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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | Latest Articles | View all Articles | | | | | Speckle-modulating optical coherence tomography in living mice and humans OPEN | | | Orly Liba, Matthew D. Lew, Elliott D. SoRelle, Rebecca Dutta, Debasish Sen, Darius M. Moshfeghi, Steven Chu and Adam de la Zerda | | | Optical coherence tomography, a technique that can image inside tissue, is susceptible to speckle noise that limits its diagnostic potential. Here, Liba et al. show that speckle noise can be removed without effectively compromising resolution, revealing previously hidden small structures within tissue. | | | 20 June 2017 | doi: 10.1038/ncomms15845 | | |
| Learning relative values in the striatum induces violations of normative decision making OPEN | | | Tilmann A. Klein, Markus Ullsperger and Gerhard Jocham | | | Though people learn that certain choices may be more advantageous, they often do not choose this option. Here, the authors explain this behaviour: people learn how good a choice is relative to the choices it has been associated with previously, and this learning takes place in the striatum. | | | 20 June 2017 | doi: 10.1038/ncomms16033 | | |
| Microscopic origins of the large piezoelectricity of leadfree (Ba,Ca)(Zr,Ti)O3 OPEN | | | Yousra Nahas, Alireza Akbarzadeh, Sergei Prokhorenko, Sergey Prosandeev, Raymond Walter, Igor Kornev, Jorge Íñiguez and L. Bellaiche | | | (Ba,Ca)(Zr,Ti)O3 ceramics have attracted interest as lead-free materials with large piezoelectric responses. Here, the authors use an atomistic model to show the electromechanical properties are due to a complex microstructure and polarization fluctuations in the narrowly stable orthorhombic phase. | | | 20 June 2017 | doi: 10.1038/ncomms15944 | | |
| Plastid thylakoid architecture optimizes photosynthesis in diatoms OPEN | | | Serena Flori, Pierre-Henri Jouneau, Benjamin Bailleul, Benoit Gallet, Leandro F Estrozi, Christine Moriscot, Olivier Bastien, Simona Eicke, Alexander Schober, Carolina Río Bártulos, Eric Maréchal, Peter G Kroth, Dimitris Petroutsos, Samuel Zeeman, Cécile Breyton, Guy Schoehn, Denis Falconet and Giovanni Finazzi | | | Phytoplankton and plant plastids have distinct evolutionary origins and membrane organization. Here Flori et al. show that diatom photosynthetic complexes spatially segregate into interconnected subdomains within loose thylakoid stacks enabling fast diffusion of electron carriers and efficient photosynthesis | | | 20 June 2017 | doi: 10.1038/ncomms15885 | | |
| Skillful prediction of northern climate provided by the ocean OPEN | | | Marius Årthun, Tor Eldevik, Ellen Viste, Helge Drange, Tore Furevik, Helen L. Johnson and Noel S. Keenlyside | | | The degree to which ocean heat is imprinted on the atmosphere and can be used to predict climate remains unclear. Here, the authors demonstrate skillful observation-based prediction of northwestern European and Arctic climate from upstream sea surface temperature anomalies in the subpolar North Atlantic. | | | 20 June 2017 | doi: 10.1038/ncomms15875 | | |
| Giant capsids from lattice self-assembly of cyclodextrin complexes OPEN | | | Shenyu Yang, Yun Yan, Jianbin Huang, Andrei V. Petukhov, Loes M. J. Kroon-Batenburg, Markus Drechsler, Chengcheng Zhou, Mei Tu, Steve Granick and Lingxiang Jiang | | | Designing and synthesizing protein mimetic molecules to form crystalline structures can be a challenge. Here the authors show lattice self-assembly of cyclodextrin complexes into a variety of capsid like structures, such as, lamellae, helical tubes and hollow rhombic dodecahedra. | | | 20 June 2017 | doi: 10.1038/ncomms15856 | | |
