The EMBO Journal Table of Contents for 01 September 2017; Vol. 36, No. 17

01 September 2017 | Volume 36, Number 17 Submit Table of Contents News & Views Review Articles Resource Corrigendum Volume 36, Number 17 News & Views A forceful connection: mechanoregulation of oncogenic YAP Recent papers reveal that YAP affects breast cancer tumorigenesis via crosstalk with both myocardin‐related transcription factors and the SKP2 cell cycle regulator. Ralph Thomas Böttcher, Zhiqi Sun and Reinhard Fässler Published online 19.07.2017 Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis Two recent studies implicate Z‐RNAs produced during viral infection as molecular patterns that induce innate immune responses. Sonia Assil and Søren R Paludan Published online 18.08.2017 Review APP mouse models for Alzheimer's disease preclinical studies Outlining the historical progression of preclinical Alzheimer's disease models, this review compares the respective strengths and limitations of different transgenic models expressing mutant amyloid precursor protein (APP). Hiroki Sasaguri, Per Nilsson, Shoko Hashimoto, Kenichi Nagata, Takashi Saito, Bart De Strooper, John Hardy, Robert Vassar, Bengt Winblad and Takaomi C Saido Published online 01.08.2017 Articles Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis The collaborative action of CDK1, PLK1 and DDK is required to facilitate synaptomenal complex removal and activation of homologous recombination repair following meiotic prophase in yeast. Bilge Argunhan, Wing‐Kit Leung, Negar Afshar, Yaroslav Terentyev, Vijayalakshmi V Subramanian, Yasuto Murayama, Andreas Hochwagen, Hiroshi Iwasaki, Tomomi Tsubouchi and Hideo Tsubouchi Published online 10.07.2017 Mechanical cue‐induced YAP instructs Skp2‐dependent cell cycle exit and oncogenic signaling YAP links mechanical stress and Skp2 transcription to instruct cell cycle progression and oncogenic functions in breast cancer growth. Wonyul Jang, Tackhoon Kim, Ja Seung Koo, Sang‐kyum Kim and Dae‐Sik Lim Published online 03.07.2017 Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis Mouse knock‐in of mutant ZBP1 confirms it as a bona fide innate nucleic acid sensor, whose recognition of Z‐form RNA rather than DNA triggers inflammatory cell death upon viral infection. Jonathan Maelfait, Layal Liverpool, Anne Bridgeman, Katherine B Ragan, Jason W Upton and Jan Rehwinkel Published online 17.07.2017 STUB1 regulates TFEB‐induced autophagy–lysosome pathway STUB1, a chaperone‐dependent ubiquitin ligase known for targeting proteins for proteasomal degradation, specifically targets the inactive phosphorylated form of the lysosomal master regulator TFEB, thereby ensuring maintenance of TFEB activity. Youbao Sha, Lang Rao, Carmine Settembre, Andrea Ballabio and N Tony Eissa Published online 28.07.2017 Centriole translocation and degeneration during ciliogenesis in Caenorhabditis elegans neurons Cilia formation in Caenorhabditis elegans sensory neurons involves dynein‐mediated centriole transport into growing dendrites, followed by sequential loss of central tube components. Wenjing Li, Peishan Yi, Zhiwen Zhu, Xianliang Zhang, Wei Li and Guangshuo Ou Published online 25.07.2017 The Shigella type III effector IpgD recodes Ca2+ signals during invasion of epithelial cells Hydrolysis of the precursor lipid PIP2 by a bacterial effector disrupts InsP3‐regulated global Ca2+ responses to cellular infection. Chun Hui Sun, Benjamin Wacquier, Daniel I Aguilar, Nathalie Carayol, Kevin Denis, Sylviane Boucherie, Cesar Valencia‐Gallardo, Ceren Simsek, Christophe Erneux, Alexandre Lehman, Jost Enninga, Laurence Arbibe, Philippe Sansonetti, Geneviève Dupont, Laurent Combettes and Guy Tran Van Nhieu Published online 12.07.2017 GT‐rich promoters can drive RNA pol II transcription and deposition of H2A.Z in African trypanosomes While trypanosomes lack classical promoter elements, they initiate transcription broadly over GT‐rich sequences that control incorporation of activating histone variants. Carolin Wedel, Konrad U Förstner, Ramona Derr and T Nicolai Siegel Published online 12.07.2017 Chromatin stiffening underlies enhanced locus mobility after DNA damage in budding yeast Live tracking of chromatin loci shows that genotoxic stress and subsequent H2A phosphorylation are associated with genome‐wide intrachromosomal distances increases. Sébastien Herbert, Alice Brion, Jean‐Michel Arbona, Mickaël Lelek, Adeline Veillet, Benoît Lelandais, Jyotsana Parmar, Fabiola García Fernández, Etienne Almayrac, Yasmine Khalil, Eleonore Birgy, Emmanuelle Fabre and Christophe Zimmer Published online 10.07.2017 Recombination at subtelomeres is regulated by physical distance, double‐strand break resection and chromatin status A new assay for subtelomeric repair pathway competition in yeast shows that gene conversion is limited by proximity between homogenous loci, but promoted by repressive chromatin. Amandine Batté, Clémentine Brocas, Hélène Bordelet, Antoine Hocher, Myriam Ruault, Adouda Adjiri, Angela Taddei and Karine Dubrana Published online 28.07.2017 Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation Repression of downstream genes upon faulty transcription termination in fission yeast exemplifies a new mode of lncRNA‐dependent gene expression control in cis. Leila Touat‐Todeschini, Yuichi Shichino, Mathieu Dangin, Nicolas Thierry‐Mieg, Benoit Gilquin, Edwige Hiriart, Ravi Sachidanandam, Emeline Lambert, Janine Brettschneider, Michael Reuter, Jan Kadlec, Ramesh Pillai, Akira Yamashita, Masayuki Yamamoto and André Verdel Published online 01.08.2017 Resource Epigenome profiling and editing of neocortical progenitor cells during development Mapping genome‐wide histone methylation in distinct mouse neural cell types reveals major changes associated with brain development, while genome editing shows how transient changes in chromatin status can affect regulation of specific genes. Mareike Albert, Nereo Kalebic, Marta Florio, Naharajan Lakshmanaperumal, Christiane Haffner, Holger Brandl, Ian Henry and Wieland B Huttner Published online 01.08.2017 Corrigendum Mitochondrial genome inheritance and replacement in the human germline Don P Wolf, Tomonari Hayama and Shoukhrat Mitalipov Published online 01.09.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.