Nature Immunology Contents: July 2017 Volume 18 pp 707 - 823

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS July 2017 Volume 18, Issue 7 Obituary News and Views Research Highlights Reviews Articles Advertisement   Nature Reviews Cancer: Poster on Multifaceted effects of the microenvironment on tumour progression Available to download free online Produced with support from  Fluidigm Corporation  Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement nature.com webcasts Springer Nature presents a custom webcast by Professor Aude Chapuis, MD on harnessing the therapeutic potential of adoptively transferred cells. Register for FREE Date: Thursday, June 22 2017 Time: 11AM PDT | 2PM EDT Register  Sponsored by:  10x Genomics   Advertisement Nature Milestones: Interactive antibody timeline Nature Milestones: Antibodies presents an interactive timeline on the history of antibodies covering everything from their initial description in antisera through to their application in immunotherapy. The timeline includes written content, video interviews and animations.  Access the timeline free online Produced with support from BioLegend UCB    Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Autophagy Machinery Regulates Cell Death Switching - New Insights with Proximity Ligation Assays Date: Wednesday, June 21, 2017 Time: 9AM CST | 10AM JST | 11AM AEST| 1PM NZST Register for FREE Sponsored by:  MilliporeSigma in U.S., Merck in ROW   Obituary Top Julius Youngner 1920-2017   p707 Vincent Racaniello doi:10.1038/ni.3779 News and Views Top Polymorphisms in IFIH1: the good and the bad   pp708 - 709 Erika Della Mina, Mathieu P Rodero and Yanick J Crow doi:10.1038/ni.3765 A study of polymorphisms in the sensor IFIH1 exposes the evolutionary trade-off between a robust antiviral type I interferon response and the risk of interferon-mediated inflammation. See also: Article by Gorman et al. A Hippo in the Fox(p3) house   pp709 - 711 Mandy J McGeachy doi:10.1038/ni.3769 The Hippo signaling pathway regulates cellular proliferation and survival during tissue growth and cancer. In CD4+ T cells, members of the Hippo family modulate autoimmune inflammation by altering interactions between the transcription factors Foxp3 and RORγt; this reveals an unexpected non-canonical role for Hippo in adaptive immunity. See also: Article by Geng et al. Atypical matters in myeloid differentiation   pp711 - 712 Massimo Locati, Alberto Mantovani and Raffaella Bonecchi doi:10.1038/ni.3776 Chemokines are important components of the hematopoietic niche. The atypical chemokine receptor 1 (ACKR1), expressed on erythrocyte precursors, regulates myeloid differentiation. See also: Article by Duchene et al. A rheostat tuning thymic selection   pp713 - 714 Gerald P Morris and Stephen M Hedrick doi:10.1038/ni.3778 Thymocytes must undergo positive selection to survive and differentiate. This process is regulated by the TCR-sensitive protein CHMPS by preventing Bcl2 oxidation and degradation. See also: Article by Adoro et al. Immunology JOBS of the week Brain Cancer Immunologist Columbia University’s Departments of Microbiology & Immunology and Neurosurgery Postdoctoral position in Experimental Immunology Universität Basel Chair, Department of Microbiology and Immunology Rosalind Franklin University of Medicine and Science Assistant or Associate Professor- Physician-Scientist, Disease-Specific Immunology / Vaccinology Brown University Co-director Positions at “Academy of Immunology and Microbiology (AIM)” of the Institute for Basic Science (IBS) Institute for Basic Science / POSTECH More Science jobs from Immunology EVENT Hallmarks of Skin Cancer (HoSC) Conference 06.11.17 Heidelberg, Germany More science events from Research Highlights Top Learning during inflammation | Highly localized memory | Tissue-specific amplifiers | Regulating hair growth | IL-22 in Peyer's patches | Epigenetic changes in TILs Reviews Top The multiple pathways to autoimmunity   pp716 - 724 Argyrios N Theofilopoulos, Dwight H Kono and Roberto Baccala doi:10.1038/ni.3731 Autoimmunity can arise when tolerance mechanisms break down. Theofilopoulos and colleagues review how loss of peripheral tolerance, often driven by innate nucleic-acid sensors, leads to the activation of autoreactive lymphocytes that underlie many autoimmune diseases. Systems immunology: just getting started   pp725 - 732 Mark M Davis, Cristina M Tato and David Furman doi:10.1038/ni.3768 Davis and colleagues review systems-biology approaches in immunology as a powerful means of understanding the immune system as a whole. Articles Top YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKϵ-mediated phosphorylation   pp733 - 743 Shuai Wang, Feng Xie, Feng Chu, Zhengkui Zhang, Bing Yang et