The EMBO Journal Table of Contents for 02 October 2017; Vol. 36, No. 19

02 October 2017 | Volume 36, Number 19 Submit Table of Contents News & Views Articles Corrigenda Volume 36, Number 19 News & Views FORMINg a link between PTSD and AD The actin regulatory protein Formin 2 provides a first molecular explanation for the clinical observation that post‐traumatic stress disorder increases the likelihood for Alzheimer's disease‐related dementia. Johannes Gräff Published online 18.09.2017 Molecular cartography of mutational landscapes in melanomas A new 3D map of DNA damage induced by sunlight provides insight into the origins of tumor‐associated gene mutations. Emily C Beckwitt and Bennett Van Houten Published online 20.09.2017 Articles Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia Deregulation of the actin cytoskeleton regulator Formin 2 is a common denominator of post‐traumatic stress disorders and age‐dependent Alzheimer's disease phenotypes, possibly explaining their clinical connection. Roberto Carlos Agís‐Balboa, Paulo S Pinheiro, Nelson Rebola, Cemil Kerimoglu, Eva Benito, Michael Gertig, Sanaz Bahari‐Javan, Gaurav Jain, Susanne Burkhardt, Ivana Delalle, Alexander Jatzko, Markus Dettenhofer, Patricia A Zunszain, Andrea Schmitt, Peter Falkai, Julius C Pape, Elisabeth B Binder, Christophe Mulle, Andre Fischer and Farahnaz Sananbenesi Published online 02.08.2017 Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis Genome‐wide maps of UV‐induced DNA lesions in primary cells correlate with mutation frequency in melanoma, and show that heterochromatin at the nuclear periphery is particularly vulnerable to carcinogenic sunlight. Pablo E García‐Nieto, Erin K Schwartz, Devin A King, Jonas Paulsen, Philippe Collas, Rafael E Herrera and Ashby J Morrison Published online 16.08.2017 Redox regulation of plant stem cell fate Superoxide regulates plant stem cell fate, and the balance between superoxide and H2O2 serves as a key switch for stem cell maintenance versus differentiation by antagonistically regulating expression of stem cell fate transcription factor WUSCHEL. Jian Zeng, Zhicheng Dong, Haijun Wu, Zhaoxia Tian and Zhong Zhao Published online 24.08.2017 Noise in a phosphorelay drives stochastic entry into sporulation in Bacillus subtilis Microfluidic analysis uncovers heterogeneity in induction of Bacillus subtilis sporulation due to fluctuations in the threshold of Spo0A phosphorylation via an upstream histidine kinase cascade. Jonathan R Russell, Matthew T Cabeen, Paul A Wiggins, Johan Paulsson and Richard Losick Published online 24.08.2017 Exosome cofactor hMTR4 competes with export adaptor ALYREF to ensure balanced nuclear RNA pools for degradation and export Factors mediating decay or export of nuclear RNA directly compete for access to the nuclear cap‐binding complex, thus forming a checkpoint to ensure that only functional mRNAs and lncRNAs are exported to the cytoplasm. Jing Fan, Bin Kuai, Guifen Wu, Xudong Wu, Binkai Chi, Lantian Wang, Ke Wang, Zhubing Shi, Heng Zhang, She Chen, Zhisong He, Siyuan Wang, Zhaocai Zhou, Guohui Li and Hong Cheng Published online 11.08.2017 The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription Hox protein binding to target genes bearing paused polymerase triggers the formation of active chromatin marks and drives RNA pol II into productive elongation. Amel Zouaz, Ankush Auradkar, Marie Claire Delfini, Meiggie Macchi, Marine Barthez, Serge Ela Akoa, Leila Bastianelli, Gengqiang Xie, Wu‐Min Deng, Stuart S Levine, Yacine Graba and Andrew J Saurin Published online 04.09.2017 BLM and SLX4 play opposing roles in recombination‐dependent replication at human telomeres Alternative lengthening of telomeres (ALT) appears as a conservative DNA replication process involving POLD3‐dependent telomeres synthesis and BLM‐TOP3A‐mediated prevention of telomere exchange. Alexander P Sobinoff, Joshua AM Allen, Axel A Neumann, Sile F Yang, Monica E Walsh, Jeremy D Henson, Roger R Reddel and Hilda A Pickett Published online 06.09.2017 Corrigenda Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage Si Tao, Duozhuang Tang, Yohei Morita, Tobias Sperka, Omid Omrani, André Lechel, Vadim Sakk, Johann Kraus, Hans A Kestler, Michael Kühl and Karl Lenhard Rudolph Published online 02.10.2017 Telomerase abrogates aneuploidy‐induced telomere replication stress, senescence and cell depletion Jitendra K Meena, Aurora Cerutti, Christine Beichler, Yohei Morita, Christopher Bruhn, Mukesh Kumar, Johann M Kraus, Michael R Speicher, Zhao‐Qi Wang, Hans A Kestler, Fabrizio d'Adda di Fagagna, Cagatay Günes and Karl Lenhard Rudolph Published online 02.10.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.