Wednesday, June 21, 2017

Nature Communications - 21 June 2017

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  Latest Articles View all Articles  
Speckle-modulating optical coherence tomography in living mice and humans OPEN
Orly Liba, Matthew D. Lew, Elliott D. SoRelle, Rebecca Dutta, Debasish Sen, Darius M. Moshfeghi, Steven Chu and Adam de la Zerda
Optical coherence tomography, a technique that can image inside tissue, is susceptible to speckle noise that limits its diagnostic potential. Here, Liba et al. show that speckle noise can be removed without effectively compromising resolution, revealing previously hidden small structures within tissue.
20 June 2017 | doi: 10.1038/ncomms15845

Learning relative values in the striatum induces violations of normative decision making OPEN
Tilmann A. Klein, Markus Ullsperger and Gerhard Jocham
Though people learn that certain choices may be more advantageous, they often do not choose this option. Here, the authors explain this behaviour: people learn how good a choice is relative to the choices it has been associated with previously, and this learning takes place in the striatum.
20 June 2017 | doi: 10.1038/ncomms16033

Microscopic origins of the large piezoelectricity of leadfree (Ba,Ca)(Zr,Ti)O3 OPEN
Yousra Nahas, Alireza Akbarzadeh, Sergei Prokhorenko, Sergey Prosandeev, Raymond Walter, Igor Kornev, Jorge Íñiguez and L. Bellaiche
(Ba,Ca)(Zr,Ti)O3 ceramics have attracted interest as lead-free materials with large piezoelectric responses. Here, the authors use an atomistic model to show the electromechanical properties are due to a complex microstructure and polarization fluctuations in the narrowly stable orthorhombic phase.
20 June 2017 | doi: 10.1038/ncomms15944

Plastid thylakoid architecture optimizes photosynthesis in diatoms OPEN
Serena Flori, Pierre-Henri Jouneau, Benjamin Bailleul, Benoit Gallet, Leandro F Estrozi, Christine Moriscot, Olivier Bastien, Simona Eicke, Alexander Schober, Carolina Río Bártulos, Eric Maréchal, Peter G Kroth, Dimitris Petroutsos, Samuel Zeeman, Cécile Breyton, Guy Schoehn, Denis Falconet and Giovanni Finazzi
Phytoplankton and plant plastids have distinct evolutionary origins and membrane organization. Here Flori et al. show that diatom photosynthetic complexes spatially segregate into interconnected subdomains within loose thylakoid stacks enabling fast diffusion of electron carriers and efficient photosynthesis
20 June 2017 | doi: 10.1038/ncomms15885

Skillful prediction of northern climate provided by the ocean OPEN
Marius Årthun, Tor Eldevik, Ellen Viste, Helge Drange, Tore Furevik, Helen L. Johnson and Noel S. Keenlyside
The degree to which ocean heat is imprinted on the atmosphere and can be used to predict climate remains unclear. Here, the authors demonstrate skillful observation-based prediction of northwestern European and Arctic climate from upstream sea surface temperature anomalies in the subpolar North Atlantic.
20 June 2017 | doi: 10.1038/ncomms15875

Giant capsids from lattice self-assembly of cyclodextrin complexes OPEN
Shenyu Yang, Yun Yan, Jianbin Huang, Andrei V. Petukhov, Loes M. J. Kroon-Batenburg, Markus Drechsler, Chengcheng Zhou, Mei Tu, Steve Granick and Lingxiang Jiang
Designing and synthesizing protein mimetic molecules to form crystalline structures can be a challenge. Here the authors show lattice self-assembly of cyclodextrin complexes into a variety of capsid like structures, such as, lamellae, helical tubes and hollow rhombic dodecahedra.
20 June 2017 | doi: 10.1038/ncomms15856

Resolving mixed mechanisms of protein subdiffusion at the T cell plasma membrane OPEN
Yonatan Golan and Eilon Sherman
Membrane protein diffusion is affected by distinct mechanisms such as molecular crowding and medium elasticity. Here the authors present an analytical approach to analyse single particle trajectories and distinguish mixed subdiffusive processes affecting membrane protein mobility in living cells.
20 June 2017 | doi: 10.1038/ncomms15851

Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid OPEN
Thomas Walther, Christopher M. Topham, Romain Irague, Clément Auriol, Audrey Baylac, Hélène Cordier, Clémentine Dressaire, Luce Lozano-Huguet, Nathalie Tarrat, Nelly Martineau, Marion Stodel, Yannick Malbert, Marc Maestracci, Robert Huet, Isabelle André, Magali Remaud-Siméon and Jean Marie François
2,4-Dihydroxybutyric acid has potential to be a precursor to a range of industrially important products, however a natural metabolic pathway for its synthesis does not exist. Here the authors rationally design a synthetic pathway in E. coli by engineering enzymes from malate metabolism.
20 June 2017 | doi: 10.1038/ncomms15828

Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss OPEN
Marco Quarta, Melinda Cromie, Robert Chacon, Justin Blonigan, Victor Garcia, Igor Akimenko, Mark Hamer, Patrick Paine, Merel Stok, Joseph B. Shrager and Thomas A. Rando
Volumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice.
20 June 2017 | doi: 10.1038/ncomms15613

Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles OPEN
Erik Bernitt, Hans-Günther Döbereiner, Nir S. Gov and Arik Yochelis
Circular dorsal ruffles (CDRs) are important for the vesicular uptake of extracellular matter, but the basis of their wave dynamics is not understood. Here, the authors propose and experimentally test a bistable reaction-diffusion system, which they show accounts for the typical CDR expansion and shrinkage and for aberrant formation of pinned waves and spirals.
19 June 2017 | doi: 10.1038/ncomms15863

A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis OPEN
Feng Xiong, Liang Lu, Tian-Yu Sun, Qian Wu, Dingyuan Yan, Ying Chen, Xinhao Zhang, Wei Wei, Yi Lu, Wei-Yin Sun, Jie Jack Li and Jing Zhao
Functionalization of C-H bonds typically requires harsh reagents or metal catalysts. Here the authors report a metal-free C-H sulfenylation/rearrangement to form C-S and S=N bonds under simple, biocompatible conditions, and apply this to the synthesis of fluorogenic phospholipid vesicles.
19 June 2017 | doi: 10.1038/ncomms15912

Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission OPEN
Johannes Schöneberg, Martin Lehmann, Alexander Ullrich, York Posor, Wen-Ting Lo, Gregor Lichtner, Jan Schmoranzer, Volker Haucke and Frank Noé
The spatiotemporal regulation of membrane scaffolds recruitment and coupling between membrane deformation and fission in endocytosis are unclear. Here the authors show that lipid conversion at endocytic pits recruits SNX9, which couples local membrane constriction to fission in endocytosis.
19 June 2017 | doi: 10.1038/ncomms15873

Cooperative tumour cell membrane targeted phototherapy OPEN
Heegon Kim, Junsung Lee, Chanhee Oh and Ji-Ho Park
Tumour distribution of targeted therapies is intrinsically heterogeneous. Here, the authors develop a strategy to decorate entire tumour membranes with synthetic receptors for amplified targeting of therapeutics and show that such cooperative membrane-targeted phototherapy results in tumour regression in mice.
19 June 2017 | doi: 10.1038/ncomms15880

Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC OPEN
Junchao Cai, Lishan Fang, Yongbo Huang, Rong Li, Xiaonan Xu, Zhihuang Hu, Le Zhang, Yi Yang, Xun Zhu, Heng Zhang, Jueheng Wu, Yan Huang, Jun Li, Musheng Zeng, Erwei Song, Yukai He, Li Zhang and Mengfeng Li
Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway.
19 June 2017 | doi: 10.1038/ncomms15870

DOT1L safeguards cartilage homeostasis and protects against osteoarthritis OPEN
Silvia Monteagudo, Frederique M. F. Cornelis, Carolina Aznar-Lopez, Ploi Yibmantasiri, Laura-An Guns, Peter Carmeliet, Frédéric Cailotto and Rik J. Lories
DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that inhibition of DOT1L can drive osteoarthritic disease in mice.
19 June 2017 | doi: 10.1038/ncomms15889

Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress OPEN
Ivan Gusarov, Bibhusita Pani, Laurent Gautier, Olga Smolentseva, Svetlana Eremina, Ilya Shamovsky, Olga Katkova-Zhukotskaya, Alexander Mironov and Evgeny Nudler
Glycogen is a storage form of glucose in cells. Here, Gusarov et al. show that glycogen-derived glucose can be used to quickly regenerate the antioxidant glutathione and that inhibiting glycogen synthesis extends C. elegans lifespan, whereas glycogen accumulation drives organismal ageing in worms.
19 June 2017 | doi: 10.1038/ncomms15868

Non-equilibrium steady states in supramolecular polymerization OPEN
Alessandro Sorrenti, Jorge Leira-Iglesias, Akihiro Sato and Thomas M. Hermans
Several cell functions are based on the fuel-driven assembly and disassembly of supramolecular polymers under non-equilibrium conditions. Here, the authors show controlled formation and breaking of a supramolecular polymer by enzymatic phosphorylation and dephosphorylation of a building block by continuously adding ATP fuel and removing waste products.
19 June 2017 | doi: 10.1038/ncomms15899

Adaptive self-assembly and induced-fit transformations of anion-binding metal-organic macrocycles OPEN
Ting Zhang, Li-Peng Zhou, Xiao-Qing Guo, Li-Xuan Cai and Qing-Fu Sun
Container-molecules capable of recognizing charged species possess great potential as sensors, but are typically limited by their rigid frameworks. Here, Sun and co-workers design a family of adaptive metal-organic macrocycles that exhibit shape and size induced-fit transformations upon anion-binding.
16 June 2017 | doi: 10.1038/ncomms15898

Lkb1 maintains Treg cell lineage identity OPEN
Di Wu, Yuechen Luo, Wei Guo, Qing Niu, Ting Xue, Fei Yang, Xiaolei Sun, Song Chen, Yuanyuan Liu, Jingru Liu, Zhina Sun, Chunxiao Zhao, Huifang Huang, Fang Liao, Zhongchao Han, Dongming Zhou, Yongguang Yang, Guogang Xu, Tao Cheng and Xiaoming Feng et al.
The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease.
16 June 2017 | doi: 10.1038/ncomms15876

Directed self-assembly of liquid crystalline blue-phases into ideal single-crystals OPEN
Jose A. Martínez-González, Xiao Li, Monirosadat Sadati, Ye Zhou, Rui Zhang, Paul F. Nealey and Juan J. de Pablo
Blue phases are a liquid crystalline state with attractive optical properties but their use in devices can be hindered by their polycrystalline nature. Here the authors create monocrystalline blue phase domains by designing substrates with patterns which are determined by field-theoretic simulations.
16 June 2017 | doi: 10.1038/ncomms15854

Francisella requires dynamic type VI secretion system and ClpB to deliver effectors for phagosomal escape OPEN
Maj Brodmann, Roland F. Dreier, Petr Broz and Marek Basler
The pathogenicity of Francisella species largely depends on their escape from phagosomes in macrophages, mediated by a type VI secretion system (T6SS). Here, the authors show dynamics of T6SS assembly and disassembly and identify the genes essential for phagosome escape and pathogenicity in mice.
16 June 2017 | doi: 10.1038/ncomms15853

Bending strain engineering in quantum spin hall system for controlling spin currents OPEN
Bing Huang, Kyung-Hwan Jin, Bin Cui, Feng Zhai, Jiawei Mei and Feng Liu
Strain engineering alters the topological properties of quantum spin Hall insulators, leading to potential applications in spintronics. Here the authors demonstrate that bending strain can be used to tune the spin transport properties and generate a non-zero spin current in curved in Bi/Cl/Si nanofilms.
16 June 2017 | doi: 10.1038/ncomms15850

