The EMBO Journal Table of Contents for 02 November 2017; Vol. 36, No. 21

02 November 2017 | Volume 36, Number 21 Submit Table of Contents News & Views Articles Volume 36, Number 21 News & Views Initiating meiosis in a dish Two new studies establish conditions for culturing ESC‐derived germ cells, enabling global DNA demethylation and subsequent female sex determination. Mark E Gill and Antoine HFM Peters Published online 04.10.2017 Articles Bone morphogenetic protein and retinoic acid synergistically specify female germ‐cell fate in mice In vitro reconstitution of female sex determination using ESC‐derived germ cells demonstrates requirement of integrated signaling and epigenetic background for fetal oocyte induction. Hidetaka Miyauchi, Hiroshi Ohta, So Nagaoka, Fumio Nakaki, Kotaro Sasaki, Katsuhiko Hayashi, Yukihiro Yabuta, Tomonori Nakamura, Takuya Yamamoto and Mitinori Saitou Published online 19.09.2017 Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn‐mediated local protein translation Aggregation of hyper‐phosphorylated Tau in the somatodendritic domain, as often seen in Alzheimer's disease, is caused by local translation triggered by the presence of amyloid‐β. Chuanzhou Li and Jürgen Götz Published online 01.09.2017 Transcriptional memory of cells of origin overrides β‐catenin requirement of MLL cancer stem cells MLL‐ENL mediated transformation of hematopoietic stem/progenitors can occur independent from beta‐catenin in leukemia mouse models. Teerapong Siriboonpiputtana, Bernd B Zeisig, Magdalena Zarowiecki, Tsz Kan Fung, Maria Mallardo, Chiou‐Tsun Tsai, Priscilla Nga Ieng Lau, Quoc Chinh Hoang, Pedro Veiga, Jo Barnes, Claire Lynn, Amanda Wilson, Boris Lenhard and Chi Wai Eric So Published online 04.10.2017 Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP Cholesterol transporter OSBP uses a large amount of phosphatidylinositol 4‐phosphate to control cholesterol distribution and consequently the gradient of membrane lipid order along the secretory pathway. Bruno Mesmin, Joëlle Bigay, Joël Polidori, Denisa Jamecna, Sandra Lacas‐Gervais and Bruno Antonny Published online 04.10.2017 Methionine metabolism is essential for SIRT1‐regulated mouse embryonic stem cell maintenance and embryonic development A SIRT1‐Myc axis affects mouse embryogenesis and epigenetic regulation of mESC function by regulating expression of methionine adenosyltransferase 2. Shuang Tang, Yi Fang, Gang Huang, Xiaojiang Xu, Elizabeth Padilla‐Banks, Wei Fan, Qing Xu, Sydney M Sanderson, Julie F Foley, Scotty Dowdy, Michael W McBurney, David C Fargo, Carmen J Williams, Jason W Locasale, Ziqiang Guan and Xiaoling Li Published online 11.10.2017 Aubergine and piRNAs promote germline stem cell self‐renewal by repressing the proto‐oncogene Cbl PIWI proteins like Aubergine protect the germline from aberrant transposon activation but also facilitate self‐renewal and differentiation of germline stem cells in flies by repressing specific mRNAs. Patricia Rojas‐Ríos, Aymeric Chartier, Stéphanie Pierson and Martine Simonelig Published online 13.10.2017 Initiation of DNA replication requires actin dynamics and formin activity Regulation of actin dynamics affects DNA synthesis in human cells and Xenopus egg extracts through multiple mechanisms, including nuclear transport and chromatin loading of replication factors. Nikolaos Parisis, Liliana Krasinska, Bethany Harker, Serge Urbach, Michel Rossignol, Alain Camasses, James Dewar, Nathalie Morin and Daniel Fisher Published online 05.10.2017 RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1 The methyl‐lysine reader L3MBTL3 switches the Notch coactivator RBPJ to a transcriptional repressor by mediating removal of activating histone marks at Notch target genes. Tao Xu, Sung‐Soo Park, Benedetto Daniele Giaimo, Daniel Hall, Francesca Ferrante, Diana M Ho, Kazuya Hori, Lucas Anhezini, Iris Ertl, Marek Bartkuhn, Honglai Zhang, Eléna Milon, Kimberly Ha, Kevin P Conlon, Rork Kuick, Brandon Govindarajoo, Yang Zhang, Yuqing Sun, Yali Dou, Venkatesha Basrur, Kojo SJ Elenitoba‐Johnson, Alexey I Nesvizhskii, Julian Ceron, Cheng‐Yu Lee, Tilman Borggrefe, Rhett A Kovall and Jean‐François Rual Published online 13.10.2017 Crosstalk between PKA and PKG controls pH‐dependent host cell egress of Toxoplasma gondii PKA1 inhibits PKG activity to prevent premature parasite exit from the host cell due to intracellular acidification. Yonggen Jia, Jean‐Baptiste Marq, Hugo Bisio, Damien Jacot, Christina Mueller, Lu Yu, Jyoti Choudhary, Mathieu Brochet and Dominique Soldati‐Favre Published online 13.10.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.