Special issue on BCL2 and p53: Landmark discoveries, unsolved issues and future directions |
|  | | This special issue brings together two review sets focused respectively on p53 and BCL2, key players in determining cell fate decisions. During the past thirty years, p53 which is mutated in most cancers, was established as a crucial hub coordinating the cellular response to a wide variety of stress cues through a myriad of biological processes. Also, in the past decades, BCL2 emerged as the founding member of an ever-growing family of apoptotic proteins. The discovery defined the molecular bases of cell death and its regulation in development and disease. This culminated in the recent identification of new powerful therapeutic approaches targeting specific cell death mechanisms. Please see articles marked  | | TABLE OF CONTENTS
| | | | | Volume 25, Issue 1 (January 2018) |  | In this issue
 Editorials
News and Commentaries
Reviews
Original Papers
Correspondence
Corrigendum
Also new
   AOP
| | | | Editorials | Top | | Reviewing the future of the P53 field Arnold J Levine Cell Death Differ 2018 25: 1-2; 10.1038/cdd.2017.181 Full Text | PDF | | | | Bcl-2 on the brink of breakthroughs in cancer treatment John C Reed Cell Death Differ 2018 25: 3-6; 10.1038/cdd.2017.188 Full Text | PDF | | News and Commentaries | Top | | BCL2: a 30-year tale of life, death and much more to come OPEN Francesca Pentimalli Cell Death Differ 2018 25: 7-9; advance online publication, November 10, 2017; 10.1038/cdd.2017.189 Full Text | PDF | | | | Updates from the TP53 universe OPEN Francesca Pentimalli Cell Death Differ 2018 25: 10-12; advance online publication, November 10, 2017; 10.1038/cdd.2017.190 Full Text | PDF | | Reviews | Top | | Viewing BCL2 and cell death control from an evolutionary perspective Andreas Strasser and David L Vaux Cell Death Differ 2018 25: 13-20; advance online publication, November 3, 2017; 10.1038/cdd.2017.145 Abstract | Full Text | | | | BCL2 and miR-15/16: from gene discovery to treatment Yuri Pekarsky, Veronica Balatti and Carlo M Croce Cell Death Differ 2018 25: 21-26; advance online publication, October 6, 2017; 10.1038/cdd.2017.159 Abstract | Full Text | | | | The BCL-2 arbiters of apoptosis and their growing role as cancer targets OPEN Jerry M Adams and Suzanne Cory Cell Death Differ 2018 25: 27-36; advance online publication, November 3, 2017; 10.1038/cdd.2017.161 Abstract | Full Text | | | | Anti-apoptotic BCL-2 family members in development OPEN Joseph T Opferman and Anisha Kothari Cell Death Differ 2018 25: 37-45; advance online publication, November 3, 2017; 10.1038/cdd.2017.170 Abstract | Full Text | | | | MOMP, cell suicide as a BCL-2 family business OPEN Halime Kalkavan and Douglas R Green Cell Death Differ 2018 25: 46-55; advance online publication, October 20, 2017; 10.1038/cdd.2017.179 Abstract | Full Text | | | | Why do BCL-2 inhibitors work and where should we use them in the clinic? OPEN Joan Montero and Antony Letai Cell Death Differ 2018 25: 56-64; advance online publication, October 27, 2017; 10.1038/cdd.2017.183 Abstract | Full Text | | | | BCL-2 family proteins: changing partners in the dance towards death OPEN Justin Kale, Elizabeth J Osterlund and David W Andrews Cell Death Differ 2018 25: 65-80; advance online publication, November 17, 2017; 10.1038/cdd.2017.186 Abstract | Full Text | | | | p53 shades of Hippo Noa Furth, Yael Aylon and Moshe Oren Cell Death Differ 2018 25: 81-92; advance online publication, October 6, 2017; 10.1038/cdd.2017.163 Abstract | Full Text | | | | Deconstructing networks of p53-mediated tumor suppression in vivo Alyssa M Kaiser and Laura D Attardi Cell Death Differ 2018 25: 93-103; advance online publication, November 3, 2017; 10.1038/cdd.2017.171 Abstract | Full Text | | | | How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Brandon