al. doi:10.1038/ni.3744 Intracellular detection of viral invasion triggers activation of the transcription factor IRF3 and antiviral interferon production. Fangfang Zhou and colleagues report that the transcription regulator YAP in the host restrains this process by preventing inadvertent spontaneous dimerization of IRF3 and its translocation to the nucleus. The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity   pp744 - 752 Jacquelyn A Gorman, Christian Hundhausen, John S Errett, Amy E Stone, Eric J Allenspach et al. doi:10.1038/ni.3766 Single-nucleotide polymorphisms in the gene encoding the cytosolic viral sensor IFIH1 are linked to a variety of autoimmune diseases. Rawlings and colleagues demonstrate that one such common polymorphism results in IFIH1 with more-potent activation and can act synergistically with other genetic backgrounds to manifest autoimmune disease. See also: News and Views by Mina et al. Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis   pp753 - 761 Johan Duchene, Igor Novitzky-Basso, Aude Thiriot, Maria Casanova-Acebes, Mariaelvy Bianchini et al. doi:10.1038/ni.3763 Genetic polymorphisms affect expression of the atypical chemokine receptor ACKR1 (Duffy) on nucleated erythrocyte precursors. Rot and colleagues show that loss of its expression alters hematopoiesis, yielding a distinct neutrophil population that rapidly exits the bloodstream to give an apparent 'neutropenia' phenotype. See also: News and Views by Locati et al. Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1   pp762 - 770 Louise A Johnson, Suneale Banerji, William Lawrance, Uzi Gileadi, Gennaro Prota et al. doi:10.1038/ni.3750 Jackson and colleagues show that dendritic cells transit to the lumen of lymphatic vessels through hyaluronan-mediated interactions with the endothelial receptor LYVE-1. CD8αα intraepithelial lymphocytes arise from two main thymic precursors   pp771 - 779 Roland Ruscher, Rebecca L Kummer, You Jeong Lee, Stephen C Jameson and Kristin A Hogquist doi:10.1038/ni.3751 TCRβ+CD8αα+ intraepithelial lymphocytes arise from CD4-CD8-CD5+ thymic cells, but the exact precursor source has been not been established. Hogquist and colleagues identify two distinct thymic populations that both give rise mainly to gut-homing intraepithelial lymphocytes. Post-translational control of T cell development by the ESCRT protein CHMP5   pp780 - 790 Stanley Adoro, Kwang Hwan Park, Sarah E Bettigole, Raphael Lis, Hee Rae Shin et al. doi:10.1038/ni.3764 Thymocytes must undergo positive selection to survive and emigrate to the periphery as mature T cells. Glimcher and colleagues identify CHMP5 as a TCR-sensitive regulator of positive selection that acts by preventing oxidation and degradation of the pro-survival protein Bcl-2. See also: News and Views by Morris & Hedrick The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection   pp791 - 799 Howell F Moffett, Adam N R Cartwright, Hye-Jung Kim, Jernej Godec, Jason Pyrdol et al. doi:10.1038/ni.3755 Wucherpfennig and colleagues show that the microRNA miR-31 increases the sensitivity of T cells to type I interferons, which interferes with effector T cell function during chronic infection. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells   pp800 - 812 Jing Geng, Shujuan Yu, Hao Zhao, Xiufeng Sun, Xun Li et al. doi:10.1038/ni.3748 Hippo signaling controls cell and tissue growth. Geng et al. show that Hippo signaling is required for TH17 cell differentiation but inhibits Treg cell differentiation. See also: News and Views by McGeachy BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency   pp813 - 823 Behdad Afzali, Juha Grönholm, Jana Vandrovcova, Charlotte O'Brien, Hong-Wei Sun et al. doi:10.1038/ni.3753 BACH2 is required for lymphocyte differentiation. Afzali et al. describe mutations that cause BACH2 disruption, immunodeficiency and autoinflammatory disease via haploinsufficiency, a mechanism shared by other super-enhancer-regulated genes. Advertisement Take part in our PhD survey for your chance to win Tell us what you love about life as PhD student, about your plans, and some of the challenges you face at this all-important career stage. Take part in Nature Research Group's biennial global PhD survey, and you'll also have the chance to enter a prize draw to win a £100/$150 Amazon gift card.   Top Advertisement A community map of cancer immunity Immunotherapy is influenced by a complex set of tumour, host and environmental factors. Such factors combine to characterise the immunological status — or cancer-immune set point — of an individual. Collaborate with peers to update, evolve and improve the cancer-immune set point framework   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2017 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.