Nature Immunology Contents: August 2017 Volume 18 pp 825 - 951

If you are unable to see the message below, click here to view.

Advertisement Open for Submissions npj Precision Oncology is a new open access, online-only, peer-reviewed journal committed to publishing cutting-edge scientific research in all aspects of precision oncology from basic science to translational applications, to clinical medicine. The journal is part of the Nature Partner Journals series and published in partnership with The Hormel Institute, University of Minnesota. Explore the benefits of submitting your manuscript. TABLE OF CONTENTS August 2017 Volume 18, Issue 8 Focus Editorial Comment Reviews News and Views Research Highlights Articles Corrigenda Errata Advertisement   Open for Submissions Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care. Explore the benefits of submitting your next research article. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement npj Vaccines is an online-only, open access, multidisciplinary journal dedicated to publishing cutting-edge research and development on human and veterinary vaccines. npj Vaccines is now open for submissions. Explore the benefits of submitting your next manuscript to the journal.   Focus Top Focus on Inflammation Contents Editorial Comment Reviews Nature Immunology presents a series of specially commissioned articles discussing the newest insights into the tissue-specific characteristics of inflammation, the roles of microbiota and nutrition in driving inflammation, and the mechanistic and genetic bases of inflammation resolution and autoinflammation. Editorial Top Focus on Inflammation A current view on inflammation   p825 doi:10.1038/ni.3798 Evolving mechanistic and conceptual understanding of inflammation drives insight into human disease and new approaches for therapy. Comment Top Focus on Inflammation A guiding map for inflammation   pp826 - 831 Mihai G Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y Donath et al. doi:10.1038/ni.3790 Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues. Reviews Top Focus on Inflammation The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation   pp832 - 842 Kalpana Manthiram, Qing Zhou, Ivona Aksentijevich and Daniel L Kastner doi:10.1038/ni.3777 Kastner and colleagues review monogenic autoinflammatory diseases and their molecular mechanisms and explore the overlap among autoinflammation, autoimmunity and immunodeficiency. Focus on Inflammation Nutrition, inflammation and cancer   pp843 - 850 Laurence Zitvogel, Federico Pietrocola and Guido Kroemer doi:10.1038/ni.3754 Kroemer and colleagues discuss the mechanisms through which nutrition modulates metabolic, microbial and neuroendocrine circuitries that affect cancer development and the response to treatment. Focus on Inflammation Regulation of inflammation by microbiota interactions with the host   pp851 - 860 J Magarian Blander, Randy S Longman, Iliyan D Iliev, Gregory F Sonnenberg and David Artis doi:10.1038/ni.3780 Magarian Blander and colleagues review the effects of the microbiome on innate and adaptive immunological players and how microbiota-derived bioactive molecules affect inflammation and the host response to infection, vaccination and cancer. Focus on Inflammation Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome   pp861 - 869 Inna S Afonina, Zhenyu Zhong, Michael Karin and Rudi Beyaert doi:10.1038/ni.3772 Beyaert, Karin and colleagues discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-κB pathway and the NLRP3 inflammasome. News and Views Top Tumor immunity requires border patrol to fight the enemy within   pp870 - 872 Derk Amsen, Pleun Hombrink and Rene A W van Lier doi:10.1038/ni.3792 The infiltration of solid tumors by CD8+ T cells is a favorable prognostic marker. Large-scale transcriptome analysis of tumor-infiltrating T cells from mucosal tumors shows that CD8+ T cells with a CD103+ tissue-resident memory T cell phenotype might be the most desirable. See also: Article by Ganesan et al. Counting the cost of lineage decisions   pp872 - 873 Alberto Yáñez, Helen S Goodridge and H Leighton Grimes doi:10.1038/ni.3794 Lineage bias among early hematopoietic progenitor cells is specified by transcription-factor programming, and lineage switching reduces the quantity of cells produced. See also: Article by Lee et al. Untangling Fc and complement receptors to kill tumors   pp874 - 875 Cees E van der Poel and Michael C Carroll doi:10.1038/ni.3797 Uncoupling of activation of Fc receptors via a mutant IgG1 Fc domain shows a direct role for complement receptors in antibody-dependent tumor killing. See also: Article by Lee et al. Immunology JOBS of the week PhD Student in Immunology Saarland University Chairs for Department of Biochemistry and Molecular Biology and Department of Immunology at Peking University The Peking University Health Science Center Postdoctoral position in mucosal immunology Sainte-Justine Hospital Research Center Postdoc in Precision Immunology Assay Development Icahn School of Medicine at Mount Sinai Post-doctoral Research Scholar - Immunology University of California San Diego (UCSD) More Science jobs from Immunology EVENT Immunology 2018 (CPD accredited) 05.07.18 Vienna, Austria More science events from Research Highlights Top Non-inflammatory IFN | Alzheimer's disease microglia | Inducing fetal tolerance | NF-κB citrullination | MAIT cell heterogeneity | Breaking down barriers Advertisement Focus on Disease models: reproducibility and translation  Lab Animal, a Nature Research journal focusing on in vivo methods, research and technology with model organisms of human health & disease, presents a special Focus on reproducibility and translation of in vivo research with disease models.  