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| | 14 February 2018 | | | | Advertisement | Nature Reviews Drug Discovery present this Poster which provides an overview of the different ways to design and produce CAR T cells and the journey that has driven these CAR T cells to FDA approval in 2017. Produced with support from: | | | | | | Advertisement | | nature.com webcasts Springer Nature presents a custom webcast on: Sequencing Structural Variants for Disease Gene Discovery and Population Genetics Date: Thursday, March 8, 2018 Register for FREE Sponsored by: PacBio | | | | | | | Nature Communications - fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | Latest Articles | View all Articles | | | Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion OPEN | | Antonia Marazioti, Ioannis Lilis, Malamati Vreka, Hara Apostolopoulou, Argyro Kalogeropoulou, Ioanna Giopanou, Georgia A. Giotopoulou, Anthi C. Krontira, Marianthi Iliopoulou, Nikolaos I. Kanellakis, Theodora Agalioti, Anastasios D. Giannou, Celestial Jones-Paris, Yoichiro Iwakura, Dimitrios Kardamakis, Timothy S. Blackwell, Stavros Taraviras, Magda Spella & Georgios T. Stathopoulos | | | Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse models. | | 14 February 2018 | doi: 10.1038/s41467-018-03051-z | | Cancer microenvironment Respiratory tract diseases Tumour immunology | 3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection OPEN | | A. M. Ortega-Prieto, J. K. Skelton, S. N. Wai, E. Large, M. Lussignol, G. Vizcay-Barrena, D. Hughes, R. A. Fleck, M. Thursz, M. T. Catanese & M. Dorner | | | Long-term in vitro models for hepatitis B virus (HBV) infection are important to understand this infection, but are lacking. Here the authors develop a microfluidic primary human hepatocyte organoid culture system that can be maintained over 40 days and recapitulates all of the steps of the HBV life cycle. | | 14 February 2018 | doi: 10.1038/s41467-018-02969-8 | | Hepatitis B virus Tissue engineering | ACKR2 in hematopoietic precursors as a checkpoint of neutrophil release and anti-metastatic activity OPEN | | Matteo Massara, Ornella Bonavita, Benedetta Savino, Nicoletta Caronni, Valeria Mollica Poeta, Marina Sironi, Elisa Setten, Camilla Recordati, Laura Crisafulli, Francesca Ficara, Alberto Mantovani, Massimo Locati & Raffaella Bonecchi | | | The atypical chemokine receptor ACKR2 regulates immune responses. Here the authors confirm that ACKR2 depletion promotes primary tumor growth but show it has an anti-metastatic effect in mouse models of breast cancer by affecting myeloid differentiation and unleashing the anti-metastatic activity of neutrophils. | | 14 February 2018 | doi: 10.1038/s41467-018-03080-8 | | Chemokines Metastasis Tumour immunology | Ultra-high thermal effusivity materials for resonant ambient thermal energy harvesting OPEN | | Anton L. Cottrill, Albert Tianxiang Liu, Yuichiro Kunai, Volodymyr B. Koman, Amir Kaplan, Sayalee G. Mahajan, Pingwei Liu, Aubrey R. Toland & Michael S. Strano | | | Ambient environmental thermal fluctuations offer an abundant yet difficult to harvest renewable energy source, when compared to static thermal gradients. Here, by tuning the thermal effusivity of composite phase change materials, the authors are able to harvest energy from diurnal ambient temperature changes. | | 14 February 2018 | doi: 10.1038/s41467-018-03029-x | | Energy harvesting Graphene | Probing electrochemical reactions in organic cathode materials via in operando infrared spectroscopy OPEN | | Alen Vizintin, Jan Bitenc, Anja Kopač Lautar, Klemen Pirnat, Jože Grdadolnik, Jernej Stare, Anna Randon-Vitanova & Robert Dominko | | | Metal-organic batteries are gaining traction as versatile, low-cost, and sustainable devices, although there are still few ways to probe internal behavior during use. Here, the authors explore organic-molecule structural changes within several battery systems by in operando infrared spectroscopy. | | 14 February 2018 | doi: 10.1038/s41467-018-03114-1 | | Batteries Characterization and analytical techniques | Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor OPEN | | David L. Gray, John A. Allen, Scot Mente, Rebecca E. O’Connor, George J. DeMarco, Ivan Efremov, Patrick Tierney, Dmitri Volfson, Jennifer Davoren, Edward Guilmette, Michelle Salafia, Rouba Kozak & Michael D. Ehlers | | | Dopamine receptor agonists