Wednesday, February 14, 2018

Nature Communications - 14 February 2018

Nature Communications

Communications Physics: Open for Submissions

Communications Physics is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of physics. The journal is now open for submissions.

Find out more >>  
Weekly Content Alert
Nature Communications is fully open access. Read more.
14 February 2018 
Latest content:
Author Corrections
Publisher Corrections

Nature Reviews Drug Discovery
present this Poster which provides an overview of the different ways to design and produce CAR T cells and the journey that has driven these CAR T cells to FDA approval in 2017.
Produced with support from:
Journal homepage
Recommend to library
Web feed

Advertisement webcasts

Springer Nature presents a custom webcast on: Sequencing Structural Variants for Disease Gene Discovery and Population Genetics

Date: Thursday, March 8, 2018 

Register for FREE 

Sponsored by: PacBio 
  Nature Communications - fully open access

All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website.

Visit our open access funding page or contact to learn more about APC funding.
  Latest Correspondence    
Correspondence: Reply to ‘Chimpanzee helping is real, not a byproduct’ OPEN
Keith Jensen, Claudio Tennie & Josep Call
12 February 2018 | doi: 10.1038/s41467-017-02328-z
Evolution  Psychology 

Correspondence: Chimpanzee helping is real, not a byproduct OPEN
Alicia P. Melis, Jan M. Engelmann & Felix Warneken
12 February 2018 | doi: 10.1038/s41467-017-02321-6
Anthropology  Evolution  Psychology 
  Latest Articles View all Articles  

Biomimetic light-harvesting funnels for re-directioning of diffuse light OPEN
Alexander Pieper, Manuel Hohgardt, Maximilian Willich, Daniel Alexander Gacek, Nour Hafi, Dominik Pfennig, Andreas Albrecht & Peter Jomo Walla

Sunlight harvesting and redirection is a promising concept for sustainable energy conversion, however losses have hindered progress. Here the authors construct a simple biomimetic device which minimises losses by using reservoirs of randomly-oriented dyes to funnel energy onto individual emitting parallel acceptors.

14 February 2018 | doi: 10.1038/s41467-018-03103-4
Antenna complex  Bioenergetics  Devices for energy harvesting 

Fourier transform spectrometer on silicon with thermo-optic non-linearity and dispersion correction OPEN
Mario C. M. M. Souza, Andrew Grieco, Newton C. Frateschi & Yeshaiahu Fainman

Miniaturized optical spectrometers have widespread applications. In this work, the authors have developed a silicon-photonics-based, thermally-tuned Fourier transform spectrometer that overcomes technological challenges in silicon integration that may enable robust, broadband portable spectrometry.

14 February 2018 | doi: 10.1038/s41467-018-03004-6
Integrated optics  Photonic devices  Silicon photonics 

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion OPEN
Antonia Marazioti, Ioannis Lilis, Malamati Vreka, Hara Apostolopoulou, Argyro Kalogeropoulou, Ioanna Giopanou, Georgia A. Giotopoulou, Anthi C. Krontira, Marianthi Iliopoulou, Nikolaos I. Kanellakis, Theodora Agalioti, Anastasios D. Giannou, Celestial Jones-Paris, Yoichiro Iwakura, Dimitrios Kardamakis, Timothy S. Blackwell, Stavros Taraviras, Magda Spella & Georgios T. Stathopoulos

Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse models.

14 February 2018 | doi: 10.1038/s41467-018-03051-z
Cancer microenvironment  Respiratory tract diseases  Tumour immunology 

A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow OPEN
Diana M. Proctor, Julia A. Fukuyama, Peter M. Loomer, Gary C. Armitage, Stacey A. Lee, Nicole M. Davis, Mark I. Ryder, Susan P. Holmes & David A. Relman

Oral microbial communities are excellent sites for examining the mechanisms of structural variation in the microbiota. Here, the authors use spatial and ecological analysis to examine over 9000 dental and mucosal microbiota samples. They find that saliva plays a key role in structuring bacterial communities in the mouth.

14 February 2018 | doi: 10.1038/s41467-018-02900-1
Clinical microbiology  Microbial ecology  Microbiome 

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection OPEN
A. M. Ortega-Prieto, J. K. Skelton, S. N. Wai, E. Large, M. Lussignol, G. Vizcay-Barrena, D. Hughes, R. A. Fleck, M. Thursz, M. T. Catanese & M. Dorner

Long-term in vitro models for hepatitis B virus (HBV) infection are important to understand this infection, but are lacking. Here the authors develop a microfluidic primary human hepatocyte organoid culture system that can be maintained over 40 days and recapitulates all of the steps of the HBV life cycle.

14 February 2018 | doi: 10.1038/s41467-018-02969-8
Hepatitis B virus  Tissue engineering 

Optomechanics with a hybrid carbon nanotube resonator OPEN
A. Tavernarakis, A. Stavrinadis, A. Nowak, I. Tsioutsios, A. Bachtold & P. Verlot

Optomechanics has recently moved into the quantum regime. Here, Tavernarakis et al. demonstrate that a hybrid optomechanical device made up of a carbon nanotube with a metal nanoparticle at its tip can push force measurements towards the quantum regime at room temperature.

14 February 2018 | doi: 10.1038/s41467-018-03097-z
Carbon nanotubes and fullerenes  Nanosensors  Optomechanics 

ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity OPEN
Matteo Massara, Ornella Bonavita, Benedetta Savino, Nicoletta Caronni, Valeria Mollica Poeta, Marina Sironi, Elisa Setten, Camilla Recordati, Laura Crisafulli, Francesca Ficara, Alberto Mantovani, Massimo Locati & Raffaella Bonecchi

The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of neutrophils.

14 February 2018 | doi: 10.1038/s41467-018-03080-8
Chemokines  Metastasis  Tumour immunology 

Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma OPEN
Biwei Yang, Meiyi Li, Wenqing Tang, Weixin Liu, Si Zhang, Luonan Chen & Jinglin Xia

Biomarkers of the tipping point before metastasis in hepatocellular carcinoma (HCC) could help stratify patient treatment. Here, the authors study dynamic network biomarkers to identify CALM3 as a potential suppressor of metastasis, the level of which can predict overall survival and relapse-free survival in postoperative HCC.

14 February 2018 | doi: 10.1038/s41467-018-03024-2
Diagnostic markers  Dynamic networks  Metastasis 

Ultra-high thermal effusivity materials for resonant ambient thermal energy harvesting OPEN
Anton L. Cottrill, Albert Tianxiang Liu, Yuichiro Kunai, Volodymyr B. Koman, Amir Kaplan, Sayalee G. Mahajan, Pingwei Liu, Aubrey R. Toland & Michael S. Strano

Ambient environmental thermal fluctuations offer an abundant yet difficult to harvest renewable energy source, when compared to static thermal gradients. Here, by tuning the thermal effusivity of composite phase change materials, the authors are able to harvest energy from diurnal ambient temperature changes.

14 February 2018 | doi: 10.1038/s41467-018-03029-x
Energy harvesting  Graphene 

Probing electrochemical reactions in organic cathode materials via in operando infrared spectroscopy OPEN
Alen Vizintin, Jan Bitenc, Anja Kopač Lautar, Klemen Pirnat, Jože Grdadolnik, Jernej Stare, Anna Randon-Vitanova & Robert Dominko

Metal-organic batteries are gaining traction as versatile, low-cost, and sustainable devices, although there are still few ways to probe internal behavior during use. Here, the authors explore organic-molecule structural changes within several battery systems by in operando infrared spectroscopy.

14 February 2018 | doi: 10.1038/s41467-018-03114-1
Batteries  Characterization and analytical techniques 

Shape anisotropy revisited in single-digit nanometer magnetic tunnel junctions OPEN
K. Watanabe, B. Jinnai, S. Fukami, H. Sato & H. Ohno

The thermal stability impedes the application of nanoscale magnetic tunnel junctions in electronic and spintronics devices. Here the authors achieved current-induced magnetization switching in magnetic tunnel junctions smaller than 10 nm with sufficient thermal stability due to the shape anisotropy without adding new material systems.

14 February 2018 | doi: 10.1038/s41467-018-03003-7
Electrical and electronic engineering  Magnetic devices  Spintronics 

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor OPEN
David L. Gray, John A. Allen, Scot Mente, Rebecca E. O’Connor, George J. DeMarco, Ivan Efremov, Patrick Tierney, Dmitri Volfson, Jennifer Davoren, Edward Guilmette, Michelle Salafia, Rouba Kozak & Michael D. Ehlers

Dopamine receptor agonists are used for the treatment of various psychiatric diseases. Here, the authors screen approximately three million compounds and identify a novel class of D1R agonists that do not have a catechol scaffold and possess promising pharmacokinetic properties.

14 February 2018 | doi: 10.1038/s41467-017-02776-7
Computational chemistry  Molecular neuroscience  Parkinson's disease  Receptor pharmacology 

53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process OPEN
Ankana Tiwari, Owen Addis Jones & Kok-Lung Chan

Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA intertwinements, which are limited by 53BP1.

14 February 2018 | doi: 10.1038/s41467-018-03098-y
Cancer genomics  Centromeres  Chromosome segregation 

Nanostructuring one-dimensional and amorphous lithium peroxide for high round-trip efficiency in lithium-oxygen batteries OPEN
Arghya Dutta, Raymond A. Wong, Woonghyeon Park, Keisuke Yamanaka, Toshiaki Ohta, Yousung Jung & Hye Ryung Byon

While lithium-oxygen batteries offer a green method to power vehicles, the sluggish decomposition of lithium peroxide limits device performance. Here, the authors direct lithium peroxide formation into amorphous nanostructures to enable its facile decomposition and improve charging efficiency.