| Resolving mixed mechanisms of protein subdiffusion at the T cell plasma membrane OPEN | | | Yonatan Golan and Eilon Sherman | | | Membrane protein diffusion is affected by distinct mechanisms such as molecular crowding and medium elasticity. Here the authors present an analytical approach to analyse single particle trajectories and distinguish mixed subdiffusive processes affecting membrane protein mobility in living cells. | | | 20 June 2017 | doi: 10.1038/ncomms15851 | | |
| Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid OPEN | | | Thomas Walther, Christopher M. Topham, Romain Irague, Clément Auriol, Audrey Baylac, Hélène Cordier, Clémentine Dressaire, Luce Lozano-Huguet, Nathalie Tarrat, Nelly Martineau, Marion Stodel, Yannick Malbert, Marc Maestracci, Robert Huet, Isabelle André, Magali Remaud-Siméon and Jean Marie François | | | 2,4-Dihydroxybutyric acid has potential to be a precursor to a range of industrially important products, however a natural metabolic pathway for its synthesis does not exist. Here the authors rationally design a synthetic pathway in E. coli by engineering enzymes from malate metabolism. | | | 20 June 2017 | doi: 10.1038/ncomms15828 | | |
| Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss OPEN | | | Marco Quarta, Melinda Cromie, Robert Chacon, Justin Blonigan, Victor Garcia, Igor Akimenko, Mark Hamer, Patrick Paine, Merel Stok, Joseph B. Shrager and Thomas A. Rando | | | Volumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice. | | | 20 June 2017 | doi: 10.1038/ncomms15613 | | |
| Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles OPEN | | | Erik Bernitt, Hans-Günther Döbereiner, Nir S. Gov and Arik Yochelis | | | Circular dorsal ruffles (CDRs) are important for the vesicular uptake of extracellular matter, but the basis of their wave dynamics is not understood. Here, the authors propose and experimentally test a bistable reaction-diffusion system, which they show accounts for the typical CDR expansion and shrinkage and for aberrant formation of pinned waves and spirals. | | | 19 June 2017 | doi: 10.1038/ncomms15863 | | |
| A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis OPEN | | | Feng Xiong, Liang Lu, Tian-Yu Sun, Qian Wu, Dingyuan Yan, Ying Chen, Xinhao Zhang, Wei Wei, Yi Lu, Wei-Yin Sun, Jie Jack Li and Jing Zhao | | | Functionalization of C-H bonds typically requires harsh reagents or metal catalysts. Here the authors report a metal-free C-H sulfenylation/rearrangement to form C-S and S=N bonds under simple, biocompatible conditions, and apply this to the synthesis of fluorogenic phospholipid vesicles. | | | 19 June 2017 | doi: 10.1038/ncomms15912 | | |
| Lipid-mediated PX-BAR domain recruitment couples local membrane constriction to endocytic vesicle fission OPEN | | | Johannes Schöneberg, Martin Lehmann, Alexander Ullrich, York Posor, Wen-Ting Lo, Gregor Lichtner, Jan Schmoranzer, Volker Haucke and Frank Noé | | | The spatiotemporal regulation of membrane scaffolds recruitment and coupling between membrane deformation and fission in endocytosis are unclear. Here the authors show that lipid conversion at endocytic pits recruits SNX9, which couples local membrane constriction to fission in endocytosis. | | | 19 June 2017 | doi: 10.1038/ncomms15873 | | |
| Cooperative tumour cell membrane targeted phototherapy OPEN | | | Heegon Kim, Junsung Lee, Chanhee Oh and Ji-Ho Park | | | Tumour distribution of targeted therapies is intrinsically heterogeneous. Here, the authors develop a strategy to decorate entire tumour membranes with synthetic receptors for amplified targeting of therapeutics and show that such cooperative membrane-targeted phototherapy results in tumour regression in mice. | | | 19 June 2017 | doi: 10.1038/ncomms15880 | | |
| Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC OPEN | | | Junchao Cai, Lishan Fang, Yongbo Huang, Rong Li, Xiaonan Xu, Zhihuang Hu, Le Zhang, Yi Yang, Xun Zhu, Heng Zhang, Jueheng Wu, Yan Huang, Jun Li, Musheng Zeng, Erwei Song, Yukai He, Li Zhang and Mengfeng Li | | | Chemoresistance and metastasis are tightly associated features in non-small cell lung cancer (NSCLC). Here, the authors show that resistant NSCLCs have high levels of miR-128-3p which promotes EMT and cancer stem cell survival through the modulation of both Wnt/B-catenin and TGF-β pathway. | | | 19 June 2017 | doi: 10.1038/ncomms15870 | | |
| DOT1L safeguards cartilage homeostasis and protects against osteoarthritis OPEN | | | Silvia Monteagudo, Frederique M. F. Cornelis, Carolina Aznar-Lopez, Ploi Yibmantasiri, Laura-An Guns, Peter Carmeliet, Frédéric Cailotto and Rik J. Lories | | | DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that inhibition of DOT1L can drive osteoarthritic disease in mice. | | | 19 June 2017 | doi: 10.1038/ncomms15889 | | |
| Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress OPEN | | | Ivan Gusarov, Bibhusita Pani, Laurent Gautier, Olga Smolentseva, Svetlana Eremina, Ilya Shamovsky, Olga Katkova-Zhukotskaya, Alexander Mironov and Evgeny Nudler | | | Glycogen is a storage form of glucose in cells. Here, Gusarov et al. show that glycogen-derived glucose can be used to quickly regenerate the antioxidant glutathione and that inhibiting glycogen synthesis extends C. elegans lifespan, whereas glycogen accumulation drives organismal ageing in worms. | | | 19 June 2017 | doi: 10.1038/ncomms15868 | | |
| Non-equilibrium steady states in supramolecular polymerization OPEN | | | Alessandro Sorrenti, Jorge Leira-Iglesias, Akihiro Sato and Thomas M. Hermans | | | Several cell functions are based on the fuel-driven assembly and disassembly of supramolecular polymers under non-equilibrium conditions. Here, the authors show controlled formation and breaking of a supramolecular polymer by enzymatic phosphorylation and dephosphorylation of a building block by continuously adding ATP fuel and removing waste products. | | | 19 June 2017 | doi: 10.1038/ncomms15899 | | |
| Adaptive self-assembly and induced-fit transformations of anion-binding metal-organic macrocycles OPEN | | | Ting Zhang, Li-Peng Zhou, Xiao-Qing Guo, Li-Xuan Cai and Qing-Fu Sun | | | Container-molecules capable of recognizing charged species possess great potential as sensors, but are typically limited by their rigid frameworks. Here, Sun and co-workers design a family of adaptive metal-organic macrocycles that exhibit shape and size induced-fit transformations upon anion-binding. | | | 16 June 2017 | doi: 10.1038/ncomms15898 | | |
| Lkb1 maintains Treg cell lineage identity OPEN | | | Di Wu, Yuechen Luo, Wei Guo, Qing Niu, Ting Xue, Fei Yang, Xiaolei Sun, Song Chen, Yuanyuan Liu, Jingru Liu, Zhina Sun, Chunxiao Zhao, Huifang Huang, Fang Liao, Zhongchao Han, Dongming Zhou, Yongguang Yang, Guogang Xu, Tao Cheng and Xiaoming Feng et al. | | | The protein kinase Lkb1 has been shown to limit conventional T cell activation and pro-inflammatory functions. Here the authors show that Lkb1 also maintains Foxp3 expression and suppressive function in regulatory T (Treg) cells, and that Treg-specific Lkb1-deficient mice develop fatal autoimmune disease. | | | 16 June 2017 | doi: 10.1038/ncomms15876 | | |