Observing electron localization in a dissociating H2+ molecule in real time OPEN
H. Xu, Zhichao Li, Feng He, X. Wang, A. Atia-Tul-Noor, D. Kielpinski, R. T. Sang and I. V. Litvinyuk
Time resolved measurements provide insights to the intriguing process of ultrafast molecular fragmentation. Here the authors use CEP-locked laser pulses in pump–probe scheme to explore the H2 + dissociation and find out that the electron localization to one of the nuclei occurs in about 15 fs.
16 June 2017 | doi: 10.1038/ncomms15849

Structural insights into the function of ZRANB3 in replication stress response OPEN
Marek Sebesta, Christopher D. O. Cooper, Antonio Ariza, Christopher J. Carnie and Dragana Ahel
ZRANB3 (Zinc-finger, RAN-Binding domain containing 3) is a structure-specific endonuclease that is recruited to DNA breaks and stressed replication forks. Here the authors present the crystal structure of the ZRANB3 endonuclease domain and analyse how ZRANB3 is regulated by the DNA clamp PCNA.
16 June 2017 | doi: 10.1038/ncomms15847

Dependence of the shape of graphene nanobubbles on trapped substance OPEN
H. Ghorbanfekr-Kalashami, K. S. Vasu, R. R. Nair, François M. Peeters and M. Neek-Amal
Graphene nanobubbles can act as enclosures for holding small volumes of substances. Here the authors find a correlation between bubble shape and the encapsulated material providing a potential method for determining the graphene bubble content by its deformation.
16 June 2017 | doi: 10.1038/ncomms15844

Targeted two-photon chemical apoptotic ablation of defined cell types in vivo OPEN
Robert A. Hill, Eyiyemisi C. Damisah, Fuyi Chen, Alex C. Kwan and Jaime Grutzendler
Investigating cell death in living organisms is hampered by a lack of techniques to induce apoptosis with spatial and temporal precision without collateral damage. Here the authors develop two-photon chemical apoptotic targeted ablation (2Phatal), allowing studies of apoptosis and its functional consequences in vivo.
16 June 2017 | doi: 10.1038/ncomms15837

Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system OPEN
H. Kaur, J. Carvalho, M. Looso, P. Singh, R. Chennupati, J. Preussner, S. Günther, J. Albarrán-Juárez, D. Tischner, S. Classen, S. Offermanns and N. Wettschureck
GPCRs are key regulators of vascular functions. By analysing single-cell GPCRs expression in vascular smooth muscle and endothelial cells from healthy and diseased murine vessels, Kaur et al. show that GPCR expression is highly heterogeneous in all cell types and that disease causes GPCR repertoire changes depending on cell type and vascular localization.
16 June 2017 | doi: 10.1038/ncomms15700

Group additivity-Pourbaix diagrams advocate thermodynamically stable nanoscale clusters in aqueous environments OPEN
Lindsay A. Wills, Xiaohui Qu, I-Ya Chang, Thomas J. L. Mustard, Douglas A. Keszler, Kristin A. Persson and Paul Ha-Yeon Cheong
Aqueous clusters are important in a variety of biological and materials systems. Here Wills et al. develop a theoretical approach based on a group additivity relationship which allows the evaluation of a wide range of clusters without the need of cumbersome ab initio calculations.
15 June 2017 | doi: 10.1038/ncomms15852

Insufficient antibody validation challenges oestrogen receptor beta research OPEN
Sandra Andersson, Mårten Sundberg, Nusa Pristovsek, Ahmed Ibrahim, Philip Jonsson, Borbala Katona, Carl-Magnus Clausson, Agata Zieba, Margareta Ramström, Ola Söderberg, Cecilia Williams and Anna Asplund
A large body of work into the role of oestrogen receptor b (ERb) in breast cancer is contradictory, hindering future progress. Here the authors conduct extensive validation of anti-ERb antibodies , and show that normal and cancerous breast tissue do not express ERb, consistent with RNA-seq data.
15 June 2017 | doi: 10.1038/ncomms15840

