Nature Reviews Genetics Contents February 2018 Volume 19 Number 2 pp 63-124

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TABLE OF CONTENTS
February 2018 Volume 19 Number 2
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews   Also this month Article series: Study designs Epigenetics Applications of next-generation sequencing  Featured article: Am I ready for CRISPR? A user's guide to genetic screens John G. Doench
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RESEARCH HIGHLIGHTS   Top Translational genetics: CRISPR therapies — making the grade not the cut p63 | doi:10.1038/nrg.2017.112 A new study uses CRISPR-based transcriptional modulation as an in vivo therapeutic in various mouse models of human diseases. PDF Splicing: Going in circles p64 | doi:10.1038/nrg.2017.111 The production of circular RNAs is enhanced when canonical splicing of parent genes or transcription termination at upstream genes is reduced. PDF Technique: Single-cell transcriptomes in space p64 | doi:10.1038/nrg.2017.114 PDF Technique: A miniature living recording device p65 | doi:10.1038/nrg.2017.110 PDF   Genetics JOBS of the week Postdoctoral Fellowship � Molecular Genetics Texas Scottish Rite Hospital for Children Postdoctoral Research Scientist Columbia University Medical Center - Department of Obstetrics and Gynecology High throughput approaches to decipher the role of Human Endothelial Cells in Chronic Disease University of Hull Open Rank, Term Tenure Track The University of Texas MD Anderson Cancer Center Postdoctoral Fellow Icahn School of Medicine at Mount Sinai More Science jobs from Genetics EVENT Advanced Bacterial Genetics 05.06.18 New York, US More science events from
REVIEWS		Top
Article series: Study designs Am I ready for CRISPR? A user's guide to genetic screens John G. Doench p67 | doi:10.1038/nrg.2017.97 The rapid development of CRISPR-based gene manipulation has enabled various approaches for high-throughput functional genomics. This Review guides users through the practicalities of CRISPR-based functional genomics screens, including study design options, best-practice approaches, pitfalls to avoid and data analysis strategies. Abstract | Full Text | PDF | Supplementary information
Article series: Epigenetics The DNA methyltransferase family: a versatile toolkit for epigenetic regulation Frank Lyko p81 | doi:10.1038/nrg.2017.80 The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes. Recent studies have increased our understanding of how DNMT activity is regulated and revealed that, in addition to establishing and maintaining DNA methylation patterns, DNMT enzymes function in transcriptional silencing, transcriptional activation and post-transcriptional regulation. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Cancer transcriptome profiling at the juncture of clinical translation Marcin Cieslik & Arul M. Chinnaiyan p93 | doi:10.1038/nrg.2017.96 Although cancer genome sequencing is becoming routine in cancer research, cancer transcriptome profiling through methods such as RNA sequencing (RNA-seq) provides information not only on mutations but also on their functional cellular consequences. This Review discusses how technical and analytical advances in cancer transcriptomics have provided various clinically valuable insights into gene expression signatures, driver gene prioritization, cancer microenvironments, immuno-oncology and prognostic biomarkers. Abstract | Full Text | PDF
Genetic architecture: the shape of the genetic contribution to human traits and disease Nicholas J. Timpson, Celia M. T. Greenwood, Nicole Soranzo, Daniel J. Lawson & J. Brent Richards p110 | doi:10.1038/nrg.2017.101 Genetic architecture describes the characteristics of genetic variation that are responsible for phenotypic variability. This Review discusses the types of genetic architecture that have been observed, how they can be measured and how genetic architecture informs the scientific and clinical goals of human genetics. Abstract | Full Text | PDF
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