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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | | | | | | Latest Articles | View all Articles | | | | | Understanding the origin of Paris Agreement emission uncertainties OPEN | | | Joeri Rogelj, Oliver Fricko, Malte Meinshausen, Volker Krey, Johanna J. J. Zilliacus and Keywan Riahi | | | The pledges put forward by each country to meet the goals of the Paris Agreement are ambiguous. Rogelj et al. quantify the uncertainty arising from the interpretation of these pledges and find that by 2030 global emissions can vary by −10% to +20% around their median estimate of 52 GtCO2e yr−1. | | | 06 June 2017 | doi: 10.1038/ncomms15748 | | |
| Extreme temperatures in Southeast Asia caused by El Niño and worsened by global warming OPEN | | | Kaustubh Thirumalai, Pedro N. DiNezio, Yuko Okumura and Clara Deser | | | Record temperatures in mainland Southeast Asia in April 2016 had severe impacts on the population. Thirumalai et al. show that all April extremes occur after El Niño years, and that global warming has increased the likelihood of such extremes. | | | 06 June 2017 | doi: 10.1038/ncomms15531 | | |
| Conserved linear dynamics of single-molecule Brownian motion OPEN | | | Maged F. Serag and Satoshi Habuchi | | | The general consensus is that random walking, such as Brownian motion, follows a linear dependence of diffusion motions with time. Here, the authors show that random motion of macromolecules in an isotropic fluid could be governed by non-random dynamics that are only detectable in their relative motions. | | | 06 June 2017 | doi: 10.1038/ncomms15675 | | |
| Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity OPEN | | | Jung-A. A. Woo, Tian Liu, Courtney Trotter, Cenxiao C. Fang, Emillio De Narvaez, Patrick LePochat, Drew Maslar, Anusha Bukhari, Xingyu Zhao, Andrew Deonarine, Sandy D. Westerheide and David E. Kang | | | Mutations in CHCHD10 have been recently associated with frontotemporal dementia and amyotrophic lateral sclerosis. Here the authors study the functions of endogenous CHCHD10 in Caenorhabditis elegans, primary neurons, and mouse, and show that it normally protects mitochondria and synaptic integrity, and retains TDP-43 in the nucleus. | | | 06 June 2017 | doi: 10.1038/ncomms15558 | | |
| Possible absence of critical thickness and size effect in ultrathin perovskite ferroelectric films OPEN | | | Peng Gao, Zhangyuan Zhang, Mingqiang Li, Ryo Ishikawa, Bin Feng, Heng-Jui Liu, Yen-Lin Huang, Naoya Shibata, Xiumei Ma, Shulin Chen, Jingmin Zhang, Kaihui Liu, En-Ge Wang, Dapeng Yu, Lei Liao, Ying-Hao Chu and Yuichi Ikuhara | | | Understanding ferroelectricity at reduced dimensions will be important for future sub-nanoscale devices based on ferroelectrics. Using high resolution electron microscopy; Gao et al., observe the existence of a measurable polarization at a thickness of just 1.5-unit cells | | | 06 June 2017 | doi: 10.1038/ncomms15549 | | |
| Compaction of quasi-one-dimensional elastoplastic materials OPEN | | | M. Reza Shaebani, Javad Najafi, Ali Farnudi, Daniel Bonn and Mehdi Habibi | | | Principles underlying crumpling of one-dimensional objects may be relevant to both biomolecular processes and to design of mechanical devices. By compacting various wires under rigid confinement and modelling observed geometric features, the authors show how friction, plasticity and torsion enhance disorder and lead to a transition from coiled to folded geometries. | | | 06 June 2017 | doi: 10.1038/ncomms15568 | | |
| Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis OPEN | | | Jaeyun Sung, Seunghyeon Kim, Josephine Jill T. Cabatbat, Sungho Jang, Yong-Su Jin, Gyoo Yeol Jung, Nicholas Chia and Pan-Jun Kim | | | The metabolic interactions between gut microbes and host cells play roles in human health. Here, Sung et al. present a literature-curated metabolic network of the human gut microbiota and three human cell types, together with a mathematical approach to identify distinct microbial and metabolic features in gut microbiomes. | | | 06 June 2017 | doi: 10.1038/ncomms15393 | | |
| Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division OPEN | | | Sylvain Loubéry, Alicia Daeden, Carole Seum, Laurent Holtzer, Ana Moraleda, Nicolas Damond, Emmanuel Derivery, Thomas Schmidt and Marcos Gonzalez-Gaitan | | | Asymmetric segregation of cell fate determinants during cell division governs daughter cell fate. Here the authors show that Sara endosomes, known to regulate Notch signalling, are targeted to the mitotic spindle and once phosphorylated are asymmetrically dispatched into a daughter cell to determine cell fate. | | | 06 June 2017 | doi: 10.1038/ncomms15285 | | |
| A molecular portrait of microsatellite instability across multiple cancers OPEN | | | Isidro Cortes-Ciriano, Sejoon Lee, Woong-Yang Park, Tae-Min Kim and Peter J. Park | | | Some cancers with DNA mismatch repair deficiency display microsatellite instability. Here the authors analyse twenty three cancer types at the exome and whole-genome level, and identify loci with recurrent microsatellite instability that could be used to identify patients who would benefit from immunotherapy. | | | 06 June 2017 | doi: 10.1038/ncomms15180 | | |
| Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery OPEN | | | Holly A. Rees, Alexis C. Komor, Wei-Hsi Yeh, Joana Caetano-Lopes, Matthew Warman, Albert S. B. Edge and David R. Liu | | | Third-generation base editors consist of a catalytically disabled Cas9 fused to a cytidine deaminase and a base excision repair inhibitor, enabling efficient, precise editing of individual base pairs in DNA. Here the authors describe engineering and protein delivery of base editors to improve their DNA specificity and enable specific base editing in live animals. | | | 06 June 2017 | doi: 10.1038/ncomms15790 | | |
| Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis OPEN | | | Snaevar Sigurdsson, Kristjan F. Alexandersson, Patrick Sulem, Bjarke Feenstra, Steinunn Gudmundsdottir, Gisli H. Halldorsson, Sigurgeir Olafsson, Asgeir Sigurdsson, Thorunn Rafnar, Thorgeir Thorgeirsson, Erik Sørensen, Andreas Nordholm-Carstensen, Jakob Burcharth, Jens Andersen, Henrik Stig Jørgensen, Emma Possfelt-Møller, Henrik Ullum, Gudmar Thorleifsson, Gisli Masson, Unnur Thorsteinsdottir et al. | | | A hallmark of diverticular disease is pouches in the bowel wall which can become infected and inflamed, causing the more severe diverticulitis. Here, the authors report the first genome-wide association study on these interconnected conditions and identify ARHGAP15, COLQ and FAM155A as novel risk loci. | | | 06 June 2017 | doi: 10.1038/ncomms15789 | | |
| Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes OPEN | | | A. S. Axelsson, T. Mahdi, H. A. Nenonen, T. Singh, S. Hänzelmann, A. Wendt, A. Bagge, T. M. Reinbothe, J. Millstein, X. Yang, B. Zhang, E. G. Gusmao, L. Shu, M. Szabat, Y. Tang, J. Wang, S. Salö, L. Eliasson, I. Artner, M. Fex et al. | | | Type 2 diabetes (T2D) is a heterogeneous disorder characterized by insulin resistance and impaired insulin secretion. Here Axelsson et al. show that Sox5, which is reduced in diabetes, regulates a set of differentially expressed genes in T2D and its genetic and pharmacological induction improves insulin secretion by diabetic islets. | | | 06 June 2017 | doi: 10.1038/ncomms15652 | | |
| Multimode entanglement in reconfigurable graph states using optical frequency combs OPEN | | | Y. Cai, J. Roslund, G. Ferrini, F. Arzani, X. Xu, C. Fabre and N. Treps | | | Multimode entanglement is an important resource for quantum information processing, but setups are often able to generate specific configurations only. Here the authors present an on-demand reconfigurable multimode entangled state source, realizing thirteen cluster states of various sizes and connectivities. | | | 06 June 2017 | doi: 10.1038/ncomms15645 | | |
| Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents OPEN | | | Choi-Fong Cho, Justin M. Wolfe, Colin M. Fadzen, David Calligaris, Kalvis Hornburg, E. Antonio Chiocca, Nathalie Y. R. Agar, Bradley L. Pentelute and Sean E. Lawler | | | In vitro blood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform to identify cell-penetrating peptides that can cross the BBB. | | | 06 June 2017 | doi: 10.1038/ncomms15623 | | |