are used for the treatment of various psychiatric diseases. Here, the authors screen approximately three million compounds and identify a novel class of D1R agonists that do not have a catechol scaffold and possess promising pharmacokinetic properties. | | 14 February 2018 | doi: 10.1038/s41467-017-02776-7 | | Computational chemistry Molecular neuroscience Parkinson's disease Receptor pharmacology | Anti-fouling graphene-based membranes for effective water desalination OPEN | | Dong Han Seo, Shafique Pineda, Yun Chul Woo, Ming Xie, Adrian T. Murdock, Elisa Y. M. Ang, Yalong Jiao, Myoung Jun Park, Sung Il Lim, Malcolm Lawn, Fabricio Frizera Borghi, Zhao Jun Han, Stephen Gray, Graeme Millar, Aijun Du, Ho Kyong Shon, Teng Yong Ng & Kostya (Ken) Ostrikov | | | Intrinsic limitations of nanoporous graphene limit its applications in water treatment. Here the authors produce post-treatment-free, low-cost graphene-based membranes from renewable biomass and demonstrate their high water permeance and antifouling properties using real seawater. | | 14 February 2018 | doi: 10.1038/s41467-018-02871-3 | | Chemical engineering Graphene Mechanical and structural properties and devices Pollution remediation | Current-induced magnetization switching in atom-thick tungsten engineered perpendicular magnetic tunnel junctions with large tunnel magnetoresistance OPEN | | Mengxing Wang, Wenlong Cai, Kaihua Cao, Jiaqi Zhou, Jerzy Wrona, Shouzhong Peng, Huaiwen Yang, Jiaqi Wei, Wang Kang, Youguang Zhang, Jürgen Langer, Berthold Ocker, Albert Fert & Weisheng Zhao | | | Perpendicular magnetic tunnel junctions with large tunnel magnetoresistance and low junction resistance are promising for the magnetic random access memories. Here the authors achieve the spin-transfer-torque switching in perpendicular magnetic tunnel junctions with 249% tunnel magnetoresistance and low resistance-area product. | | 14 February 2018 | doi: 10.1038/s41467-018-03140-z | | Electronic and spintronic devices Electronic devices | Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone OPEN | | Xiao-Feng Li, Hao-Long Dong, Hong-Jiang Wang, Xing-Yao Huang, Ye-Feng Qiu, Xue Ji, Qing Ye, Chunfeng Li, Yang Liu, Yong-Qiang Deng, Tao Jiang, Gong Cheng, Fu-Chun Zhang, Andrew D. Davidson, Ya-Jun Song, Pei-Yong Shi & Cheng-Feng Qin | | | Given the recent Zika virus (ZIKV) epidemic, development of an effective vaccine is of high importance. Here, the authors use a licensed live-attenuated flavivirus vaccine backbone to develop a ZIKV vaccine and determine immunogenicity, safety and protection profiles in different animal models. | | 14 February 2018 | doi: 10.1038/s41467-018-02975-w | | Infection Live attenuated vaccines Virology | Ecology and genomics of an important crop wild relative as a prelude to agricultural innovation OPEN | | Eric J.B. von Wettberg, Peter L. Chang, Fatma Başdemir, Noelia Carrasquila-Garcia, Lijalem Balcha Korbu, Susan M. Moenga, Gashaw Bedada, Alex Greenlon, Ken S. Moriuchi, Vasantika Singh, Matilde A. Cordeiro, Nina V. Noujdina, Kassaye Negash Dinegde, Syed Gul Abbas Shah Sani, Tsegaye Getahun, Lisa Vance, Emily Bergmann, Donna Lindsay, Bullo Erena Mamo, Emily J. Warschefsky et al. | | | Domestication reduces genetic diversity and constrains crop improvement. Here the authors identify factors that shaped species diversity in the wild progenitors of chickpea, and produce wild introgression populations that increase diversity for breeding by ~100-fold, including traits of agronomic relevance. | | 13 February 2018 | doi: 10.1038/s41467-018-02867-z | | Plant breeding Plant domestication Plant ecology Plant genetics | The effects of death and post-mortem cold ischemia on human tissue transcriptomes OPEN | | Pedro G. Ferreira, Manuel Muñoz-Aguirre, Ferran Reverter, Caio P. Sá Godinho, Abel Sousa, Alicia Amadoz, Reza Sodaei, Marta R. Hidalgo, Dmitri Pervouchine, Jose Carbonell-Caballero, Ramil Nurtdinov, Alessandra Breschi, Raziel Amador, Patrícia Oliveira, Cankut Çubuk, João Curado, François Aguet, Carla Oliveira, Joaquin Dopazo, Michael Sammeth et al. | | | RNA levels in post-mortem tissue can differ greatly from those before death. Studying the effect of post-mortem interval on the transcriptome in 36 human tissues, Ferreira et al. find that the response to death is largely tissue-specific and develop a model to predict time since death based on RNA