14 February 2018 | doi: 10.1038/s41467-017-02727-2
Batteries  Structural properties 

Anti-fouling graphene-based membranes for effective water desalination OPEN
Dong Han Seo, Shafique Pineda, Yun Chul Woo, Ming Xie, Adrian T. Murdock, Elisa Y. M. Ang, Yalong Jiao, Myoung Jun Park, Sung Il Lim, Malcolm Lawn, Fabricio Frizera Borghi, Zhao Jun Han, Stephen Gray, Graeme Millar, Aijun Du, Ho Kyong Shon, Teng Yong Ng & Kostya (Ken) Ostrikov

Intrinsic limitations of nanoporous graphene limit its applications in water treatment. Here the authors produce post-treatment-free, low-cost graphene-based membranes from renewable biomass and demonstrate their high water permeance and antifouling properties using real seawater.

14 February 2018 | doi: 10.1038/s41467-018-02871-3
Chemical engineering  Graphene  Mechanical and structural properties and devices  Pollution remediation 

Current-induced magnetization switching in atom-thick tungsten engineered perpendicular magnetic tunnel junctions with large tunnel magnetoresistance OPEN
Mengxing Wang, Wenlong Cai, Kaihua Cao, Jiaqi Zhou, Jerzy Wrona, Shouzhong Peng, Huaiwen Yang, Jiaqi Wei, Wang Kang, Youguang Zhang, Jürgen Langer, Berthold Ocker, Albert Fert & Weisheng Zhao

Perpendicular magnetic tunnel junctions with large tunnel magnetoresistance and low junction resistance are promising for the magnetic random access memories. Here the authors achieve the spin-transfer-torque switching in perpendicular magnetic tunnel junctions with 249% tunnel magnetoresistance and low resistance-area product.

14 February 2018 | doi: 10.1038/s41467-018-03140-z
Electronic and spintronic devices  Electronic devices 

Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone OPEN
Xiao-Feng Li, Hao-Long Dong, Hong-Jiang Wang, Xing-Yao Huang, Ye-Feng Qiu, Xue Ji, Qing Ye, Chunfeng Li, Yang Liu, Yong-Qiang Deng, Tao Jiang, Gong Cheng, Fu-Chun Zhang, Andrew D. Davidson, Ya-Jun Song, Pei-Yong Shi & Cheng-Feng Qin

Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models.

14 February 2018 | doi: 10.1038/s41467-018-02975-w
Infection  Live attenuated vaccines  Virology 

Ecology and genomics of an important crop wild relative as a prelude to agricultural innovation OPEN
Eric J.B. von Wettberg, Peter L. Chang, Fatma Başdemir, Noelia Carrasquila-Garcia, Lijalem Balcha Korbu, Susan M. Moenga, Gashaw Bedada, Alex Greenlon, Ken S. Moriuchi, Vasantika Singh, Matilde A. Cordeiro, Nina V. Noujdina, Kassaye Negash Dinegde, Syed Gul Abbas Shah Sani, Tsegaye Getahun, Lisa Vance, Emily Bergmann, Donna Lindsay, Bullo Erena Mamo, Emily J. Warschefsky et al.

Domestication reduces genetic diversity and constrains crop improvement. Here the authors identify factors that shaped species diversity in the wild progenitors of chickpea, and produce wild introgression populations that increase diversity for breeding by ~100-fold, including traits of agronomic relevance.

13 February 2018 | doi: 10.1038/s41467-018-02867-z
Plant breeding  Plant domestication  Plant ecology  Plant genetics 

The effects of death and post-mortem cold ischemia on human tissue transcriptomes OPEN
Pedro G. Ferreira, Manuel Muñoz-Aguirre, Ferran Reverter, Caio P. Sá Godinho, Abel Sousa, Alicia Amadoz, Reza Sodaei, Marta R. Hidalgo, Dmitri Pervouchine, Jose Carbonell-Caballero, Ramil Nurtdinov, Alessandra Breschi, Raziel Amador, Patrícia Oliveira, Cankut Çubuk, João Curado, François Aguet, Carla Oliveira, Joaquin Dopazo, Michael Sammeth et al.

RNA levels in post-mortem tissue can differ greatly from those before death. Studying the effect of post-mortem interval on the transcriptome in 36 human tissues, Ferreira et al. find that the response to death is largely tissue-specific and develop a model to predict time since death based on RNA data.

13 February 2018 | doi: 10.1038/s41467-017-02772-x
Data mining  Gene expression  Genomics  Machine learning 

Dynamics of starvation and recovery predict extinction risk and both Damuth’s law and Cope’s rule OPEN
Justin D. Yeakel, Christopher P. Kempes & Sidney Redner

Energetic constraints produce a fundamental tradeoff in starvation and recovery rates, impacting eco-evolutionary dynamics. Here, Yeakel et al. develop a nutritional state-structured model that predicts population size as a function of body mass known as Damuth’s law, and a mechanism for Cope’s rule, the evolutionary trend towards larger body mass.

13 February 2018 | doi: 10.1038/s41467-018-02822-y
Evolutionary theory  Population dynamics 

High enthalpy storage thermoset network with giant stress and energy output in rubbery state OPEN
Jizhou Fan & Guoqiang Li

Energy storage in thermoset shape memory polymers happens through entropy reduction during the programming step, but low energy release is known to be a bottleneck for wide-spread application. Here, the authors show a thermoset network that stores energy primarily through enthalpy increase by bond length change, which leads to an improved energy output.

13 February 2018 | doi: 10.1038/s41467-018-03094-2
Mechanical engineering  Mechanical properties  Polymers 

A CNOT gate between multiphoton qubits encoded in two cavities OPEN
S. Rosenblum, Y. Y. Gao, P. Reinhold, C. Wang, C. J. Axline, L. Frunzio, S. M. Girvin, Liang Jiang, M. Mirrahimi, M. H. Devoret & R. J. Schoelkopf

Quantum computing platforms allowing quantum error correction usually rely on complex redundant encoding within multiple two-level systems. Here, instead, the authors realize a CNOT gate between two qubits encoded in the multiphoton states of two microwave cavities nonlinearly coupled by a transmon.

13 February 2018 | doi: 10.1038/s41467-018-03059-5
Quantum information  Qubits  Single photons and quantum effects  Superconducting devices 

Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging OPEN
Gabriel Oh, Sasha Ebrahimi, Matthew Carlucci, Aiping Zhang, Akhil Nair, Daniel E. Groot, Viviane Labrie, Peixin Jia, Edward S. Oh, Richie H. Jeremian, Miki Susic, Tenjin C. Shrestha, Martin R. Ralph, Juozas Gordevičius, Karolis Koncevičius & Art Petronis

While epigenetic factors have been implicated in the circadian rhythm, the detection of circadian cytosine modifications has remained elusive. Here the authors identify a large number of epigenetically variable cytosines that show circadian oscillations in their modification status in mice.

13 February 2018 | doi: 10.1038/s41467-018-03073-7
Ageing  Circadian rhythms  DNA methylation 

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms OPEN
Christopher H. Douse, Stuart Bloor, Yangci Liu, Maria Shamin, Iva A. Tchasovnikarova, Richard T. Timms, Paul J. Lehner & Yorgo Modis

Microrchidia CW-type zinc finger protein 2 (MORC2) is an effector of epigenetic silencing by the human silencing hub (HUSH). Here the authors present the crystal structures of MORC2 and disease-causing MORC2 mutants and give mechanistic insights into how MORC2 mediates HUSH-dependent silencing.

13 February 2018 | doi: 10.1038/s41467-018-03045-x
Chromatin remodelling  Gene silencing  Neuromuscular disease  Nucleotide-binding proteins  X-ray crystallography 

A defensin-like protein drives cadmium efflux and allocation in rice OPEN
Jin-Song Luo, Jing Huang, Da-Li Zeng, Jia-Shi Peng, Guo-Bin Zhang, Hai-Ling Ma, Yuan Guan, Hong-Ying Yi, Yan-Lei Fu, Bin Han, Hong-Xuan Lin, Qian Qian & Ji-Ming Gong

Crops that allocate heavy metals to leaves rather than grains could allow phytoremediation of polluted soil while producing food that is safe to eat. Here, the authors show that a defensin-like protein promotes cadmium secretion from rice cells and allocation to leaves without causing accumulation in grain.

13 February 2018 | doi: 10.1038/s41467-018-03088-0
Natural variation in plants  Plant biotechnology  Plant genetics 

Detecting RNA base methylations in single cells by in situ hybridization OPEN
Rohan T. Ranasinghe, Martin R. Challand, Kristina A. Ganzinger, Benjamin W. Lewis, Charlotte Softley, Wolfgang H. Schmied, Mathew H. Horrocks, Nadia Shivji, Jason W. Chin, James Spencer & David Klenerman

Methylated RNA bases influence many life processes, but current detection methods lack the ability to detect individual methylations in single cells. Here, the authors use fluorescence hybridization probes sensitive to methylation to detect specific epitranscriptomic modifications at the single-cell level.