| Mechanism of microtubule stabilization by taccalonolide AJ OPEN | | | Yuxi Wang, Yamei Yu, Guo-Bo Li, Shu-Ang Li, Chengyong Wu, Benoît Gigant, Wenming Qin, Hao Chen, Yangping Wu, Qiang Chen and Jinliang Yang | | | Microtubule-stabilizing agents (MSAs) promote the polymerization of tubulin and are of great interest as anticancer drugs. Here the authors present the crystal structure of the MSA taccalonolide AJ bound to tubulin and give insights into its mode of action, which might help in the design of novel MSAs. | | | 06 June 2017 | doi: 10.1038/ncomms15787 | | |
| IL-21-mediated reversal of NK cell exhaustion facilitates anti-tumour immunity in MHC class I-deficient tumours OPEN | | | Hyungseok Seo, Insu Jeon, Byung-Seok Kim, Myunghwan Park, Eun-Ah Bae, Boyeong Song, Choong-Hyun Koh, Kwang-Soo Shin, Il-Kyu Kim, Kiyoung Choi, Taegwon Oh, Jiyoun Min, Byung Soh Min, Yoon Dae Han, Suk-Jo Kang, Sang Joon Shin, Yeonseok Chung and Chang-Yuil Kang | | | Loss of major histocompatibility complex MHC-I expression contributes to cancer immune evasion. Here, the authors show that, in both mice and humans, MHC-I downregulation is associated with the induction of NK-cell exhaustion and that IL-21 restores NK-cell function and inhibits tumours progression. | | | 06 June 2017 | doi: 10.1038/ncomms15776 | | |
| Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase OPEN | | | David Forrest, Katherine James, Yulia Yuzenkova and Nikolay Zenkin | | | Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage of Bacillus subtilis, which shares homology to multi-subunit enzymes. | | | 06 June 2017 | doi: 10.1038/ncomms15774 | | |
| Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex OPEN | | | Youwei Xu, Carrie Bernecky, Chung-Tien Lee, Kerstin C. Maier, Björn Schwalb, Dimitry Tegunov, Jürgen M. Plitzko, Henning Urlaub and Patrick Cramer | | | The Paf1 complex (Paf1C) is an elongation factor assembly that forms the interface between transcribing Pol II and chromatin factors. Here the authors describe the architecture of Paf1C and its interface with Pol II, and show that Paf1C is globally required for normal mRNA transcription in yeast. | | | 06 June 2017 | doi: 10.1038/ncomms15741 | | |
| Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment OPEN | | | Ariane-Saskia Ries, Tim Hermanns, Burkhard Poeck and Roland Strauss | | | Features of major depressive disorder including lack of motivation, sleep disruption and cognitive deficit have been modelled in rodents. Here, the authors develop a new method to elicit a depression-like state in Drosophila, and uncover separable roles for different serotonin receptors in depression-like behaviour. | | | 06 June 2017 | doi: 10.1038/ncomms15738 | | |
| Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 OPEN | | | Masaki Takasugi, Ryo Okada, Akiko Takahashi, David Virya Chen, Sugiko Watanabe and Eiji Hara | | | Although senescent cell secretome can promote the growth of surrounding cancer cells, the role of extracellular vesicles in this process has not been well understood. Here the authors show that ROS increase the sorting of EphA2 into extracellular vesicles in senescent cells, which promotes proliferation of cancer cells. | | | 06 June 2017 | doi: 10.1038/ncomms15728 | | |
| Structural basis of HypK regulating N-terminal acetylation by the NatA complex OPEN | | | Felix Alexander Weyer, Andrea Gumiero, Karine Lapouge, Gert Bange, Jürgen Kopp and Irmgard Sinning | | | N-terminal acetylation is a common eukaryotic protein modification that is primarily catalysed by the N-acetyl transferase complex A (NatA). Here, the authors present the crystal structure of NatA bound to Huntingtin yeast two-hybrid protein K (HypK) and show that HypK is a negative regulator of NatA. | | | 06 June 2017 | doi: 10.1038/ncomms15726 | | |
| Tailoring protein nanomechanics with chemical reactivity OPEN | | | Amy E. M. Beedle, Marc Mora, Steven Lynham, Guillaume Stirnemann and Sergi Garcia-Manyes | | | Post-translational modifications modulate nanomechanics of proteins. Here the authors use single-molecule force-clamp spectroscopy supported by density functional theory calculations to show how reactive low-weight molecular thiol compounds directly affect mechanical protein folding. | | | 06 June 2017 | doi: 10.1038/ncomms15658 | | |