| Directed self-assembly of liquid crystalline blue-phases into ideal single-crystals OPEN | | | Jose A. Martínez-González, Xiao Li, Monirosadat Sadati, Ye Zhou, Rui Zhang, Paul F. Nealey and Juan J. de Pablo | | | Blue phases are a liquid crystalline state with attractive optical properties but their use in devices can be hindered by their polycrystalline nature. Here the authors create monocrystalline blue phase domains by designing substrates with patterns which are determined by field-theoretic simulations. | | | 16 June 2017 | doi: 10.1038/ncomms15854 | | |
| Bending strain engineering in quantum spin hall system for controlling spin currents OPEN | | | Bing Huang, Kyung-Hwan Jin, Bin Cui, Feng Zhai, Jiawei Mei and Feng Liu | | | Strain engineering alters the topological properties of quantum spin Hall insulators, leading to potential applications in spintronics. Here the authors demonstrate that bending strain can be used to tune the spin transport properties and generate a non-zero spin current in curved in Bi/Cl/Si nanofilms. | | | 16 June 2017 | doi: 10.1038/ncomms15850 | | |
| Observing electron localization in a dissociating H2+ molecule in real time OPEN | | | H. Xu, Zhichao Li, Feng He, X. Wang, A. Atia-Tul-Noor, D. Kielpinski, R. T. Sang and I. V. Litvinyuk | | | Time resolved measurements provide insights to the intriguing process of ultrafast molecular fragmentation. Here the authors use CEP-locked laser pulses in pump–probe scheme to explore the H2 + dissociation and find out that the electron localization to one of the nuclei occurs in about 15 fs. | | | 16 June 2017 | doi: 10.1038/ncomms15849 | | |
| Structural insights into the function of ZRANB3 in replication stress response OPEN | | | Marek Sebesta, Christopher D. O. Cooper, Antonio Ariza, Christopher J. Carnie and Dragana Ahel | | | ZRANB3 (Zinc-finger, RAN-Binding domain containing 3) is a structure-specific endonuclease that is recruited to DNA breaks and stressed replication forks. Here the authors present the crystal structure of the ZRANB3 endonuclease domain and analyse how ZRANB3 is regulated by the DNA clamp PCNA. | | | 16 June 2017 | doi: 10.1038/ncomms15847 | | |
| Dependence of the shape of graphene nanobubbles on trapped substance OPEN | | | H. Ghorbanfekr-Kalashami, K. S. Vasu, R. R. Nair, François M. Peeters and M. Neek-Amal | | | Graphene nanobubbles can act as enclosures for holding small volumes of substances. Here the authors find a correlation between bubble shape and the encapsulated material providing a potential method for determining the graphene bubble content by its deformation. | | | 16 June 2017 | doi: 10.1038/ncomms15844 | | |
| Targeted two-photon chemical apoptotic ablation of defined cell types in vivo OPEN | | | Robert A. Hill, Eyiyemisi C. Damisah, Fuyi Chen, Alex C. Kwan and Jaime Grutzendler | | | Investigating cell death in living organisms is hampered by a lack of techniques to induce apoptosis with spatial and temporal precision without collateral damage. Here the authors develop two-photon chemical apoptotic targeted ablation (2Phatal), allowing studies of apoptosis and its functional consequences in vivo. | | | 16 June 2017 | doi: 10.1038/ncomms15837 | | |
| Single-cell profiling reveals heterogeneity and functional patterning of GPCR expression in the vascular system OPEN | | | H. Kaur, J. Carvalho, M. Looso, P. Singh, R. Chennupati, J. Preussner, S. Günther, J. Albarrán-Juárez, D. Tischner, S. Classen, S. Offermanns and N. Wettschureck | | | GPCRs are key regulators of vascular functions. By analysing single-cell GPCRs expression in vascular smooth muscle and endothelial cells from healthy and diseased murine vessels, Kaur et al. show that GPCR expression is highly heterogeneous in all cell types and that disease causes GPCR repertoire changes depending on cell type and vascular localization. | | | 16 June 2017 | doi: 10.1038/ncomms15700 | | |