13 February 2018 | doi: 10.1038/s41467-017-02714-7
Bacteriology  DNA probes  Fluorescence imaging  RNA modification 

Conductance quantization suppression in the quantum Hall regime OPEN
José M. Caridad, Stephen R. Power, Mikkel R. Lotz, Artsem A. Shylau, Joachim D. Thomsen, Lene Gammelgaard, Timothy J. Booth, Antti-Pekka Jauho & Peter Bøggild

Conductance quantization is the hallmark of non-interacting confined systems. The authors show that the quantization in graphene nanoconstrictions with low edge disorder is suppressed in the quantum Hall regime. This is explained by the addition of new conductance channels due to electrostatic screening.

13 February 2018 | doi: 10.1038/s41467-018-03064-8
Electronic properties and devices  Quantum Hall 

Understanding the plume dynamics of explosive super-eruptions OPEN
Antonio Costa, Yujiro J. Suzuki & Takehiro Koyaguchi

Super-eruptions such as Toba generate large co-ignimbrite plumes, but their behaviour is not fully understood. Here, the authors show that super-eruption plumes behave differently to Plinian eruptions and can generate over-plumes into the mesosphere, which would amplify their impact on the climate.

13 February 2018 | doi: 10.1038/s41467-018-02901-0
Fluid dynamics  Palaeoclimate  Volcanology 

Direct measurement of superdiffusive energy transport in disordered granular chains OPEN
Eunho Kim, Alejandro J. Martínez, Sean E. Phenisee, P. G. Kevrekidis, Mason A. Porter & Jinkyu Yang

Wave propagation is often nonlinear in character, yet the interplay between disorder and nonlinearity remains elusive. Kim et al. use experiments and corroborating numerical simulations to investigate this phenomenon and demonstrate superdiffusive energy transport in disordered granular chains.

13 February 2018 | doi: 10.1038/s41467-018-03015-3
Applied mathematics  Condensed-matter physics 

Fluorogenic RNA Mango aptamers for imaging small non-coding RNAs in mammalian cells OPEN
Alexis Autour, Sunny C. Y. Jeng, Adam D. Cawte, Amir Abdolahzadeh, Angela Galli, Shanker S. S. Panchapakesan, David Rueda, Michael Ryckelynck & Peter J. Unrau

Many aptamer-fluorophore complexes suffer from low quantum yield and low extinction coefficients limiting their usability. Here the authors isolate new Mango aptamers with improved fluorescent properties for both fixed and live-cell imaging by using competitive ligand binding microfluidic selection.

13 February 2018 | doi: 10.1038/s41467-018-02993-8
Fluorescence imaging  RNA 

21st Century drought-related fires counteract the decline of Amazon deforestation carbon emissions OPEN
Luiz E. O. C. Aragão, Liana O. Anderson, Marisa G. Fonseca, Thais M. Rosan, Laura B. Vedovato, Fabien H. Wagner, Camila V. J. Silva, Celso H. L. Silva Junior, Egidio Arai, Ana P. Aguiar, Jos Barlow, Erika Berenguer, Merritt N. Deeter, Lucas G. Domingues, Luciana Gatti, Manuel Gloor, Yadvinder Malhi, Jose A. Marengo, John B. Miller, Oliver L. Phillips et al.

Deforestation carbon emissions from the Brazilian Amazon have declined steeply, but how much drought-induced forest fire emissions add to this process is still unclear. Here the authors show that gross emissions from forest fires are more than half as great as those from deforestation during drought years.

13 February 2018 | doi: 10.1038/s41467-017-02771-y
Carbon cycle  Climate-change mitigation  Environmental impact 

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models OPEN
Upneet K. Sokhi, Mark P. Liber, Laura Frye, Sungho Park, Kyuho Kang, Tania Pannellini, Baohong Zhao, Rada Norinsky, Lionel B. Ivashkiv & Shiaoching Gong

The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3.

13 February 2018 | doi: 10.1038/s41467-018-03081-7
Autoimmunity  Gene regulation  Genetic engineering  Lupus nephritis 

Toward a consistent modeling framework to assess multi-sectoral climate impacts OPEN
Erwan Monier, Sergey Paltsev, Andrei Sokolov, Y.-H. Henry Chen, Xiang Gao, Qudsia Ejaz, Evan Couzo, C. Adam Schlosser, Stephanie Dutkiewicz, Charles Fant, Jeffery Scott, David Kicklighter, Jennifer Morris, Henry Jacoby, Ronald Prinn & Martin Haigh

Climate impact assessments usually rely on modeling approaches that are either comprehensive but inflexible and inefficient, or lacking sufficient detail. Here the authors describe a framework to assess multi-sectoral climate impacts and show its capability and timely responsiveness to new policies.

13 February 2018 | doi: 10.1038/s41467-018-02984-9
Climate and Earth system modelling  Climate-change impacts  Environmental impact 

Nanobody-triggered lockdown of VSRs reveals ligand reloading in the Golgi OPEN
Simone Früholz, Florian Fäßler, Üner Kolukisaoglu & Peter Pimpl

Vacuolar sorting receptors (VSRs) are suggested to efficiently transport hydrolases by continuous cycling. Here, the authors use a nanobody-epitope interaction-based labeling approach to trace VSR recycling from the TGN/EE to the cis-Golgi and reveal ligand reloading of recycled VSRs.

13 February 2018 | doi: 10.1038/s41467-018-02909-6
Golgi  Protein trafficking in plants  Vacuole 

Reversible chromism of spiropyran in the cavity of a flexible coordination cage OPEN
Dipak Samanta, Daria Galaktionova, Julius Gemen, Linda J. W. Shimon, Yael Diskin-Posner, Liat Avram, Petr Král & Rafal Klajn

Under confinement, molecular switches lose the conformational freedom often needed to isomerize. Here, the authors show that a flexible coordination cage can adapt its shape to guide the photoisomerization of encapsulated spiropyrans, rendering them reversibly photochromic even within the confines of the cavity.

13 February 2018 | doi: 10.1038/s41467-017-02715-6
Molecular capsules  Molecular machines and motors  Self-assembly 

Energy use and life cycle greenhouse gas emissions of drones for commercial package delivery OPEN
Joshuah K. Stolaroff, Constantine Samaras, Emma R. O’Neill, Alia Lubers, Alexandra S. Mitchell & Daniel Ceperley

The use of drones to deliver commercial packages is poised to become a new industry. Here the authors show that replacing truck delivery by drones can reduce greenhouse gas emissions and energy use when the drone size and additional warehousing requirements are limited.

13 February 2018 | doi: 10.1038/s41467-017-02411-5
Climate-change mitigation  Energy efficiency  Energy science and technology 

A secondary RET mutation in the activation loop conferring resistance to vandetanib OPEN
Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald & Koichi Goto

Mechanisms of acquired resistance to RET tyrosine kinase inhibitors in lung cancers are largely unknown. Here, the authors report in a lung adenocarcinoma patient harboring a CCDC6-RET mutation in the RET kinase (S904F) that results in resistance to the kinase inhibitor vandetanib by increasing the ATP affinity and autophosphorylation activity of RET kinase.

12 February 2018 | doi: 10.1038/s41467-018-02994-7
Cancer genomics  Non-small-cell lung cancer 

A human endothelial cell-based recycling assay for screening of FcRn targeted molecules OPEN
Algirdas Grevys, Jeannette Nilsen, Kine M. K. Sand, Muluneh B. Daba, Inger Øynebråten, Malin Bern, Martin B. McAdam, Stian Foss, Tilman Schlothauer, Terje E. Michaelsen, Gregory J. Christianson, Derry C. Roopenian, Richard S. Blumberg, Inger Sandlie & Jan Terje Andersen

The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without chemical labelling and prior to animal testing.

12 February 2018 | doi: 10.1038/s41467-018-03061-x
Drug screening  High-throughput screening 

Rationally designed synthetic protein hydrogels with predictable mechanical properties OPEN
Junhua Wu, Pengfei Li, Chenling Dong, Heting Jiang, Bin Xue, Xiang Gao, Meng Qin, Wei Wang, Bin Chen & Yi Cao

Mechanical properties of protein hydrogels are critical to mimic natural tissue but correlating bulk properties on the molecular level remains challenging. Here the authors show that the hierarchy of crosslinkers and load-bearing modules on a molecular level defines the mechanical properties of the hydrogel.

12 February 2018 | doi: 10.1038/s41467-018-02917-6
Biological physics  Biomaterials – proteins  Gels and hydrogels  Single-molecule biophysics 

Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood OPEN
Xunmei Yuan, Kazutaka Tsujimoto, Koshi Hashimoto, Kenichi Kawahori, Nozomi Hanzawa, Miho Hamaguchi, Takami Seki, Makiko Nawa, Tatsuya Ehara, Yohei Kitamura, Izuho Hatada, Morichika Konishi, Nobuyuki Itoh, Yoshimi Nakagawa, Hitoshi Shimano, Takako Takai-Igarashi, Yasutomi Kamei & Yoshihiro Ogawa

FGF21 exerts beneficial metabolic effects on multiple tissues. Here the authors show that the Fgf21 gene is demethylated during the postnatal suckling period, creating an epigenetic memory that determines the responsiveness of the Fgf21 gene to inducers such as PPARα activators or fasting in adulthood.

12 February 2018 | doi: 10.1038/s41467-018-03038-w
DNA methylation  Epigenetic memory  Obesity 

Absolute marine gravimetry with matter-wave interferometry OPEN
Y. Bidel, N. Zahzam, C. Blanchard, A. Bonnin, M. Cadoret, A. Bresson, D. Rouxel & M. F. Lequentrec-Lalancette

Measuring gravitational and inertial acceleration in a moving platform is important for sensing and navigation but is also very challenging. Here the authors demonstrate the ship-borne absolute gravity acceleration measurements using an atom interferometer.

