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TABLE OF CONTENTS
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| March 2018 Volume 20, Issue 3 |
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 |  Editorial
Research Highlights
News & Views
Review Articles
Articles
Resources
Technical Reports
Amendments & Corrections
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Nikon's all-new A1R HD confocal features a High Definition 1K resonant scanner, which delivers high resolution images at ultra-high speed. The new scanner also provides 4x the field of view at the same resolution usually generated by a normal 512x512 scanner.
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| A new open access, multi- and interdisciplinary journal dedicated to publishing the highest quality papers on aging and age-related diseases, the journal is now open for submissions. |  | | |
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Editorial | |
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| Highlighting advances in autophagy p223
doi:10.1038/s41556-018-0061-z |
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Research Highlights | |
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| A STING in ER-phagy p224
Christina Kary
doi:10.1038/s41556-018-0057-8 |
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| Splitting up for mitophagy p224
Christina Kary
doi:10.1038/s41556-018-0058-7 |
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| Liver autophagy's sweet side p224
Christina Kary
doi:10.1038/s41556-018-0059-6 |
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| Acetylation rules VPS34 p224
Christina Kary
doi:10.1038/s41556-018-0060-0 |
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News & Views | |
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Review Articles | |
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| Cargo recognition and degradation by selective autophagy pp233 - 242
Damián Gatica, Vikramjit Lahiri & Daniel J. Klionsky
doi:10.1038/s41556-018-0037-z
In this Review Article, Klionsky and co-authors discuss selective autophagy pathways that degrade unwanted cytosolic components and organelles, and how these pathways require ligand receptors and scaffold proteins for cargo specificity. |
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| The autophagic network and cancer pp243 - 251
Marissa D. Rybstein, José Manuel Bravo-San Pedro, Guido Kroemer & Lorenzo Galluzzi
doi:10.1038/s41556-018-0042-2
Autophagy and cancer: In this Review, Galluzzi and colleagues discuss the cellular and molecular mechanisms whereby autophagy functions in multiple aspects of malignant disease, including cancer initiation, progression and responses to therapy. |
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The ASCB Public Engagement Grants will provide funding, mentoring, and project assessment to ASCB members interested in public outreach in scientific areas. Funded by the Simons Foundation's Science Sandbox.
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Articles | |
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| Local control of intracellular microtubule dynamics by EB1 photodissociation pp252 - 261
Jeffrey van Haren, Rabab A. Charafeddine, Andreas Ettinger, Hui Wang, Klaus M. Hahn et al.
doi:10.1038/s41556-017-0028-5
van Haren et al. develop a tool to rapidly dissociate proteins from the growing end of microtubules through photo-induced disassembly of end-binding protein 1 (EB1), and find that this reduces microtubule growth and alters cell migration. |
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| Nanopillar force measurements reveal actin-cap-mediated YAP mechanotransduction pp262 - 271
Jau-Ye Shiu, Lina Aires, Zhe Lin & Viola Vogel
doi:10.1038/s41556-017-0030-y
Using nanopillars with increased spatial resolution, Shiu et al. identify high perinuclear forces that originate from contractile apical actin filaments that span across the nucleus and are dependent on lamin A and the LINC complex. |
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| RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells pp272 - 284
Mark A. Hawk, Cassandra L. Gorsuch, Patrick Fagan, Chan Lee, Sung Eun Kim et al.
doi:10.1038/s41556-018-0034-2
Hawk et al. show that RIPK1 activation during extracellular matrix detachment induces mitophagy through mitochondrial phosphatase PGAM5 to increase reactive oxygen species and non-apoptotic cell death, and that antagonizing RIPK1/PGAM5 enhances tumour formation. |
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| Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation pp285 - 295
Huilin Huang, Hengyou Weng, Wenju Sun, Xi Qin, Hailing Shi et al.
doi:10.1038/s41556-018-0045-z
Huang et al. identify IGF2BPs as an additional class of N6-methyladenosine (m6A) reader proteins. They find that IGF2BPs selectively bind to m6A-containing mRNAs and promote their stability. |
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| Tumour spheres with inverted polarity drive the formation of peritoneal metastases in patients with hypermethylated colorectal carcinomas pp296 - 306
Olivier Zajac, Joel Raingeaud, Fotine Libanje, Celine Lefebvre, Dora Sabino et al.
doi:10.1038/s41556-017-0027-6
Zajac et al. show that in colorectal cancer, decreased TGF-ß signalling promotes apical actomyosin contractility and collective apical budding of invading tumour spheres with inverted polarity that drive metastatic spread. |
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| Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons pp307 - 319
Arnau Hervera, Francesco De Virgiliis, Ilaria Palmisano, Luming Zhou, Elena Tantardini et al.
doi:10.1038/s41556-018-0039-x
Hervera et al. show that extracellular vesicles containing NOX2 complexes are released from macrophages and incorporated into injured axons, leading to axonal regeneration through PI3K–p-Akt signalling. |
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| The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168 pp320 - 331
Xiaoduo Xie, Hongli Hu, Xinyuan Tong, Long Li, Xiangyuan Liu et al.
doi:10.1038/s41556-017-0033-8
Xie and colleagues find that activated mTORC1 growth signalling impairs DNA repair through S6K-mediated phosphorylation and inhibition of the RNF168 ligase. |
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| Communications Biology: now publishing content Communications Biology is a new open access journal publishing high-quality primary research articles, reviews and commentary which represent significant advances and new insights in the field of biology. Visit the website to access all the latest content as it becomes available. |  | | |
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Resources | |
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| Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation pp332 - 343
Haiying Zhang, Daniela Freitas, Han Sang Kim, Kristina Fabijanic, Zhong Li et al.
doi:10.1038/s41556-018-0040-4
Lyden and colleagues use asymmetric flow field-flow fractionation to classify nanoparticles derived from cell lines and human samples, including previously uncharacterized large, Exo-L and small, Exo-S, exosome subsets. |
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Technical Reports | |
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| Non-invasive perturbations of intracellular flow reveal physical principles of cell organization pp344 - 351
Matthäus Mittasch, Peter Gross, Michael Nestler, Anatol W. Fritsch, Christiane Iserman et al.
doi:10.1038/s41556-017-0032-9
Mittasch et al. show that controlling cytoplasmic flow via focused-light-induced cytoplasmic streaming (FLUCS), a non-invasive technique, can be used to invert asymmetric cell division in Caenorhabditis elegans zygotes. |
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| Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism pp352 - 360
Arnaud Ahier, Chuan-Yang Dai, Andrea Tweedie, Ayenachew Bezawork-Geleta, Ina Kirmes et al.
doi:10.1038/s41556-017-0023-x
Ahier et al. describe a method to isolate intact mitochondria from specific cells in Caenorhabditis elegans and show that the germline is more prone to propagating deleterious mitochondrial genomes than somatic lineages. |
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Amendments & Corrections | |
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| Publisher Correction: Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism p361
Arnaud Ahier, Chuan-Yang Dai, Andrea Tweedie, Ayenachew Bezawork-Geleta, Ina Kirmes et al.
doi:10.1038/s41556-018-0055-x |
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