| | | | | Table of ContentsNews & Views Review Articles Corrigenda | Volume 36, Number 11 | News & Views | ER–mitochondria contacts control glycan surface expression and immune sensitivity of glioma stem cells. Sowmya Lakshminarayanan and Luca Scorrano Published online 16.03.2017 | | A single fly protein combines the respective roles of vertebrate sororin and shugoshin in establishment and protection of sister chromatid cohesion. Adele L Marston Published online 08.05.2017 | | Intragenic DNA methylation by DNMT3B prevents spurious transcription initiation in murine embryonic stem cells. Aurélie Teissandier and Déborah Bourc'his Published online 25.04.2017 | Review | As part of our metabolism focus, this review provides an overview of cellular and molecular mechanisms that regulate brain energy metabolism and how such mechanisms are altered during aging and disease. Simonetta Camandola and Mark P Mattson Published online 24.04.2017 | Articles | The increased immune sensitivity of glioma stem‐like cells is linked to mitochondrial morphology and dynamics, which affect presentation of sialylated glycan markers. Esen Yonca Bassoy, Atsuko Kasahara, Valentina Chiusolo, Guillaume Jacquemin, Emma Boydell, Sebastian Zamorano, Cristina Riccadonna, Serena Pellegatta, Nicolas Hulo, Valérie Dutoit, Madiha Derouazi, Pierre Yves Dietrich, Paul R Walker, and Denis Martinvalet Published online 10.03.2017 | | The ortholog of vertebrate sororin combines classical Wapl‐counteracting functions for mitotic cohesin establishment with shugoshin‐like, heterochromatin‐dependent cohesin maintenance activities. Takashi Yamada, Eri Tahara, Mai Kanke, Keiko Kuwata, and Tomoko Nishiyama Published online 08.05.2017 | | In addition to activating expression of brown fat‐specific genes, PRDM16 prevents the induction of type I interferon‐stimulated genes, thereby ensuring maintenance of mitochondrial function and brown and beige adipocyte character. Megan Kissig, Jeff Ishibashi, Matthew J Harms, Hee‐Woong Lim, Rachel R Stine, Kyoung‐Jae Won, and Patrick Seale Published online 13.04.2017 | | Mitofusin 2 (Mfn2) is critical for brown adipose tissue thermogenic function and participates in the functional relationship between mitochondria and lipid droplets. Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valera‐Alberni, Roy Combe, Antonio Zorzano, and Carles Cantó | | Oceanic algae can be metabolically re‐wired for lipid production. In the unicellular photosynthetic eukaryote P. tricornutum, the widely conserved transcription factor bZIP14 is linked to TCA cycle modulation upon reduced nitrogen availability and diurnal changes. Michiel Matthijs, Michele Fabris, Toshihiro Obata, Imogen Foubert, José Manuel Franco‐Zorrilla, Roberto Solano, Alisdair R Fernie, Wim Vyverman, and Alain Goossens Published online 18.04.2017 | | Electron cryotomography of intact Gram‐negative bacteria shows asymmetric initiation of the division furrow, accompanied by localized peptidoglycan synthesis and incomplete FtsZ ring formation. Qing Yao, Andrew I Jewett, Yi‐Wei Chang, Catherine M Oikonomou, Morgan Beeby, Cristina V Iancu, Ariane Briegel, Debnath Ghosal, and Grant J Jensen Published online 24.04.2017 | | The core domain of RNA helicase Sen1 displays unique structural features that contribute to RNA unwinding activity and transcription termination, and explains the impact of patient mutations from the human ortholog senataxin. Bronislava Leonaitė, Zhong Han, Jérôme Basquin, Fabien Bonneau, Domenico Libri, Odil Porrua, and Elena Conti | | Formation of a ssDNA gap and involvement of PARP1, RECQ1 and ERCC1‐XPF in response to various forms of oxidative and alkylation damage challenge current models of mammalian base excision repair. Jordan Woodrick, Suhani Gupta, Sharon Camacho, Swetha Parvathaneni, Sujata Choudhury, Amrita Cheema, Yi Bai, Pooja Khatkar, Hayriye Verda Erkizan, Furqan Sami, Yan Su, Orlando D Schärer, Sudha Sharma, and Rabindra Roy Published online 03.04.2017 | | Reversible ubiquitination controls dynamic SMAD4 activity in mESCs and zebrafish, showing that the SMURF2 ubiquitin ligase is not only involved in initiation but also in termination of TGF‐β family signaling. Fangfang Zhou, Feng Xie, Ke Jin, Zhengkui Zhang, Marcello Clerici, Rui Gao, Maarten van Dinther, Titia K Sixma, Huizhe Huang, Long Zhang, and Peter ten Dijke Published online 03.05.2017 | Corrigenda | Karen Castillo, Diego Rojas‐Rivera, Fernanda Lisbona, Benjamín Caballero, Melissa Nassif, Felipe A Court, Sebastian Schuck, Consuelo Ibar, Peter Walter, Jimena Sierralta, Alvaro Glavic, and Claudio Hetz Published online 01.06.2017 | | Éva Várallyay, Anna Válóczi, Ákos Ágyi, József Burgyán, and Zoltán Havelda Published online 01.06.2017 | | | |
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