EMBO reports Table of Contents for December 2017; Vol. 18, No. 12

December 2017 | Volume 18, Number 12 Submit Table of Contents Obituary Opinion Correspondence Science & Society Review Scientific Reports Articles Corrigendum Volume 18, Number 12 Obituary Denise Barlow (1950–2017)—pioneer of genomic imprinting Anton Wutz Published online 21.11.2017 Opinion Conflicts of interest in scientific publishing Gold OA as a publishing model has created conflicts of interest for authors and journals that create a risk for research integrity. Alternative models of publishing and peer review could resolve some of these conflicts. Ignacio Amigo and Alberto Pascual‐García Published online 20.11.2017 Correspondence The Council of Europe and the prohibition on human germline genome editing Comment on “The Council of Europe should not reaffirm the ban on germline genome editing in humans” by Sykora & Caplan. Françoise Baylis and Lisa Ikemoto Published online 15.11.2017 Germline gene therapy is compatible with human dignity The response by the authors. Peter Sykora and Arthur Caplan Published online 15.11.2017 Science & Society Don't just dump your data and run: Authors should submit as much experimental information as possible when uploading sequence data The growing importance of nucleotide sequence databases for research and the need for reproducibility necessitates that scientists should provide as much as experimental detail as possible when submitting sequence data to electronic archives. Matheus Sanitá Lima and David Roy Smith Published online 27.10.2017 Why are NGOs sceptical of genome editing?: NGOs’ opposition to agricultural biotechnologies is rooted in scepticism about the framing of problems and solutions, rather than just emotion and dogma Environmental NGOs have various concerns about agricultural biotechnologies including gene editing. Accepting their skepticism of problems and solutions could help to build mutual understanding and find acceptable solutions to global food vulnerabilities. Richard Helliwell, Sarah Hartley, Warren Pearce and Liz O'Neill Published online 02.11.2017 We're on a road to nowhere: Culture and adaptation to the environment are driving human evolution, but the destination of this journey is unpredictable The invention of culture allowed mankind to create its own ecological niches. But does it mean that humans have stopped evolving biologically or are we still adapting to our artificial environment? Andrea Rinaldi Published online 21.11.2017 Advanced therapies push regulatory boundaries: Novel therapeutic approaches require more regulatory flexibility and transparency Novel therapies, such as gene or cell therapy, don not require radical changes of the regulatory framework for medicinal products. Yet, both new and old developments cannot be easily accommodated by existing regulations. Philip Hunter Published online 09.11.2017 Review Cell fate decisions: emerging roles for metabolic signals and cell morphology Cell fate decisions are mainly considered to be regulated via transcriptional programming, epigenetic modifications, and biochemical differentiation triggers. This review discusses how different cell biological cues acting upstream and downstream of developmental signaling pathways influence lineage determination. Sumitra Tatapudy, Francesca Aloisio, Diane Barber and Todd Nystul Published online 20.11.2017 Scientific Reports Intersectin‐s interaction with DENND2B facilitates recycling of epidermal growth factor receptor Whether EGFR is recycled or degraded is critical for growth signalling in cancer. The endocytic adaptor intersectin binds the Rab13 exchange factor DENND2B and drives unliganded EGFR into a recycling pathway, while EGF disrupts this interaction and targets EGFR for degradation. Maria S Ioannou, Gopinath Kulasekaran, Maryam Fotouhi, Justin J Morein, Chanshuai Han, Sarah Tse, Nadya Nossova, Tony Han, Erin Mannard and Peter S McPherson Published online 13.10.2017 JMJD5 cleaves monomethylated histone H3 N‐tail under DNA damaging stress The histone demethylase JMJD5 cleaves the histone H3 N‐tail between K9me1 and S10 under DNA damaging stress. Cleavage occurs at gene promoters bound and repressed by JMJD5 suggesting a role in gene expression regulation. Jing Shen, Xueping Xiang, Lihan Chen, Haiyi Wang, Li Wu, Yanyun Sun, Li Ma, Xiuting Gu, Hong Liu, Lishun Wang, Ying‐nian Yu, Jimin Shao, Chao Huang and Y Eugene Chin Published online 05.10.2017 Articles Mycobacteria exploit nitric oxide‐induced transformation of macrophages into permissive giant cells Immunity to mycobacteria triggers granulomas, involving multinucleated giant cells as a unique macrophage species. Dysregulation of the TLR‐induced antimicrobial molecule nitric oxide propagates their transformation by interfering with the DNA damage response. Kourosh Gharun, Julia Senges, Maximilian Seidl, Anne Lösslein, Julia Kolter, Florens Lohrmann, Manfred Fliegauf, Magdeldin Elgizouli, Martina Vavra, Kristina Schachtrup, Anna L Illert, Martine Gilleron, Carsten J Kirschning, Antigoni Triantafyllopoulou and Philipp Henneke Published online 02.11.2017 NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus‐induced apoptosis The MAVS signalosome mediates RIG‐I‐like receptor‐induced anti‐viral innate immune responses. NLRP11 inhibits MAVS‐dependent type I interferon signaling and virus‐induced apoptosis by disrupting the signalosome and promoting proteasomal degradation of TRAF6. Yunfei Qin, Zexiong Su, Yaoxing Wu, Chenglei Wu, Shouheng Jin, Weihong Xie, Wei Jiang, Rongbin Zhou and Jun Cui Published online 02.11.2017 Branched‐chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype Glioblastoma cells excrete branched‐chain ketoacids (BCKAs) through the monocarboxylate transporter MCT1. BCKAs are taken up by macrophages and alter their metabolism and phagocytic capacity, possibly enhancing immune suppression in glioblastoma. Lidia Santos Silva, Gernot Poschet, Yannic Nonnenmacher, Holger M Becker, Sean Sapcariu, Ann‐Christin Gaupel, Magdalena Schlotter, Yonghe Wu, Niclas Kneisel, Martina Seiffert, Rüdiger Hell, Karsten Hiller, Peter Lichter and Bernhard Radlwimmer Published online 24.10.2017 Antisense transcription represses Arabidopsis seed dormancy QTL DOG1 to regulate drought tolerance Antisense transcription from the same locus is required for DOG1 silencing in mature Arabidopsis plants under non‐stress conditions. Drought and ABA signalling alleviate asDOG1 expression, promoting DOG1 sense transcription and drought tolerance. Ruslan Yatusevich, Halina Fedak, Arkadiusz Ciesielski, Katarzyna Krzyczmonik, Anna Kulik, Grazyna Dobrowolska and Szymon Swiezewski Published online 13.10.2017 TORC1 and TORC2 converge to regulate the SAGA co‐activator in response to nutrient availability The Schizosaccharomyces pombe SAGA co‐activator regulates gene expression and cell fate decisions in response to nutrient availability. This study shows that TORC1 and TORC2 modulate the phosphorylation of the SAGA subunit Taf12, to control commitment to sexual differentiation upon starvation. Thomas Laboucarié, Dylane Detilleux, Ricard A Rodriguez‐Mias, Céline Faux, Yves Romeo, Mirita Franz‐Wachtel, Karsten Krug, Boris Maček, Judit Villén, Janni Petersen and Dominique Helmlinger Published online 27.10.2017 Corrigendum Mitochondrial permeability transition, F1FO‐ATPase and calcium: an enigmatic triangle Salvatore Nesci Published online 01.12.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.