EMBO reports Table of Contents for August 2017; Vol. 18, No. 8

August 2017 | Volume 18, Number 8 Submit Table of Contents Opinion News & Views Correspondence Science & Society Articles Volume 18, Number 8 Opinion Mitochondrial permeability transition, F1FO‐ATPase and calcium: an enigmatic triangle In response to calcium mitochondria can undergo a permeability transition—a sudden increase of the permeability of the inner mitochondrial membrane to ions and solutes resulting in cell death. Salvatore Nesci discusses recent advances in the identification of the structure that forms the mitochondria permeability transition pore. Salvatore Nesci Published online 25.07.2017 News & Views Tetanus neurotoxin: conformational plasticity as an adaptive strategy A study in this issue describes the structural plasticity of individual domains of the tetanus neurotoxin in response to environmental pH, a key factor modulating transport and action of the toxin. Mauricio Montal Published online 12.07.2017 Correspondence Proactive epigenesis and ethics Comment on “Proactive epigenesis and ethical innovation: A neuronal hypothesis for the genesis of ethical rules”. Arleen Salles Published online 25.07.2017 Response by the authors The response by the authors. Kathinka Evers and Jean‐Pierre Changeux Published online 25.07.2017 Science & Society Archives of and for science: Archives for molecular biology preserve the heritage of science beyond the published record for future scholars Through preservation, cataloguing and guaranteeing the authenticity of historical evidence, scientific archives provide unique insight for future scholars into the history of science. Anne‐Flore Laloë Published online 20.07.2017 GWAS and cognitive abilities: Why correlations are inevitable and meaningless: GWA studies to identify genetic factors for educational achievements largely ignore underlying social structures and dynamics Genomewide association studies that describe genetic variation linked to educational and professional success are heralded as a future basis for personalized learning. Such portents are misleading as these studies do not take more complex social factors into account. Ken Richardson Published online 04.07.2017 Biology goes in the air: Unmanned aerial vehicles offer biologists an efficient tool for observation and sampling from a safe distance Drones are becoming popular among biologists as a tool to observe wildlife, take samples from the air or remote locations, or even perform in‐flight DNA analysis. Howard Wolinsky Published online 25.07.2017 Tackling the great challenges in biology: Beyond evolution, defining the greatest challenges in biology is a challenge itself A ‘Millennium Prize’ for biology could inspire research into the most challenging scientific puzzles. However, the problem starts with defining the most intricate scientific challenges in biology in the first place. Philip Hunter Published online 25.07.2017 Articles Rtt101‐Mms1‐Mms22 coordinates replication‐coupled sister chromatid cohesion and nucleosome assembly Genetic and biochemical assays reveal a role of Cul4‐Ddb1 (yeast Rtt101‐Mms1) ubiquitin ligases in promoting Eco1‐catalyzed Smc3 acetylation and thus sister chromatid cohesion establishment during S phase, which is critical for maintaining chromosome stability. Jingjing Zhang, Di Shi, Xiaoli Li, Lin Ding, Jun Tang, Cong Liu, Katsuhiko Shirahige, Qinhong Cao, and Huiqiang Lou Published online 14.06.2017 The structure of the tetanus toxin reveals pH‐mediated domain dynamics Tetanus toxin is a deadly neurotoxin targeting the central nervous system. The structure of the holotoxin reveals pH‐mediated domain rearrangements important for sorting, stability, receptor‐interactions and the response to the environments encountered during intoxication. Geoffrey Masuyer, Julian Conrad, and Pål Stenmark Published online 23.06.2017 Gli1‐induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1 Inappropriate Hedgehog signaling drives cancer formation. This study identifies USP48 as a new regulator of Gli1 stability and function and provides evidence that the Gli1‐USP48 regulatory axis is required for glioma cell growth and tumorigenesis. Aidong Zhou, Kangyu Lin, Sicong Zhang, Li Ma, Jianfei Xue, Saint‐Aaron Morris, Kenneth D Aldape, and Suyun Huang Published online 16.06.2017 The mutant p53‐ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1 The oncogenic lncRNA MALAT1 controls alternative splicing by modulating the distribution of splicing factors. This study describes a