data. | | 13 February 2018 | doi: 10.1038/s41467-017-02772-x | | Data mining Gene expression Genomics Machine learning | A CNOT gate between multiphoton qubits encoded in two cavities OPEN | | S. Rosenblum, Y. Y. Gao, P. Reinhold, C. Wang, C. J. Axline, L. Frunzio, S. M. Girvin, Liang Jiang, M. Mirrahimi, M. H. Devoret & R. J. Schoelkopf | | | Quantum computing platforms allowing quantum error correction usually rely on complex redundant encoding within multiple two-level systems. Here, instead, the authors realize a CNOT gate between two qubits encoded in the multiphoton states of two microwave cavities nonlinearly coupled by a transmon. | | 13 February 2018 | doi: 10.1038/s41467-018-03059-5 | | Quantum information Qubits Single photons and quantum effects Superconducting devices | Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging OPEN | | Gabriel Oh, Sasha Ebrahimi, Matthew Carlucci, Aiping Zhang, Akhil Nair, Daniel E. Groot, Viviane Labrie, Peixin Jia, Edward S. Oh, Richie H. Jeremian, Miki Susic, Tenjin C. Shrestha, Martin R. Ralph, Juozas Gordevičius, Karolis Koncevičius & Art Petronis | | | While epigenetic factors have been implicated in the circadian rhythm, the detection of circadian cytosine modifications has remained elusive. Here the authors identify a large number of epigenetically variable cytosines that show circadian oscillations in their modification status in mice. | | 13 February 2018 | doi: 10.1038/s41467-018-03073-7 | | Ageing Circadian rhythms DNA methylation | A defensin-like protein drives cadmium efflux and allocation in rice OPEN | | Jin-Song Luo, Jing Huang, Da-Li Zeng, Jia-Shi Peng, Guo-Bin Zhang, Hai-Ling Ma, Yuan Guan, Hong-Ying Yi, Yan-Lei Fu, Bin Han, Hong-Xuan Lin, Qian Qian & Ji-Ming Gong | | | Crops that allocate heavy metals to leaves rather than grains could allow phytoremediation of polluted soil while producing food that is safe to eat. Here, the authors show that a defensin-like protein promotes cadmium secretion from rice cells and allocation to leaves without causing accumulation in grain. | | 13 February 2018 | doi: 10.1038/s41467-018-03088-0 | | Natural variation in plants Plant biotechnology Plant genetics | Detecting RNA base methylations in single cells by in situ hybridization OPEN | | Rohan T. Ranasinghe, Martin R. Challand, Kristina A. Ganzinger, Benjamin W. Lewis, Charlotte Softley, Wolfgang H. Schmied, Mathew H. Horrocks, Nadia Shivji, Jason W. Chin, James Spencer & David Klenerman | | | Methylated RNA bases influence many life processes, but current detection methods lack the ability to detect individual methylations in single cells. Here, the authors use fluorescence hybridization probes sensitive to methylation to detect specific epitranscriptomic modifications at the single-cell level. | | 13 February 2018 | doi: 10.1038/s41467-017-02714-7 | | Bacteriology DNA probes Fluorescence imaging RNA modification | 21st Century drought-related fires counteract the decline of Amazon deforestation carbon emissions OPEN | | Luiz E. O. C. Aragão, Liana O. Anderson, Marisa G. Fonseca, Thais M. Rosan, Laura B. Vedovato, Fabien H. Wagner, Camila V. J. Silva, Celso H. L. Silva Junior, Egidio Arai, Ana P. Aguiar, Jos Barlow, Erika Berenguer, Merritt N. Deeter, Lucas G. Domingues, Luciana Gatti, Manuel Gloor, Yadvinder Malhi, Jose A. Marengo, John B. Miller, Oliver L. Phillips et al. | | | Deforestation carbon emissions from the Brazilian Amazon have declined steeply, but how much drought-induced forest fire emissions add to this process is still unclear. Here the authors show that gross emissions from forest fires are more than half as great as those from deforestation during drought years. | | 13 February 2018 | doi: 10.1038/s41467-017-02771-y | | Carbon cycle Climate-change mitigation Environmental impact | Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models OPEN | | Upneet K. Sokhi, Mark P. Liber, Laura Frye, Sungho Park, Kyuho Kang, Tania Pannellini, Baohong Zhao, Rada Norinsky, Lionel B. Ivashkiv & Shiaoching Gong | | | The human TNFAIP3 gene, which encodes for A20, is associated with autoimmune diseases. Here, the authors use BAC transgenics combined with CRISPR- and recombineering-mediated genome editing to dissect in vivo and in primary immune cells, the role of enhancers regulating TNFAIP3. | | 13 February 2018 | doi: 10.1038/s41467-018-03081-7 | | Autoimmunity Gene regulation Genetic engineering Lupus nephritis | Toward a consistent modeling framework to assess multi-sectoral climate impacts OPEN | | Erwan Monier, Sergey Paltsev, Andrei Sokolov, Y.