| Group additivity-Pourbaix diagrams advocate thermodynamically stable nanoscale clusters in aqueous environments OPEN | | | Lindsay A. Wills, Xiaohui Qu, I-Ya Chang, Thomas J. L. Mustard, Douglas A. Keszler, Kristin A. Persson and Paul Ha-Yeon Cheong | | | Aqueous clusters are important in a variety of biological and materials systems. Here Wills et al. develop a theoretical approach based on a group additivity relationship which allows the evaluation of a wide range of clusters without the need of cumbersome ab initio calculations. | | | 15 June 2017 | doi: 10.1038/ncomms15852 | | |
| Insufficient antibody validation challenges oestrogen receptor beta research OPEN | | | Sandra Andersson, Mårten Sundberg, Nusa Pristovsek, Ahmed Ibrahim, Philip Jonsson, Borbala Katona, Carl-Magnus Clausson, Agata Zieba, Margareta Ramström, Ola Söderberg, Cecilia Williams and Anna Asplund | | | A large body of work into the role of oestrogen receptor b (ERb) in breast cancer is contradictory, hindering future progress. Here the authors conduct extensive validation of anti-ERb antibodies , and show that normal and cancerous breast tissue do not express ERb, consistent with RNA-seq data. | | | 15 June 2017 | doi: 10.1038/ncomms15840 | | |
| A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis OPEN | | | Sebastian Dütting, Frederique Gaits-Iacovoni, David Stegner, Michael Popp, Adrien Antkowiak, Judith M.M. van Eeuwijk, Paquita Nurden, Simon Stritt, Tobias Heib, Katja Aurbach, Oguzhan Angay, Deya Cherpokova, Niels Heinz, Ayesha A. Baig, Maximilian G. Gorelashvili, Frank Gerner, Katrin G. Heinze, Jerry Ware, Georg Krohne, Zaverio M. Ruggeri et al. | | | Platelets derive from large precursor cells (megakaryocytes) in the bone marrow. Dütting et al. show that megakaryocyte polarization and platelet biogenesis in the bone-marrow sinusoids are directed by adhesion receptor GPIb signalling and resulting balanced antagonism between RhoA (stop-signal) and Cdc42 (go-signal). | | | 15 June 2017 | doi: 10.1038/ncomms15838 | | |
| The genomic landscape of tuberous sclerosis complex OPEN | | | Katie R. Martin, Wanding Zhou, Megan J. Bowman, Juliann Shih, Kit Sing Au, Kristin E. Dittenhafer-Reed, Kellie A. Sisson, Julie Koeman, Daniel J. Weisenberger, Sandra L. Cottingham, Steven T. DeRoos, Orrin Devinsky, Mary E. Winn, Andrew D. Cherniack, Hui Shen, Hope Northrup, Darcy A. Krueger and Jeffrey P. MacKeigan | | | Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem tumour growth. Here the authors analyse 111 TSC-associated tissues for TSC1/TSC2 status, DNA mutations, copy number aberrations, differential gene expression and DNA methylation patterns providing a comprehensive genomic landscape. | | | 15 June 2017 | doi: 10.1038/ncomms15816 | | |
| Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification OPEN | | | Susann Kugel, Martin Baunach, Philipp Baer, Mie Ishida-Ito, Srividhya Sundaram, Zhongli Xu, Michael Groll and Christian Hertweck | | | The biosynthesis of xiamycin, an antimicrobial bacterial indolosesquiterpenoid, involves an unusual cyclization cascade. Here, the authors characterise the XiaF enzyme, which resembles xenobiont-degrading enzymes and is responsible for a hidden indole hydroxylation step that triggers the cyclization reaction. | | | 15 June 2017 | doi: 10.1038/ncomms15804 | | |
