The EMBO Journal Table of Contents for 01 February 2018; Vol. 37, No. 3

01 February 2018 | Volume 37, Number 3 Submit Table of Contents Articles Resource Volume 37, Number 3 Articles Miro proteins coordinate microtubule‐ and actin‐dependent mitochondrial transport and distribution In addition to controlling mitochondrial retrograde trafficking along microtubules, Miro GTPases also mediate actin‐dependent movements via recruitment of mitochondrial myosin 19. Guillermo López‐Doménech, Christian Covill‐Cooke, Davor Ivankovic, Els F Halff, David F Sheehan, Rosalind Norkett, Nicol Birsa and Josef T Kittler Published online 08.01.2018 High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins While amyloidogenic proteins drive formation of toxic aggregates in the cytoplasm, they are tolerated in the ER by being kept in a liquid‐like state, illustrating compartment‐specific responses to protein misfolding. Lisa Vincenz‐Donnelly, Hauke Holthusen, Roman Körner, Erik C Hansen, Jenny Presto, Jan Johansson, Ritwick Sawarkar, F Ulrich Hartl and Mark S Hipp Published online 15.12.2017 LRRC25 inhibits type I IFN signaling by targeting ISG15‐associated RIG‐I for autophagic degradation Upon RNA virus infection, LRRC25 recognizes ISG15‐associated immune receptor RIG‐I and facilitates its degradation via p62‐mediated selective autophagy, thereby limiting RIG‐I‐dependent type I interferon signaling. Yang Du, Tianhao Duan, Yanchun Feng, Qingxiang Liu, Meng Lin, Jun Cui and Rong‐Fu Wang Published online 29.12.2017 Structure of the human myostatin precursor and determinants of growth factor latency The crystal structure of a myostatin/GDF8 precursor reveals an open‐armed conformation and provides insight into the sequential activation of this muscle mass regulator upon proteolytic cleavage. Thomas R Cotton, Gerhard Fischer, Xuelu Wang, Jason C McCoy, Magdalena Czepnik, Thomas B Thompson and Marko Hyvönen Published online 12.01.2018 Tolloid cleavage activates latent GDF8 by priming the pro‐complex for dissociation Structural and dynamics analysis shows that Tolloid cleavage destabilizes the precursor of the muscle mass regulator myostatin/GDF8 to promote release of mature growth factor. Viet Q Le, Roxana E Iacob, Yuan Tian, William McConaughy, Justin Jackson, Yang Su, Bo Zhao, John R Engen, Michelle Pirruccello‐Straub and Timothy A Springer Published online 17.01.2018 Regulatory T cells constrain the TCR repertoire of antigen‐stimulated conventional CD4 T cells High‐throughput sequencing of T‐cell receptor genes from antigen‐stimulated CD4 T cells demonstrates that Tregs control both the magnitude and the breadth of an immune response. Martina Fontaine, Isabel Vogel, Yves‐Rémi Van Eycke, Adrien Galuppo, Yousra Ajouaou, Christine Decaestecker, George Kassiotis, Muriel Moser and Oberdan Leo Published online 20.12.2017 OxyS small RNA induces cell cycle arrest to allow DNA damage repair Repression of the bacterial termination factor nusG by an oxidative stress‐induced sRNA allows read‐through transcription of a prophage‐encoded FtsZ inhibitor, delaying cell division to allow stress recovery. Shir Barshishat, Maya Elgrably‐Weiss, Jonathan Edelstein, Jens Georg, Sutharsan Govindarajan, Meytal Haviv, Patrick R Wright, Wolfgang R Hess and Shoshy Altuvia Published online 13.12.2017 Resource Mapping protein interactions of sodium channel NaV1.7 using epitope‐tagged gene‐targeted mice Combining mouse genetics and proteomics reveals various new interactors of a voltage‐gated channel with key roles in pain perception, including direct links to opoid signalling and potential targets for better pain treatment. Alexandros H Kanellopoulos, Jennifer Koenig, Honglei Huang, Martina Pyrski, Queensta Millet, Stéphane Lolignier, Toru Morohashi, Samuel J Gossage, Maude Jay, John E Linley, Georgios Baskozos, Benedikt M Kessler, James J Cox, Annette C Dolphin, Frank Zufall, John N Wood and Jing Zhao Published online 15.01.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.