-H. Henry Chen, Xiang Gao, Qudsia Ejaz, Evan Couzo, C. Adam Schlosser, Stephanie Dutkiewicz, Charles Fant, Jeffery Scott, David Kicklighter, Jennifer Morris, Henry Jacoby, Ronald Prinn & Martin Haigh | | | Climate impact assessments usually rely on modeling approaches that are either comprehensive but inflexible and inefficient, or lacking sufficient detail. Here the authors describe a framework to assess multi-sectoral climate impacts and show its capability and timely responsiveness to new policies. | | 13 February 2018 | doi: 10.1038/s41467-018-02984-9 | | Climate and Earth system modelling Climate-change impacts Environmental impact | A secondary RET mutation in the activation loop conferring resistance to vandetanib OPEN | | Takashi Nakaoku, Takashi Kohno, Mitsugu Araki, Seiji Niho, Rakhee Chauhan, Phillip P. Knowles, Katsuya Tsuchihara, Shingo Matsumoto, Yoko Shimada, Sachiyo Mimaki, Genichiro Ishii, Hitoshi Ichikawa, Satoru Nagatoishi, Kouhei Tsumoto, Yasushi Okuno, Kiyotaka Yoh, Neil Q. McDonald & Koichi Goto | | | Mechanisms of acquired resistance to RET tyrosine kinase inhibitors in lung cancers are largely unknown. Here, the authors report in a lung adenocarcinoma patient harboring a CCDC6-RET mutation in the RET kinase (S904F) that results in resistance to the kinase inhibitor vandetanib by increasing the ATP affinity and autophosphorylation activity of RET kinase. | | 12 February 2018 | doi: 10.1038/s41467-018-02994-7 | | Cancer genomics Non-small-cell lung cancer | A human endothelial cell-based recycling assay for screening of FcRn targeted molecules OPEN | | Algirdas Grevys, Jeannette Nilsen, Kine M. K. Sand, Muluneh B. Daba, Inger Øynebråten, Malin Bern, Martin B. McAdam, Stian Foss, Tilman Schlothauer, Terje E. Michaelsen, Gregory J. Christianson, Derry C. Roopenian, Richard S. Blumberg, Inger Sandlie & Jan Terje Andersen | | | The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without chemical labelling and prior to animal testing. | | 12 February 2018 | doi: 10.1038/s41467-018-03061-x | | Drug screening High-throughput screening | Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood OPEN | | Xunmei Yuan, Kazutaka Tsujimoto, Koshi Hashimoto, Kenichi Kawahori, Nozomi Hanzawa, Miho Hamaguchi, Takami Seki, Makiko Nawa, Tatsuya Ehara, Yohei Kitamura, Izuho Hatada, Morichika Konishi, Nobuyuki Itoh, Yoshimi Nakagawa, Hitoshi Shimano, Takako Takai-Igarashi, Yasutomi Kamei & Yoshihiro Ogawa | | | FGF21 exerts beneficial metabolic effects on multiple tissues. Here the authors show that the Fgf21 gene is demethylated during the postnatal suckling period, creating an epigenetic memory that determines the responsiveness of the Fgf21 gene to inducers such as PPARα activators or fasting in adulthood. | | 12 February 2018 | doi: 10.1038/s41467-018-03038-w | | DNA methylation Epigenetic memory Obesity | Resonance Raman signature of intertube excitons in compositionally-defined carbon nanotube bundles OPEN | | Jeffrey R. Simpson, Oleksiy Roslyak, Juan G. Duque, Erik H. Hároz, Jared J. Crochet, Hagen Telg, Andrei Piryatinski, Angela R. Hight Walker & Stephen K. Doorn | | | Bundles of single-wall carbon nanotubes with enriched chirality can be used as model systems for exploring exciton physics in low-dimensional nanostructures. Here, the authors use resonant Raman spectroscopy to probe intertube interactions in bundles of (6,5)-enriched carbon nanotubes, and observe a Fano resonance arising from coupling between intertube and intratube excitons. | | 12 February 2018 | doi: 10.1038/s41467-018-03057-7 | | Carbon nanotubes and fullerenes Nanoscale materials Nanoscience and technology Raman spectroscopy | CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity OPEN | | Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog & Rugang Zhang | | | CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor suppressor gene silencing. | | 12 February 2018 | doi: 10.1038/s41467-018-03031-3 | | Gene silencing Ovarian cancer | Glacigenic sedimentation pulses triggered post-glacial gas hydrate dissociation OPEN | | Jens Karstens, Haflidi Haflidason, Lukas W. M. Becker, Christian Berndt, Lars Rüpke, Sverre Planke, Volker