| Split-BioID a conditional proteomics approach to monitor the composition of spatiotemporally defined protein complexes OPEN | | | Isabel Myriam Schopp, Cinthia Claudia Amaya Ramirez, Jerneja Debeljak, Elisa Kreibich, Merle Skribbe, Klemens Wild and Julien Béthune | | | The BioID approaches takes advantage of the promiscuous biotinylation enzyme (BirA*) to identify proteins that closely interact. Here the authors improve the resolution of BioID using a protein fragment complementation approach that allows the assignment of protein-protein interactions to specific complexes within a common interactome. | | | 06 June 2017 | doi: 10.1038/ncomms15690 | | |
| Crop wild relative populations of Beta vulgaris allow direct mapping of agronomically important genes OPEN | | | Gina G. Capistrano-Gossmann, D. Ries, D. Holtgräwe, A. Minoche, T. Kraft, S.L.M. Frerichmann, T. Rosleff Soerensen, J. C. Dohm, I. González, M. Schilhabel, M. Varrelmann, H. Tschoep, H. Uphoff, K. Schütze, D. Borchardt, O. Toerjek, W. Mechelke, J. C. Lein, A. W. Schechert, L. Frese et al. | | | Variation among wild relatives of crop plants can be used to identify genes underlying traits of agronomic importance. Here, the authors show that a modified mapping-by-sequencing approach can rapidly identify the genetic basis for viral resistance in sugar beet using wild beet populations in their natural habitat. | | | 06 June 2017 | doi: 10.1038/ncomms15708 | | |
| Lithospheric foundering and underthrusting imaged beneath Tibet OPEN | | | Min Chen, Fenglin Niu, Jeroen Tromp, Adrian Lenardic, Cin-Ty A. Lee, Wenrong Cao and Julia Ribeiro | | | The timing and mechanism of uplift of the Tibetan plateau continues to be a source of debate. Here, the authors present a new tomographic model revealing a T-shaped high wave speed structure beneath South-Central Tibet and interpret this an upper-mantle remnant from lithospheric foundering. | | | 06 June 2017 | doi: 10.1038/ncomms15659 | | |
| Organic narrowband near-infrared photodetectors based on intermolecular charge-transfer absorption OPEN | | | Bernhard Siegmund, Andreas Mischok, Johannes Benduhn, Olaf Zeika, Sascha Ullbrich, Frederik Nehm, Matthias Böhm, Donato Spoltore, Hartmut Fröb, Christian Körner, Karl Leo and Koen Vandewal | | | Interfaces of organic donor-acceptor blends provide intermolecular charge-transfer states with red-shifted but weak absorption. By introducing an optical micro-cavity; Siegmund et al., enhance their photoresponse to achieve narrowband NIR photodetection with broad spectral tunability. | | | 05 June 2017 | doi: 10.1038/ncomms15421 | | |
| Three-dimensional Pentagon Carbon with a genesis of emergent fermions OPEN | | | Chengyong Zhong, Yuanping Chen, Zhi-Ming Yu, Yuee Xie, Han Wang, Shengyuan A. Yang and Shengbai Zhang | | | Whether carbon allotropes may host emergent topological fermions is unknown. Here, Zhong et al. predict a three-dimensional carbon allotrope entirely composed of pentagon rings, showing a plethora of topological fermions under strain. | | | 05 June 2017 | doi: 10.1038/ncomms15641 | | |
| Ultrathin metal-organic framework array for efficient electrocatalytic water splitting OPEN | | | Jingjing Duan, Sheng Chen and Chuan Zhao | | | Metal-organic frameworks are generally considered to be inert catalysts for many electrochemical reactions, however this is not always the case. Here the authors fabricate an ultrathin nanosheet array of metal-organic frameworks exhibiting enhanced performance toward electrocatalytic water splitting. | | | 05 June 2017 | doi: 10.1038/ncomms15341 | | |
| Melting temperatures of MgO under high pressure by micro-texture analysis OPEN | | | T. Kimura, H. Ohfuji, M. Nishi and T. Irifune | | | Melting behaviour of MgO under pressure remains unclear despite the importance of constraining the rheology and composition of the Earth’s mantle. Here, the authors show that melting temperatures in earlier static experiments were underestimated based on micro-texture analysis of the quenched samples. | | | 05 June 2017 | doi: 10.1038/ncomms15735 | | |
