EMBO reports Table of Contents for October 2017; Vol. 18, No. 10

October 2017 | Volume 18, Number 10 Submit Table of Contents News & Views Science & Society Scientific Reports Articles Corrigendum < a style="display:inline-block;" href="http://EMBOr.embopress.org/content/18/10"> Volume 18, Number 10 News & Views Chromatin remodeling: a complex affair The human ISWI family of chromatin remodelers is more polymorphic than anticipated indicating that it has the potential to create enzymes with novel biochemical activities and novel regulatory wiring. Nathan Gioacchini and Craig L Peterson Published online 23.08.2017 Length does matter for cGAS A study in this issue describes that the detection of cytoplasmic dsDNA by the immune sensor cGAS is more effective for longer fragments, suggesting that length is the predominant factor governing the discrimination between self and non‐self DNA. Michael P Gantier Published online 21.08.2017 Science & Society The biosocial genome?: Interdisciplinary perspectives on environmental epigenetics, health and society Environmental epigenetics has attracted attention in the media owing to its potential for informing public health policies. It is therefore important to take its societal implications into consideration by cooperating with researchers in the social sciences and humanities. Ruth Müller, Clare Hanson, Mark Hanson, Michael Penkler, Georgia Samaras, Luca Chiapperino, John Dupré, Martha Kenney, Christopher Kuzawa, Joanna Latimer, Stephanie Lloyd, Astrid Lunkes, Molly Macdonald, Maurizio Meloni, Brigitte Nerlich, Francesco Panese, Martyn Pickersgill, Sarah Richardson, Joëlle Rüegg, Sigrid Schmitz, Aleksandra Stelmach and Paula‐Irene Villa Published online 20.09.2017 A cooperative governance network for crop genome editing: The success of governance networks in other areas could help to find common ground for applying genome editing in agriculture The application of genome editing for crop improvement has been lagging mainly owing to public debate about and continued activism against genetically modified crops. Cooperative Governance networks could be way out of the conundrum to enable safe and acceptable use of genome editing in agriculture. Nicholas R Jordan, Kevin M Dorn, Timothy M Smith, Katie E Wolf, Patrick M Ewing, Adria L Fernandez, Bryan C Runck, Alwyn Williams, You Lu and Jennifer Kuzma Published online 19.09.2017 Swimming in a sea of drugs: Psychiatric drugs in the aquatic environment could have severe adverse effects on wildlife and ecosystems There have long been concerns about the impact of residues of pharmaceuticals in water on aquatic life. The effects of psychoactive drugs in particular could have dire consequences for whole ecosystems. Katrin Weigmann Published online 01.09.2017 Viral taxonomy: The effect of metagenomics on understanding the diversity and evolution of viruses The advent of next‐generation sequencing and metagenomics is challenging viral taxonomy to define and characterize viruses along with providing novel insights into the vast diversity of viruses and their evolution. Philip Hunter Published online 06.09.2017 Scientific Reports Expansion of the ISWI chromatin remodeler family with new active complexes This study identifies novel ISWI regulatory subunit‐ATPase pairings in cells and shows that the complexes within the expanded ISWI family exhibit distinct remodeling activities in vitro, suggesting different biological functions. Mariano Oppikofer, Tianyi Bai, Yutian Gan, Benjamin Haley, Peter Liu, Wendy Sandoval, Claudio Ciferri and Andrea G Cochran Published online 11.08.2017 cGAS is activated by DNA in a length‐dependent manner Cytosolic DNA stimulates innate immunity via cGAS‐STING signaling. The response to dsDNA depends on DNA length at physiological DNA concentrations. Activation of cGAS occurs more efficiently with long DNA. This preference is an intrinsic property of cGAS. Stefanie Luecke, Andreas Holleufer, Maria H Christensen, Kasper L Jønsson, Gerardo A Boni, Lambert K Sørensen, Mogens Johannsen, Martin R Jakobsen, Rune Hartmann and Søren R Paludan Published online 10.08.2017 The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF‐16/FOXO transcription factors FOXO transcription factors regulate stress resistance and longevity in diverse organisms. Here, the MYST family HAT complex is shown to increase FOXO transcription and thus promote longevity and stress resistance in C. elegans and human cells. Takako Ikeda, Masaharu Uno, Sakiko Honjoh and Eisuke Nishida Published online 09.08.2017 Rab7b modulates autophagic flux by interacting with Atg4B The small GTPase Rab7b regulates autophagic flux by promoting the activity of the cysteine protease Atg4B, the key autophagic enzyme responsible for cleaving the precursor form of LC3. Ingrid Kjos, Marita Borg Distefano, Frank Sætre, Urska Repnik, Petter Holland, Arwyn T Jones, Nikolai Engedal, Anne Simonsen, Oddmund Bakke and Cinzia Progida Published online 23.08.2017 IFITM3 requires an amphipathic helix for antiviral activity Interferon‐induced transmembrane protein 3 (IFITM3) is a cellular factor that blocks virus fusion with cell membranes. This study discovers an