Wednesday, June 21, 2017

Nature Reviews Molecular Cell Biology contents July 2017 Volume 18 Number 7 pp 403-465

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Nature Reviews Molecular Cell Biology

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Article series:
RNA processing and modifications
Post-translational modifications
 Featured article:
Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cedric R. Clapier Janet Iwasa Bradley R. Cairns & Craig L. Peterson
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Stem cells: Stem cell-based therapies threatened by the accumulation of p53 mutations
p403 | doi:10.1038/nrm.2017.52
Cultured pluripotent stem cells can accumulate TP53 mutations, and these mutations confer a strong selective advantage to these cells.

Autophagy: Membrane contacts lend a hand
p404 | doi:10.1038/nrm.2017.55
Extended synaptotagmins that tether ER and cell membranes also promote autophagy by regulating phosphoinositide 3-kinase.

Transcription: Paused means poised
p404 | doi:10.1038/nrm.2017.57
Promoter-proximal pausing of RNA polymerase II inhibits transcription reinitiation, especially in genes with lower steady-state expression levels.

Gene expression: ACSS2 boosts local histone acetylation
p405 | doi:10.1038/nrm.2017.61
During metabolic stress in cancer cells, ACSS2 binds to TFEB to locally boost the production of acetyl-CoA, thereby facilitating the expression of lysosomal and autophagy genes.

Cytoplasmic movements outside the living cell

p406 | doi:10.1038/nrm.2017.54
Thomas D. Pollard discusses the early work of Thompson and Wolpert on cytoplasmic extract from amoebae, which laid the foundation for studies of actin-driven cell motility.

Translation: RAPping with ribosomes
p406 | doi:10.1038/nrm.2017.62
Various proteins interact with ribosomes [mdash] this ribosome-protein interactome functionally diversifies ribosomes, thereby providing an additional means of translation regulation.

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Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes
Cedric R. Clapier, Janet Iwasa, Bradley R. Cairns & Craig L. Peterson
p407 | doi:10.1038/nrm.2017.26
Nucleosome-remodelling complexes can slide or eject histones, or incorporate histone variants, but they share an ATPase-translocase 'motor' and a common DNA translocation mechanism. In a unifying 'hourglass' model of remodeller function, the different remodeller subfamilies use different modules for targeting to nucleosomes but converge on a DNA translocation mechanism and then diverge again to achieve various outcomes.
Abstract | Full Text | PDF | Supplementary information
The development and functions of multiciliated epithelia
Nathalie Spassky & Alice Meunier
p423 | doi:10.1038/nrm.2017.21
Multiciliated cells line the lumen of the vertebrate central nervous system and respiratory and reproductive tracts, where the unidirectional beating of cilia assemblies supports the polarized flow of fluids or movement of cells or particles. Recent studies shed new light on how multiciliated cells arise and how they function.
Abstract | Full Text | PDF
Article series: RNA processing and modifications
Alternative splicing as a regulator of development and tissue identity
Francisco E. Baralle & Jimena Giudice
p437 | doi:10.1038/nrm.2017.27
Alternative splicing expands the complexity of the proteome by generating multiple transcript isoforms from a single gene. Numerous alternative splicing events occur during cell differentiation and tissue maturation, suggesting that alternative splicing supports proper development. Recent studies shed light on how alternative splicing and its coordination contribute to organ development and tissue homeostasis.
Abstract | Full Text | PDF | Supplementary information
Article series: Post-translational modifications
Protein O-GlcNAcylation: emerging mechanisms and functions
Xiaoyong Yang & Kevin Qian
p452 | doi:10.1038/nrm.2017.22
Many cellular proteins are reversibly modified by O-linked N-acetylglucosamine (O-GlcNAc) moieties on Ser and Thr residues. Studies on the mechanisms and functions of O-GlcNAcylation and its links to metabolism reveal the importance of this modification in the maintenance of cellular and organismal homeostasis.
Abstract | Full Text | PDF
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