Liebetrau, Mark Schmidt & Jürgen Mienert | | | Triggers of gas hydrate instability along continental margins remain debated. Here, via numerical simulations, the authors show that pulses in sedimentation, rather than bottom water temperature or sea level change, likely triggered gas hydrate dissociation offshore Norway at the end of the last glaciation. | | 12 February 2018 | doi: 10.1038/s41467-018-03043-z | | Geophysics Sedimentology | Absence of warmth permits epigenetic memory of winter in Arabidopsis OPEN | | Jo Hepworth, Rea L. Antoniou-Kourounioti, Rebecca H. Bloomer, Catja Selga, Kristina Berggren, Deborah Cox, Barley R. Collier Harris, Judith A. Irwin, Svante Holm, Torbjörn Säll, Martin Howard & Caroline Dean | | | Plants use multiple cues to monitor seasonal temperatures. Here, the authors show that Arabidopsis requires not only prolonged cold, but the absence of temperature spikes above 15 °C to epigenetically silence FLC during winter. | | 12 February 2018 | doi: 10.1038/s41467-018-03065-7 | | Applied mathematics Gene silencing Plant development Vernalization | Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses OPEN | | Courtney S. Malo, Matthew A. Huggins, Emma N. Goddery, Heather M. A. Tolcher, Danielle N. Renner, Fang Jin, Michael J. Hansen, Larry R. Pease, Kevin D. Pavelko & Aaron J. Johnson | | | Dendritic cell antigen presentation is central to CD8+ T cell responses, but surprisingly little is known about the requirement for this functionality in the central nervous system. Here, the authors use three different models of neuroinflammation to show the importance of these cells in the CNS and in response to cerebral malaria, picornavirus infection and experimental glioma. | | 12 February 2018 | doi: 10.1038/s41467-018-03037-x | | Antigen-presenting cells MHC class I Neuroimmunology | Minimising efficiency roll-off in high-brightness perovskite light-emitting diodes OPEN | | Wei Zou, Renzhi Li, Shuting Zhang, Yunlong Liu, Nana Wang, Yu Cao, Yanfeng Miao, Mengmeng Xu, Qiang Guo, Dawei Di, Li Zhang, Chang Yi, Feng Gao, Richard H. Friend, Jianpu Wang & Wei Huang | | | Large drop in efficiency at high brightness has been holding back the development of various light-emitting diodes including halide perovskite. Here Zou et al. achieve high quantum efficiency of 10% under a high current density of 500 mA cm−2 in perovskite-based diodes by reducing luminescence quenching. | | 09 February 2018 | doi: 10.1038/s41467-018-03049-7 | | Lasers, LEDs and light sources Optical materials and structures | Laboratory evidence of dynamo amplification of magnetic fields in a turbulent plasma OPEN | | P. Tzeferacos, A. Rigby, A. F. A. Bott, A. R. Bell, R. Bingham, A. Casner, F. Cattaneo, E. M. Churazov, J. Emig, F. Fiuza, C. B. Forest, J. Foster, C. Graziani, J. Katz, M. Koenig, C.-K. Li, J. Meinecke, R. Petrasso, H.-S. Park, B. A. Remington et al. | | | Exploring astrophysical turbulent effects in laboratory plasma is challenging due to high threshold values of relevant parameters, such as the magnetic Reynolds number. Here the authors demonstrate the turbulent dynamo effect at large magnetic Reynolds numbers in laser-generated magnetized plasma. | | 09 February 2018 | doi: 10.1038/s41467-018-02953-2 | | Interstellar medium Laser-produced plasmas | Deficiency of a triterpene pathway results in humidity-sensitive genic male sterility in rice OPEN | | Zheyong Xue, Xia Xu, Yuan Zhou, Xiaoning Wang, Yingchun Zhang, Dan Liu, Binbin Zhao, Lixin Duan & Xiaoquan Qi | | | In flowering plants, the pollen coat surrounds the male germ cells and protects against dehydration, damage and pathogen attack. Here, the authors show that a deficiency in terpenoid synthesis results in rice pollen over-dehydration and leads to a humidity-sensitive conditional male sterile phenotype. | | 09 February 2018 | doi: 10.1038/s41467-018-03048-8 | | Plant breeding Plant regeneration Pollen | Leucine-rich repeat receptor-like gene screen reveals that Nicotiana RXEG1 regulates glycoside hydrolase 12 MAMP detection OPEN | | Yan Wang, Yuanpeng Xu, Yujing Sun, Huibin Wang, Jiaming Qi, Bowen Wan, Wenwu Ye, Yachun Lin, Yuanyuan Shao, Suomeng Dong, Brett M. Tyler & Yuanchao Wang | | | The role of most plant leucine-rich repeat (LRR) receptors in innate immunity is unknown. Here, the authors develop virus-based constructs to silence LRR receptor-like genes