12 February 2018 | doi: 10.1038/s41467-018-03040-2
Matter waves and particle beams  Solid Earth sciences  Techniques and instrumentation  Ultracold gases 

The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution OPEN
Li Lu, Xiangsong Chen, Shuiming Qian & Xuehua Zhong

The canonical histone variant H3.1 of vascular plants contains a conserved Phe residue at position 41 that is unique to the plant kingdom. Here, Lu et al. provide evidence that H3.1Phe41 acts collaboratively with the H3.1 core domain to restrict H3.1 deposition to silent regions of the genome.

12 February 2018 | doi: 10.1038/s41467-018-02976-9
Epigenetics  Plant genetics  Plant sciences 

CellCycleTRACER accounts for cell cycle and volume in mass cytometry data OPEN
Maria Anna Rapsomaniki, Xiao-Kang Lun, Stefan Woerner, Marco Laumanns, Bernd Bodenmiller & María Rodríguez Martínez

Mass cytometry is a powerful method of single cell analysis, but potential confounding effects of cell cycle and cell volume are not taken into account. Here the authors present a combined experimental and computational method to correct for these effects and reveal features of TNFα stimulation that are otherwise masked.

12 February 2018 | doi: 10.1038/s41467-018-03005-5
Mass spectrometry  Protein analysis  Software 

Resonance Raman signature of intertube excitons in compositionally-defined carbon nanotube bundles OPEN
Jeffrey R. Simpson, Oleksiy Roslyak, Juan G. Duque, Erik H. Hároz, Jared J. Crochet, Hagen Telg, Andrei Piryatinski, Angela R. Hight Walker & Stephen K. Doorn

Bundles of single-wall carbon nanotubes with enriched chirality can be used as model systems for exploring exciton physics in low-dimensional nanostructures. Here, the authors use resonant Raman spectroscopy to probe intertube interactions in bundles of (6,5)-enriched carbon nanotubes, and observe a Fano resonance arising from coupling between intertube and intratube excitons.

12 February 2018 | doi: 10.1038/s41467-018-03057-7
Carbon nanotubes and fullerenes  Nanoscale materials  Nanoscience and technology  Raman spectroscopy 

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity OPEN
Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog & Rugang Zhang

CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor suppressor gene silencing.

12 February 2018 | doi: 10.1038/s41467-018-03031-3
Gene silencing  Ovarian cancer 

Single-cell full-length total RNA sequencing uncovers dynamics of recursive splicing and enhancer RNAs OPEN
Tetsutaro Hayashi, Haruka Ozaki, Yohei Sasagawa, Mana Umeda, Hiroki Danno & Itoshi Nikaido

Total RNA sequencing has been used to profile poly(A) and non-poly(A) RNA expression, processing and the activity of enhancers. Here the authors develop RamDA-seq, a method for full-length total RNA sequencing in single cells.

12 February 2018 | doi: 10.1038/s41467-018-02866-0
Functional genomics  High-throughput screening  Long non-coding RNAs  RNA sequencing 

Residential energy use emissions dominate health impacts from exposure to ambient particulate matter in India OPEN
Luke Conibear, Edward W. Butt, Christoph Knote, Stephen R. Arnold & Dominick V. Spracklen

Exposure to ambient particulate matter is a key contributor to disease in India and source attribution is vital for pollution control. Here the authors use a high-resolution regional model to show residential emissions dominate particulate matter concentrations and associated premature mortality.

12 February 2018 | doi: 10.1038/s41467-018-02986-7
Atmospheric chemistry  Energy and society  Environmental impact  Pollution remediation 

Glacigenic sedimentation pulses triggered post-glacial gas hydrate dissociation OPEN
Jens Karstens, Haflidi Haflidason, Lukas W. M. Becker, Christian Berndt, Lars Rüpke, Sverre Planke, Volker Liebetrau, Mark Schmidt & Jürgen Mienert

Triggers of gas hydrate instability along continental margins remain debated. Here, via numerical simulations, the authors show that pulses in sedimentation, rather than bottom water temperature or sea level change, likely triggered gas hydrate dissociation offshore Norway at the end of the last glaciation.

12 February 2018 | doi: 10.1038/s41467-018-03043-z
Geophysics  Sedimentology 

Phonon-driven spin-Floquet magneto-valleytronics in MoS2 OPEN
Dongbin Shin, Hannes Hübener, Umberto De Giovannini, Hosub Jin, Angel Rubio & Noejung Park

In 2H semiconducting transition-metal dichalcogenides the valley-selective excitation has been achieved with circularly polarized photons. Here, the authors show that circularly polarized phonons produce a valley-dependent dynamic spin state as a result of strong spin-phonon coupling.

12 February 2018 | doi: 10.1038/s41467-018-02918-5
Electronic structure  Spintronics  Two-dimensional materials 

Protactinium and the intersection of actinide and transition metal chemistry OPEN
Richard E. Wilson, Stephanie De Sio & Valérie Vallet

The role of the 5f and 6d orbitals in the chemical bonding of the actinide elements remains debated. Here, the authors synthesize and study a tetranuclear protactinium peroxo cluster and demonstrate that protactinium represents an intersection of actinide (5f) and transition metal (6d) chemistries.

12 February 2018 | doi: 10.1038/s41467-018-02972-z
Chemical bonding  Theoretical chemistry 

Peridotite weathering is the missing ingredient of Earth’s continental crust composition OPEN
Andreas Beinlich, Håkon Austrheim, Vasileios Mavromatis, Ben Grguric, Christine V. Putnis & Andrew Putnis

The concentration of Ni and Cr of the continental crust cannot be explained by formation models involving differentiated magmatic rocks. Here, the authors show that hydrothermal alteration and chemical weathering of ultramafic rock compensates for the low Ni and Cr concentrations of island arc-type magmatic rocks.

12 February 2018 | doi: 10.1038/s41467-018-03039-9
Geochemistry  Mineralogy  Petrology  Precambrian geology 

Plasma density limits for hole boring by intense laser pulses OPEN
Natsumi Iwata, Sadaoki Kojima, Yasuhiko Sentoku, Masayasu Hata & Kunioki Mima

Different energy transport mechanisms come into play when intense laser pulses interact with dense plasma. Here the authors provide a limit on the plasma density reachable with an intense laser and an insight into the hole boring process.

12 February 2018 | doi: 10.1038/s41467-018-02829-5
Laser-produced plasmas  Plasma-based accelerators 

Absence of warmth permits epigenetic memory of winter in Arabidopsis OPEN
Jo Hepworth, Rea L. Antoniou-Kourounioti, Rebecca H. Bloomer, Catja Selga, Kristina Berggren, Deborah Cox, Barley R. Collier Harris, Judith A. Irwin, Svante Holm, Torbjörn Säll, Martin Howard & Caroline Dean

Plants use multiple cues to monitor seasonal temperatures. Here, the authors show that Arabidopsis requires not only prolonged cold, but the absence of temperature spikes above 15 °C to epigenetically silence FLC during winter.

12 February 2018 | doi: 10.1038/s41467-018-03065-7
Applied mathematics  Gene silencing  Plant development  Vernalization 

Sustained micellar delivery via inducible transitions in nanostructure morphology OPEN
Nicholas B. Karabin, Sean Allen, Ha-Kyung Kwon, Sharan Bobbala, Emre Firlar, Tolou Shokuhfar, Kenneth R. Shull & Evan A. Scott

Nanocarrier administration is often performed via intermittent bolus injection while sustained delivery platforms are rarely reported. Here the authors demonstrate that the cylinder-to-sphere transitions of self-assembled filomicelle scaffolds can be used for sustained delivery with improved resorptive capacity and biocompatibility.

12 February 2018 | doi: 10.1038/s41467-018-03001-9
Biomaterials  Biomedical engineering 

Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses OPEN
Courtney S. Malo, Matthew A. Huggins, Emma N. Goddery, Heather M. A. Tolcher, Danielle N. Renner, Fang Jin, Michael J. Hansen, Larry R. Pease, Kevin D. Pavelko & Aaron J. Johnson

Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and in response to cerebral malaria, picornavirus infection and experimental glioma.

12 February 2018 | doi: 10.1038/s41467-018-03037-x
Antigen-presenting cells  MHC class I  Neuroimmunology 

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts OPEN
Marietta Armaka, Caroline Ospelt, Manolis Pasparakis & George Kollias

TNF is a major therapeutic target for rheumatoid arthritis (RA) and synovial fibroblasts are central to the pathogenesis of RA. Here the authors dissect TNF-induced death and activation signalling in RA synovial fibroblasts and TNF-driven arthritis and indicate that a successful therapeutic strategy might be to target both IKK2 and RIPK3 at the same time.

12 February 2018 | doi: 10.1038/s41467-018-02935-4
Cell death and immune response  Chronic inflammation  Rheumatoid arthritis 

Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation OPEN
Jun Guo, Weiwei Fang, Libo Sun, Yonggang Lu, Lin Dou, Xiuqing Huang, Weiqing Tang, Liqing Yu & Jian Li

Ultraconserved RNAs are a class of long non-coding RNAs whose functions are yet to be identified. Here Guo and colleagues show that an ultraconserved RNA uc.372 promotes lipogenesis and lipid accumulation within the hepatocytes by suppressing the maturation of miR-195/miR-4668 that inhibits lipogenic gene expression.

