Nature Reviews Immunology Contents July 2017 Volume 17 Number 7 pp 401-460

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TABLE OF CONTENTS
July 2017 Volume 17 Number 7		Advertisement
2016 2-year Impact Factor 39.932 Journal Metrics 2-year Median 29	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Does niche competition determine the origin of tissue-resident macrophages? Martin Guilliams & Charlotte L. Scott	Call for nominations: 2017 John Maddox Prize for Standing up for Science. Recognising the work of individuals who promote science in the face of hostility. Winners will be announced at a reception in London, as well as in Nature, and will receive £2,000. Closing date for nominations is 31st July 2017. Click to learn more
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RESEARCH HIGHLIGHTS Top Regulatory T cells: Subset-specific suppression p401 | doi:10.1038/nri.2017.68 T-bet+ regulatory T cells form a stable subset with specific suppressive activity towards T-bet+ effector T cells. PDF Tumour Immunology: LAP targeting reduces tolerogenic cells in cancer p402 | doi:10.1038/nri.2017.65 Anti-LAP antibodies show promising anticancer properties. PDF Regulatory T cells: Keep your hair on p402 | doi:10.1038/nri.2017.72 Regulatory T cells modulate the hair follicle regeneration cycle by inducing stem cell proliferation and differentiation. PDF Germinal centres: An ephrin B1-based guidance system p403 | doi:10.1038/nri.2017.71 Ephrin B1 controls T follicular helper cell residence and function in germinal centres. PDF Antiviral immunity: IFNλ offers frontline protection p404 | doi:10.1038/nri.2017.70 Lambda interferons have a non-redundant role in protecting airway epithelial cells from influenza A virus infection without inducing immunopathology. PDF T cells: Staying alive with S1P p404 | doi:10.1038/nri.2017.73 Sphingosine 1-phosphate promotes naive T cell survival by supporting their mitochondrial function. PDF JOURNAL CLUB Neuroendrocrine effects on autoimmunity p405 | doi:10.1038/nri.2017.47 Anne Cooke discusses a 1989 paper by Don Mason and colleagues that described a role for adrenal corticosteroids in modulating autoimmune pathology. PDF Nature Reviews Immunology JOBS of the week Brain Cancer Immunologist Columbia University's Departments of Microbiology & Immunology and Neurosurgery Postdoctoral position in Experimental Immunology Universität Basel Chair, Department of Microbiology and Immunology Rosalind Franklin University of Medicine and Science Assistant or Associate Professor- Physician-Scientist, Disease-Specific Immunology / Vaccinology Brown University Co-director Positions at "Academy of Immunology and Microbiology (AIM)” of the Institute for Basic Science (IBS) Institute for Basic Science / POSTECH More Science jobs from Nature Reviews Immunology EVENT Hallmarks of Skin Cancer (HoSC) Conference 06.11.17 Heidelberg, Germany More science events from
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REVIEWS		Top
The immunopathology of sepsis and potential therapeutic targets Tom van der Poll, Frank L. van de Veerdonk, Brendon P. Scicluna & Mihai G. Netea p407 | doi:10.1038/nri.2017.36 Sepsis — which is caused by a dysregulated host response to infection — is a life-threatening organ dysfunction. This Review describes the recent advances in our understanding of sepsis pathogenesis and discusses strategies for the development of successful therapies. Abstract | Full Text | PDF
Altered B cell signalling in autoimmunity David J. Rawlings, Genita Metzler, Michelle Wray-Dutra & Shaun W. Jackson p421 | doi:10.1038/nri.2017.24 In this Review, the authors propose that disease-associated genetic variants modulate signalling downstream of B cell receptors, Toll-like receptors and cytokine receptors in B cells to drive autoimmune responses. This altered signalling favours a naive B cell repertoire that is skewed towards self-reactivity and promotes the peripheral activation of autoreactive B cell clones. Abstract | Full Text | PDF
BACH transcription factors in innate and adaptive immunity Kazuhiko Igarashi, Tomohiro Kurosaki & Rahul Roychoudhuri p437 | doi:10.1038/nri.2017.26 The transcriptional repressors BTB and CNC homology 1 (BACH1) and BACH2 compete with transcriptional activators of the basic region leucine zipper (bZIP) family to control widespread functions of the innate and adaptive immune systems. Abstract | Full Text | PDF
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Call for nominations: 2017 John Maddox Prize for Standing up for Science. Recognising the work of individuals who promote science in the face of hostility. Winners will be announced at a reception in London, as well as in Nature, and will receive £2,000. Closing date for nominations is 31st July 2017. Click to learn more
PERSPECTIVES		Top
OPINION Does niche competition determine the origin of tissue-resident macrophages? Martin Guilliams & Charlotte L. Scott p451 | doi:10.1038/nri.2017.42 In this Opinion article, the authors discuss the limitations of categorizing tissue-resident macrophages based on their ontogeny. Instead, they propose that competition for a limited number of tissue niches may serve as a better framework for understanding the origins and functions of tissue macrophages. Abstract | Full Text | PDF
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