in the Nicotiana benthamiana genome and identify Response to XEG1 that specifically recognizes the glycoside hydrolase 12 protein XEG1. | | 09 February 2018 | doi: 10.1038/s41467-018-03010-8 | | High-throughput screening Pattern recognition receptors in plants Plant signalling | Genome-wide tracking of dCas9-methyltransferase footprints OPEN | | Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller & Alexander Meissner | | | Catalytically inactive Cas9 fused to a methyltransferase has emerged as a promising epigenome modifying tool. Here the authors generate a methylation depleted but maintenance competent mouse ES cell line and find ubiquitous off-target activity. | | 09 February 2018 | doi: 10.1038/s41467-017-02708-5 | | CRISPR-Cas systems Epigenomics | Molecular-channel driven actuator with considerations for multiple configurations and color switching OPEN | | Jiuke Mu, Gang Wang, Hongping Yan, Huayu Li, Xuemin Wang, Enlai Gao, Chengyi Hou, Anh Thi Cam Pham, Lianjun Wu, Qinghong Zhang, Yaogang Li, Zhiping Xu, Yang Guo, Elsa Reichmanis, Hongzhi Wang & Meifang Zhu | | | Intrinsic deformation with fast response in commercially available materials that can safely contact skin continues to be a challenge for artificial actuating materials. Here the authors incorporate nanoscale molecular channels within perfluorosulfonic acid ionomer for self-adaptive and ambient-driven actuation. | | 09 February 2018 | doi: 10.1038/s41467-018-03032-2 | | Actuators Mechanical properties Synthesis and processing | Self-assembly of emissive supramolecular rosettes with increasing complexity using multitopic terpyridine ligands OPEN | | Guang-Qiang Yin, Heng Wang, Xu-Qing Wang, Bo Song, Li-Jun Chen, Lei Wang, Xin-Qi Hao, Hai-Bo Yang & Xiaopeng Li | | | Metal coordination of multitopic ligands is a powerful approach to building complex, functional architectures. Here, the authors construct three generations of fluorescent supramolecular rosettes by coordination of aggregation-induced emissive ligands, including a 2nd-generation macrocycle that emits pure white light. | | 08 February 2018 | doi: 10.1038/s41467-018-02959-w | | Optical materials Self-assembly Chemical synthesis | Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer OPEN | | Alison P. Klein, Brian M. Wolpin, Harvey A. Risch, Rachael Z. Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J. Childs, Jason W. Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A. Arslan, Ana Babic, William R. Bamlet, Laura Beane-Freeman, Sonja I. Berndt, Amanda Blackford et al. | | | Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer. | | 08 February 2018 | doi: 10.1038/s41467-018-02942-5 | | Cancer epidemiology Pancreatic cancer | Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase OPEN | | Praveena S. Thiagarajan, Maksim Sinyuk, Soumya M. Turaga, Erin E. Mulkearns-Hubert, James S. Hale, Vinay Rao, Abeba Demelash, Caner Saygin, Arnab China, Tyler J. Alban, Masahiro Hitomi, Luke A. Torre-Healy, Alvaro G. Alvarado, Awad Jarrar, Andrew Wiechert, Valery Adorno-Cruz, Paul L. Fox, Benjamin C. Calhoun, Jun-Lin Guan, Huiping Liu et al. | | | Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG. | | 08 February 2018 | doi: 10.1038/s41467-018-02938-1 | | Cancer stem cells Self-renewal | The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma OPEN | | Irene Soncin, Jianpeng Sheng, Qi Chen, Shihui Foo, Kaibo Duan, Josephine Lum, Michael Poidinger, Francesca Zolezzi, Klaus Karjalainen & Christiane Ruedl | | | Tissue-resident F4/80hi macrophages can be found both in normal gut as well as in intestinal tumours. Here the authors show that in the colon these macrophages are CCR2-dependent, while in tumours they gain the ability to self-renew, relying on CSF1 and promoting cancer progression. | | 08 February 2018 | doi: 10.1038/s41467-018-02834-8 | | Monocytes and macrophages Mucosal immunology Myelopoiesis Tumour immunology | Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity OPEN | | Will J. R. Stone, Joseph J. Campo, André Lin Ouédraogo, Lisette Meerstein-Kessel, Isabelle Morlais, Dari Da, Anna Cohuet, Sandrine Nsango, Colin J. Sutherland, Marga van de Vegte-Bolmer, Rianne Siebelink-Stoter, Geert-Jan van Gemert, Wouter Graumans, Kjerstin Lanke, Adam D. Shandling, Jozelyn V. Pablo, Andy A. Teng, Sophie Jones, Roos M. de Jong, Amanda Fabra-García et al. | | | Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel