EMBO reports Table of Contents for September 2017; Vol. 18, No. 9

September 2017 | Volume 18, Number 9 Submit Table of Contents News & Views Correspondence Science & Society Review Scientific Reports Articles Corrigendum Volume 18, Number 9 News & Views The greatest kinetochore show on earth A study in this issue provides a comprehensive evolutionary analysis of kinetochore composition across phylogenetically diverse eukaryotes using comparative genomics, providing new insights into the origins, function, and flexibility of eukaryotic kinetochores. Gerben Vader and Andrea Musacchio Published online 18.07.2017 Salmonella ubiquitination: ARIH1 enters the fray A study in this issue describes that the Ring‐between‐Ring E3 ligase ARIH1 is involved in the formation of the ubiquitin coat surrounding cytosolic Salmonella, suggesting that ARIH1 modulates the recognition of intracellular bacteria for cell‐autonomous immunity. Damián Lobato‐Márquez and Serge Mostowy Published online 18.08.2017 Correspondence Unintended consequences of 21st century technology for agricultural pest management Comment on “Agricultural pest control with CRISPR‐based gene drive: time for public debate” by Courtier‐Orgogozo et al. Stephen L Young Published online 07.08.2017 CRISPR‐based gene drive in agriculture will face technical and governance challenges Comment on “Agricultural pest control with CRISPR‐based gene drive: time for public debate” by Courtier‐Orgogozo et al. Nicole Gutzmann, Johanna E Elsensohn, Jessica Cavin Barnes, Jennifer Baltzegar, Michael S Jones and Jayce Sudweeks Published online 07.08.2017 Using CRISPR‐based gene drive for agriculture pest control Response by the authors. Virginie Courtier‐Orgogozo, Baptiste Morizot and Christophe Boëte Published online 07.08.2017 Science & Society The problem with pseudoscience: Pseudoscience is not the antithesis of professional science but thrives in science's shadow Pseudoscience has been the bane of science since the latter became a professional activity. Rather than dismissing it as wrong, the more efficient way of dealing with pseudoscience's false claims is to stress the nature of science itself with all its problems and pitfalls. Michael D Gordin Published online 09.08.2017 Marching for the myth of science: A self‐destructive celebration of scientific exceptionalism The Marches for Science this April celebrated the unique role of science as well as nerd culture. But their portrayal of science's exceptionalism and elitism did little to convince citizens wary of how science affects politics and their lives. Bart Penders Published online 18.08.2017 Expanding the 3R principles: More rigour and transparency in research using animals The implementation of the 3R in research using animals has already improved animal welfare and benefited science. Further progress could be achieved by expanding the 3R to include “Robustness” and “Reproducibility”. Kim Charles Aske and Courtney Alice Waugh Published online 25.07.2017 The reproducibility “crisis”: Reaction to replication crisis should not stifle innovation The purported reproducibility crisis has triggered both studies to analyze the problem and proposals to address it. However, it is important to not stifle exploratory, cutting‐edge research. Philip Hunter Published online 09.08.2017 Review Animal regeneration: ancestral character or evolutionary novelty? Jonathan Slack discusses recent evidence from diverse animal models suggesting that whole body regeneration is an ancestral trait while appendage regrowth is adaptive. Jonathan MW Slack Published online 26.07.2017 Scientific Reports Loss of the canonical spindle orientation function in the Pins/LGN homolog AGS3 Using planar divisions in the vertebrate neuroepithelium as a model, the authors uncover multiple differences that contribute to the functional divergence of AGS3 and LGN, the two vertebrate homologs of Drosophila Pins. Mehdi Saadaoui, Daijiro Konno, Karine Loulier, Rosette Goiame, Vaibhav Jadhav, Marina Mapelli, Fumio Matsuzaki and Xavier Morin Published online 06.07.2017 The ciliary membrane‐associated proteome reveals actin‐binding proteins as key components of cilia Primary cilia are important mediators of human disease and cell signaling. A local proximity labeling strategy to identify the ciliary membrane‐associated proteome (cmAPEX) reveals the close association of actin binding proteins with the ciliary membrane. Priyanka Kohli, Martin Höhne, Christian Jüngst, Sabine Bertsch, Lena K Ebert, Astrid C Schauss, Thomas Benzing, Markus M Rinschen and Bernhard Schermer Published online 14.07.2017 Aβ seeding potency peaks in the early stages of cerebral β‐amyloidosis The highest biological seeding activity of Aβ occurs at the onset of plaque deposition. This points to the need for therapeutic targeting of Aβ at the very early stages of Alzheimer's disease. Lan Ye, Jay Rasmussen, Stephan A Kaeser, Anne‐Marie Marzesco, Ulrike Obermüller, Jasmin Mahler, Juliane Schelle, Jörg