Access this Focus > Produced with support from:  Taconic Biosciences, Inc.  Charles River   Articles Top Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors   pp877 - 888 Jaeyop Lee, Yu Jerry Zhou, Wenji Ma, Wanwei Zhang, Arafat Aljoufi et al. doi:10.1038/ni.3789 Liu and colleagues show that specification of the dendritic-cell lineage occurs in parallel with specification of the myeloid and lymphoid lineages in or around the hematopoietic-stem-cell stage, starting as a lineage bias defined by transcriptional programs that correlate with the combinatorial dose of IRF8 and PU.1. See also: News and Views by Yanez et al. IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions   pp889 - 898 Chang-Han Lee, Gabrielle Romain, Wupeng Yan, Makiko Watanabe, Wissam Charab et al. doi:10.1038/ni.3770 Monoclonal antibody (mAb) therapy is now commonplace in the clinic, yet such reagents can elicit unwanted side effects due to interactions with Fcγ receptors. Georgiou and colleagues have engineered mAbs that lack such FcγR interactions but retain the ability to activate complement and show that these modified mAbs have efficacious effector function. See also: News and Views by van der Poel & Carroll Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense   pp899 - 910 Miwa Sasai, Naoya Sakaguchi, Ji Su Ma, Shuhei Nakamura, Tsuyoshi Kawabata et al. doi:10.1038/ni.3767 Various intracellular pathogens attempt to hide from innate cytosolic sensors by forming vacuoles. Yamamoto and colleagues show that the autophagy-related protein Gate-16, which is induced by interferon-γ, is required for noncanonical autophagy to control infection by Toxoplasma gondii. The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex   pp911 - 920 Elmar Dolezal, Simona Infantino, Friedel Drepper, Theresa Börsig, Aparajita Singh et al. doi:10.1038/ni.3774 Expression of a competent Igh heavy chain initiates a pre-BCR checkpoint during B cell development. Reth and colleagues show that protein arginine methylation by a BTG2-PRMT1 complex is required to inactivate CDK4 and thereby establish pre-B cell arrest. Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells   pp921 - 930 Yifeng Wang, Jingwen Shi, Jiacong Yan, Zhengtao Xiao, Xiaoxiao Hou et al. doi:10.1038/ni.3788 Germinal centers generate high-affinity memory B cells. Qi and colleagues identify a precursor of memory B cells in germinal centers and demonstrate that the cytokine IL-9-derived from follicular helper T cells is important for their development into full-fledged memory cells. The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage   pp931 - 939 Qiang Shan, Zhouhao Zeng, Shaojun Xing, Fengyin Li, Stacey M Hartwig et al. doi:10.1038/ni.3773 Xue and colleagues show that Runx3-/- CD8+ T effector cells aberrantly upregulate genes characteristic of TFH cell lineage and exhibit impaired induction of cytotoxic molecules. Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer   pp940 - 950 Anusha-Preethi Ganesan, James Clarke, Oliver Wood, Eva M Garrido-Martin, Serena J Chee et al. doi:10.1038/ni.3775 Vijayanand and colleagues use genome-wide RNA sequencing for transcriptional profiling of CD8+ T cells from tumors and adjacent uninvolved lung tissue from patients with early-stage lung cancer. A tissue-resident memory signature is associated with enhanced cytotoxicity and improved survival. See also: News and Views by Amsen et al. Advertisement Thousands of single cells. One solution.  Gain high-resolution insight into gene expression with a single comprehensive workflow from Illumina and Bio-Rad.  Learn more   Corrigenda Top Corrigendum: TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells   p951 Joshua A Vieth, Joy Das, Fanomezana M Ranaivoson, Davide Comoletti, Lisa K Denzin et al. doi:10.1038/ni0817-951a Corrigendum: Spontaneous partial loss of the OT-I transgene   p951 Gretchen Harms Pritchard, Eric W Cross, Marjorie Strobel, Stephen C Jameson, Ross M Kedl et al. doi:10.1038/ni0817-951b Errata Top Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes   p951 Eliana Mariño, James L Richards, Keiran H McLeod, Dragana Stanley, Yu Anne Yap et al. doi:10.1038/ni0817-951c Erratum: Ontogeny and homeostasis of CNS myeloid cells   p951 Marco Prinz, Daniel Erny and Nora Hagemeyer doi:10.1038/ni0817-951d Erratum: NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth   p951 Liang Chen, Justin E Wilson, Mark J Koenigsknecht, Wei-Chun Chou, Stephanie A Montgomery et al. doi:10.1038/ni0817-951e Top Advertisement HIV IMMUNITY AND ERADICATION, A HERRENHAUSEN SYMPOSIUM November 2-3, 2017 | Hanover, Germany REGISTER NOW!   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.