Nature Cell Biology contents: December 2017 Volume 19 Number 12, pp 1381 - 1443

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TABLE OF CONTENTS December 2017 Volume 19, Issue 12 Editorial News and Views Articles Letters Errata Corrigendum Addendum   Advertisement   Do You Treat Your Cells the Same Way Every Time?  Explore how GCCP can simplify generation of highly reproducible results in cell culture experiments with comparable parameters, independent of the person performing the experiments. www.eppendorf.com/reproducibility/   Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Healthy Ageing: From Molecules to Organisms (31 Jan - 2 Feb 2018) The second conference in this series will focus on recent discoveries and current challenges in ageing research, with a focus on translating basic research insights into health improvement for older people. Registration deadline: 12 Dec   Advertisement Is your organization planning a scientific event or conference for 2018?  Looking for a way to increase the number of attendees? Advertise in the Natureevents Directory 2018.  Available online and in print. Ad close deadline: 4 December, 2017   Editorial Top Of stem cells and ethics   p1381 doi:10.1038/ncb3652 Advances in stem cell research offer unprecedented insights into human biology and opportunities for clinical translation. They also raise many questions with social and ethical implications.   News and Views Top RNA takes over control of DNA break repair   pp1382 - 1384 Francesca Storici and Ailone E. Tichon doi:10.1038/ncb3645 Small RNAs generated at DNA break sites are implicated in mammalian DNA repair. Now, a study shows that following the formation of DNA double-strand breaks, bidirectional transcription events adjacent to the break generate small RNAs that trigger the DNA damage response by local RNA:RNA interactions. See also: Article by Michelini et al. Capturing endosomal vesicles at the Golgi   pp1384 - 1386 J. Christopher Fromme and Mary Munson doi:10.1038/ncb3649 Membrane trafficking specificity between distinct compartments ensures that cargo proteins and lipids are delivered to their target organelle. However, accurate recognition of cargo carriers by tethering factors on target membranes is poorly understood. TBC1D23 is now identified as an adaptor that links endosome-derived vesicles with golgins at the trans-Golgi. See also: Letter by Shin et al. F-actin organizes the nucleus   pp1386 - 1388 Henna M. Moore and Maria K. Vartiainen doi:10.1038/ncb3650 After mitosis, the nucleus must be rebuilt and chromatin decondensed to permit interphase genomic functions, but decondensation mechanisms are poorly understood. Now, the traditional cytoskeletal protein actin is shown to form transient nuclear filaments that are required for chromatin decondensation and nuclear expansion at mitotic exit. See also: Article by Baarlink et al. Nature Cell Biology JOBS of the week NIDDK / NIH Post-Doctoral Fellowship position National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Scientific Editor Elsevier Research Assistant - FMI Group Liberali Friedrich Miescher Institute for Biomedical Research (FMI) Postdoctoral Research Fellow Boston Children's Hospital Scientist (Bioinformatics) IARC More Science jobs from Nature Cell Biology EVENT Single Cell Biology 06.03.18 Hinxton, UK More science events from Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    Articles Top A transient pool of nuclear F-actin at mitotic exit controls chromatin organization   pp1389 - 1399 Christian Baarlink, Matthias Plessner, Alice Sherrard, Kohtaro Morita, Shinji Misu et al. doi:10.1038/ncb3641 Baarlink et al. identify a transient pool of nuclear F-actin, the dynamics of which are controlled by cofilin-1 that accumulates after mitosis and is important for chromatin reorganization in G1. See also: News and Views by Moore & Vartiainen Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks   pp1400 - 1411 Flavia Michelini, Sethuramasundaram Pitchiaya, Valerio Vitelli, Sheetal Sharma, Ubaldo Gioia et al. doi:10.1038/ncb3643 Michelini et al. show that RNA polymerase II is recruited to double-strand breaks to induce long non-coding RNAs and the generation of small DNA damage response RNAs that promote recruitment of DNA repair factors and repair. See also: News and Views by Storici & Tichon Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation   pp1412 - 1423 Fergal O'Farrell, Viola Hélène Lobert, Marte Sneeggen, Ashish Jain, Nadja Sandra Katheder et al. doi:10.1038/ncb3631 O'Farrell et al. show that class III PI3K regulates epithelial integrity through endosomal LKB1. Class III PI3K inactivation dysregulates LKB1 to alter cell polarity, and the PtdIns3P effector WDFY2 regulates LKB1.   Advertisement Poster on: The expanding CRISPR toolbox  The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR.  Available to download free online >>   Produced with support from:  Dharmacon    Letters Top TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi   pp1424 - 1432 John J. H. Shin, Alison K. Gillingham, Farida Begum, Jessica Chadwick and Sean Munro doi:10.1038/ncb3627 Shin et al. identify TBC1D23 as an adaptor that interacts both with golgins and endosomal WASH and is required for the delivery of endosome-derived vesicles to the trans-Golgi. See also: News and Views by Fromme & Munson Distinct kinetics of serine and threonine dephosphorylation are essential for mitosis   pp1433 - 1440 Jamin B. Hein, Emil P. T. Hertz, Dimitriya H. Garvanska, Thomas Kruse and Jakob Nilsson doi:10.1038/ncb3634 Cdk1-mediated phosphorylation of threonine and serine residues on cell cycle regulators needs to be removed after mitosis. Hein et al. show that the known preference of the PP2A–B55 phosphatase for threonine provides temporal regulation of mitotic exit.   Errata Top Erratum: DNA sensing in senescence   p1441 Marina Ruiz de Galarreta and Amaia Lujambio doi:10.1038/ncb3644   Erratum: EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity   p1442 Zarah M. Löf-Öhlin, Pia Nyeng, Matthew E. Bechard, Katja Hess, Eric Bankaitis et al. doi:10.1038/ncb3646   Erratum: PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis   p1442 Fabao Liu, Fengfei Ma, Yuyuan Wang, Ling Hao, Hao Zeng et al. doi:10.1038/ncb3648   Corrigendum Top Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation   p1441 Yong-Jian Wang, Yan Bian, Jie Luo, Ming Lu, Ying Xiong et al. doi:10.1038/ncb3651   Addendum Top Addendum: A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression   p1443 Simon Grelet, Laura A. Link, Breege Howley, Clémence Obellianne, Viswanathan Palanisamy et al. doi:10.1038/ncb3647   Top Advertisement An open access journal dedicated to highlighting the most important scientific advances in Parkinson's disease research, spanning the motor and non-motor disorders of Parkinson's disease. 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