Nature Reviews Molecular Cell Biology contents November 2017 Volume 18 Number 12 pp 711-783

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TABLE OF CONTENTS
December 2017 Volume 18 Number 12		Advertisement
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5	In this issue Comment Research Highlights Focus on: Mechanobiology Reviews Correction   Also this month  Focus: Mechanobiology  Collection: mRNA splicing: 40 years on  Featured article: Regulation of genome organization and gene expression by nuclear mechanotransduction Caroline Uhler & G. V. Shivashankar	Is your organization planning a scientific event or conference for 2018? Looking for a way to increase the number of attendees?  Advertise in the Natureevents Directory 2018. Available online and in print. Ad close deadline: 4 December, 2017
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Nature Collection: 2017 Nobel Prize in Physiology or Medicine  The 2017 Nobel Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their pioneering work in Drosophila that elucidated the molecular mechanisms controlling circadian rhythm. Access this collection free online  Produced with support from: Vanda Pharmaceuticals
Comment: Mechanobiology by the numbers: a close relationship between biology and physics Ulrich S. Schwarz p711 | doi:10.1038/nrm.2017.109 Studies of mechanobiology lie at the interface of various scientific disciplines from biology to physics. Ulrich Schwarz discusses the importance of technological advances, quantification and modelling for the progress in understanding the role of forces in biology. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS   Top Mechanotransduction: Enforcing protein import p713 | doi:10.1038/nrm.2017.114 Applying force to the nucleus reduces the diffusion barrier at nuclear pores and promotes nuclear import of certain proteins, including the transcription regulator YAP, depending on their molecular properties. PDF Transcription: Intragenic enhancers dampen gene expression p714 | doi:10.1038/nrm.2017.111 Transcription of enhancer RNA at intragenic enhancers can attenuate the expression of the host gene. PDF Translation: Immature ribosomes under surveillance p714 | doi:10.1038/nrm.2017.117 Ribosome subunits that fail to properly mature enter translation, cause translational stress and become targets of translation surveillance pathways. PDF JOURNAL CLUB Forces as regulators of cell adhesions p715 | doi:10.1038/nrm.2017.112 Christopher Chen highlights the early studies of mechanoregulation of cell-matrix adhesions that established mechanobiology as a cross-discplinary research field PDF   Molecular Cell Biology JOBS of the week NIDDK / NIH Post-Doctoral Fellowship position National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Program Officer, Crohn's Disease The Leona M. and Harry B. Helmsley Charitable Trust Research Scientist in Epidemiology Alberta Health Services, Cancer Epidemiology Postdoctoral Fellowship in Metabolism or Tissue Fibrosis University of California - San Francisco Postdoctoral Postion - The University of Pittsburgh School of Medicine University of Pittsbugh, School of Medicine More Science jobs from Molecular Cell Biology EVENT Essential Molecular Biology - Hands-On Laboratory Course - 12th edition 22.01.18 Porto, Portugal More science events from
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Nature Reviews Collection — The obesity epidemic: molecular and clinical considerations  This collection of articles describes the latest efforts to understand the molecular mechanisms underlying obesity against a complex backdrop of factors that include socioeconomic status, environment and personal behaviour, as well as advances in treatment.  View the collection
Focus on: Mechanobiology REVIEWS Top Regulation of genome organization and gene expression by nuclear mechanotransduction Caroline Uhler & G. V. Shivashankar p717 | doi:10.1038/nrm.2017.101 Mechanical cues from the microenvironment can be efficiently transmitted to the nucleus to engage in the regulation of genome organization and gene expression. Recent technological and theoretical progress sheds new light on the relationships between cell mechanics, nuclear and chromosomal architecture and gene transcription. Abstract | Full Text | PDF   Mechanical forces direct stem cell behaviour in development and regeneration Kyle H. Vining & David J. Mooney p728 | doi:10.1038/nrm.2017.108 Physical cues regulate stem cell fate and function during embryonic development and in adult tissues. The biophysical and biochemical properties of the stem cell microenvironment can be precisely manipulated using synthetic niches, which provide key insights into how mechanical stimuli regulate stem cell function and can be used to maintain and guide stem cells for regenerative therapies. Abstract | Full Text | PDF | Supplementary information   Mechanobiology of collective cell behaviours Benoit Ladoux & Rene-Marc Mege p743 | doi:10.1038/nrm.2017.98 Coordinated movements of cell collectives are important for morphogenesis, tissue regeneration and cancer cell dissemination. Recent studies, mainly using novel in vitro approaches, have provided new insights into the mechanisms governing this multicellular coordination, highlighting the key role of the mechanosensitivity of adherens junctions and mechanical cell-cell coupling in collective cell behaviours. Abstract | Full Text | PDF | Supplementary information   Mechanobiology of YAP and TAZ in physiology and disease Tito Panciera, Luca Azzolin, Michelangelo Cordenonsi & Stefano Piccolo p758 | doi:10.1038/nrm.2017.87 The transcription factors YAP and TAZ have recently emerged as being conserved transducers of mechanical signals into cells and mediators of processes such as proliferation, migration and cell fate decision. The roles of YAP-mediated and TAZ-mediated mechanotransduction have now been documented in many physiological and pathological contexts, providing novel insights into cellular mechano-responses and their consequences. Abstract | Full Text | PDF   Piezos thrive under pressure: mechanically activated ion channels in health and disease Swetha E. Murthy, Adrienne E. Dubin & Ardem Patapoutian p771 | doi:10.1038/nrm.2017.92 Soon after their discovery in 2010, Piezo channels became a paradigm for studying mechanosensitive ion channels. These channels respond to physiologically relevant forces in diverse cellular contexts, and their dysfunction has been linked to various diseases. We are now starting to understand gating mechanisms of Piezo channels and their key roles in physiology. Abstract | Full Text | PDF
CORRECTION		Top
Publisher correction: The essential kinase ATR: ensuring faithful duplication of a challenging genome. Joshua C. Saldivar, David Cortez & Karlene A. Cimprich p783 | doi:10.1038/nrm.2017.116 Full Text | PDF
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Web collection: Archaea and the tree of life  To mark 40 years of archaea research, Nature Reviews Microbiology presents a collection of articles from across Nature Research which explore the fundamental biology, evolution, metabolic versatility and ecological impact of archaea, and how the discovery of new species is reshaping the tree of life.  Access the collection online - select content free to read for a limited time.
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Focus issue on Mechanobiology  Nature Reviews Molecular Cell Biology presents a focus issue highlighting the importance of mechanotransduction — the conversion of mechanical forces into biochemical signals — in morphogenesis, tissue regeneration and disease, including tumorigenesis. The articles discuss our understanding of how mechanical forces are transduced into the cell, including the nucleus, to regulate gene expression, and the therapeutic potential of modulating the mechanobiology of cells and tissues.  Free access to select content for a limited time.
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