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis OPEN
Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Judith M.M. van Eeuwijk, Paquita Nurden, Simon Stritt, Tobias Heib, Katja Aurbach, Oguzhan Angay, Deya Cherpokova, Niels Heinz, Ayesha A. Baig, Maximilian G. Gorelashvili, Frank Gerner, Katrin G. Heinze, Jerry Ware, Georg Krohne, Zaverio M. Ruggeri et al.
Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Dütting et al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting balanced antagonism between RhoA (stop-signal) and Cdc42 (go-signal).
15 June 2017 | doi: 10.1038/ncomms15838

The genomic landscape of tuberous sclerosis complex OPEN
Katie R. Martin, Wanding Zhou, Megan J. Bowman, Juliann Shih, Kit Sing Au, Kristin E. Dittenhafer-Reed, Kellie A. Sisson, Julie Koeman, Daniel J. Weisenberger, Sandra L. Cottingham, Steven T. DeRoos, Orrin Devinsky, Mary E. Winn, Andrew D. Cherniack, Hui Shen, Hope Northrup, Darcy A. Krueger and Jeffrey P. MacKeigan
Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem tumour growth. Here the authors analyse 111 TSC-associated tissues for TSC1/TSC2 status, DNA mutations, copy number aberrations, differential gene expression and DNA methylation patterns providing a comprehensive genomic landscape.
15 June 2017 | doi: 10.1038/ncomms15816

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification OPEN
Susann Kugel, Martin Baunach, Philipp Baer, Mie Ishida-Ito, Srividhya Sundaram, Zhongli Xu, Michael Groll and Christian Hertweck
The biosynthesis of xiamycin, an antimicrobial bacterial indolosesquiterpenoid, involves an unusual cyclization cascade. Here, the authors characterise the XiaF enzyme, which resembles xenobiont-degrading enzymes and is responsible for a hidden indole hydroxylation step that triggers the cyclization reaction.
15 June 2017 | doi: 10.1038/ncomms15804

January 2016 extensive summer melt in West Antarctica favoured by strong El Niño OPEN
Julien P. Nicolas, Andrew M. Vogelmann, Ryan C. Scott, Aaron B. Wilson, Maria P. Cadeddu, David H. Bromwich, Johannes Verlinde, Dan Lubin, Lynn M. Russell, Colin Jenkinson, Heath H. Powers, Maciej Ryczek, Gregory Stone and Jonathan D. Wille
Sporadic surface melt over the West Antarctic Ice Sheet is not fully understood. Here, the authors report on an extensive melting episode in the Ross Ice Shelf area in 2016 and use comprehensive in situ observations and model simulations to highlight the role of the strong El Niño event.
15 June 2017 | doi: 10.1038/ncomms15799

Terahertz saturable absorbers from liquid phase exfoliation of graphite OPEN
Vezio Bianchi, Tian Carey, Leonardo Viti, Lianhe Li, Edmund H. Linfield, A. Giles Davies, Alessandro Tredicucci, Duhee Yoon, Panagiotis G. Karagiannidis, Lucia Lombardi, Flavia Tomarchio, Andrea C. Ferrari, Felice Torrisi and Miriam S. Vitiello
Graphene shows promise for saturable absorption, a key property for ultrafast lasing, yet graphene saturable absorbers operating in the terahertz region suffer from low absorption modulation. Here, the authors report terahertz saturable absorbers based on inkjet printed graphene with 80% transparency modulation.
15 June 2017 | doi: 10.1038/ncomms15763

Tidal dynamics and mangrove carbon sequestration during the Oligo–Miocene in the South China Sea OPEN
Daniel S. Collins, Alexandros Avdis, Peter A. Allison, Howard D. Johnson, Jon Hill, Matthew D. Piggott, Meor H. Amir Hassan and Abdul Razak Damit
Mangroves are important carbon-rich biomes, but their long-term impact on the global carbon cycle is relatively unknown. Here, the authors show that the Oligo–Miocene mangroves in the South China Sea stored in excess of 4,000 Gt, demonstrating the long-term impact of mangroves on carbon storage.
15 June 2017 | doi: 10.1038/ncomms15698