amphipathic helix within IFITM3 that is required for its inhibition of infection by diverse pathogenic viruses. Nicholas M Chesarino, Alex A Compton, Temet M McMichael, Adam D Kenney, Lizhi Zhang, Victoria Soewarna, Matthew Davis, Olivier Schwartz and Jacob S Yount Published online 23.08.2017 Pre‐initiation complex assembly functions as a molecular switch that splits the Mcm2‐7 double hexamer This study reveals how the pre‐initiation complex (pre‐IC) during DNA replication initiation is assembled, and shows that pre‐IC assembly separates the core component of the replicative helicase, the Mcm2–7 double hexamer. Mayumi Miyazawa‐Onami, Hiroyuki Araki and Seiji Tanaka Published online 17.08.2017 A retained intron in the 3′‐UTR of Calm3 mRNA mediates its Staufen2‐ and activity‐dependent localization to neuronal dendrites This study shows that Stau2 binds 28 transcripts through a retained intron in their 3′‐UTR. Stau2 binding to the 3′‐UTR intron and synaptic activity both promote the dendritic localization of Calm3 mRNA. Tejaswini Sharangdhar, Yoichiro Sugimoto, Jacqueline Heraud‐Farlow, Sandra M Fernández‐Moya, Janina Ehses, Igor Ruiz de los Mozos, Jernej Ule and Michael A Kiebler Published online 01.08.2017 Regulation of perforin activation and pre‐synaptic toxicity through C‐terminal glycosylation N‐linked glycosylation of the perforin C‐terminus inhibits oligomerisation of perforin monomers, protecting the host cell from premature pore formation. Removal of this glycan in secretory granules through proteolytic processing is imperative for perforin activation. Imran G House, Colin M House, Amelia J Brennan, Omer Gilan, Mark A Dawson, James C Whisstock, Ruby HP Law, Joseph A Trapani and Ilia Voskoboinik Published online 14.08.2017 Articles Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo‐tomography CryoET and biochemical assays reveal that ribosomes interact specifically with the TOM complex and that nascent chain binding is crucial for ribosome recruitment and stabilization, providing evidence for the coupling of protein synthesis and transport. Vicki AM Gold, Piotr Chroscicki, Piotr Bragoszewski and Agnieszka Chacinska Published online 21.08.2017 LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination A high ratio of M1 versus M2 polarized microglia is a major pathological feature of multiple sclerosis. The lncRNA GAS5 is a negative regulator of M2 polarization, is highly expressed in amoeboid‐shaped microglia of MS patients and promotes demyelination. Dingya Sun, Zhongwang Yu, Xue Fang, Mingdong Liu, Yingyan Pu, Qi Shao, Dan Wang, Xiaolin Zhao, Aijun Huang, Zhenghua Xiang, Chao Zhao, Robin JM Franklin, Li Cao and Cheng He Published online 14.08.2017 ER remodeling by the large GTPase atlastin promotes vacuolar growth of Legionella pneumophila The intracellular pathogen Legionella pneumophila replicates within a distinct ER‐associated compartment, the Legionella‐containing vacuole (LCV). The large, dynamin‐like GTPase atlastin3/Sey1 contributes to LCV maturation and growth by promoting ER tubule dynamics and organelle remodeling. Bernhard Steiner, Anna Leoni Swart, Amanda Welin, Stephen Weber, Nicolas Personnic, Andres Kaech, Christophe Freyre, Urs Ziegler, Robin W Klemm and Hubert Hilbi Published online 23.08.2017 LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis Long noncoding RNAs play roles in the development and progression of many cancers. In this study the lncRNA PAGBC is identified as promoting tumorigenesis in human gallbladder cancer by competitive binding to the tumour suppressive microRNAs miR‐133b and miR‐511. Xiang‐Song Wu, Fang Wang, Huai‐Feng Li, Yun‐Ping Hu, Lin Jiang, Fei Zhang, Mao‐Lan Li, Xu‐An Wang, Yun‐Peng Jin, Yi‐Jian Zhang, Wei Lu, Wen‐Guang Wu, Yi‐Jun Shu, Hao Weng, Yang Cao, Run‐Fa Bao, Hai‐Bin Liang, Zheng Wang, Yi‐Chi Zhang, Wei Gong, Lei Zheng, Shu‐Han Sun and Ying‐Bin Liu Published online 08.09.2017 Chromosome topology guides the Drosophila Dosage Compensation Complex for target gene activation X chromosome loci with binding sites for the Drosophila MSL dosage compensation complex are engaged in long‐range interactions within the active compartment. The constitutive chromosome folding likely facilitates vital gene activation in male flies. Tamás Schauer, Yad Ghavi‐Helm, Tom Sexton, Christian Albig, Catherine Regnard, Giacomo Cavalli, Eileen EM Furlong and Peter B Becker Published online 09.08.2017 Corrigendum Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP‐dependent biogenesis pathway Monika Sinzel, Tao Tan, Philipp Wendling, Hubert Kalbacher, Cagakan Özbalci, Xenia Chelius, Benedikt Westermann, Britta Brügger, Doron Rapaport and Kai Stefan Dimmer Published online 02.10.2017 ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules Marta Gai, Federico T Bianchi, Cristiana Vagnoni, Fiammetta Vernì, Silvia Bonaccorsi, Selina Pasquero, Gaia E Berto, Francesco Sgrò, Alessandra A Chiotto, Laura Annaratone, Anna Sapino, Anna Bergo, Nicoletta Landsberger, Jacqueline Bond, Wieland B Huttner and Ferdinando Di Cunto Published online 02.10.2017   Unsubscribe from or edit your subscription for this service. 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