Thursday, June 29, 2017

Nature Reviews Drug Discovery contents July 2017 Volume 16 Number 7 pp 441-511

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Nature Reviews Drug Discovery

 
TABLE OF CONTENTS
 
July 2017 Volume 16 Number 7Advertisement

Nature Reviews Drug Discovery cover
2016 2-year Impact Factor 57.000 Journal Metrics 2-year Median 38
In this issue
Comment
News and Analysis
Research Highlights
Reviews

Also this month
 Featured article:
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Beth Levine, Douglas R. Green & Guido Kroemer


 

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BioPharma DealmakersCompany Profiles and Partnering Opportunities


 
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Comment: Implications of cancer evolution for drug development
Samra Turajlic & Charles Swanton
p441 | doi:10.1038/nrd.2017.78
Tumour evolution, which results in the existence of multiple distinct populations of cancer cells within the same tumour and the same patient, is increasingly appreciated to have a key role in drug resistance. In this article, we discuss the implications for drug development, including approaches to reduce the likelihood of the emergence of drug resistance.
Full Text | PDF


 
NEWS AND ANALYSIS

Top
Chinese biopharma starts feeding the global pipeline
Asher Mullard
p443 | doi:10.1038/nrd.2017.94
A handful of discovered-in-China candidates have entered the global clinic, including a few first-in-class contenders.
PDF

NEWS IN BRIEF
Genetic biomarker trumps tissue type in landmark oncology approval
Asher Mullard
p447 | doi:10.1038/nrd.2017.128
PDF

Finding fault with Bial's fatal FAAH inhibitor
Asher Mullard
p447 | doi:10.1038/nrd.2017.129
PDF

Biotech R&D spending continues to rise
Asher Mullard
p447 | doi:10.1038/nrd.2017.130
PDF

BIOBUSINESS BRIEFS
Market watch: Landscape for medical countermeasure development
Christopher Milne, Zachary Peter Smith & Ranjana Chakravarthy
p448 | doi:10.1038/nrd.2017.80
PDF

BIOBUSINESS BRIEFS
Market watch: Upcoming market catalysts in Q3 2017
Sonny Nghiem
p449 | doi:10.1038/nrd.2017.117
PDF

AN AUDIENCE WITH
Yong-Jun Liu
p450 | doi:10.1038/nrd.2017.127
Yong-Jun Liu, head of research at Sanofi, discusses his push to refocus the company on internal early-stage drug discovery.
PDF

FROM THE ANALYST'S COUCH
The ovarian cancer drug market
Jennifer Bamford & Rachel M. Webster
p451 | doi:10.1038/nrd.2017.92
This article discusses the impact of the recent approvals of poly ADP ribose polymerase (PARP) inhibitors on the market for ovarian cancer drugs, as well as potential future treatments such as immunotherapies.
PDF

RESEARCH HIGHLIGHTS

Top

Cardiovascular disease: BET inhibitor attenuates heart failure
p453 | doi:10.1038/nrd.2017.125
PDF


Endocrinology: Reducing fat and building bone
p454 | doi:10.1038/nrd.2017.121
PDF


Transporters: Natural product provides alternative transport for iron
p454 | doi:10.1038/nrd.2017.124
PDF


Cancer immunotherapy: Macrophages steal the show
p455 | doi:10.1038/nrd.2017.126
PDF


Ageing: Old bone removal
p456 | doi:10.1038/nrd.2017.123
PDF



IN BRIEF

Cancer: Targeting MYC-driven translation | Genetic disorders: Repurposing metformin in FXS | G Protein-Coupled Receptors: Crystal structure of glucagon family receptors
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REVIEWS

Top
Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance
Seth W. Dickey, Gordon Y. C. Cheung & Michael Otto
p457 | doi:10.1038/nrd.2017.23
Efforts to combat bacterial infections by targeting virulence factors are gaining traction, fuelled by the potential to circumvent the development of antibacterial resistance and recent landmark approvals of antivirulence drugs. Here, Otto and colleagues examine the antivirulence drugs in development, highlighting the most promising targets and strategies, as well as caveats to using this approach.
Abstract | Full Text | PDF


Targeting glutamate signalling in depression: progress and prospects
James W. Murrough, Chadi G. Abdallah & Sanjay J. Mathew
p472 | doi:10.1038/nrd.2017.16
Changes in glutamate signalling have been implicated in major depression, and ketamine, which was recently found to act as a rapid-acting antidepressant, affects glutamate signalling in several ways. Murrough and colleagues give an overview of the development of glutamate-signalling modulators for depression and examine studies on the mechanisms of these agents.
Abstract | Full Text | PDF


Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Beth Levine, Douglas R. Green & Guido Kroemer
p487 | doi:10.1038/nrd.2017.22
Dysregulated autophagy is associated with a variety of conditions, including cancer, neurodegenerative diseases, cardiovascular disorders and infectious diseases. However, despite significant efforts, no specific modulators of autophagy have yet been moved into the clinic. Here, Galluzzi et al. discuss the therapeutic potential of autophagy modulators and consider the key challenges that have limited their development.
Abstract | Full Text | PDF


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