Water scarcity hotspots travel downstream due to human interventions in the 20th and 21st century OPEN
T.I.E. Veldkamp, Y. Wada, J.C.J.H. Aerts, P. Döll, S. N. Gosling, J. Liu, Y. Masaki, T. Oki, S. Ostberg, Y. Pokhrel, Y. Satoh, H. Kim and P. J. Ward
Water scarcity threatens a growing number of global catchments. Here, the authors examine how human interventions (HI) affected water scarcity between 1971 and 2010 and find that HI caused increases in the average duration and occurrence of water scarcity for 32% and 34% of the global population, respectively.
15 June 2017 | doi: 10.1038/ncomms15697

In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules OPEN
Yunjie Li, Xiaoxiao Hu, Ding Ding, Yuxiu Zou, Yiting Xu, Xuewei Wang, Yin Zhang, Long Chen, Zhuo Chen and Weihong Tan
The effective detection of Helicobacter pylori has been a challenge clinically. Here, the authors demonstrate the potential of magnetic nanoparticles for non-invasive diagnosis of H. pylori using magnetic resonance imaging in vivo.
15 June 2017 | doi: 10.1038/ncomms15653

Dynamics of valence-shell electrons and nuclei probed by strong-field holography and rescattering OPEN
Samuel G. Walt, Niraghatam Bhargava Ram, Marcos Atala, Nikolay I Shvetsov-Shilovski, Aaron von Conta, Denitsa Baykusheva, Manfred Lein and Hans Jakob Wörner
Capturing ultrafast molecular dynamics is difficult as the process involves coupled and very fast motions of electrons and nuclei. Here the authors study non-adiabatic dynamics in the NO molecule using strong-field photoelectron holography to shed light on the valence-shell electron dynamics.
15 June 2017 | doi: 10.1038/ncomms15651

VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2 OPEN
Yao-Hui Gao, Zhao-Xia Wu, Li-Qi Xie, Cai-Xia Li, Yu-Qin Mao, Yan-Tao Duan, Bing Han, San-Feng Han, Yun Yu, Hao-Jie Lu, Peng-Yuan Yang, Tian-Rui Xu, Jing-Lin Xia, Guo-Qiang Chen and Li-Shun Wang
The VHL tumour suppressor gene is lost in approximately 70% of clear cell renal cell carcinoma (ccRCC). In this study, the authors demonstrate that VHL loss in these tumours augments anthracyclines chemotherapy by down-regulation of ALDH2.
15 June 2017 | doi: 10.1038/ncomms15337

Ablation-resistant carbide Zr0.8Ti0.2C0.74B0.26 for oxidizing environments up to 3,000 °C OPEN
Yi Zeng, Dini Wang, Xiang Xiong, Xun Zhang, Philip J. Withers, Wei Sun, Matthew Smith, Mingwen Bai and Ping Xiao
Hypersonic and aerospace applications motivate development of materials with improved resistance against ablation and oxidation at high temperatures. Here authors demonstrate a quaternary carbide, where sealing by surface oxides, slow oxygen diffusion and a graded structure yield improved ablation resistance over established ceramics.
14 June 2017 | doi: 10.1038/ncomms15836

Genetic loci associated with heart rate variability and their effects on cardiac disease risk OPEN
Ilja M. Nolte, M. Loretto Munoz, Vinicius Tragante, Azmeraw T. Amare, Rick Jansen, Ahmad Vaez, Benedikt von der Heyde, Christy L. Avery, Joshua C. Bis, Bram Dierckx, Jenny van Dongen, Stephanie M. Gogarten, Philippe Goyette, Jussi Hernesniemi, Ville Huikari, Shih-Jen Hwang, Deepali Jaju, Kathleen F. Kerr, Alexander Kluttig, Bouwe P. Krijthe et al.
Heart rate variability (HRV) describes the individual variation in cardiac cycle duration and is a measure of vagal control of heart rate. Here, the authors identify seventeen single-nucleotide polymorphisms associated with HRV, lending new insight into the vagal regulation of heart rhythm.
14 June 2017 | doi: 10.1038/ncomms15805

