Nature Reviews Molecular Cell Biology contents July 2017 Volume 18 Number 7 pp 403-465

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TABLE OF CONTENTS
July 2017 Volume 18 Number 7		Advertisement
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews Also this month Article series: RNA processing and modifications Post-translational modifications  Featured article: Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes Cedric R. Clapier Janet Iwasa Bradley R. Cairns & Craig L. Peterson	Springer Nature presents a custom webcast by Professor Aude Chapuis, MD on harnessing the therapeutic potential of adoptively transferred cells. Date: Thursday, June 22 2017 Time: 11AM PDT | 2PM EDT  Register for FREE Sponsored by:  10x Genomics
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RESEARCH HIGHLIGHTS Top Stem cells: Stem cell-based therapies threatened by the accumulation of p53 mutations p403 | doi:10.1038/nrm.2017.52 Cultured pluripotent stem cells can accumulate TP53 mutations, and these mutations confer a strong selective advantage to these cells. PDF Autophagy: Membrane contacts lend a hand p404 | doi:10.1038/nrm.2017.55 Extended synaptotagmins that tether ER and cell membranes also promote autophagy by regulating phosphoinositide 3-kinase. PDF Transcription: Paused means poised p404 | doi:10.1038/nrm.2017.57 Promoter-proximal pausing of RNA polymerase II inhibits transcription reinitiation, especially in genes with lower steady-state expression levels. PDF Gene expression: ACSS2 boosts local histone acetylation p405 | doi:10.1038/nrm.2017.61 During metabolic stress in cancer cells, ACSS2 binds to TFEB to locally boost the production of acetyl-CoA, thereby facilitating the expression of lysosomal and autophagy genes. PDF JOURNAL CLUB Cytoplasmic movements outside the living cell p406 | doi:10.1038/nrm.2017.54 Thomas D. Pollard discusses the early work of Thompson and Wolpert on cytoplasmic extract from amoebae, which laid the foundation for studies of actin-driven cell motility. PDF Translation: RAPping with ribosomes p406 | doi:10.1038/nrm.2017.62 Various proteins interact with ribosomes [mdash] this ribosome-protein interactome functionally diversifies ribosomes, thereby providing an additional means of translation regulation. PDF Molecular Cell Biology JOBS of the week Postdoctoral position in Experimental Immunology Universität Basel Research Fellow Longwood Medical Area (Dana-Farber Cancer Institute) Postdoctoral Fellow in Interneuron Development National Institute of Child Health and Human Development (NICHD) Postdoctoral fellowship in Tissue Fibrosis University of California - San Francisco Multiple Opportunities in Molecular Neuroscience Loyola University Chicago - Stritch School of Medicine More Science jobs from Molecular Cell Biology EVENT Molecular Perspectives on Protein-Protein Interactions (PPI2017) 03.12.17 Eilat, Israel More science events from
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REVIEWS		Top
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes Cedric R. Clapier, Janet Iwasa, Bradley R. Cairns & Craig L. Peterson p407 | doi:10.1038/nrm.2017.26 Nucleosome-remodelling complexes can slide or eject histones, or incorporate histone variants, but they share an ATPase-translocase 'motor' and a common DNA translocation mechanism. In a unifying 'hourglass' model of remodeller function, the different remodeller subfamilies use different modules for targeting to nucleosomes but converge on a DNA translocation mechanism and then diverge again to achieve various outcomes. Abstract | Full Text | PDF | Supplementary information
The development and functions of multiciliated epithelia Nathalie Spassky & Alice Meunier p423 | doi:10.1038/nrm.2017.21 Multiciliated cells line the lumen of the vertebrate central nervous system and respiratory and reproductive tracts, where the unidirectional beating of cilia assemblies supports the polarized flow of fluids or movement of cells or particles. Recent studies shed new light on how multiciliated cells arise and how they function. Abstract | Full Text | PDF
Article series: RNA processing and modifications Alternative splicing as a regulator of development and tissue identity Francisco E. Baralle & Jimena Giudice p437 | doi:10.1038/nrm.2017.27 Alternative splicing expands the complexity of the proteome by generating multiple transcript isoforms from a single gene. Numerous alternative splicing events occur during cell differentiation and tissue maturation, suggesting that alternative splicing supports proper development. Recent studies shed light on how alternative splicing and its coordination contribute to organ development and tissue homeostasis. Abstract | Full Text | PDF | Supplementary information
Article series: Post-translational modifications Protein O-GlcNAcylation: emerging mechanisms and functions Xiaoyong Yang & Kevin Qian p452 | doi:10.1038/nrm.2017.22 Many cellular proteins are reversibly modified by O-linked N-acetylglucosamine (O-GlcNAc) moieties on Ser and Thr residues. Studies on the mechanisms and functions of O-GlcNAcylation and its links to metabolism reveal the importance of this modification in the maintenance of cellular and organismal homeostasis. Abstract | Full Text | PDF
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