09 February 2018 | doi: 10.1038/s41467-018-03072-8
Metabolic syndrome  miRNAs  Non-alcoholic fatty liver disease 

Statistical modeling of RNA structure profiling experiments enables parsimonious reconstruction of structure landscapes OPEN
Hua Li & Sharon Aviran

Different experimental and computational approaches can be used to study RNA structures. Here, the authors present a computational method for data-directed reconstruction of complex RNA structure landscapes, which predicts a parsimonious set of co-existing structures and estimates their abundances from structure profiling data.

09 February 2018 | doi: 10.1038/s41467-018-02923-8
Computational science  Statistical methods 

Minimising efficiency roll-off in high-brightness perovskite light-emitting diodes OPEN
Wei Zou, Renzhi Li, Shuting Zhang, Yunlong Liu, Nana Wang, Yu Cao, Yanfeng Miao, Mengmeng Xu, Qiang Guo, Dawei Di, Li Zhang, Chang Yi, Feng Gao, Richard H. Friend, Jianpu Wang & Wei Huang

Large drop in efficiency at high brightness has been holding back the development of various light-emitting diodes including halide perovskite. Here Zou et al. achieve high quantum efficiency of 10% under a high current density of 500 mA cm−2 in perovskite-based diodes by reducing luminescence quenching.

09 February 2018 | doi: 10.1038/s41467-018-03049-7
Lasers, LEDs and light sources  Optical materials and structures 

The WDR11 complex facilitates the tethering of AP-1-derived vesicles OPEN
Paloma Navarro Negredo, James R. Edgar, Paul T. Manna, Robin Antrobus & Margaret S. Robinson

Trafficking from endosomes to the trans-Golgi network requires recognition of vesicle tethers during membrane docking. Here, the authors identify a complex localised to AP-1 generated vesicles containing WDR11, C17orf75 and FAM91A, which together with TBC1D23 facilitates vesicle capture on Golgi membranes

09 February 2018 | doi: 10.1038/s41467-018-02919-4
Membrane trafficking  Organelles 

Visualizing catalyst heterogeneity by a  multifrequential oscillating reaction OPEN
Yuri Suchorski, Martin Datler, Ivan Bespalov, Johannes Zeininger, Michael Stöger-Pollach, Johannes Bernardi, Henrik Grönbeck & Günther Rupprechter

The structurally different domains of a polycrystalline material may exhibit differing catalytic properties. Here, the authors directly visualize this phenomenon by observing the catalytic hydrogen oxidation that oscillates, simultaneously exhibiting different frequencies for structurally different rhodium domains.

09 February 2018 | doi: 10.1038/s41467-018-03007-3
Materials for energy and catalysis  Surface chemistry 

Enantioselective [3+3] atroposelective annulation catalyzed by N-heterocyclic carbenes OPEN
Changgui Zhao, Donghui Guo, Kristin Munkerup, Kuo-Wei Huang, Fangyi Li & Jian Wang

Axially chiral compounds are commonly found in nature. Here, the authors show the highly enantioselective construction of axially chiral biaryls via an N-heterocyclic carbenes-catalyzed [3+3] atroposelective annulation of ynals with cyclic 1,3-diones.

09 February 2018 | doi: 10.1038/s41467-018-02952-3
Asymmetric catalysis  Synthetic chemistry methodology  Organocatalysis 

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing OPEN
Gil Ju Seo, Charlotte Kim, Woo-Jin Shin, Ella H. Sklan, Hyungjin Eoh & Jae U. Jung

The protein cGAS responds to the presence of cytosolic DNA by producing the second messenger cGAMP, which triggers antiviral interferon responses. Here, Seo et al. show that ubiquitination by the E3 ligase TRIM56 enhances cGAS activity and is important for the immune response against DNA viruses.

09 February 2018 | doi: 10.1038/s41467-018-02936-3
Herpes virus  RIG-I-like receptors 

Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments OPEN
Sebastián L. Vega, Mi Y. Kwon, Kwang Hoon Song, Chao Wang, Robert L. Mauck, Lin Han & Jason A. Burdick

Tools to investigate a wide range of 3D microenvironmental parameters are important for understanding and controlling cell fate. Here, the authors develop hydrogels with orthogonal biochemical gradients and use this screening system to identify microenvironments that induce mesenchymal stem cell chondrogenesis.

09 February 2018 | doi: 10.1038/s41467-018-03021-5
Adult stem cells  Biomedical engineering  Chemical modification 

Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation OPEN
Jia Yuan, Wenbo Deng, Jeeyeon Cha, Xiaofei Sun, Jean-Paul Borg & Sudhansu. K. Dey

Embryo implantation initiates the interaction of the blastocyst with the uterus and occurs within a specialised crypt formed by uterine epithelial cells. Here, using 3D imaging techniques of wild type and mutant uteri, the authors show that crypt formation occurs with preexisting glands of the uterus, opening communication between glands and the implanting embryo.

09 February 2018 | doi: 10.1038/s41467-018-03092-4
3-D reconstruction  Embryogenesis  Infertility  Intrauterine growth 

Spectroscopy of bulk and few-layer superconducting NbSe2 with van der Waals tunnel junctions OPEN
T. Dvir, F. Massee, L. Attias, M. Khodas, M. Aprili, C. H. L. Quay & H. Steinberg

Ideal tunnel junctions require high-quality, defect-free insulating barriers. Here, the authors demonstrate that van der Waals tunnel barriers atop bulk and ultrathin superconducting NbSe2 sustain a stable tunneling current and allow mapping of the spectral evolution of layered superconductors.

09 February 2018 | doi: 10.1038/s41467-018-03000-w
Electronic properties and materials  Superconducting properties and materials  Two-dimensional materials 

Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma OPEN

For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.

09 February 2018 | doi: 10.1038/s41467-017-02674-y
Melanoma  Oncology 

The IAP family member BRUCE regulates autophagosome–lysosome fusion OPEN
Petra Ebner, Isabella Poetsch, Luiza Deszcz, Thomas Hoffmann, Johannes Zuber & Fumiyo Ikeda

The inhibitor of apoptosis (IAP) protein, BRUCE is known to ubiquitinate apoptosis regulators for proteasomal degradation. Here the authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autophagosome-lysosome fusion.

09 February 2018 | doi: 10.1038/s41467-018-02823-x
Apoptosis  Macroautophagy 

Lifting the bandwidth limit of optical homodyne measurement with broadband parametric amplification OPEN
Yaakov Shaked, Yoad Michael, Rafi Z. Vered, Leon Bello, Michael Rosenbluh & Avi Pe’er

Standard homodyne detection is intrinsically limited by the electronic bandwidth of the photo-detectors. Here, the authors exploit parametric amplification to demonstrate sub-shot-noise optical quadrature measurement across a bandwidth of 55 THz.

09 February 2018 | doi: 10.1038/s41467-018-03083-5
Quantum information  Quantum optics 

Laboratory evidence of dynamo amplification of magnetic fields in a turbulent plasma OPEN
P. Tzeferacos, A. Rigby, A. F. A. Bott, A. R. Bell, R. Bingham, A. Casner, F. Cattaneo, E. M. Churazov, J. Emig, F. Fiuza, C. B. Forest, J. Foster, C. Graziani, J. Katz, M. Koenig, C.-K. Li, J. Meinecke, R. Petrasso, H.-S. Park, B. A. Remington et al.

Exploring astrophysical turbulent effects in laboratory plasma is challenging due to high threshold values of relevant parameters, such as the magnetic Reynolds number. Here the authors demonstrate the turbulent dynamo effect at large magnetic Reynolds numbers in laser-generated magnetized plasma.

09 February 2018 | doi: 10.1038/s41467-018-02953-2
Interstellar medium  Laser-produced plasmas 

Additive manufacturing of 3D nano-architected metals OPEN
Andrey Vyatskikh, Stéphane Delalande, Akira Kudo, Xuan Zhang, Carlos M. Portela & Julia R. Greer

Most current methods for additive manufacturing of complex metallic 3D structures are limited to a resolution of 20–50 µm. Here, the authors developed a lithography-based process to produce 3D nanoporous nickel nanolattices with octet geometries and a resolution of 100 nm.

09 February 2018 | doi: 10.1038/s41467-018-03071-9
Design, synthesis and processing  Metals and alloys  Nanoscale materials 

Deficiency of a triterpene pathway results in humidity-sensitive genic male sterility in rice OPEN
Zheyong Xue, Xia Xu, Yuan Zhou, Xiaoning Wang, Yingchun Zhang, Dan Liu, Binbin Zhao, Lixin Duan & Xiaoquan Qi

In flowering plants, the pollen coat surrounds the male germ cells and protects against dehydration, damage and pathogen attack. Here, the authors show that a deficiency in terpenoid synthesis results in rice pollen over-dehydration and leads to a humidity-sensitive conditional male sterile phenotype.

09 February 2018 | doi: 10.1038/s41467-018-03048-8
Plant breeding  Plant regeneration  Pollen 

Leucine-rich repeat receptor-like gene screen reveals that Nicotiana RXEG1 regulates glycoside hydrolase 12 MAMP detection OPEN
Yan Wang, Yuanpeng Xu, Yujing Sun, Huibin Wang, Jiaming Qi, Bowen Wan, Wenwu Ye, Yachun Lin, Yuanyuan Shao, Suomeng Dong, Brett M. Tyler & Yuanchao Wang

The role of most plant leucine-rich repeat (LRR) receptors in innate immunity is unknown. Here, the authors develop virus-based constructs to silence LRR receptor-like genes in the Nicotiana benthamiana genome and identify Response to XEG1 that specifically recognizes the glycoside hydrolase 12 protein XEG1.

