The EMBO Journal Table of Contents for 01 December 2017; Vol. 36, No. 23

01 December 2017 | Volume 36, Number 23 Submit Table of Contents News & Views Review Articles Volume 36, Number 23 News & Views Shoring up DNA methylation and H3K27me3 domain demarcation at developmental genes A specific isoform of de novo DNA methyltransferase DNMT3A acts on the “shores” of hypomethylated CpG islands at bivalent promoters. Richard R Meehan and Sari Pennings Published online 22.11.2017 Review Focus: Metabolism: MYC and tumor metabolism: chicken and egg This review summarises the reciprocal interplay between expression levels of oncogenic MYC and the metabolic programs active in cancer cells exposed to environmental changes. Francesca R Dejure and Martin Eilers Published online 10.11.2017 Articles Isoform‐specific localization of DNMT3A regulates DNA methylation fidelity at bivalent CpG islands Genome‐wide binding data for de novo DNA methyltransferase DNMT3A show the long isoform of the protein to target CpG island shores of Polycomb‐regulated promoters and regulate the turnover of DNA methylation. Massimiliano Manzo, Joël Wirz, Christina Ambrosi, Rodrigo Villaseñor, Bernd Roschitzki and Tuncay Baubec Published online 26.10.2017 KTN80 confers precision to microtubule severing by specific targeting of katanin complexes in plant cells Microtubule‐severing complex katanin is guided to crossover and branching nucleation sites by subunit p80, which in turn recruits the catalytic subunit p60. Chaofeng Wang, Weiwei Liu, Guangda Wang, Jun Li, Li Dong, Libo Han, Qi Wang, Juan Tian, Yanjun Yu, Caixia Gao and Zhaosheng Kong Published online 04.10.2017 Real‐time detection of condensin‐driven DNA compaction reveals a multistep binding mechanism Single‐molecule experiments suggest that condensin contacts DNA via electrostatic interactions before ATP hydrolysis, resulting in topological entrapment and compaction of DNA. Jorine M Eeftens, Shveta Bisht, Jacob Kerssemakers, Marc Kschonsak, Christian H Haering and Cees Dekker Published online 08.11.2017 Molecular basis for inner kinetochore configuration through RWD domain–peptide interactions Integrated molecular and structural characterization of the yeast COMA complex reveals the CENP‐Q homolog Okp1 as a central organizer of constitutive centromere‐associated network (CCAN) assembly. Florian Schmitzberger, Magdalena M Richter, Yuliya Gordiyenko, Carol V Robinson, Michał Dadlez and Stefan Westermann Published online 18.10.2017 The p53‐inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation Nutrient removal from cancer cells is counterbalanced through p53‐dependent induction of pro‐survival lncRNA TRINGS and suppression of cell death signalling. Muhammad Riaz Khan, Shaoxun Xiang, Zhiyin Song and Mian Wu Published online 18.10.2017 A TNF‐p100 pathway subverts noncanonical NF‐κB signaling in inflamed secondary lymphoid organs Depletion of homeostatic chemokines associated with microbial infection is also observed during non‐infectious and chronic inflammation, resulting in diminished lymphocyte trafficking. Tapas Mukherjee, Budhaditya Chatterjee, Atika Dhar, Sachendra S Bais, Meenakshi Chawla, Payel Roy, Anna George, Vineeta Bal, Satyajit Rath and Soumen Basak Published online 23.10.2017 Hierarchical protein targeting and secretion is controlled by an affinity switch in the type III secretion system of enteropathogenic Escherichia coli In vitro reconstitution shows that the Escherichia coli gatekeeper SepL and chaperone SepD prevent premature effector protein secretion by regulating their affinity to the export machinery. Athina G Portaliou, Konstantinos C Tsolis, Maria S Loos, Vassileia Balabanidou, Josep Rayo, Alexandra Tsirigotaki, Valerie F Crepin, Gad Frankel, Charalampos G Kalodimos, Spyridoula Karamanou and Anastassios Economou Published online 06.11.2017 Human THO–Sin3A interaction reveals new mechanisms to prevent R‐loops that cause genome instability Functional interplay of the THO mRNP biogenesis factor and the Sin3A deacetylase complex reveals a role for co‐transcriptional histone deacetylation in restraining accumulation of harmful DNA–RNA hybrids. Irene Salas‐Armenteros, Carmen Pérez‐Calero, Aleix Bayona‐Feliu, Emanuela Tumini, Rosa Luna and Andrés Aguilera Published online 26.10.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.