Experimental neutron scattering evidence for proton polaron in hydrated metal oxide proton conductors OPEN
Artur Braun and Qianli Chen
Hydration of oxygen vacancies could form hydroxyl groups with interstitial structural protons. Here a quasi-elastic neutron scattering study reveals proton polarons in proton-conducting ceramic electrolytes, and the proton transport turns out to be a cooperative process.
14 June 2017 | doi: 10.1038/ncomms15830

Imaging metal-like monoclinic phase stabilized by surface coordination effect in vanadium dioxide nanobeam OPEN
Zejun Li, Jiajing Wu, Zhenpeng Hu, Yue Lin, Qi Chen, Yuqiao Guo, Yuhua Liu, Yingcheng Zhao, Jing Peng, Wangsheng Chu, Changzheng Wu and Yi Xie
Identifying intermediates during phase transitions is critical for our understanding of correlated materials, but difficult to achieve experimentally. Here, the authors report a surface coordination route to stabilize and directly image a phase-transition intermediate during the metal-insulator transition in vanadium dioxide.
14 June 2017 | doi: 10.1038/ncomms15561
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  Latest Corrigenda  
Corrigendum: Ruthenium-cobalt nanoalloys encapsulated in nitrogen-doped graphene as active electrocatalysts for producing hydrogen in alkaline media OPEN
Jianwei Su, Yang Yang, Guoliang Xia, Jitang Chen, Peng Jiang and Qianwang Chen
20 June 2017 | doi: 10.1038/ncomms16028

Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress OPEN
Begoña Porteiro, Marcos F. Fondevila, Teresa C. Delgado, Cristina Iglesias, Monica Imbernon, Paula Iruzubieta, Javier Crespo, Amaia Zabala-Letona, Johan Fernø, Bárbara González-Terán, Nuria Matesanz, Lourdes Hernández-Cosido, Miguel Marcos, Sulay Tovar, Anxo Vidal, Julia Sánchez-Ceinos, Maria M. Malagon, Celia Pombo, Juan Zalvide, Arkaitz Carracedo et al.
16 June 2017 | doi: 10.1038/ncomms16059

Corrigendum: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation OPEN
Yapeng Ji, Chuanzhen Yang, Zefang Tang, Yongfeng Yang, Yonglu Tian, Hongwei Yao, Xi Zhu, Zemin Zhang, Jiafu Ji and Xiaofeng Zheng
16 June 2017 | doi: 10.1038/ncomms16000

Corrigendum: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance OPEN
Lingling Jiang, Yingying Shen, Danfeng Guo, Diya Yang, Jiajun Liu, Xuefeng Fei, Yunshan Yang, Buyi Zhang, Zhendong Lin, Fei Yang, Xiaojian Wang, Keyi Wang, Jianli Wang and Zhijian Cai
14 June 2017 | doi: 10.1038/ncomms16006
  Latest Erratum  
Erratum: Ruthenium-cobalt nanoalloys encapsulated in nitrogen-doped graphene as active electrocatalysts for producing hydrogen in alkaline media OPEN
Jianwei Su, Yang Yang, Guoliang Xia, Jitang Chen, Peng Jiang and Qianwang Chen
20 June 2017 | doi: 10.1038/ncomms16029

Leukemia: Collection on Acute Myeloid Leukemia

AML is an area of focus for Leukemia and this collection brings together a number of recent key articles published in the journal. 

Access this collection free online for six months

Funded by a grant from Astex Pharmaceuticals, Inc.
(a member of the Otsuka group)

Call for nominations: 2017 John Maddox Prize for Standing up for Science.

Recognising the work of individuals who promote science in the face of hostility. Winners will be announced at a reception in London, as well as in Nature, and will receive £2,000.

Closing date for nominations is 31st July 2017.

Click to learn more

Nature Awards for Mentoring in Science — Spain

Your mentor could win €10,000

Nominations are now open
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