09 February 2018 | doi: 10.1038/s41467-018-03010-8
High-throughput screening  Pattern recognition receptors in plants  Plant signalling 

Three-dimensional structural dynamics of DNA origami Bennett linkages using individual-particle electron tomography OPEN
Dongsheng Lei, Alexander E. Marras, Jianfang Liu, Chao-Min Huang, Lifeng Zhou, Carlos E. Castro, Hai-Jun Su & Gang Ren

Scaffolded DNA origami by folding single-stranded DNA into three-dimensional nanostructures holds promise for building functional nanomachines, yet their dynamic structures remain largely unknown. Here, Lei et al. address this issue using individual-particle electron tomography at 6–14 nm resolution.

09 February 2018 | doi: 10.1038/s41467-018-03018-0
Cryoelectron tomography  DNA and RNA  Molecular machines and motors  Organizing materials with DNA 

Cellular imaging by targeted assembly of hot-spot SERS and photoacoustic nanoprobes using split-fluorescent protein scaffolds OPEN
Tuğba Köker, Nathalie Tang, Chao Tian, Wei Zhang, Xueding Wang, Richard Martel & Fabien Pinaud

Traditional methods for the assembly of plasmonic nanoparticles into photo-responsive probes suffer from multiple problems. Here the authors use split fluorescent protein fragments as molecular glue to form stable nanoclusters for surface enhanced Raman scattering and photoacoustic imaging in live cells.

09 February 2018 | doi: 10.1038/s41467-018-03046-w
Imaging  Nanoparticles  Surface plasmon resonance 

Similarity of stream width distributions across headwater systems OPEN
George H. Allen, Tamlin M. Pavelsky, Eric A. Barefoot, Michael P. Lamb, David Butman, Arik Tashie & Colin J. Gleason

The morphology and abundance of streams control the rates of hydraulic and biogeochemical exchange between streams, groundwater and the atmosphere. Here, the authors show that stream hydromorphology is predictable within headwater catchments with implications for stream-atmosphere gas exchange estimates.

09 February 2018 | doi: 10.1038/s41467-018-02991-w
Carbon cycle  Freshwater ecology  Hydrology 

Genome-wide tracking of dCas9-methyltransferase footprints OPEN
Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller & Alexander Meissner

Catalytically inactive Cas9 fused to a methyltransferase has emerged as a promising epigenome modifying tool. Here the authors generate a methylation depleted but maintenance competent mouse ES cell line and find ubiquitous off-target activity.

09 February 2018 | doi: 10.1038/s41467-017-02708-5
CRISPR-Cas systems  Epigenomics 

A printable hydrogel microarray for drug screening avoids false positives associated with promiscuous aggregating inhibitors OPEN
Rabia Mateen, M. Monsur Ali & Todd Hoare

False positive results significantly slow down the drug discovery process. Here, the authors developed a gel serving as a screening platform in which enzymes can be stored, stabilized, and protected from most of the compounds that typically cause these misleading results.

09 February 2018 | doi: 10.1038/s41467-018-02956-z
High-throughput screening  Sensors and biosensors 

Molecular-channel driven actuator with considerations for multiple configurations and color switching OPEN
Jiuke Mu, Gang Wang, Hongping Yan, Huayu Li, Xuemin Wang, Enlai Gao, Chengyi Hou, Anh Thi Cam Pham, Lianjun Wu, Qinghong Zhang, Yaogang Li, Zhiping Xu, Yang Guo, Elsa Reichmanis, Hongzhi Wang & Meifang Zhu

Intrinsic deformation with fast response in commercially available materials that can safely contact skin continues to be a challenge for artificial actuating materials. Here the authors incorporate nanoscale molecular channels within perfluorosulfonic acid ionomer for self-adaptive and ambient-driven actuation.

09 February 2018 | doi: 10.1038/s41467-018-03032-2
Actuators  Mechanical properties  Synthesis and processing 

Patterns of island change and persistence offer alternate adaptation pathways for atoll nations OPEN
Paul S. Kench, Murray R. Ford & Susan D. Owen

Inundation and erosion could make many atoll islands uninhabitable over the next century. Here the authors present an analysis of change in the atoll nation of Tuvalu that shows a 2.9% increase in land area over the past four decades, with 74% of islands increasing in size, despite rising sea levels.

09 February 2018 | doi: 10.1038/s41467-018-02954-1
Climate-change impacts  Developing world  Environmental impact  Geomorphology 

LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast OPEN
Amanda K. Mennie, Bettina A. Moser & Toru M. Nakamura

A functional telomerase complex requires that the catalytic TERT subunit be assembled with the template RNA TER1. Here the authors show that Pof8, a possible LARP7 family protein, is required for assembly of the telomerase complex, and repression of lncRNA transcripts at telomeres in S. pombe.

08 February 2018 | doi: 10.1038/s41467-018-02874-0
Non-coding RNAs  RNA  RNA-binding proteins  Telomeres 

Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast OPEN
Diego J. Páez-Moscoso, Lili Pan, Rutendo F. Sigauke, Morgan R. Schroeder, Wen Tang & Peter Baumann

The core of the telomerase holoenzyme is composed of the reverse transcriptase and the non-coding RNA template. Here the authors identify Pof8 as a new constitutive component of fission yeast telomerase, loss of which causes telomerase assembly defects and critically short telomeres.

08 February 2018 | doi: 10.1038/s41467-017-02284-8
Non-coding RNAs  RNA  RNA-binding proteins  Telomeres 

Self-assembly of emissive supramolecular rosettes with increasing complexity using multitopic terpyridine ligands OPEN
Guang-Qiang Yin, Heng Wang, Xu-Qing Wang, Bo Song, Li-Jun Chen, Lei Wang, Xin-Qi Hao, Hai-Bo Yang & Xiaopeng Li

Metal coordination of multitopic ligands is a powerful approach to building complex, functional architectures. Here, the authors construct three generations of fluorescent supramolecular rosettes by coordination of aggregation-induced emissive ligands, including a 2nd-generation macrocycle that emits pure white light.

08 February 2018 | doi: 10.1038/s41467-018-02959-w
Optical materials  Self-assembly  Chemical synthesis 

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer OPEN
Alison P. Klein, Brian M. Wolpin, Harvey A. Risch, Rachael Z. Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J. Childs, Jason W. Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A. Arslan, Ana Babic, William R. Bamlet, Laura Beane-Freeman, Sonja I. Berndt, Amanda Blackford et al.

Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer.

08 February 2018 | doi: 10.1038/s41467-018-02942-5
Cancer epidemiology  Pancreatic cancer 

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase OPEN
Praveena S. Thiagarajan, Maksim Sinyuk, Soumya M. Turaga, Erin E. Mulkearns-Hubert, James S. Hale, Vinay Rao, Abeba Demelash, Caner Saygin, Arnab China, Tyler J. Alban, Masahiro Hitomi, Luke A. Torre-Healy, Alvaro G. Alvarado, Awad Jarrar, Andrew Wiechert, Valery Adorno-Cruz, Paul L. Fox, Benjamin C. Calhoun, Jun-Lin Guan, Huiping Liu et al.

Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG.

08 February 2018 | doi: 10.1038/s41467-018-02938-1
Cancer stem cells  Self-renewal 

Efficient green light-emitting diodes based on quasi-two-dimensional composition and phase engineered perovskite with surface passivation OPEN
Xiaolei Yang, Xingwang Zhang, Jinxiang Deng, Zema Chu, Qi Jiang, Junhua Meng, Pengyang Wang, Liuqi Zhang, Zhigang Yin & Jingbi You

Solution-processable halide perovskites have high luminous efficiency and excellent chemical tunability, making them ideal candidates for light-emitting diodes. Here Yang et al. achieve high external quantum efficiency of 14% in the devices by fine-tuning the phase and passivating the surface defects.

08 February 2018 | doi: 10.1038/s41467-018-02978-7
Materials for devices  Organic LEDs 

The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma OPEN
Irene Soncin, Jianpeng Sheng, Qi Chen, Shihui Foo, Kaibo Duan, Josephine Lum, Michael Poidinger, Francesca Zolezzi, Klaus Karjalainen & Christiane Ruedl

Tissue-resident F4/80hi macrophages can be found both in normal gut as well as in intestinal tumours. Here the authors show that in the colon these macrophages are CCR2-dependent, while in tumours they gain the ability to self-renew, relying on CSF1 and promoting cancer progression.

08 February 2018 | doi: 10.1038/s41467-018-02834-8
Monocytes and macrophages  Mucosal immunology  Myelopoiesis  Tumour immunology 

Optimal compressed representation of high throughput sequence data via light assembly OPEN
Antonio A. Ginart, Joseph Hui, Kaiyuan Zhu, Ibrahim Numanagić, Thomas A. Courtade, S. Cenk Sahinalp & David N. Tse

Increase in high throughput sequencing (HTS) data warrants compression methods to facilitate better storage and communication. Here, Ginart et al. introduce Assembltrie, a reference-free compression tool which is guaranteed to achieve optimality for error-free reads.

08 February 2018 | doi: 10.1038/s41467-017-02480-6
Computational biology and bioinformatics  Computer science 

Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer OPEN
Rengyun Liu, Tao Zhang, Guangwu Zhu & Mingzhao Xing

The mechanism of tumor progression robustly promoted by co-existing BRAF V600E and TERT promoter mutations is not known. Here, the authors show a mechanism of mutant TERT activation by BRAF V600E and MAPK pathways in which FOS, as a transcription factor of the GABPB promoter, functionally links the two oncogenes.