antibody correlates of transmission-reducing activity. | | 08 February 2018 | doi: 10.1038/s41467-017-02646-2 | | Antibodies Biomarkers Parasite host response | Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α OPEN | | Qirui Wang, Zhenqiang He, Menggui Huang, Tianrun Liu, Yanling Wang, Haineng Xu, Hao Duan, Peihong Ma, Lin Zhang, Scott S. Zamvil, Juan Hidalgo, Zhenfeng Zhang, Donald M. O’Rourke, Nadia Dahmane, Steven Brem, Yonggao Mou, Yanqing Gong & Yi Fan | | | Macrophages in the tumour microenvironment (TME) acquire tumour-promoting functions upon M2 polarization. Here the authors show, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-6 improves survival. | | 08 February 2018 | doi: 10.1038/s41467-018-03050-0 | | Cancer microenvironment CNS cancer | Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance OPEN | | Hai Wang, Zan Gao, Xuanyou Liu, Pranay Agarwal, Shuting Zhao, Daniel W. Conroy, Guang Ji, Jianhua Yu, Christopher P. Jaroniec, Zhenguo Liu, Xiongbin Lu, Xiaodong Li & Xiaoming He | | | Multidrug resistance is a major challenge in cancer therapy. Here, the authors develop a mitochondria-targeting nanoparticle system that inhibits adenosine triphosphate transporter activity via reactive oxygen species generation and can thus be used to target multidrug-resistant cancer. | | 08 February 2018 | doi: 10.1038/s41467-018-02915-8 | | Biomedical engineering Cancer therapeutic resistance Drug delivery | SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α OPEN | | Emilia Mira, Lorena Carmona-Rodríguez, Beatriz Pérez-Villamil, Josefina Casas, María Jesús Fernández-Aceñero, Diego Martínez-Rey, Paula Martín-González, Ignacio Heras-Murillo, Mateo Paz-Cabezas, Manuel Tardáguila, Tim D. Oury, Silvia Martín-Puig, Rosa Ana Lacalle, Gemma Fabriás, Eduardo Díaz-Rubio & Santos Mañes | | | Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway. | | 08 February 2018 | doi: 10.1038/s41467-018-03079-1 | | Adherens junctions Cancer microenvironment Transcriptional regulatory elements Tumour angiogenesis | Influences of organic carbon speciation on hyporheic corridor biogeochemistry and microbial ecology OPEN | | James C. Stegen, Tim Johnson, James K. Fredrickson, Michael J. Wilkins, Allan E. Konopka, William C. Nelson, Evan V. Arntzen, William B. Chrisler, Rosalie K. Chu, Sarah J. Fansler, Emily B. Graham, David W. Kennedy, Charles T. Resch, Malak Tfaily & John Zachara | | | The mechanisms responsible for stimulating biogeochemical activity in the hyporheic corridor (HC) are poorly understood. Here, the authors find that previously unrecognized thermodynamic mechanisms regulated by groundwater-river water mixing may strongly influence HC biogeochemical and microbial dynamics. | | 08 February 2018 | doi: 10.1038/s41467-018-02922-9 | | Carbon cycle Geochemistry Hydrology Microbial ecology | Transformable masks for colloidal nanosynthesis OPEN | | Zhenxing Wang, Bowen He, Gefei Xu, Guojing Wang, Jiayi Wang, Yuhua Feng, Dongmeng Su, Bo Chen, Hai Li, Zhonghua Wu, Hua Zhang, Lu Shao & Hongyu Chen | | | The synthesis of patchy colloids is limited by poor control over the location and shape of ligand domains. Here, the authors use adaptable polymer masks to protect select areas of the particle during functionalization, allowing them to create patchy colloids with unconventional surface morphologies. | | 08 February 2018 | doi: 10.1038/s41467-018-02958-x | | Nanoparticles Synthesis and processing | Ultrafast ion sieving using nanoporous polymeric membranes OPEN | | Pengfei Wang, Mao Wang, Feng Liu, Siyuan Ding, Xue Wang, Guanghua Du, Jie Liu, Pavel Apel, Patrick Kluth, Christina Trautmann & Yugang Wang | | | Nanoporous membranes show great potential for ionic separations, but the typical trade-off between permeability and selectivity hinders their applicability. Here the authors fabricate nanoporous polymeric membranes with a high density of 0.5 nm pores and demonstrate their exceptional performance for ion sieving. | | 08 February 2018 | doi: 10.1038/s41467-018-02941-6 | | Fluidics Materials chemistry Nanopores | IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation OPEN | | Ming Zhao, Yixin Tan, Qiao Peng, Cancan Huang, Yu Guo, Gongping Liang, Bochen Zhu, Yi Huang, Aiyun Liu, Zijun Wang, Mengying Li, Xiaofei Gao, Ruifang Wu, Haijing Wu, Hai Long & Qianjin Lu | | | Th17 cells are a common