| | Encoding of danger by parabrachial CGRP neurons
Single-cell recordings show that CGRP-expressing neurons in the parabrachial nucleus in mice respond to both noxious stimuli and signals of feeding satiety. | Extensive impact of non-antibiotic drugs on human gut bacteria
A screen of more than 1,000 drugs shows that about a quarter of the non-antibiotic drugs inhibit the growth of at least one commensal bacterial strain in vitro. | De novo mutations in regulatory elements in neurodevelopmental disorders
Analysis of rare de novo mutations in gene regulatory elements suggests that 1–3% of patients with neurodevelopmental disorders carry such mutations in elements that are active in the fetal brain. | Massive Dirac fermions in a ferromagnetic kagome metal
Fe3Sn2 hosts massive Dirac fermions, owing to the underlying symmetry properties of the bilayer kagome lattice in the ferromagnetic state and the atomic spin–orbit coupling. | Insulin resistance in cavefish as an adaptation to a nutrient-limited environment
Cavefish populations of the Mexican tetra, Astyanax mexicanus, carry a mutation in the insulin receptor gene that renders them insulin- and starvation-resistant relative to surface populations of the same species. | Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance
Hepatocytes secrete DPP4, which promotes adipose tissue inflammation and insulin resistance in obese mice, suggesting a new specific target for treatment of metabolic disorders. | Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel
Structures of the voltage-gated and phosphatidylinositol 3,5-bisphosphate-activated mouse two-pore channel TPC1 in apo and ligand-bound states provide insights into the selectivity and gating mechanisms of mammalian two-pore channels. | The protein histidine phosphatase LHPP is a tumour suppressor
Decreased expression of histidine phosphatase LHPP, a novel tumour suppressor, results in increased global histidine phosphorylation and hepatocellular carcinoma. | Optogenetic regulation of engineered cellular metabolism for microbial chemical production
Finely tuned optogenetic control of engineered Saccharomyces cerevisiae enhances the biosynthesis of valuable products such as isobutanol in laboratory-scale fermenters. | Timing of oceans on Mars from shoreline deformation
Ancient shorelines on Mars must have formed before and during the emplacement of the Tharsis volcanic province, instead of afterwards as previously assumed, suggesting that oceans on Mars formed early. | Moving magnetoencephalography towards real-world applications with a wearable system
A new magnetoencephalography system allows high-spatiotemporal-resolution imaging of human brain function in moving subjects. | Reconstructing the genetic history of late Neanderthals
Genetic similarity among late Neanderthals is predicted well by their geographical location, and although some of these Neanderthals were contemporaneous with early modern humans, their genomes show no evidence of recent gene flow from modern humans. | Shifts in tree functional composition amplify the response of forest biomass to climate
Forest inventory data from the 1980s and 2000s show the response of eastern USA forests to climate variability; direct effects of climate on forest biomass are amplified by changes in tree species composition. | | | Brief Communications Arising | | | | Developmental diversification of cortical inhibitory interneurons
The embryonic emergence of interneuron subtypes in mice is revealed by integrated single-cell transcriptomic analysis along a developmental time course.
Christian Mayer, Christoph Hafemeister, Rachel C. Bandler et al. | Placentation defects are highly prevalent in embryonic lethal mouse mutants
Analysis of embryonic lethal and sub-viable mouse knockout lines reveals that ablation of many genes affects placental development, and that the occurrence of placental defects is co-associated with abnormal brain, heart and vascular system development.
Vicente Perez-Garcia, Elena Fineberg, Robert Wilson et al. | DNA methylation-based classification of central nervous system tumours
An online approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups has been developed to help to improve current diagnostic standards.
David Capper, David T. W. Jones, Martin Sill et al. | Integrative structure and functional anatomy of a nuclear pore complex
The structure of the yeast nuclear pore complex, determined with sub-nanometre precision using an integrative approach that combines a wide range of data, reveals details of its architecture, transport mechanism and evolutionary origins.
Seung Joong Kim, Javier Fernandez-Martinez, Ilona Nudelman et al. | | A single population of red globular clusters around the massive compact galaxy NGC 1277
The massive relic galaxy NGC 1277 has few blue globular clusters, indicating that it has undergone little mass accretion and is a candidate ‘red nugget’ in the nearby Universe.
Michael A. Beasley, Ignacio Trujillo, Ryan Leaman et al. | Image reconstruction by domain-transform manifold learning
Image reconstruction is reformulated using a data-driven, supervised machine learning framework that allows a mapping between sensor and image domains to emerge from even noisy and undersampled data, improving accuracy and reducing image artefacts.