08 February 2018 | doi: 10.1038/s41467-018-03033-1
Cancer genetics  Oncogenes  Thyroid cancer 

High-throughput immune repertoire analysis with IGoR OPEN
Quentin Marcou, Thierry Mora & Aleksandra M. Walczak

B and T cell receptor diversity can be studied by high-throughput immune receptor sequencing. Here, the authors develop a software tool, IGoR, that calculates the likelihoods of potential V(D)J recombination and somatic hypermutation scenarios from raw immune sequence reads.

08 February 2018 | doi: 10.1038/s41467-018-02832-w
Computational biology and bioinformatics  Data processing  Immunogenetics  Statistical methods 

Boosting lithium storage in covalent organic framework via activation of 14-electron redox chemistry OPEN
Zhendong Lei, Qinsi Yang, Yi Xu, Siyu Guo, Weiwei Sun, Hao Liu, Li-Ping Lv, Yong Zhang & Yong Wang

Conjugated polymeric molecules are promising electrode materials for batteries. Here the authors show a two-dimensional few-layered covalent organic framework that delivers a large reversible capacity of more than 1500 mAh g−1 with the storage mechanism governed by 14-electron redox chemistry.

08 February 2018 | doi: 10.1038/s41467-018-02889-7

Extreme rejuvenation and softening in a bulk metallic glass OPEN
J. Pan, Y. X. Wang, Q. Guo, D. Zhang, A. L. Greer & Y. Li

Deforming metallic glasses can rejuvenate them to higher energy states, but only in the shear bands where deformation is usually concentrated. Here, the authors use a notched setup to suppress shear banding and promote significant bulk softening of a zirconium-based metallic glass.

08 February 2018 | doi: 10.1038/s41467-018-02943-4
Glasses  Mechanical properties  Metals and alloys 

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity OPEN
Will J. R. Stone, Joseph J. Campo, André Lin Ouédraogo, Lisette Meerstein-Kessel, Isabelle Morlais, Dari Da, Anna Cohuet, Sandrine Nsango, Colin J. Sutherland, Marga van de Vegte-Bolmer, Rianne Siebelink-Stoter, Geert-Jan van Gemert, Wouter Graumans, Kjerstin Lanke, Adam D. Shandling, Jozelyn V. Pablo, Andy A. Teng, Sophie Jones, Roos M. de Jong, Amanda Fabra-García et al.

Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity.

08 February 2018 | doi: 10.1038/s41467-017-02646-2
Antibodies  Biomarkers  Parasite host response 

Evolution and stabilization of subnanometric metal species in confined space by in situ TEM OPEN
Lichen Liu, Dmitri N. Zakharov, Raul Arenal, Patricia Concepcion, Eric A. Stach & Avelino Corma

Understanding the behavior and structural transformation of metal species under reaction conditions is instrumental for developing more efficient and stable catalysts. Here, the authors reveal the evolution and stabilization of subnanometric Pt species confined in MCM-22 zeolite using in situ transmission electron microscopy.

08 February 2018 | doi: 10.1038/s41467-018-03012-6
Catalyst synthesis  Heterogeneous catalysis  Reaction kinetics and dynamics 

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α OPEN
Qirui Wang, Zhenqiang He, Menggui Huang, Tianrun Liu, Yanling Wang, Haineng Xu, Hao Duan, Peihong Ma, Lin Zhang, Scott S. Zamvil, Juan Hidalgo, Zhenfeng Zhang, Donald M. O’Rourke, Nadia Dahmane, Steven Brem, Yonggao Mou, Yanqing Gong & Yi Fan

Macrophages in the tumour microenvironment (TME) acquire tumour-promoting functions upon M2 polarization. Here the authors show, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-6 improves survival.

08 February 2018 | doi: 10.1038/s41467-018-03050-0
Cancer microenvironment  CNS cancer 

Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance OPEN
Hai Wang, Zan Gao, Xuanyou Liu, Pranay Agarwal, Shuting Zhao, Daniel W. Conroy, Guang Ji, Jianhua Yu, Christopher P. Jaroniec, Zhenguo Liu, Xiongbin Lu, Xiaodong Li & Xiaoming He

Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer.

08 February 2018 | doi: 10.1038/s41467-018-02915-8
Biomedical engineering  Cancer therapeutic resistance  Drug delivery 

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α OPEN
Emilia Mira, Lorena Carmona-Rodríguez, Beatriz Pérez-Villamil, Josefina Casas, María Jesús Fernández-Aceñero, Diego Martínez-Rey, Paula Martín-González, Ignacio Heras-Murillo, Mateo Paz-Cabezas, Manuel Tardáguila, Tim D. Oury, Silvia Martín-Puig, Rosa Ana Lacalle, Gemma Fabriás, Eduardo Díaz-Rubio & Santos Mañes

Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.

08 February 2018 | doi: 10.1038/s41467-018-03079-1
Adherens junctions  Cancer microenvironment  Transcriptional regulatory elements  Tumour angiogenesis 

Influences of organic carbon speciation on hyporheic corridor biogeochemistry and microbial ecology OPEN
James C. Stegen, Tim Johnson, James K. Fredrickson, Michael J. Wilkins, Allan E. Konopka, William C. Nelson, Evan V. Arntzen, William B. Chrisler, Rosalie K. Chu, Sarah J. Fansler, Emily B. Graham, David W. Kennedy, Charles T. Resch, Malak Tfaily & John Zachara

The mechanisms responsible for stimulating biogeochemical activity in the hyporheic corridor (HC) are poorly understood. Here, the authors find that previously unrecognized thermodynamic mechanisms regulated by groundwater-river water mixing may strongly influence HC biogeochemical and microbial dynamics.

08 February 2018 | doi: 10.1038/s41467-018-02922-9
Carbon cycle  Geochemistry  Hydrology  Microbial ecology 

Transformable masks for colloidal nanosynthesis OPEN
Zhenxing Wang, Bowen He, Gefei Xu, Guojing Wang, Jiayi Wang, Yuhua Feng, Dongmeng Su, Bo Chen, Hai Li, Zhonghua Wu, Hua Zhang, Lu Shao & Hongyu Chen

The synthesis of patchy colloids is limited by poor control over the location and shape of ligand domains. Here, the authors use adaptable polymer masks to protect select areas of the particle during functionalization, allowing them to create patchy colloids with unconventional surface morphologies.

08 February 2018 | doi: 10.1038/s41467-018-02958-x
Nanoparticles  Synthesis and processing 

Ultrafast ion sieving using nanoporous polymeric membranes OPEN
Pengfei Wang, Mao Wang, Feng Liu, Siyuan Ding, Xue Wang, Guanghua Du, Jie Liu, Pavel Apel, Patrick Kluth, Christina Trautmann & Yugang Wang

Nanoporous membranes show great potential for ionic separations, but the typical trade-off between permeability and selectivity hinders their applicability. Here the authors fabricate nanoporous polymeric membranes with a high density of 0.5 nm pores and demonstrate their exceptional performance for ion sieving.

08 February 2018 | doi: 10.1038/s41467-018-02941-6
Fluidics  Materials chemistry  Nanopores 

Genetic control of meristem arrest and life span in Arabidopsis by a FRUITFULL-APETALA2 pathway OPEN
Vicente Balanzà, Irene Martínez-Fernández, Shusei Sato, Martin F. Yanofsky, Kerstin Kaufmann, Gerco C. Angenent, Marian Bemer & Cristina Ferrándiz

The lifespan of monocarpic plants is determined by coordinated arrest of shoot meristems. Here the authors show that this process is promoted by the FRUITFULL transcription factor which negatively regulates expression of the meristem maintenance factor WUSCHEL in an AP2-dependent manner.

08 February 2018 | doi: 10.1038/s41467-018-03067-5
Plant development 

Stimuli-responsive hydroxyapatite liquid crystal with macroscopically controllable ordering and magneto-optical functions OPEN
Masanari Nakayama, Satoshi Kajiyama, Akihito Kumamoto, Tatsuya Nishimura, Yuichi Ikuhara, Masafumi Yamato & Takashi Kato

Liquid crystals comprising inorganic species are far less common than their organic-based counterparts. Here, the authors report a magneto-optically responsive liquid crystal based on nanorods of the biomineral hydroxyapatite, representing a new type of biologically-based, dynamic inorganic material.

08 February 2018 | doi: 10.1038/s41467-018-02932-7
Biomineralization  Liquid crystals  Self-assembly 

Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin OPEN

Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from distinct keratinocyte differentiation stages.

08 February 2018 | doi: 10.1038/s41467-018-03025-1
DNA methylation  Squamous cell carcinoma 

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation OPEN
Ming Zhao, Yixin Tan, Qiao Peng, Cancan Huang, Yu Guo, Gongping Liang, Bochen Zhu, Yi Huang, Aiyun Liu, Zijun Wang, Mengying Li, Xiaofei Gao, Ruifang Wu, Haijing Wu, Hai Long & Qianjin Lu

Th17 cells are a common pathogenic effector cell in autoimmune inflammatory diseases. Here the authors show that the transcription factor RFX1 limits Th17 differentiation and is protective against the pathogenesis of Th17-driven autoimmune diseases.

