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Do You Know What's in Your Cell Culture? There might be other things on your plate than expected. Unlock some secrets of small additional steps you can take to become an expert in cell handling mastering the daily challenge of contamination prevention. Eppendorf AG | | | |
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TABLE OF CONTENTS
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February 2018 Volume 20, Issue 2 |
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| Editorial News & Views Letters Articles Amendments & Corrections | |
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Stem cell flow cytometry training course (Mar 14-15, 2018) This 2-day hands-on training course at Miltenyi Biotec/Germany focuses on the basic principles of stem cell research. Combining lectures and practical lab sessions, a complete workflow covering flow cytometric analysis, cultivation and characterization methods will be introduced. | | | |
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Editorial | |
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Means and myths of mentoring p117 doi:10.1038/s41556-018-0041-3 |
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News & Views | |
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Letters | |
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Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation pp127 - 134 Ximena Ibarra-Soria, Wajid Jawaid, Blanca Pijuan-Sala, Vasileios Ladopoulos, Antonio Scialdone et al. doi:10.1038/s41556-017-0013-z Ibarra-Soria et al. study cellular diversity, transcriptional signatures, lineage specification and somitogenesis on a single-cell level in E8.25 mouse embryos, and reveal the regulation of blood progenitor formation by the leukotriene pathway. |
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Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy pp135 - 143 Heeseon An & J. Wade Harper doi:10.1038/s41556-017-0007-x An and Harper quantify ribophagy in mammalian cells and show that nutrient-deprivation-induced ribophagy is independent of the ATG8 conjugation system, whereas proteotoxic stress-induced ribophagy requires ATG5 and VPS34. |
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Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos pp144 - 151 Vasileios I. Floros, Angela Pyle, Sabine Dietmann, Wei Wei, Walfred W. C. Tang et al. doi:10.1038/s41556-017-0017-8 Floros et al. show that mtDNA copy number is reduced and non-synonymous mtDNA mutations are eliminated to prevent mtDNA mutation accumulation in germ cells during human primordial germ cell development. |
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Receive up to $35,000 to fund your science outreach project The ASCB Public Engagement Grants will provide funding, mentoring, and project assessment to ASCB members interested in public outreach in scientific areas. Funded by the Simons Foundation's Science Sandbox. Apply for a Grant | | | |
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Articles | |
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Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells pp152 - 161 Jun Chen, Na Xu, Chenhui Wang, Pin Huang, Huanwei Huang et al. doi:10.1038/s41556-017-0020-0 Chen et al. demonstrate that transient Scute activation induces asymmetric division in Drosophila intestinal stem cells, which generates enteroendocrine progenitor cells that divide once before differentiation to yield a pair of enteroendocrine cells. |
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EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation pp162 - 174 Joana Silva, Suvi Aivio, Philip A. Knobel, Laura J. Bailey, Andreu Casali et al. doi:10.1038/s41556-017-0016-9 By analysing the exonuclease EXD2, Silva et al. find that it localizes to mitochondria, and that its loss alters metabolism by affecting mitochondrial translation and causes developmental delay and lifespan extension in flies. |
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Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis pp175 - 185 Chien-Ting Wu, Hsin-Yi Chen & Tang K. Tang doi:10.1038/s41556-017-0018-7 Wu et al. show that myosin-Va is needed for the initiation of primary cilia formation by transporting preciliary vesicles to the distal appendages of the mother centriole in a manner dependent on both microtubules and centrosomal actin. |
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RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis pp186 - 197 Zhentao Yang, Yan Wang, Yingying Zhang, Xiadi He, Chuan-Qi Zhong et al. doi:10.1038/s41556-017-0022-y RIP3 regulates mitochondrial metabolism. Yang et al. show that RIP3 activates the pyruvate dehydrogenase complex to enhance aerobic respiration and increase mitochondrial ROS during necroptosis, and MLKL is required for RIP3 translocation to mitochondria. |
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The MTM1UBQLN2HSP complex mediates degradation of misfolded intermediate filaments in skeletal muscle pp198 - 210 Christos Gavriilidis, Leila Laredj, Romain Solinhac, Nadia Messaddeq, Julien Viaud et al. doi:10.1038/s41556-017-0024-9 Gavriilidis et al. show that MTM1, which is mutated in X-linked centronuclear myopathy, and UBQLN2 recognize misfolded desmin and vimentin and trigger their degradation to clear misfolded intermediated filaments prior to aggregate formation. |
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MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer pp211 - 221 Sylwia Gawrzak, Lorenzo Rinaldi, Sara Gregorio, Enrique J. Arenas, Fernando Salvador et al. doi:10.1038/s41556-017-0021-z Gawrzak et al. show that MSK1 regulates bone metastatic dormancy of ER+ breast cancer. MSK1 affects histone modifications at luminal transcription factor promoters to prevent cell differentiation and bone homing. |
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Amendments & Corrections | |
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Author Correction: TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi p222 doi:10.1038/s41556-017-0026-7 |
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