Bo Zhu, Jeremiah Z. Liu, Stephen F. Cauley et al. | Continuous-wave room-temperature diamond maser
A continuous-wave room-temperature maser is demonstrated by combining a cavity with a high Purcell factor with the narrow linewidth of nitrogen–vacancy defect centres in diamond.
Jonathan D. Breeze, Enrico Salvadori, Juna Sathian et al. | Maximizing and stabilizing luminescence from halide perovskites with potassium passivation
Modifying the surfaces and grain boundaries of perovskites with passivating potassium halide layers can mitigate non-radiative losses and photoinduced ion migration, increasing luminescence yields and improving charge transport and interfaces with device electrodes.
Mojtaba Abdi-Jalebi, Zahra Andaji-Garmaroudi, Stefania Cacovich et al. | A lithium–oxygen battery with a long cycle life in an air-like atmosphere
A lithium–oxygen battery, comprising a lithium carbonate-based protected anode, a molybdenum disulfide cathode and an ionic liquid/dimethyl sulfoxide electrolyte, operates in a simulated air atmosphere with a long cycle life of up to 700 cycles.
Mohammad Asadi, Baharak Sayahpour, Pedram Abbasi et al. | Isotopic evolution of the protoplanetary disk and the building blocks of Earth and the Moon
The mass-independent calcium isotope composition of inner-Solar-System bodies is correlated with their masses and accretion ages, indicating a rapid growth for the precursors of Earth and the Moon during the protoplanetary disk’s lifetime.
Martin Schiller, Martin Bizzarro, Vera Assis Fernandes | Humans thrived in South Africa through the Toba eruption about 74,000 years ago
Youngest Toba Tuff glass shards found together with evidence of human occupation at two archaeological sites from the southern coast of South Africa indicate that early modern humans thrived in this region despite the eruption of the Toba supervolcano about 74,000 years ago.
Eugene I. Smith, Zenobia Jacobs, Racheal Johnsen et al. | Carbon dioxide addition to coral reef waters suppresses net community calcification
In situ carbon dioxide enrichment experiments show that ocean acidification poses a threat to coral reefs by reducing the saturation state of aragonite and the concentration of carbonate ions and that this impairs community calcification.
Rebecca Albright, Yuichiro Takeshita, David A. Koweek et al. | Dysregulation of expression correlates with rare-allele burden and fitness loss in maize
A multi-tissue gene expression resource representative of the genotypic and phenotypic diversity of modern inbred maize reveals the effect of rare alleles and evolutionary history on the regulation of gene expression.
Karl A. G. Kremling, Shu-Yun Chen, Mei-Hsiu Su et al. | A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex
Analysis of gene expression at single-cell resolution in the developing prefrontal cortex of the human embryo reveals a diversity of cell types, elucidates cell lineages and identifies signalling pathways that regulate development.
Suijuan Zhong, Shu Zhang, Xiaoying Fan et al. | Diffusible repression of cytokinin signalling produces endodermal symmetry and passage cells
In an Arabidopsis model, repression of cytokinin in the root meristem produces a distinct population of xylem-pole endodermal cells, which resist suberization to become passage cells that enable transport across the otherwise-impermeable endodermis.
Tonni Grube Andersen, Sadaf Naseer, Robertas Ursache et al. | Carbonate-sensitive phytotransferrin controls high-affinity iron uptake in diatoms
Phytotransferrin, a functional analogue of transferrin, has an obligate requirement for carbonate to bind iron, which suggests that acidification-driven declines in the concentration of seawater carbonate ions may negatively affect diatom iron acquisition.
Jeffrey B. McQuaid, Adam B. Kustka, Miroslav Oborník et al. | The cis-regulatory dynamics of embryonic development at single-cell resolution
An improved assay for chromatin accessibility at single-cell resolution in Drosophila melanogaster embryos enables identification of developmental-stage- and cell-lineage-specific patterns of chromatin-level transcriptional regulation.
Darren A. Cusanovich, James P. Reddington, David A. Garfield et al. | | | | | | On April 22, 2017, more than one million marchers worldwide took to the streets to stand up for science in society and their own lives--and each of them has a story to tell. Through signs, artwork, stories, and photographs, Science Not Silence shares some of the voices from the March for Science movement. Science Not Silence celebrates the success of the movement, amplifies the passion and creativity of its supporters, and reminds everyone how important it is to keep marching. | | | | | | | | | | | | | | | |
No comments:
Post a Comment