pathogenic effector cell in autoimmune inflammatory diseases. Here the authors show that the transcription factor RFX1 limits Th17 differentiation and is protective against the pathogenesis of Th17-driven autoimmune diseases. | | 08 February 2018 | doi: 10.1038/s41467-018-02890-0 | | Autoimmunity Rheumatic diseases T-helper 17 cells | A quantum optical study of thresholdless lasing features in high-β nitride nanobeam cavities OPEN | | Stefan T. Jagsch, Noelia Vico Triviño, Frederik Lohof, Gordon Callsen, Stefan Kalinowski, Ian M. Rousseau, Roy Barzel, Jean-François Carlin, Frank Jahnke, Raphaël Butté, Christopher Gies, Axel Hoffmann, Nicolas Grandjean & Stephan Reitzenstein | | | Here the authors present temperature dependent studies of GaN nanobeam lasers grown on a silicon substrate and demonstrate high-βlasing at room temperature. Comprehensive optical and quantum-optical characterization, complemented by microscopic modeling, of the nanolasers allow identification of lasing behavior. | | 08 February 2018 | doi: 10.1038/s41467-018-02999-2 | | Lasers, LEDs and light sources Nanocavities Nanophotonics and plasmonics | LARP7 family proteins have conserved function in telomerase assembly OPEN | | Laura C. Collopy, Tracy L. Ware, Tomas Goncalves, Sunnvør í Kongsstovu, Qian Yang, Hanna Amelina, Corinne Pinder, Ala Alenazi, Vera Moiseeva, Siân R. Pearson, Christine A. Armstrong & Kazunori Tomita | | | The telomerase holoenzyme is minimally composed of the reverse transcriptase and the RNA template. Here the authors identify Lar7 as a member of the full complex that helps to stabilise it and protect telomerase RNA from degradation. | | 08 February 2018 | doi: 10.1038/s41467-017-02296-4 | | Non-coding RNAs RNA RNA-binding proteins Telomeres | | | | | | | | Latest Addendum | | | | | | | | Latest Author Corrections | | | | Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia OPEN | | Xi Jiang , Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, Liting Cheng, Zhixiang Zuo, William Seibel, Chunjiang He, Yixuan Tang, Jennifer R. Skibbe, Mark Wunderlich, William C. Reinhold, Lei Dong, Chao Shen, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, Hengyou Weng et al. | | 09 February 2018 | doi: 10.1038/s41467-018-02947-0 | | Acute myeloid leukaemia Drug development Target validation | Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice OPEN | | Barbara Juarez , Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edwards, Amanda Roberts, Georgia E. Hodes, Yongke Lu et al. | | 08 February 2018 | doi: 10.1038/s41467-018-02921-w | | Addiction Intrinsic excitability Neural circuits | | | | | Latest Publisher Corrections | | | | Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway OPEN | | Elisa Benedetti , Maja Pučić-Baković, Toma Keser, Annika Wahl, Antti Hassinen, Jeong-Yeh Yang, Lin Liu, Irena Trbojević-Akmačić, Genadij Razdorov, Jerko Štambuk, Lucija Klarić, Ivo Ugrina, Maurice H. J. Selman, Manfred Wuhrer, Igor Rudan, Ozren Polasek, Caroline Hayward, Harald Grallert, Konstantin Strauch, Annette Peters et al. | | 13 February 2018 | doi: 10.1038/s41467-017-02379-2 | | Publisher Correction: Maturation of the gut microbiome and risk of asthma in childhood OPEN | | Jakob Stokholm, Martin J. Blaser, Jonathan Thorsen, Morten A. Rasmussen, Johannes Waage, Rebecca K. Vinding, Ann-Marie M. Schoos, Asja Kunøe, Nadia R. Fink, Bo L. Chawes, Klaus Bønnelykke, Asker D. Brejnrod, Martin S. Mortensen, Waleed Abu Al-Soud, Søren J. Sørensen & Hans Bisgaard | | 13 February 2018 | doi: 10.1038/s41467-018-03150-x | | Inflammatory diseases Microbiome Paediatric research | Publisher Correction: A Co3O4-CDots-C3N4 three component electrocatalyst design concept for efficient and tunable CO2 reduction to syngas OPEN | | Sijie Guo, Siqi Zhao, Xiuqin Wu, Hao Li, Yunjie Zhou, Cheng Zhu, Nianjun Yang, Xin Jiang, Jin Gao, Liang Bai, Yang Liu, Yeshayahu Lifshitz, Shuit-Tong Lee & Zhenhui Kang | | 08 February 2018 | doi: 10.1038/s41467-018-02848-2 | | Carbon capture and storage Electrocatalysis Environmental, health and safety issues Renewable energy | | | | | Advertisement | | Nature Special 2017: The Year in Science The people, events and discoveries that made a difference Access Now | | | | | | Advertisement | | | | | Advertisement | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. 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