08 February 2018 | doi: 10.1038/s41467-018-02890-0
Autoimmunity  Rheumatic diseases  T-helper 17 cells 

Site-specific phosphorylation of TRANSPARENT TESTA GLABRA1 mediates carbon partitioning in Arabidopsis seeds OPEN
Chengxiang Li, Bin Zhang, Bin Chen, Lianghui Ji & Hao Yu

Seed development relies upon carbon supplied by the parent plant. Here the authors propose that in Arabidopsis, phosphorylation of TTG1 by SHAGGY-like kinases 11/12 acts to regulate carbon flow between fatty acid synthesis in the embryo and mucilage and flavonoid production in the seed coat.

08 February 2018 | doi: 10.1038/s41467-018-03013-5
Plant development 

A quantum optical study of thresholdless lasing features in high-β nitride nanobeam cavities OPEN
Stefan T. Jagsch, Noelia Vico Triviño, Frederik Lohof, Gordon Callsen, Stefan Kalinowski, Ian M. Rousseau, Roy Barzel, Jean-François Carlin, Frank Jahnke, Raphaël Butté, Christopher Gies, Axel Hoffmann, Nicolas Grandjean & Stephan Reitzenstein

Here the authors present temperature dependent studies of GaN nanobeam lasers grown on a silicon substrate and demonstrate high-βlasing at room temperature. Comprehensive optical and quantum-optical characterization, complemented by microscopic modeling, of the nanolasers allow identification of lasing behavior.

08 February 2018 | doi: 10.1038/s41467-018-02999-2
Lasers, LEDs and light sources  Nanocavities  Nanophotonics and plasmonics 

No tension between assembly models of super massive black hole binaries and pulsar observations OPEN
Hannah Middleton, Siyuan Chen, Walter Del Pozzo, Alberto Sesana & Alberto Vecchio

Pulsar timing arrays enable the search for the isotropic gravitational-wave (GW) background originating from super massive black hole binary populations, but impose a stringent upper limit on the GW characteristic amplitude. Here, the authors use Bayesian hierarchical modelling applied to a range of astrophysical scenarios to revisit the implications of this upper limit.

08 February 2018 | doi: 10.1038/s41467-018-02916-7
Astronomy and astrophysics  Cosmology  Galaxies and clusters 

LARP7 family proteins have conserved function in telomerase assembly OPEN
Laura C. Collopy, Tracy L. Ware, Tomas Goncalves, Sunnvør í Kongsstovu, Qian Yang, Hanna Amelina, Corinne Pinder, Ala Alenazi, Vera Moiseeva, Siân R. Pearson, Christine A. Armstrong & Kazunori Tomita

The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation.

08 February 2018 | doi: 10.1038/s41467-017-02296-4
Non-coding RNAs  RNA  RNA-binding proteins  Telomeres 
Nature Communications
JOBS of the week
Deputy Principal (Research and Enterprise)
St. George's University of London
A New Opportunity for Early Career Researchers
CIFAR Canadian Institute for Advanced Research
Director of the NIH BRAIN Initiative
National Institues of Health (NIH) National Institue of Neurological Disorders and Stroke (NINDS)
Independent Junior Research Group Leader
University of Würzburg / Helmholtz Institute for RNA-Based Infection Research
Scientist Position (f / m)
Universitatsklinikum Munster
Research Associate
The University of Manchester
Biomedical IT manager
Université Libre de Bruxelles (ULB)
Account Manager
Springer Nature
Cancer Editor
The Rockefeller University Press
NSRRC Director
National Synchrotron Radiation Research Center (NSRRC)
More Science jobs from
Nature Communications
Conference on Global Climate (CGC 2018)
Guilin, China
More science events from
  Latest Addendum    
Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification OPEN
Jennifer S. Fang, Brian G. Coon, Noelle Gillis, Zehua Chen, Jingyao Qiu, Thomas W. Chittenden, Janis M. Burt, Martin A. Schwartz & Karen K. Hirschi
14 February 2018 | doi: 10.1038/s41467-018-03076-4
Angiogenesis  Differentiation 
  Latest Author Corrections    
Author Correction: Uncovering active precursors in colloidal quantum dot synthesis OPEN
Leah C. Frenette & Todd D. Krauss
09 February 2018 | doi: 10.1038/s41467-018-02946-1
Materials chemistry  Nanoparticle synthesis  Quantum dots 

Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia OPEN
Xi Jiang , Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, Liting Cheng, Zhixiang Zuo, William Seibel, Chunjiang He, Yixuan Tang, Jennifer R. Skibbe, Mark Wunderlich, William C. Reinhold, Lei Dong, Chao Shen, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, Hengyou Weng et al.
09 February 2018 | doi: 10.1038/s41467-018-02947-0
Acute myeloid leukaemia  Drug development  Target validation 

Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice OPEN
Barbara Juarez , Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edwards, Amanda Roberts, Georgia E. Hodes, Yongke Lu et al.
08 February 2018 | doi: 10.1038/s41467-018-02921-w
Addiction  Intrinsic excitability  Neural circuits 
  Latest Publisher Corrections    
Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway OPEN
Elisa Benedetti , Maja Pučić-Baković, Toma Keser, Annika Wahl, Antti Hassinen, Jeong-Yeh Yang, Lin Liu, Irena Trbojević-Akmačić, Genadij Razdorov, Jerko Štambuk, Lucija Klarić, Ivo Ugrina, Maurice H. J. Selman, Manfred Wuhrer, Igor Rudan, Ozren Polasek, Caroline Hayward, Harald Grallert, Konstantin Strauch, Annette Peters et al.
13 February 2018 | doi: 10.1038/s41467-017-02379-2

Publisher Correction: Maturation of the gut microbiome and risk of asthma in childhood OPEN
Jakob Stokholm, Martin J. Blaser, Jonathan Thorsen, Morten A. Rasmussen, Johannes Waage, Rebecca K. Vinding, Ann-Marie M. Schoos, Asja Kunøe, Nadia R. Fink, Bo L. Chawes, Klaus Bønnelykke, Asker D. Brejnrod, Martin S. Mortensen, Waleed Abu Al-Soud, Søren J. Sørensen & Hans Bisgaard
13 February 2018 | doi: 10.1038/s41467-018-03150-x
Inflammatory diseases  Microbiome  Paediatric research 

Publisher Correction: Sumatran tiger survival threatened by deforestation despite increasing densities in parks OPEN
Matthew Scott Luskin, Wido Rizki Albert & Mathias W. Tobler
12 February 2018 | doi: 10.1038/s41467-018-03055-9
Biogeography  Conservation biology  Population dynamics 

Publisher Correction: Mapping microscale wetting variations on biological and synthetic water-repellent surfaces OPEN
Ville Liimatainen, Maja Vuckovac, Ville Jokinen, Veikko Sariola, Matti J. Hokkanen, Quan Zhou & Robin H. A. Ras
09 February 2018 | doi: 10.1038/s41467-018-03042-0
Bioinspired materials  Characterization and analytical techniques  Imaging  Scanning probe microscopy 

Publisher Correction: Development of a genetically encodable FRET system using fluorescent RNA aptamers OPEN
Mette D. E. Jepsen, Steffen M. Sparvath, Thorbjørn B. Nielsen, Ane H. Langvad, Guido Grossi, Kurt V. Gothelf & Ebbe S. Andersen
09 February 2018 | doi: 10.1038/s41467-018-03075-5
Biosensors  Nanostructures  RNA nanotechnology 

Publisher Correction: Role of outer surface probes for regulating ion gating of nanochannels OPEN
Xinchun Li, Tianyou Zhai, Pengcheng Gao, Hongli Cheng, Ruizuo Hou, Xiaoding Lou & Fan Xia
08 February 2018 | doi: 10.1038/s41467-018-03030-4
Biomimetics  Nanobiotechnology 

Publisher Correction: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway OPEN
Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T. H. Yeh, Bart O. Williams, Ling Zheng & Tao Yang
08 February 2018 | doi: 10.1038/s41467-018-03177-0
Bone development  Cartilage development  Mesenchymal stem cells  Senescence 

Publisher Correction: A Co3O4-CDots-C3N4 three component electrocatalyst design concept for efficient and tunable CO2 reduction to syngas OPEN
Sijie Guo, Siqi Zhao, Xiuqin Wu, Hao Li, Yunjie Zhou, Cheng Zhu, Nianjun Yang, Xin Jiang, Jin Gao, Liang Bai, Yang Liu, Yeshayahu Lifshitz, Shuit-Tong Lee & Zhenhui Kang
08 February 2018 | doi: 10.1038/s41467-018-02848-2
Carbon capture and storage  Electrocatalysis  Environmental, health and safety issues  Renewable energy 

Nature Special

2017: The Year in Science

The people, events and discoveries that made a difference 

Access Now 

Advertisement webcasts

Springer Nature presents a custom webcast on: Multiplex Assays of the Anti-Apoptotic BCL-2 Family

Date: Wednesday, February 28, 2018 

Register for the webcast and live Q&A session 

Sponsored by: Merck

Advertisement webcasts

Springer Nature presents a custom webcast on: Precision over Bulk: Opportunities for Single-Cell DNA Analysis in Oncology

Date: Tuesday, March 13, 2018 

Register for the webcast and live Q&A session 

Sponsored by: Mission Bio 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on For event advertising opportunities across the Nature Publishing Group portfolio please contact
 More Nature Events
You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your account
(You will need to log in to be recognised as a registrant)

For further technical assistance, please contact our registration department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS.

© 2018 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Springer Nature

No comments: