Nature Biotechnology Contents: Volume 35 pp 597 - 688

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Advertisement From Bench to Bedside and Back Again Charles River has proudly partnered with the EBD Group to provide the scientific program for this year's BioPharm America™ Conference. Be a part of this two-day conference that aims to bridge the gap between drug discovery and clinical application. Register now>> TABLE OF CONTENTS July 2017 Volume 35, Issue 7 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Research Careers and Recruitment Advertisement   TLC/MS for Real-Time Reaction Monitoring of a Solution-Phase Peptide Synthesis Real-time reaction monitoring based on a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way to identify reactants, products and side products of a chemical peptide synthesis reaction, providing detailed analyte detection. Learn more. Japanese table of contents Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Outlook: University Spin-offs  This Outlook presents a portrait of 22 science-based start-up ventures that have emerged from universities around the world to turn laboratory research into practical, profitable products.  Access the Outlook free online for six months.    Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Index China 2017 China continues to increase its global share of research papers, but publication numbers are just one indicator that a country's science is thriving. Read the full supplement free for six months   Advertisement NATURE CONFERENCE ON INFLAMMATORY DISEASES Presented by: Chinese Academy of Medical Sciences & Peking Union Medical College | Chinese Society for Immunology (CSI) | Nature Reviews Immunology | Nature Immunology | Nature | Nature Communications This conference will feature sessions on microbiota, cell death, metabolism, technologies, and innate sensing and signaling as they relate to inflammatory diseases and cancer. September 17-20, 2017 | Beijing, China REGISTER NOW!   Editorial Top Wanted: biotech for an aging population   p597 doi:10.1038/nbt.3925 Digital medicine's extraordinary ability to communicate with patients, especially in under-served communities, could help reorient the biotech industry to better address aging and its associated diseases. News Top CAR-Ts move beyond B-cell cancers to myeloma   pp599 - 601 Elie Dolgin doi:10.1038/nbt0717-599 First state-approved embryonic stem cell trials in China   p600 doi:10.1038/nbt0717-600 Merck KGaA, F-Star shake on immune-oncology bispecifics   p601 doi:10.1038/nbt0717-601 Faster, deeper, smaller—the rise of antibody-like scaffolds   pp602 - 603 Brian Owens doi:10.1038/nbt0717-602 AI-powered drug discovery captures pharma interest   pp604 - 605 Eric Smalley doi:10.1038/nbt0717-604 FDA deems in vitro data on mutations sufficient to expand cystic fibrosis drug label   p606 Mark Ratner doi:10.1038/nbt0717-606 Around the world in a month   p607 doi:10.1038/nbt0717-607 Advertisement Enhanced MALDI-TOF MS Performance and Flexibility  From a linear-only system to a unique QIT-TOF configuration to a high-resolution, high-energy TOF-TOF, Shimadzu's suite of MALDI mass spectrometers easily meets the needs of researchers with varying applications and budgets. Mine your data using our comprehensive software solutions. Learn more. Bioentrepreneur Top Building a business An emerging model for life sciences commercialization   pp608 - 613 Ashley J Stevens doi:10.1038/nbt.3911 Podcast First rounders: Jan Vilcek   p613 doi:10.1038/nbt.3910 Opinion and Comment Top Correspondence Payer coverage policies for multigene tests   pp614 - 617 Kathryn A Phillips, Patricia A Deverka, Julia R Trosman, Michael P Douglas, James D Chambers et al. doi:10.1038/nbt.3912 Consent and engagement, security, and authentic living using wearable and mobile health technology   pp617 - 620 Karola V Kreitmair, Mildred K Cho and David C Magnus doi:10.1038/nbt.3887 FDA is the wrong agency to regulate genetically engineered animals   pp620 - 622 John J Cohrssen and Henry I Miller doi:10.1038/nbt.3915 Features Top Public biotech in 2016—the numbers   pp623 - 629 Chris Morrison and Riku Lahteenmaki doi:10.1038/nbt.3917 The anticipated decline in the biotech industry's ability to raise capital from public investors and an accompanying slump in biotech markets materialized in 2016, but all is not gloom and doom. Patents CRISPR-Cas9 claim sets and the potential to stifle innovation   pp630 - 633 Benjamin N Gray and W Murray Spruill doi:10.1038/nbt.3913 Extremely broad claims surrounding Cas9 nucleases have the potential to stifle innovation in the field of genome editing. Recent patents in optogenetics and optochemistry   p634 doi:10.1038/nbt.3922 Advertisement Focus on Disease models: reproducibility and translation  Lab Animal, a Nature Research journal focusing on in vivo methods, research and technology with model organisms of human health & disease, presents a special Focus on reproducibility and translation of in vivo research with disease models.  Access this Focus > Produced with support from:  Taconic Biosciences, Inc.   Charles River   News and Views Top Single-cell genomics for the masses   pp635 - 636 Susannah G Tringe doi:10.1038/nbt.3914 Microbial communities are rapidly sequenced at the single-cell level using droplet microfluidics. See also: Research by Lan et al. Algal oil productivity gets a fat bonus   pp636 - 638 Matthew C Posewitz doi:10.1038/nbt.3920 Partitioning of carbon to lipids is engineered to improve oil accumulation in an industrial alga. See also: Research by Ajjawi et al. Research Highlights   p638 doi:10.1038/nbt.3921 Permeability rules for antibiotic design   p639 Susan Jones doi:10.1038/nbt.3919 Research Top Articles Single-cell genome sequencing at ultra-high-throughput with microfluidic droplet barcoding   pp640 - 646 Freeman Lan, Benjamin Demaree, Noorsher Ahmed and Adam R Abate doi:10.1038/nbt.3880 More than 50,000 single-cell genomes are sequenced in a single run using droplet barcoding. See also: News and Views by Tringe Lipid production in Nannochloropsis gaditana is doubled by decreasing expression of a single transcriptional regulator   pp647 - 652 Imad Ajjawi, John Verruto, Moena Aqui, Leah B Soriaga, Jennifer Coppersmith et al. doi:10.1038/nbt.3865 Lipid production in the oleaginous microalga Nannocholoropsis gaditana is doubled by decreasing the expression of a transcriptional regulator identified through a CRISPR-Cas9 reverse-genetics approach. See also: News and Views by Posewitz Letters Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation   pp653 - 658 David T Riglar, Tobias W Giessen, Michael Baym, S Jordan Kerns, Matthew J Niederhuber et al. doi:10.1038/nbt.3879 An engineered commensal E. coli strain can function as a living diagnostic for a marker of inflammation in the murine gut for 200 days. Guided self-organization and cortical plate formation in human brain organoids   pp659 - 666 Madeline A Lancaster, Nina S Corsini, Simone Wolfinger, E Hilary Gustafson, Alex W Phillips et al. doi:10.1038/nbt.3906 Engineering human brain organoids with floating scaffolds enhances the maturity and reproducibility of cortical tissue structure. Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site   pp667 - 671 Eva-Maria Strauch, Steffen M Bernard, David La, Alan J Bohn, Peter S Lee et al. doi:10.1038/nbt.3907 A method to target trimeric membrane proteins by designing geometrically matched trimeric protein binders is demonstrated for the influenza-virus glycoprotein hemagglutinin. Digital-to-biological converter for on-demand production of biologics   pp672 - 675 Kent S Boles, Krishna Kannan, John Gill, Martina Felderman, Heather Gouvis et al. doi:10.1038/nbt.3859 Sequence information is converted into nucleic acids, proteins and phage particles without human intervention to enable on-demand bio-manufacturing. Resources 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life OPEN   pp676 - 683 Supratim Mukherjee, Rekha Seshadri, Neha J Varghese, Emiley A Eloe-Fadrosh, Jan P Meier-Kolthoff et al. doi:10.1038/nbt.3886 Metagenomic and microbial sequence data are made easier to interpret with the addition of 1,003 genomes to the Genomic Encyclopedia of Bacteria and Archaea. Careers and Recruitment Top Unlocking Big Data for better health   pp684 - 686 Steven Munevar doi:10.1038/nbt.3918 As the volume of biomedical data being created grows, so does the need for data analytics training for life science researchers. People People   p688 doi:10.1038/nbt.3924 Advertisement Nature Awards for Mentoring in Science — Spain Your mentor could win €10,000 Nominations are now open   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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