer are dramatically improving care for many people, and research is rapidly moving ahead in the lab and the clinic.  Access this Outlook free >> Produced with support from  F. Hoffmann-La Roche Ltd Medimmune  Produced with support of a grant from Merck & Co., Inc.
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Article series: Clinical insights Comment: Tumour budding in colorectal cancer: molecular rationale for clinical translation Inti Zlobec & Alessandro Lugli p203 | doi:10.1038/nrc.2018.1 Precision medicine and personalized health care call for reproducible and standardized predictive and prognostic biomarkers that can influence the clinical management of patients with cancer. In colorectal cancer, tumour budding — a histological manifestation of tumour cell invasion that is likened to epithelial-mesenchymal transition — is now emerging as one such factor. In this Comment, the authors outline the emerging rationale for the clinical use of tumour budding, a histological manifestation of tumour cell invasion, as a diagnostic tool and biomarker in colorectal cancer. Full Text | PDF
RESEARCH HIGHLIGHTS   Top Immunotherapy: Tear down this wall p205 | doi:10.1038/nrc.2018.22 Activation of TGFβ signalling in invasive margins of metastatic tumours can contribute to T cell exclusion and reduced immune checkpoint therapy response. Inhibition of TGFβ in non-responders can potentially help to improve outcomes in these patients. PDF Epigenetics: Methylating patterns p206 | doi:10.1038/nrc.2018.21 Xie et al. show that senescence-associated DNA methylation changes evolve independently of stochastic tumour-associated methylation changes and that a subset of commonly methylated genes with the highest gains are associated with early tumorigenesis and ageing. PDF Immunotherapy: A therapeutic reservoir p206 | doi:10.1038/nrc.2018.23 Wang, C., Wang, J. et al. show that local injection of a hydrogel scaffold degraded by reactive oxygen species in the tumour microenvironment releases chemotherapy and an immune checkpoint inhibitor with kinetics that increase antitumour responses. PDF Drug delivery: DNA nanorobots — seek and destroy p208 | doi:10.1038/nrc.2018.19 Li et al. report the development of 'DNA nanorobots' carrying a thrombin protease payload that induce coagulation and necrosis at the tumour site, illustrating their therapeutic potential as drug delivery systems. PDF Metastasis: Staying organized p208 | doi:10.1038/nrc.2018.20 A recent study published in Nature Cell Biology has shown that tumour spheres that maintain an inverted epithelial architecture originate from primary colorectal cancers and can collectively invade the peritoneum, initiating metastasis. PDF Targeted therapy: Tipping the splicing balance to kill cancer cells p209 | doi:10.1038/nrc.2018.27 A paper in Nature Medicine describes a novel, orally available splicing modulator that preferentially kills cancer cells with mutations in splicing factors in culture and in mouse models. PDF   IN BRIEF Immunosurveillance: Presentation skills | Metastasis: Go with the flow | Immunotherapy: iPSC-based vaccines provoke a response PDF Nature Reviews Cancer JOBS of the week Postdoctoral Fellow / Doctoral Student Helmholtz Centre for Environmental Research - UFZ - UFZ - Helmholtz Association PhD position in cancer biology Bar-Ilan University Post-doctoral fellow Washington University School of Medicine, St. Louis New Postdoctoral Positions The University of Texas MD Anderson Cancer Center, Department of Genertics Senior Project Manager University of Glasgow More Science jobs from Nature Reviews Cancer EVENT 8th EACR-OECI Joint Course: Molecular Pathology Approach to Cancer 04.06.18 Amsterdam, Netherlands More science events from
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REVIEWS		Top
Genetic insights into the morass of metastatic heterogeneity Kent W. Hunter et al. p211 | doi:10.1038/nrc.2017.126 In this Review, Hunter et al. discuss how genetic heterogeneity impacts metastatic disease and outline the implications of our current knowledge in this area for future research efforts and therapeutic interventions. Abstract | Full Text | PDF
From genetics to the clinic: a translational perspective on follicular lymphoma Sarah Huet, Pierre Sujobert & Gilles Salles p224 | doi:10.1038/nrc.2017.127 This Review discusses the mutational landscape and evolution of follicular lymphoma. Deciphering the earliest initiating lesions and the molecular alterations leading to disease progression might help identify the most relevant targets for therapy of these tumours. Abstract | Full Text | PDF
Opportunities and challenges for human papillomavirus vaccination in cancer Richard B. S. Roden & Peter L. Stern p240 | doi:10.1038/nrc.2018.13 To efficiently prevent cancers associated with human papillomavirus (HPV) infection, especially cervical cancer, effective vaccines and high vaccination coverage are required. This Review provides insight into virological, immunological and strategical progress in HPV vaccines as well as implementation and potential advances. Abstract | Full Text | PDF
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Nature Collection: 2017 Nobel Prize in Physiology or Medicine The 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their pioneering work in Drosophila that elucidated the molecular mechanisms controlling circadian rhythm.  Access this collection free online>> Produced with support from:  Vanda Pharmaceuticals
PERSPECTIVES		Top
OPINION Targeting minimal residual disease: a path to cure? Marlise R. Luskin, Mark A. Murakami, Scott R. Manalis & David M. Weinstock p255 | doi:10.1038/nrc.2017.125 Improved therapies have allowed many patients with cancer to achieve complete remission, but they retain minimal residual disease (MRD), which causes relapse. This Opinion article argues that iterative detection, profiling and targeting of MRD could improve outcomes, including cure rates. Abstract | Full Text | PDF
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Key Advances in Medicine eBook from Nature Reviews - FREE to download!   This essential resource summarizes the ground-breaking clinical and biomedical discoveries of 2017 and highlights the trends to watch out for in 2018, making it a must read eBook for anyone with an interest in medical science. Download for free
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