J Aubrey, Gemma L Kelly, Ana Janic, Marco J Herold and Andreas Strasser Cell Death Differ 2018 25: 104-113; advance online publication, November 17, 2017; 10.1038/cdd.2017.169 Abstract | Full Text | | | | Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM OPEN Kurt Engeland Cell Death Differ 2018 25: 114-132; advance online publication, November 10, 2017; 10.1038/cdd.2017.172 Abstract | Full Text | | | | Mechanisms of transcriptional regulation by p53 OPEN Kelly D Sullivan, Matthew D Galbraith, Zdenek Andrysik and Joaquin M Espinosa Cell Death Differ 2018 25: 133-143; advance online publication, November 10, 2017; 10.1038/cdd.2017.174 Abstract | Full Text | | | | Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism OPEN Alice Nemajerova, Ivano Amelio, Jakob Gebel, Volker Dötsch, Gerry Melino and Ute M Moll Cell Death Differ 2018 25: 144-153; advance online publication, October 27, 2017; 10.1038/cdd.2017.178 Abstract | Full Text | | | | Why are there hotspot mutations in the TP53 gene in human cancers? Evan H Baugh, Hua Ke, Arnold J Levine, Richard A Bonneau and Chang S Chan Cell Death Differ 2018 25: 154-160; advance online publication, November 3, 2017; 10.1038/cdd.2017.180 Abstract | Full Text | | | | Mutant p53 partners in crime OPEN Michael P Kim and Guillermina Lozano Cell Death Differ 2018 25: 161-168; advance online publication, November 3, 2017; 10.1038/cdd.2017.185 Abstract | Full Text | | | | Relevance of the p53–MDM2 axis to aging Danyi Wu and Carol Prives Cell Death Differ 2018 25: 169-179; advance online publication, December 1, 2017; 10.1038/cdd.2017.187 Abstract | Full Text | | Original Papers | Top | | Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation OPEN Zijing Huang, Tian Zhou, Xiaowei Sun, Yingfeng Zheng, Bing Cheng, Mei Li, Xialin Liu and Chang He Cell Death Differ 2018 25: 180-189; advance online publication, September 8, 2017; 10.1038/cdd.2017.141 Abstract | Full Text | | | | Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis Cédric Castrogiovanni, Béranger Waterschoot, Olivier De Backer and Patrick Dumont Cell Death Differ 2018 25: 190-203; advance online publication, September 22, 2017; 10.1038/cdd.2017.143 Abstract | Full Text | | | | BH3 mimetics efficiently induce apoptosis in mouse basophils and mast cells OPEN Ramona Reinhart, Lionel Rohner, Simone Wicki, Michaela Fux and Thomas Kaufmann Cell Death Differ 2018 25: 204-216; advance online publication, September 29, 2017; 10.1038/cdd.2017.154 Abstract | Full Text | | | | Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice Jibran A Wali, Sandra Galic, Christina YR Tan, Esteban N Gurzov, Ann E Frazier, Timothy Connor, Jingjing Ge, Evan G Pappas, David Stroud, L Chitra Varanasi, Claudia Selck, Michael T Ryan, David R Thorburn, Bruce E Kemp, Balasubramanian Krishnamurthy, Thomas WH Kay, Sean L McGee and Helen E Thomas Cell Death Differ 2018 25: 217-225; advance online publication, October 20, 2017; 10.1038/cdd.2017.168 Abstract | Full Text | | Correspondence | Top | | A role for caspase-8 and TRAIL-R2/DR5 in ER-stress-induced apoptosis Cristina Muñoz-Pinedo and Abelardo López-Rivas Cell Death Differ 2018 25: 226; advance online publication, October 6, 2017; 10.1038/cdd.2017.155 Full Text | | Corrigendum | Top | | The oncolytic compound LTX-401 targets the Golgi apparatus Heng Zhou, Allan Sauvat, Lígia C Gomes-da-Silva, Sylvère Durand, Sabrina Forveille, Kristina Iribarren, Takahiro Yamazaki, Sylvie Souquere, Lucillia Bezu, Kevin Müller, Marion Leduc, Peng Liu, Liwei Zhao, Aurélien Marabelle, Laurence Zitvogel, Øystein Rekdal, Oliver Kepp and Guido Kroemer Cell Death Differ 2018 25: 227-228; advance online publication, November 10, 2017; 10.1038/cdd.2017.148 Full Text | | | |  | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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