Wednesday, July 19, 2017

Nature Immunology Contents: August 2017 Volume 18 pp 825 - 951

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Focus on Inflammation
Nature Immunology presents a series of specially commissioned articles discussing the newest insights into the tissue-specific characteristics of inflammation, the roles of microbiota and nutrition in driving inflammation, and the mechanistic and genetic bases of inflammation resolution and autoinflammation.



Focus on Inflammation
A current view on inflammation   p825
Evolving mechanistic and conceptual understanding of inflammation drives insight into human disease and new approaches for therapy.



Focus on Inflammation
A guiding map for inflammation   pp826 - 831
Mihai G Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y Donath et al.
Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues.



Focus on Inflammation
The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation   pp832 - 842
Kalpana Manthiram, Qing Zhou, Ivona Aksentijevich and Daniel L Kastner
Kastner and colleagues review monogenic autoinflammatory diseases and their molecular mechanisms and explore the overlap among autoinflammation, autoimmunity and immunodeficiency.

Focus on Inflammation
Nutrition, inflammation and cancer   pp843 - 850
Laurence Zitvogel, Federico Pietrocola and Guido Kroemer
Kroemer and colleagues discuss the mechanisms through which nutrition modulates metabolic, microbial and neuroendocrine circuitries that affect cancer development and the response to treatment.

Focus on Inflammation
Regulation of inflammation by microbiota interactions with the host   pp851 - 860
J Magarian Blander, Randy S Longman, Iliyan D Iliev, Gregory F Sonnenberg and David Artis
Magarian Blander and colleagues review the effects of the microbiome on innate and adaptive immunological players and how microbiota-derived bioactive molecules affect inflammation and the host response to infection, vaccination and cancer.

Focus on Inflammation
Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome   pp861 - 869
Inna S Afonina, Zhenyu Zhong, Michael Karin and Rudi Beyaert
Beyaert, Karin and colleagues discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-κB pathway and the NLRP3 inflammasome.

News and Views


Tumor immunity requires border patrol to fight the enemy within   pp870 - 872
Derk Amsen, Pleun Hombrink and Rene A W van Lier
The infiltration of solid tumors by CD8+ T cells is a favorable prognostic marker. Large-scale transcriptome analysis of tumor-infiltrating T cells from mucosal tumors shows that CD8+ T cells with a CD103+ tissue-resident memory T cell phenotype might be the most desirable.

See also: Article by Ganesan et al.

Counting the cost of lineage decisions   pp872 - 873
Alberto Yáñez, Helen S Goodridge and H Leighton Grimes
Lineage bias among early hematopoietic progenitor cells is specified by transcription-factor programming, and lineage switching reduces the quantity of cells produced.

See also: Article by Lee et al.

Untangling Fc and complement receptors to kill tumors   pp874 - 875
Cees E van der Poel and Michael C Carroll
Uncoupling of activation of Fc receptors via a mutant IgG1 Fc domain shows a direct role for complement receptors in antibody-dependent tumor killing.

See also: Article by Lee et al.

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Research Highlights


Non-inflammatory IFN | Alzheimer's disease microglia | Inducing fetal tolerance | NF-κB citrullination | MAIT cell heterogeneity | Breaking down barriers

Focus on Disease models: reproducibility and translation 

Lab Animal, a Nature Research journal focusing on in vivo methods, research and technology with model organisms of human health & disease, presents a special Focus on reproducibility and translation of in vivo research with disease models. 

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Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors   pp877 - 888
Jaeyop Lee, Yu Jerry Zhou, Wenji Ma, Wanwei Zhang, Arafat Aljoufi et al.
Liu and colleagues show that specification of the dendritic-cell lineage occurs in parallel with specification of the myeloid and lymphoid lineages in or around the hematopoietic-stem-cell stage, starting as a lineage bias defined by transcriptional programs that correlate with the combinatorial dose of IRF8 and PU.1.

See also: News and Views by Yanez et al.

IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions   pp889 - 898
Chang-Han Lee, Gabrielle Romain, Wupeng Yan, Makiko Watanabe, Wissam Charab et al.
Monoclonal antibody (mAb) therapy is now commonplace in the clinic, yet such reagents can elicit unwanted side effects due to interactions with Fcγ receptors. Georgiou and colleagues have engineered mAbs that lack such FcγR interactions but retain the ability to activate complement and show that these modified mAbs have efficacious effector function.

See also: News and Views by van der Poel & Carroll

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense   pp899 - 910
Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata et al.
Various intracellular pathogens attempt to hide from innate cytosolic sensors by forming vacuoles. Yamamoto and colleagues show that the autophagy-related protein Gate-16, which is induced by interferon-γ, is required for noncanonical autophagy to control infection by Toxoplasma gondii.

The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex   pp911 - 920
Elmar Dolezal, Simona Infantino, Friedel Drepper, Theresa Börsig, Aparajita Singh et al.
Expression of a competent Igh heavy chain initiates a pre-BCR checkpoint during B cell development. Reth and colleagues show that protein arginine methylation by a BTG2-PRMT1 complex is required to inactivate CDK4 and thereby establish pre-B cell arrest.

Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells   pp921 - 930
Yifeng Wang, Jingwen Shi, Jiacong Yan, Zhengtao Xiao, Xiaoxiao Hou et al.
Germinal centers generate high-affinity memory B cells. Qi and colleagues identify a precursor of memory B cells in germinal centers and demonstrate that the cytokine IL-9-derived from follicular helper T cells is important for their development into full-fledged memory cells.

The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage   pp931 - 939
Qiang Shan, Zhouhao Zeng, Shaojun Xing, Fengyin Li, Stacey M Hartwig et al.
Xue and colleagues show that Runx3-/- CD8+ T effector cells aberrantly upregulate genes characteristic of TFH cell lineage and exhibit impaired induction of cytotoxic molecules.

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer   pp940 - 950
Anusha-Preethi Ganesan, James Clarke, Oliver Wood, Eva M Garrido-Martin, Serena J Chee et al.
Vijayanand and colleagues use genome-wide RNA sequencing for transcriptional profiling of CD8+ T cells from tumors and adjacent uninvolved lung tissue from patients with early-stage lung cancer. A tissue-resident memory signature is associated with enhanced cytotoxicity and improved survival.

See also: News and Views by Amsen et al.

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Corrigendum: TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells   p951
Joshua A Vieth, Joy Das, Fanomezana M Ranaivoson, Davide Comoletti, Lisa K Denzin et al.

Corrigendum: Spontaneous partial loss of the OT-I transgene   p951
Gretchen Harms Pritchard, Eric W Cross, Marjorie Strobel, Stephen C Jameson, Ross M Kedl et al.



Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes   p951
Eliana Mariño, James L Richards, Keiran H McLeod, Dragana Stanley, Yu Anne Yap et al.

Erratum: Ontogeny and homeostasis of CNS myeloid cells   p951
Marco Prinz, Daniel Erny and Nora Hagemeyer

Erratum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth   p951
Liang Chen, Justin E Wilson, Mark J Koenigsknecht, Wei-Chun Chou, Stephanie A Montgomery et al.


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