Nature Structural & Molecular Biology Contents: 2017 Volume #24 pp 491 - 553

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Advertisement npj Molecular Phenomics is an online-only, open access journal that provides a forum for cutting-edge scientific advances in the emerging field of phenomics, the study of the physical and chemical characteristics of an individual in quantitative terms. Part of the Nature Partner Journals series, npj Molecular Phenomics is published in partnership with Fudan University. The journal is now open for submissions.  Find out more >>> TABLE OF CONTENTS June 2017 Volume 24, Issue 6 Meeting Report News and Views Perspective Articles Erratum Corrigendum Advertisement   Collection: On Growth and Form Centenary Join Nature in celebrating the centenary of D'Arcy Wentworth Thompson's seminal publication "On Growth and Form". We present an online collection of research and comment reflecting the diversity of explorative activity across the physical and biological sciences over the past 100 years.  Access the On Growth and Form Centenary Collection Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Special offer! Recruit for less this summer!  10% discount on our Enhanced job posting package  20% discount on our Premium job posting package Be displayed alongside relevant content across nature.com reaching a potential audience of 10.8 million users.* Post a job now. * Publisher data 2016 Offer ends June 19, 2017   Advertisement Nature Reviews Microbiology: Collection on Antimicrobial Resistance  This collection of articles from several Nature journals describes how antimicrobial resistance emerges and details discovery strategies for urgently needed new antimicrobials.  Access this collection free online for six months Produced with support from  Merck & Co., Inc., Kenilworth, NJ, USA   Meeting Report Top Gathering by the Red Sea highlights links between environment and epigenetics   pp491 - 493 Mo Li, Emiliana Borrelli, Pierre J Magistretti, Juan Carlos Izpisua Belmonte, Paolo Sassone-Corsi et al. doi:10.1038/nsmb.3422 The number of conferences on epigenetics has been increasing in the past decade, underscoring the impact of the field on a variety of areas in biology and medicine. However, the mechanistic role of the epigenome in adaptation and inheritance, and how the environment may impinge on epigenetic control, are topics of growing debate. Those themes were the focus of the inaugural international King Abdullah University of Science and Technology (KAUST) Research Conference on Environmental Epigenetics in Saudi Arabia, where more than 100 participants from 19 countries enjoyed vibrant scientific discussions and a pleasant February breeze from the Red Sea. News and Views Top Promoter interactions direct chromatin folding in embryonic stem cells   pp494 - 495 Swastika Sanyal, Lucia Molnarova and Juraj Gregan doi:10.1038/nsmb.3421 The spatial organization of the genome profoundly influences how genes are regulated in normal development or dysregulated in disease. A new study of the murine HoxB locus illustrates how promoter interactions direct higher-order chromatin folding. See also: Article by Barbieri et al. Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism   pp496 - 498 Reyad A Elbarbary and Lynne E Maquat doi:10.1038/nsmb.3416 Two new studies show that RNA-binding proteins can mediate distinct and beneficial effects to cells by binding to the extensive double-stranded RNA (dsRNA) structures of inverted-repeat Alu elements (IRAlus). One study reports stress-induced export of the 110-kDa isoform of the adenosine deaminase acting on RNA 1 protein (ADAR1p110) to the cytoplasm, where it binds IRAlus so as to protect many mRNAs encoding anti-apoptotic proteins from degradation. The other study demonstrates that binding of the nuclear helicase DHX9 to IRAlus embedded within RNAs minimizes defects in RNA processing. See also: Article by Sakurai et al. A glimpse into chromatin remodeling   pp498 - 500 Dale B Wigley and Gregory D Bowman doi:10.1038/nsmb.3415 Chromatin remodelers are ATP-driven enzymes that can slide nucleosomes along DNA. Chen and colleagues present a tantalizing ~4-A view of the SWI/SNF ATPase motor bound to the nucleosome, which offers novel structural clues into the remodeling process. Frozen in action: cryo-EM structure of a GPCR-G-protein complex   pp500 - 502 Mithu Baidya, Hemlata Dwivedi and Arun K Shukla doi:10.1038/nsmb.3418 Interaction with heterotrimeric G proteins is a hallmark of G-protein-coupled receptor (GPCR) family members, and it is the key step for a diverse range of cell-signaling cascades. A