Nature Biotechnology Contents: Volume 35 pp 1113 - 1216

If you are unable to see the message below, click here to view.

Advertisement Signal for easy to use phosphorylation assays  TABLE OF CONTENTS December 2017 Volume 35, Issue 12 Editorial News Correction Bioentrepreneur Opinion and Comment Features News and Views Research Corrigenda Erratum Careers and Recruitment   Advertisement   Discover a new path to your success via Human Data Science. IMS Health and Quintiles are now IQVIA™ - created to advance your pursuits of human science by unleashing the power of data science and human ingenuity. We are here to help you find solutions to drive healthcare forward. Join the journey today.   Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Are you up for a challenge? The Merck Innovation Cup is your chance to join international graduate students & postdoctoral researchers for a week-long innovation camp. Learn about industrial research & development, network with professionals and win $20,000 team prize. All expenses paid by Merck. Take up the challenge & apply now at innovationcup.merckgroup.com   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Index 2017: Innovation The Nature Index Innovation supplement examines the link between high-quality research and the commercialization of products and services, with particular focus on scientific discoveries and its economic potential. Read the full supplement free for six months     Advertisement Nature Outlook: Blood  Blood is the epicentre of much biomedical research, from fighting disease to creating artificial substitutes for this vital fluid. This Outlook discusses topics such as a gene-editing treatment for sickle-cell disease and keeping the blood supply safe from pathogens.  Get free access  Produced with support from: Grifols    Editorial Top Methods, preprints and papers   p1113 doi:10.1038/nbt.4044 This journal supports preprints as a means to rapidly share research, but discourages their use as stand-alone citations disclosing a new method integral to the key results in a paper.   News Top Ablynx's nanobody fragments go places antibodies cannot   pp1115 - 1117 Cormac Sheridan doi:10.1038/nbt1217-1115   Amgen cholesterol antibody feud could kill key IP rule   pp1118 - 1119 Mark Ratner doi:10.1038/nbt1217-1118   California cracks down on stem cell cowboys   p1119 Laura DeFrancesco doi:10.1038/nbt1217-1119   A new crop of microbe startups raises big bucks, takes on the establishment   pp1120 - 1122 Emily Waltz doi:10.1038/nbt1217-1120   Around the world in a month   p1122 doi:10.1038/nbt1217-1122   The Broad and Johns Hopkins lure deep-pocketed investors   p1123 Eva von Schaper doi:10.1038/nbt1217-1123   Activists bury India's GM mustard hopes   p1124 Killugudi Jayaraman doi:10.1038/nbt1217-1124a   Correction Top Corrections   p1124 doi:10.1038/nbt1217-1124b   News Top Data Page Drug pipeline 3Q17   p1125 Laura DeFrancesco doi:10.1038/nbt.4032   Profile DNA, RNA, protein, and phospho-protein targets up to 800-plex from a single sample. With curated content for specific research areas, including Immuno-Oncology, Solid Tumor, and Heme Profiling, get more data from less sample.  Learn more about 3D Biology™ Technology Bioentrepreneur Top Data Page Top 20 translational researchers of 2016   p1126 Brady Huggett and Kathryn Paisner doi:10.1038/nbt.4028   Opinion and Comment Top Correspondence The international MAQC Society launches to enhance reproducibility of high-throughput technologies   pp1127 - 1128 Leming Shi, Rebecca Kusko, Russell D Wolfinger, Benjamin Haibe-Kains, Matthias Fischer et al. doi:10.1038/nbt.4029   Challenges and recommendations for epigenomics in precision health   pp1128 - 1132 Ava C Carter, Howard Y Chang, George Church, Ashley Dombkowski, Joseph R Ecker et al. doi:10.1038/nbt.4030   Characterize the epitope landscape of your entire antibody library at the earliest stages of discovery to make smart decisions: Maximize epitope diversity Identify unique epitopes Build your IP portfolio Learn about the rapid assessment of an antibody library's epitopic diversity by reading this application note. Download the Application Note >>       Features Top When pig organs will fly   pp1133 - 1138 Emily Waltz doi:10.1038/nbt.4027 Regulators, scientists and surgeons are preparing the groundwork for human trials of engineered pig organs[mdash]and industry is starting to take notice.   Patents Will inter partes review speed US generic drug entry?   pp1139 - 1141 Jonathan J Darrow, Reed F Beall and Aaron S Kesselheim doi:10.1038/nbt.4036 A new extra-judicial pathway for challenging pharmaceutical patents has intensified patent challenges and helped to clear the way for earlier generic entry.   