 |  |  |  |  | Table of ContentsNews & Views Articles |  Volume 37, Number 2 |
News & Views  | Surprising new findings show that a well‐studied histone methyltransferase can modify mycobacterial cell surface proteins in the cytosol of infected macrophages. Claude Gutierrez, Yves‐Marie Boudehen and Olivier Neyrolles Published online 04.01.2018 |
 | A new study shows that intestinal tissue damage can induce fetal‐like stem cells through ECM remodeling and increasing FAK/Src signaling. Rui Chen and Kun‐Liang Guan Published online 27.12.2017 |
Articles  | Environmental stimuli and voluntary exercise, known to ameliorate dementia rescue adult neurogenesis in transgenic mouse models by activating phagocytic microglia to reduce amyloid‐β seeding. Stephanie Ziegler‐Waldkirch, Paolo d′Errico, Jonas‐Frederic Sauer, Daniel Erny, Shakuntala Savanthrapadian, Desirée Loreth, Natalie Katzmarski, Thomas Blank, Marlene Bartos, Marco Prinz and Melanie Meyer‐Luehmann |
 | While best known for its role in establishing repressive chromatin, histone methyltransferase SUV39H1 helps prevent mycobacterial infection by targeting a mycobacterial protein in the cytoplasm. Imtiyaz Yaseen, Mitali Choudhury, Manjula Sritharan and Sanjeev Khosla Published online 23.11.2017 |
 | A combination of targeted chromosome losses and breakage–fusion–bridge (BFB)–mediated genomic instability, in the context of tetraploidy, is found to be a potent driver of tumorigenesis in a mouse allograft model. Rozario Thomas, Daniel Henry Marks, Yvette Chin and Robert Benezra Published online 01.12.2017 |
 | The C2A and C2C domains of extended synaptotagmin 1 (E‐Syt1) regulate both its lipid transport and membrane tethering activity in a Ca2+‐dependent manner. Xin Bian, Yasunori Saheki and Pietro De Camilli Published online 08.12.2017 |
 | Restriction of RAB7 GTPase activity and localization to specific endomembrane domains depends on the RAB7 effector retromer, thus equipping it with a function in autophagosome formation that is independent of its canonical endocytic recycling role. Ana Jimenez‐Orgaz, Arunas Kvainickas, Heike Nägele, Justin Denner, Stefan Eimer, Jörn Dengjel and Florian Steinberg |
 | The plant ortholog of the cullin‐ring ubiquitin ligase regulator glomulin inhibits SCFTIR1 in vitro but stabilizes CUL1 in vivo, thereby decreasing the levels of Aux/IAA proteins and modulating the auxin hormone response. Rammyani Bagchi, Charles W Melnyk, Gideon Christ, Martin Winkler, Kerstin Kirchsteiner, Mohammad Salehin, Julia Mergner, Michael Niemeyer, Claus Schwechheimer, Luz Irina A Calderón Villalobos and Mark Estelle Published online 12.12.2017 |
 | Cryo‐EM analysis of a Cep3‐Skp1‐Ctf13 core complex provides insight into the key DNA binding factor at the budding yeast point centromere, as well as into Skp1/F‐box protein interactions. Vera Leber, Andrea Nans and Martin R Singleton |
 | A dynamic chaperone complex of Hsc70, Hsp110 and J‐protein dissolves pathological Huntingtin fibrils in vitro and prevents aggregate formation in Huntington's disease patient‐derived neurons. Annika Scior, Alexander Buntru, Kristin Arnsburg, Anne Ast, Manuel Iburg, Katrin Juenemann, Maria Lucia Pigazzini, Barbara Mlody, Dmytro Puchkov, Josef Priller, Erich E Wanker, Alessandro Prigione and Janine Kirstein Published online 06.12.2017 |
 | Phosphorylation by Src‐family kinases allows acute negative regulation of synaptic vesicle priming at the post‐docking step of SNARE complex templating and membrane fusion. Marieke Meijer, Bernhard Dörr, Hanna CA Lammertse, Chrysanthi Blithikioti, Jan RT van Weering, Ruud FG Toonen, Thomas H Söllner and Matthijs Verhage |
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