Nature Reviews Genetics Contents March 2018 Volume 19 Number 3 pp 125-185

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TABLE OF CONTENTS
March 2018 Volume 19 Number 3		Advertisement
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews Perspectives Correspondence   Also this month Article series: Epigenetics Disease mechanisms Translational genetics  Featured article: Prioritizing diversity in human genomics research Lucia A. Hindorff, Vence L. Bonham, Lawrence C. Brody, Margaret E. C. Ginoza, Carolyn M. Hutter, Teri A. Manolio & Eric D. Green	nature.com webcasts Springer Nature presents a custom webcast on: Sequencing Structural Variants for Disease Gene Discovery and Population Genetics Date: Thursday, March 8, 2018 Register for FREE Sponsored by: PacBio
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Poster on: The expanding CRISPR toolbox The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR.  Available to download free online >>  Produced with support from:  Dharmacon
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RESEARCH HIGHLIGHTS   Top Genomics: Next regeneration sequencing for reference genomes p125 | doi:10.1038/nrg.2018.5 PDF Functional genomics: A drop in an ocean of gene variants p126 | doi:10.1038/nrg.2018.1 PDF Technique: SNP-CLINGing onto your post in the genome p126 | doi:10.1038/nrg.2018.2 PDF Plant genetics: Parasites plant microRNAs in the host p127 | doi:10.1038/nrg.2018.3 PDF   Genetics JOBS of the week Postdoctoral Research Training Fellowship City of Hope Postdoctoral Fellow University Health Network (Toronto) Postdoc University of Virginia Postdoctoral Associate University of Pittsburgh Junior Group Leader Positions Insitut Curie More Science jobs from Genetics EVENT Genetics & Neurobiology of Language 30.07.18 Cold Spring Harbor, US More science events from
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Nature Collection: 2017 Nobel Prize in Physiology or Medicine The 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their pioneering work in Drosophila that elucidated the molecular mechanisms controlling circadian rhythm.  Access this collection free online>> Produced with support from:  Vanda Pharmaceuticals
REVIEWS		Top
Article series: Epigenetics Statistical and integrative system-level analysis of DNA methylation data Andrew E. Teschendorff & Caroline L. Relton p129 | doi:10.1038/nrg.2017.86 The wealth of DNA methylation data continues to grow rapidly, including from epigenome-wide association studies (EWAS). However, extracting meaningful biological and clinical information requires diverse computational approaches for data analysis. This Review discusses the range of statistical tools available, including for cell-type deconvolution, identification of important methylation data features, causation and system-level integration with other types of omic data. Abstract | Full Text | PDF
The new genetics of intelligence Robert Plomin & Sophie von Stumm p148 | doi:10.1038/nrg.2017.104 Recent genome-wide association studies have catapulted the search for genes underlying human intelligence into a new era. Genome-wide polygenic scores promise to transform research on individual differences in intelligence, but not without societal and ethical implications, as the authors discuss in this Review. Abstract | Full Text | PDF
Article series: Disease mechanisms Nuclear receptors in cancer — uncovering new and evolving roles through genomic analysis Vineet K. Dhiman, Michael J. Bolt & Kevin P. White p160 | doi:10.1038/nrg.2017.102 Genomic technologies are providing a clearer picture of how nuclear receptors (NRs) regulate complex transcriptional networks and contribute to the development and progression of cancer. This deeper understanding of NRs will hopefully lead to improved prognostic tools and new therapeutic targets. Abstract | Full Text | PDF
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nature.com webcasts Springer Nature presents a custom webcast on: Precision over Bulk: Opportunities for Single-Cell DNA Analysis in Oncology Date: Tuesday, March 13, 2018  Register for the webcast and live Q&A session  Sponsored by: Mission Bio
PERSPECTIVES		Top
SCIENCE AND SOCIETY Article series: Translational genetics Prioritizing diversity in human genomics research Lucia A. Hindorff, Vence L. Bonham, Lawrence C. Brody, Margaret E. C. Ginoza, Carolyn M. Hutter, Teri A. Manolio & Eric D. Green p175 | doi:10.1038/nrg.2017.89 Including diverse populations in genomic studies has the potential to improve the use of genomic data in the clinic. Here, members of the National Human Genome Research Institute review the benefits of increasing diversity, the challenges to overcome and key recommendations for how to achieve this goal. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Using partitioned heritability methods to explore genetic architecture Luke M. Evans & Matthew C. Keller p185 | doi:10.1038/nrg.2018.6 Full Text | PDF
Heritable contributions versus genetic architecture Nicholas J. Timpson, Celia M. T. Greenwood, Nicole Soranzo, Daniel J. Lawson & J. Brent Richards p185 | doi:10.1038/nrg.2018.7 Full Text | PDF
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