Recent patents in xenotransplantation   p1142 doi:10.1038/nbt.4040   News and Views Top DNA sequencing at ultra-high fidelity   pp1143 - 1144 Robert Sebra doi:10.1038/nbt.4001 Built-in error-correction and novel fluorogenic chemistry open a path to perfect read quality. See also: Research by Chen et al. Tuning up T-cell receptors   pp1145 - 1146 C Garrett Rappazzo and Michael E Birnbaum doi:10.1038/nbt.4009 T-cell receptors with higher affinity for tumor antigens are discovered by harnessing T-cell development. See also: Research by Schmitt et al. Research Highlights   p1146 doi:10.1038/nbt.4031   MAGE in yeast is a go   pp1147 - 1148 Susan Jones doi:10.1038/nbt.4033   Biotechnology JOBS of the week Posdoctoral position CNRS & Bordeaux University Postdoctoral Research Scientist / Fellow Columbia University Program Officer, Crohn's Disease The Leona M. and Harry B. Helmsley Charitable Trust Faculty Positions Thomas Jefferson University (TJU) Associate Editor at Genome Research Cold Spring Harbor Laboratory (CSHL) More Science jobs from Research Top Perspective Just how good an investment is the biopharmaceutical sector?   pp1149 - 1157 Richard T Thakor, Nicholas Anaya, Yuwei Zhang, Christian Vilanilam, Kien Wei Siah et al. doi:10.1038/nbt.4023 An analysis of biotech and pharma stock prices since 1930 reveals sharp differences in the risk-adjusted returns of the two sectors.   Review Microbial synthesis of medium-chain chemicals from renewables   pp1158 - 1166 Stephen Sarria, Nicholas S Kruyer and Pamela Peralta-Yahya doi:10.1038/nbt.4022 Strategies to engineer microorganisms to produce medium-chain hydrocarbon chemicals are reviewed.   Brief Communications Accurate assembly of transcripts through phase-preserving graph decomposition   pp1167 - 1169 Mingfu Shao and Carl Kingsford doi:10.1038/nbt.4020 Scallop improves identification of multi-exon and transcripts expressed at low levels by retaining phasing information during assembly.   Articles Highly accurate fluorogenic DNA sequencing with information theory-based error correction   pp1170 - 1178 Zitian Chen, Wenxiong Zhou, Shuo Qiao, Li Kang, Haifeng Duan et al. doi:10.1038/nbt.3982 The error rate of DNA sequencing is much reduced by combining an improved fluorogenic sequencing chemistry with a new error-correction scheme. See also: News and Views by Sebra Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing   pp1179 - 1187 Hao Yin, Chun-Qing Song, Sneha Suresh, Qiongqiong Wu, Stephen Walsh et al. doi:10.1038/nbt.4005 Efficient Cas9 genome editing in vivo is achieved without viral vectors using chemically modified single-guide RNAs.   Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro    pp1188 - 1195 Thomas M Schmitt, David H Aggen, Kumiko Ishida-Tsubota, Sebastian Ochsenreither, David M Kranz et al. doi:10.1038/nbt.4004 The affinity of T cells for tumor self-antigens is improved by a culture system that identifies optimal T-cell-receptor B chains. See also: News and Views by Rappazzo & Birnbaum Letter Cell-type-specific metabolic labeling of nascent proteomes in vivo    pp1196 - 1201 Beatriz Alvarez-Castelao, Christoph T Schanzenbacher, Cyril Hanus, Caspar Glock, Susanne tom Dieck et al. doi:10.1038/nbt.4016 Proteomes of distinct cell types in the brains of live mice are labeled and quantitated with a genetically encoded non-canonical amino-acid labeling method and click chemistry.   Resources Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules   pp1202 - 1210 Daniel L Coutu, Konstantinos D Kokkaliaris, Leo Kunz and Timm Schroeder doi:10.1038/nbt.4006 A compendium detailing the localization of bone and bone-marrow-microenvironment cells and proteins will enable efforts to understand the functions of this niche.   Careers and Recruitment Top Institutional culture is the key to team science   pp1212 - 1214 Sandra Soo-Jin Lee and Anna Jabloner doi:10.1038/nbt.4026 Institutional leadership in creating a culture of cooperation and pathways for multidisciplinary collaboration is critical to achieving the goals of academic translation and innovation.   People People   p1216 doi:10.1038/nbt.4041   Corrigenda Top Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis   p1211 Jatin Roper, Tuomas Tammela, Naniye Malli Cetinbas, Adam Akkad, Ali Roghanian et al. doi:10.1038/nbt1217-1211a   Corrigendum: Shotgun metagenomics, from sampling to analysis   p1211 Christopher Quince, Alan W Walker, Jared T Simpson, Nicholas J Loman and Nicola Segata doi:10.1038/nbt1217-1211b   Corrigendum: Development and function of human innate immune cells in a humanized mouse model   p1211 Anthony Rongvaux, Tim Willinger, Jan Martinek, Till Strowig, Sofia V Gearty et al. doi:10.1038/nbt1217-1211c   Erratum Top Erratum: Revisiting the Warnock rule   p1211 J Benjamin Hurlbut, Insoo Hyun, Aaron D Levine, Robin Lovell-Badge, Jeantine E Lunshof et al. doi:10.1038/nbt1217-1211d   Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.