Odenthal, Christian Krüger, Sarah K Fritschi, Lary C Walker, Matthias Staufenbiel, Frank Baumann and Mathias Jucker Published online 12.07.2017 Articles Identification of a novel population of highly cytotoxic c‐Met‐expressing CD8+ T lymphocytes Cytotoxic T lymphocytes (CTLs) play a critical role in cancer immunity. A fraction of murine effector CTLs expresses the HGF receptor c‐Met, and the HGF/c‐MET signaling pathway has a specific role in modulating CTL responses. Mahdia Benkhoucha, Nicolas Molnarfi, Gürkan Kaya, Elodie Belnoue, Kristbjörg Bjarnadóttir, Pierre‐Yves Dietrich, Paul R Walker, Denis Martinvalet, Madiha Derouazi and Patrice H Lalive Published online 27.07.2017 Evolutionary dynamics of the kinetochore network in eukaryotes as revealed by comparative genomics During cell division, the kinetochore connects centromeric DNA to spindle microtubules, which is essential for eukaryotic chromosome segregation. This study uncovers and describes the evolution and diversity of eukaryotic kinetochores by comparative genomics. Jolien JE van Hooff, Eelco Tromer, Leny M van Wijk, Berend Snel and Geert JPL Kops Published online 22.06.2017 Expanding the host cell ubiquitylation machinery targeting cytosolic Salmonella ARIH1 contributes to the formation of an ubiquitin coat on cytosolic S. Typhimurium. Together with LRSAM1 and HOIP, ARIH1 forms a network of E3 ligases that recognize cytosolic bacteria and mediate xenophagic degradation and host immune response. Mira Polajnar, Marina S Dietz, Mike Heilemann and Christian Behrends Published online 06.08.2017 Remodeling of ER‐exit sites initiates a membrane supply pathway for autophagosome biogenesis Autophagosome biogenesis requires membrane supply from the endomembrane system. A starvation‐induced remodeling of the ER‐exit sites, dependent on CTAGE5 and FIP200, initiates the membrane supply process by promoting the relocation of SEC12 to the ERGIC, an essential step for generating the LC3 lipidation membrane. Liang Ge, Min Zhang, Samuel J Kenny, Dawei Liu, Miharu Maeda, Kota Saito, Anandita Mathur, Ke Xu and Randy Schekman Published online 28.07.2017 The miR‐15 family reinforces the transition from proliferation to differentiation in pre‐B cells Pre‐B cells lacking the miR‐15 family display prolonged proliferation and fail to efficiently induce differentiation‐specific transcriptional reprogramming. This results in delayed B‐cell development, and identifies the miR‐15 family as a novel regulator of early B cell lymphopoiesis. Silke E Lindner, Michael Lohmüller, Bianka Kotkamp, Fabian Schuler, Zeynep Knust, Andreas Villunger and Sebastian Herzog Published online 13.07.2017 Allosteric auto‐inhibition and activation of the Nedd4 family E3 ligase Itch Structural and biochemical analyses of the Nedd4 family E3 ligases Itch and WWP1/2 reveal an intramolecular WW‐HECT interaction, suggesting a new mechanism governing the regulation and activation of several Nedd4 family E3s. Kang Zhu, Zelin Shan, Xing Chen, Yuqun Cai, Lei Cui, Weiyi Yao, Zhen Wang, Pan Shi, Changlin Tian, Jizhong Lou, Yunli Xie and Wenyu Wen Published online 26.07.2017 Control of box C/D snoRNP assembly by N6‐methylation of adenine N6‐methylation of adenine disrupts sheared A·G basepairs, but not Watson–Crick pairs. Some human box C/D RNAs are methylated in their k‐turns; this disrupts 15.5k protein binding and folding of the k‐turn, and likely prevents box C/D snoRNP assembly. Lin Huang, Saira Ashraf, Jia Wang and David MJ Lilley Published online 16.06.2017 CircHIPK3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells Circular RNAs are suggested to exert crucial functions in regulating gene expression. Here, deregulated circRNAs in human bladder cancer tissues are identified, and circHIPK3 is shown to act as a tumour suppressive microRNA sponge. Yawei Li, Fuxin Zheng, Xingyuan Xiao, Fei Xie, Dan Tao, Chao Huang, Dong Liu, Miao Wang, Liang Wang, Fuqing Zeng and Guosong Jiang Published online 09.08.2017 Morphology of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis Archaeal motility is driven by rotary motors attached to extracellular filaments. This study presents the morphology of the archaellar basal body and an associated structure, which anchors the archaellar bundle and/or could serve as a polar organizing centre. Ariane Briegel, Catherine M Oikonomou, Yi‐Wei Chang, Andreas Kjær, Audrey N Huang, Ki Woo Kim, Debnath Ghosal, Hong H Nguyen, Dorothy Kenny, Rachel R Ogorzalek Loo, Robert P Gunsalus and Grant J Jensen Published online 19.07.2017 Corrigendum Glioma‐derived cancer stem cells are hypersensitive to proteasomal inhibition Young Dong Yoo, Dae‐Hee Lee, Hyunjoo Cha‐Molstad, Hyungsin Kim, Su Ran Mun, Changhoon Ji, Seong Hye Park, Ki Sa Sung, Seung A Choi, Joonsung Hwang, Deric M Park, Seung Ki Kim, Kyung‐Jae Park, Shin‐Hyuk Kang, Sang Cheul Oh, Aaron Ciechanover, Yong J Lee, Bo Yeon Kim and Yong Tae Kwon Published online 01.09.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.