MALAT1‐containing ribonucleoprotein complex, which promotes the expression of pro‐angiogenic VEGFA isoforms in breast cancer. Magdalena Pruszko, Elisa Milano, Mattia Forcato, Sara Donzelli, Federica Ganci, Silvia Di Agostino, Simone De Panfilis, Francesco Fazi, David O Bates, Silvio Bicciato, Maciej Zylicz, Alicja Zylicz, Giovanni Blandino, and Giulia Fontemaggi Published online 26.06.2017 Cellular mechanism of fibril formation from serum amyloid A1 protein Internalization of SAA1 protein via clathrin‐dependent endocytosis leads to formation of intercellular aggregates and cellular toxicity. The aggregates are released into the extracellular space where they initiate the growth of an amyloid deposit. Stephanie Claus, Katrin Meinhardt, Tobias Aumüller, Ioana Puscalau‐Girtu, Julia Linder, Christian Haupt, Paul Walther, Tatiana Syrovets, Thomas Simmet, and Marcus Fändrich Published online 21.06.2017 Perception of root‐active CLE peptides requires CORYNE function in the phloem vasculature The plant membrane receptor kinase BAM3 acts as receptor for the CLE45 peptide ligand independent of SERK family co‐receptor kinases. Moreover, different CLE peptides suppress root growth via inhibition of protophloem development, a process that depends on the pseudokinase CRN. Ora Hazak, Benjamin Brandt, Pietro Cattaneo, Julia Santiago, Antia Rodriguez‐Villalon, Michael Hothorn, and Christian S Hardtke Published online 12.06.2017 Structural and functional analysis of the GABARAP interaction motif (GIM) Mammalian LC3 and GABARAP family proteins interact with autophagy receptors or adaptors via an LC3 interaction region (LIR). This study defines a GABARAP interaction motif (GIM) to aid our understanding of the individual families’ function. Vladimir V Rogov, Alexandra Stolz, Arvind C Ravichandran, Diana O Rios‐Szwed, Hironori Suzuki, Andreas Kniss, Frank Löhr, Soichi Wakatsuki, Volker Dötsch, Ivan Dikic, Renwick CJ Dobson, and David G McEwan Published online 27.06.2017 High‐affinity cooperative Ca2+ binding by MICU1–MICU2 serves as an on–off switch for the uniporter The MICU1–MICU2 heterodimer binds Ca2+ cooperatively with high affinity, which sets a sharp threshold for the uniporter, and allows direct response to cytosolic Ca2+ signals. Interaction with cardiolipin facilitates tethering of MICU1–MICU2 to the inner membrane. Kimberli J Kamer, Zenon Grabarek, and Vamsi K Mootha Published online 14.06.2017 Looping‐out mechanism for resolution of replicative stress at telomeres Replication stress in telomeric DNA is resolved by a “looping‐out” mechanism, in which Topo II excises the stalled fork from the genome, NHEJ cyclizes cut DNA into t‐circle‐tail structures, and broken telomeric DNA is re‐ligated. Tianpeng Zhang, Zepeng Zhang, Feng Li, Qian Hu, Haiying Liu, Mengfan Tang, Wenbin Ma, Junjiu Huang, Zhou Songyang, Yikang Rong, Shichuan Zhang, Benjamin PC Chen, and Yong Zhao Published online 14.06.2017 Murine cytomegalovirus IE3‐dependent transcription is required for DAI/ZBP1‐mediated necroptosis DAI/ZBP1‐mediated necroptosis triggered by cytomegalovirus infection requires nascent transcription mediated by the viral transactivator IE3. The Z‐RNA binding domain of DAI is critical for this, suggesting that DAI acts as an RNA sensor of DNA virus infection. Haripriya Sridharan, Katherine B Ragan, Hongyan Guo, Ryan P Gilley, Vanessa J Landsteiner, William J Kaiser, and Jason W Upton Published online 12.06.2017 A post‐translational modification switch controls coactivator function of histone methyltransferases G9a and GLP Cooperative coactivator activity of G9a and GLP with glucocorticoid receptor and HP1γ is regulated by adjacent methylation and phosphorylation on G9a and GLP, which control binding to HP1γ. G9a, GLP and HP1γ are required for glucocorticoid activation of genes that inhibit cell migration. Coralie Poulard, Danielle Bittencourt, Dai‐Ying Wu, Yixin Hu, Daniel S Gerke, and Michael R Stallcup Published online 14.06.2017 Tctex‐1 controls ciliary resorption by regulating branched actin polymerization and endocytosis Ciliary resorption is causally linked to the G1‐S transition during the cell cycle. This study shows that Tctex‐1 phosphorylated at Thr94 triggers actin polymerization and periciliary endocytosis required for the initial phase of ciliary resorption. Masaki Saito, Wataru Otsu, Kuo‐Shun Hsu, Jen‐Zen Chuang, Teruyuki Yanagisawa, Vincent Shieh, Taku Kaitsuka, Fan‐Yan Wei, Kazuhito Tomizawa, and Ching‐Hwa Sung Published online 12.06.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.