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TABLE OF CONTENTS |
July 2017 Volume 13, Issue 7 |
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| Research Highlights News and Views Perspective Brief Communication Articles
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Naturejobs Career Guide Melbourne 2017 Melbourne's institutes cluster into discrete geographic hubs, with a solid culture of collaboration and an emphasis on biomedical research. Learn more about the area's leading scientific entities; their ties to each other; success from a scientific data-driven perspective and much more. Read the full Career Guide | | | |
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Research Highlights | Top |
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Metal homeostasis: Pumping iron | Antimicrobials: Targeting fungal chromatin | Synthetic biology: Playing favorites | Circadian regulation: Switching periods
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News and Views | Top |
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Perspective | Top |
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Brief Communication | Top |
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Engineering RGB color vision into Escherichia coli pp706 - 708 Jesus Fernandez-Rodriguez, Felix Moser, Miryoung Song and Christopher A Voigt doi:10.1038/nchembio.2390
A synthetic biology system composed of light-wavelength-responsive genetic regulators, signal-processing circuits and pigment-production pathways have resulted in an Escherichia coli strain that can record color images in RGB format.
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Articles | Top |
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Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells pp724 - 729 Kadla R Rosholm, Natascha Leijnse, Anna Mantsiou, Vadym Tkach, Soren L Pedersen et al. doi:10.1038/nchembio.2372
Membrane curvature induces sorting of GPCRs within live-cell-membrane protrusions, and the curvature-dependent sorting is affected by agonist binding. Thermodynamic modeling suggests that this is due to an energetic drive to match receptor shape and elasticity to membrane curvature.
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Functional selectivity of GPCR-directed drug action through location bias pp799 - 806 Roshanak Irannejad, Veronica Pessino, Delphine Mika, Bo Huang, Philip B Wedegaertner et al. doi:10.1038/nchembio.2389
Intracellular Gs-cAMP signaling from β1-adrenergic receptors residing in the Golgi represents /`location bias/', a new form of GPCR functional selectivity. Inactive Golgi-localized receptors can be activated by some β1-targeting drugs.
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Structural basis for high-affinity fluorophore binding and activation by RNA Mango pp807 - 813 Robert J Trachman III, Natalia A Demeshkina, Matthew W L Lau, Shanker Shyam S Panchapakesan, Sunny C Y Jeng et al. doi:10.1038/nchembio.2392
A crystal structure of the RNA aptamer Mango bound to a thiazole orange-derived fluorophore reveals a three-tiered G-quadruplex structure, which, together with three flap-like nucleotides, constrains the fluorophore into its active conformation.
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