| January 2016 extensive summer melt in West Antarctica favoured by strong El Niño OPEN | | | Julien P. Nicolas, Andrew M. Vogelmann, Ryan C. Scott, Aaron B. Wilson, Maria P. Cadeddu, David H. Bromwich, Johannes Verlinde, Dan Lubin, Lynn M. Russell, Colin Jenkinson, Heath H. Powers, Maciej Ryczek, Gregory Stone and Jonathan D. Wille | | | Sporadic surface melt over the West Antarctic Ice Sheet is not fully understood. Here, the authors report on an extensive melting episode in the Ross Ice Shelf area in 2016 and use comprehensive in situ observations and model simulations to highlight the role of the strong El Niño event. | | | 15 June 2017 | doi: 10.1038/ncomms15799 | | |
| Terahertz saturable absorbers from liquid phase exfoliation of graphite OPEN | | | Vezio Bianchi, Tian Carey, Leonardo Viti, Lianhe Li, Edmund H. Linfield, A. Giles Davies, Alessandro Tredicucci, Duhee Yoon, Panagiotis G. Karagiannidis, Lucia Lombardi, Flavia Tomarchio, Andrea C. Ferrari, Felice Torrisi and Miriam S. Vitiello | | | Graphene shows promise for saturable absorption, a key property for ultrafast lasing, yet graphene saturable absorbers operating in the terahertz region suffer from low absorption modulation. Here, the authors report terahertz saturable absorbers based on inkjet printed graphene with 80% transparency modulation. | | | 15 June 2017 | doi: 10.1038/ncomms15763 | | |
| Tidal dynamics and mangrove carbon sequestration during the Oligo–Miocene in the South China Sea OPEN | | | Daniel S. Collins, Alexandros Avdis, Peter A. Allison, Howard D. Johnson, Jon Hill, Matthew D. Piggott, Meor H. Amir Hassan and Abdul Razak Damit | | | Mangroves are important carbon-rich biomes, but their long-term impact on the global carbon cycle is relatively unknown. Here, the authors show that the Oligo–Miocene mangroves in the South China Sea stored in excess of 4,000 Gt, demonstrating the long-term impact of mangroves on carbon storage. | | | 15 June 2017 | doi: 10.1038/ncomms15698 | | |
| Water scarcity hotspots travel downstream due to human interventions in the 20th and 21st century OPEN | | | T.I.E. Veldkamp, Y. Wada, J.C.J.H. Aerts, P. Döll, S. N. Gosling, J. Liu, Y. Masaki, T. Oki, S. Ostberg, Y. Pokhrel, Y. Satoh, H. Kim and P. J. Ward | | | Water scarcity threatens a growing number of global catchments. Here, the authors examine how human interventions (HI) affected water scarcity between 1971 and 2010 and find that HI caused increases in the average duration and occurrence of water scarcity for 32% and 34% of the global population, respectively. | | | 15 June 2017 | doi: 10.1038/ncomms15697 | | |
| In situ targeted MRI detection of Helicobacter pylori with stable magnetic graphitic nanocapsules OPEN | | | Yunjie Li, Xiaoxiao Hu, Ding Ding, Yuxiu Zou, Yiting Xu, Xuewei Wang, Yin Zhang, Long Chen, Zhuo Chen and Weihong Tan | | | The effective detection of Helicobacter pylori has been a challenge clinically. Here, the authors demonstrate the potential of magnetic nanoparticles for non-invasive diagnosis of H. pylori using magnetic resonance imaging in vivo. | | | 15 June 2017 | doi: 10.1038/ncomms15653 | | |
| Dynamics of valence-shell electrons and nuclei probed by strong-field holography and rescattering OPEN | | | Samuel G. Walt, Niraghatam Bhargava Ram, Marcos Atala, Nikolay I Shvetsov-Shilovski, Aaron von Conta, Denitsa Baykusheva, Manfred Lein and Hans Jakob Wörner | | | Capturing ultrafast molecular dynamics is difficult as the process involves coupled and very fast motions of electrons and nuclei. Here the authors study non-adiabatic dynamics in the NO molecule using strong-field photoelectron holography to shed light on the valence-shell electron dynamics. | | | 15 June 2017 | doi: 10.1038/ncomms15651 | | |
| VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2 OPEN | | | Yao-Hui Gao, Zhao-Xia Wu, Li-Qi Xie, Cai-Xia Li, Yu-Qin Mao, Yan-Tao Duan, Bing Han, San-Feng Han, Yun Yu, Hao-Jie Lu, Peng-Yuan Yang, Tian-Rui Xu, Jing-Lin Xia, Guo-Qiang Chen and Li-Shun Wang | | | The VHL tumour suppressor gene is lost in approximately 70% of clear cell renal cell carcinoma (ccRCC). In this study, the authors demonstrate that VHL loss in these tumours augments anthracyclines chemotherapy by down-regulation of ALDH2. | | | 15 June 2017 | doi: 10.1038/ncomms15337 | | |
| Ablation-resistant carbide Zr0.8Ti0.2C0.74B0.26 for oxidizing environments up to 3,000 °C OPEN | | | Yi Zeng, Dini Wang, Xiang Xiong, Xun Zhang, Philip J. Withers, Wei Sun, Matthew Smith, Mingwen Bai and Ping Xiao | | | Hypersonic and aerospace applications motivate development of materials with improved resistance against ablation and oxidation at high temperatures. Here authors demonstrate a quaternary carbide, where sealing by surface oxides, slow oxygen diffusion and a graded structure yield improved ablation resistance over established ceramics. | | | 14 June 2017 | doi: 10.1038/ncomms15836 | | |
| Genetic loci associated with heart rate variability and their effects on cardiac disease risk OPEN | | | Ilja M. Nolte, M. Loretto Munoz, Vinicius Tragante, Azmeraw T. Amare, Rick Jansen, Ahmad Vaez, Benedikt von der Heyde, Christy L. Avery, Joshua C. Bis, Bram Dierckx, Jenny van Dongen, Stephanie M. Gogarten, Philippe Goyette, Jussi Hernesniemi, Ville Huikari, Shih-Jen Hwang, Deepali Jaju, Kathleen F. Kerr, Alexander Kluttig, Bouwe P. Krijthe et al. | | | Heart rate variability (HRV) describes the individual variation in cardiac cycle duration and is a measure of vagal control of heart rate. Here, the authors identify seventeen single-nucleotide polymorphisms associated with HRV, lending new insight into the vagal regulation of heart rhythm. | | | 14 June 2017 | doi: 10.1038/ncomms15805 | | |
| Imaging metal-like monoclinic phase stabilized by surface coordination effect in vanadium dioxide nanobeam OPEN | | | Zejun Li, Jiajing Wu, Zhenpeng Hu, Yue Lin, Qi Chen, Yuqiao Guo, Yuhua Liu, Yingcheng Zhao, Jing Peng, Wangsheng Chu, Changzheng Wu and Yi Xie | | | Identifying intermediates during phase transitions is critical for our understanding of correlated materials, but difficult to achieve experimentally. Here, the authors report a surface coordination route to stabilize and directly image a phase-transition intermediate during the metal-insulator transition in vanadium dioxide. | | | 14 June 2017 | doi: 10.1038/ncomms15561 | | | | | | | | | | | | | Latest Corrigenda | | | | |
| | | | | Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress OPEN | | | Begoña Porteiro, Marcos F. Fondevila, Teresa C. Delgado, Cristina Iglesias, Monica Imbernon, Paula Iruzubieta, Javier Crespo, Amaia Zabala-Letona, Johan Fernø, Bárbara González-Terán, Nuria Matesanz, Lourdes Hernández-Cosido, Miguel Marcos, Sulay Tovar, Anxo Vidal, Julia Sánchez-Ceinos, Maria M. Malagon, Celia Pombo, Juan Zalvide, Arkaitz Carracedo et al. | | | 16 June 2017 | doi: 10.1038/ncomms16059 | | |
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| | | | | Corrigendum: EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance OPEN | | | Lingling Jiang, Yingying Shen, Danfeng Guo, Diya Yang, Jiajun Liu, Xuefeng Fei, Yunshan Yang, Buyi Zhang, Zhendong Lin, Fei Yang, Xiaojian Wang, Keyi Wang, Jianli Wang and Zhijian Cai | | | 14 June 2017 | doi: 10.1038/ncomms16006 | | | | | | | | | | Latest Erratum | | | | | | | | | |
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