recent cryo-EM structure of the human calcitonin receptor (CTR) in complex with a G-protein heterotrimer reveals novel insights into receptor-G-protein coupling. RNA base-pairing drives phase transitions   p502 Anke Sparmann doi:10.1038/nsmb.3425 Structural & Molecular Biology JOBS of the week Post-doctoral Positions in Skeletal muscle Stem Cells and molecular medicine Biology of the neuromuscular system Team IMRB U955-E10 POSTDOC in Cardiopulmonary Molecular Biology Hannover Medical School (MHH) A Postdoctoral Research Fellow position is available in the laboratory of Dr. Karen Mann, Department of Molecular Oncology and Cancer Biology and Evolution Program Moffitt Cancer Center Director for the Molecular Oncology Programme Spanish National Research Centre (CNIO) Molecular Geneticist / Computational Biologist Deep Genomics More Science jobs from Structural & Molecular Biology EVENT The 3rd Conference on Advances in Biochemistry and Molecular Biology (CABMB 2017) 01.12.17 Sanya, China More science events from Perspective Top DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?   pp503 - 506 Guan-Zheng Luo and Chuan He doi:10.1038/nsmb.3412 The DNA-adenine modification 6mA has recently been identified in metazoans. This Perspective summarizes the latest discoveries and suggests potential functional roles for 6mA in metazoan genomes. Advertisement nature.com webcasts Springer Nature presents a custom webcast by Professor Aude Chapuis, MD on harnessing the therapeutic potential of adoptively transferred cells. Register for FREE Date: Thursday, June 22 2017 Time: 11AM PDT | 2PM EDT Register  Sponsored by:  10x Genomics   Articles Top Human CTP synthase filament structure reveals the active enzyme conformation   pp507 - 514 Eric M Lynch, Derrick R Hicks, Matthew Shepherd, James A Endrizzi, Allison Maker et al. doi:10.1038/nsmb.3407 The human enzyme CTP synthase forms polymeric filaments with increased catalytic activity, in contrast to the inactive filaments formed by bacterial CTP synthase. Cryo-EM and crystallographic analyses explain the structural bases for those different behaviors. Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells   pp515 - 524 Mariano Barbieri, Sheila Q Xie, Elena Torlai Triglia, Andrea M Chiariello, Simona Bianco et al. doi:10.1038/nsmb.3402 Homotypic interactions between active and Polycomb-repressed promoters co-occurring in the same DNA fiber, rather than CTCF occupancy, explain the 3D HoxB folding pattern. See also: News and Views by Sanyal et al. The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations   pp525 - 533 Suman Nag, Darshan V Trivedi, Saswata S Sarkar, Arjun S Adhikari, Margaret S Sunitha et al. doi:10.1038/nsmb.3408 A working model for β-cardiac myosin in the sequestered state and binding assays reveal interactions between the myosin head and tail that are disrupted by mutations associated with hypertrophic cardiomyopathy. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay   pp534 - 543 Masayuki Sakurai, Yusuke Shiromoto, Hiromitsu Ota, Chunzi Song, Andrew V Kossenkov et al. doi:10.1038/nsmb.3403 In stressed cells, the ADAR1p110 isoform is phosphorylated and translocated from the nucleus to the cytoplasm, where it protects transcripts with 3′-UTR dsRNA structures from Staufen1-mediated decay, thus suppressing cellular apoptosis. See also: News and Views by Elbarbary & Maquat 5-Formylcytosine does not change the global structure of DNA   pp544 - 552 Jack S Hardwick, Denis Ptchelkine, Afaf H El-Sagheer, Ian Tear, Daniel Singleton et al. doi:10.1038/nsmb.3411 X-ray crystallography and NMR analysis demonstrate that, contrary to previous observations, fC does not significantly alter DNA structure, thus suggesting an alternative basis for recognition of fC-DNA by epigenome-modifying enzymes. Advertisement Special offer! Recruit for less this summer!  10% discount on our Enhanced job posting package  20% discount on our Premium job posting package Be displayed alongside relevant content across nature.com reaching a potential audience of 10.8 million users.* Post a job now. * Publisher data 2016 Offer ends June 19, 2017   Erratum Top Erratum: Molecular basis of telomere dysfunction in human genetic diseases   p553 Grzegorz Sarek, Paulina Marzec, Pol Margalef and Simon J Boulton doi:10.1038/nsmb0617-553a Top Corrigendum Top Corrigendum: Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer   p553 Qingbo Liu, Priyamvada Acharya, Michael A Dolan, Peng Zhang, Christina Guzzo et al. doi:10.1038/nsmb0617-553b Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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