| Pacific plate motion change caused the Hawaiian-Emperor Bend OPEN | | | Trond H. Torsvik, Pavel V. Doubrovine, Bernhard Steinberger, Carmen Gaina, Wim Spakman and Mathew Domeier | | | The Hawaiian-Emperor Chain has a 60° bend that has been interpreted as the result of Pacific plate motion at 47 Ma or drift of the Hawaiian hotspot. Here, the authors show that hotspot drift cannot be the dominant mechanism for bend formation, but involves a change in the direction of Pacific plate motion at ∼47 Ma. | | | 05 June 2017 | doi: 10.1038/ncomms15660 | | |
| Coupled multiferroic domain switching in the canted conical spin spiral system Mn2GeO4 OPEN | | | T. Honda, J. S. White, A. B. Harris, L. C. Chapon, A. Fennell, B. Roessli, O. Zaharko, Y. Murakami, M. Kenzelmann and T. Kimura | | | The coexistence of ferromagnetism and ferroelectricity in a multiferroic material often arises from complex magnetoelectric couplings. Here, the authors observe switching of domains in Mn2GeO4 using neutron diffraction and develop a phenomenological theory to explain their results. | | | 05 June 2017 | doi: 10.1038/ncomms15457 | | |
| The genetic landscape of benign thyroid nodules revealed by whole exome and transcriptome sequencing OPEN | | | Lei Ye, Xiaoyi Zhou, Fengjiao Huang, Weixi Wang, Yicheng Qi, Heng Xu, Shu Yang, Liyun Shen, Xiaochun Fei, Jing Xie, Min Cao, Yulin Zhou, Wei Zhu, Shu Wang, Guang Ning and Weiqing Wang | | | Papillary thyroid carcinomas are often found with coincidental benign thyroid nodules. Here, the authors provide genomic evidence that papillary thyroid carcinomas and coincidental benign thyroid nodules originate and evolve independently. | | | 05 June 2017 | doi: 10.1038/ncomms15533 | | |
| Enantioselective decarboxylative chlorination of β-ketocarboxylic acids OPEN | | | Kazutaka Shibatomi, Kazumasa Kitahara, Nozomi Sasaki, Yohei Kawasaki, Ikuhide Fujisawa and Seiji Iwasa | | | Due to the synthetic utility of the products, stereoselective halogenation is a powerful method for the synthesis of chiral compounds. Here the authors report an enantioselective decarboxylative chlorination, giving access to a range of α-chloroketones. | | | 05 June 2017 | doi: 10.1038/ncomms15600 | | |
| Hafnium—an optical hydrogen sensor spanning six orders in pressure OPEN | | | C. Boelsma, L. J. Bannenberg, M. J. van Setten, N.-J. Steinke, A. A. van Well and B. Dam | | | For monitoring hydrogen partial pressure, optical sensors have a particular safety advantage due to absence of wiring in operation area. Here authors show hysteresis-free, reproducible change in optical transmission in palladium-capped hafnium hydride films over six orders of magnitude in hydrogen partial pressure. | | | 05 June 2017 | doi: 10.1038/ncomms15718 | | |
| Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease OPEN | | | Awo Akosua Kesewa Layman, Guoping Deng, Claire E. O’Leary, Samuel Tadros, Rajan M. Thomas, Joseph M. Dybas, Emily K. Moser, Andrew D. Wells, Nicolai M. Doliba and Paula M. Oliver | | | T regulatory (Treg) cells are essential for maintaining immune homeostasis, but how the stability of their lineage and function is regulated is unclear. Here the authors show that Ndfip1 is essential for suppressing Treg cell IL-4 production and metabolic alteration to preserve Treg lineage and function. | | | 05 June 2017 | doi: 10.1038/ncomms15677 | | |
| Functional evolution of Lepidoptera olfactory receptors revealed by deorphanization of a moth repertoire OPEN | | | Arthur de Fouchier, William B. Walker, Nicolas Montagné, Claudia Steiner, Muhammad Binyameen, Fredrik Schlyter, Thomas Chertemps, Annick Maria, Marie-Christine François, Christelle Monsempes, Peter Anderson, Bill S. Hansson, Mattias C. Larsson and Emmanuelle Jacquin-Joly | | | The range of odours that an insect can detect depends on its olfactory receptors. Here, the authors functionally characterize the olfactory receptor repertoire of the moth Spodoptera littoralis using the Drosophila empty neuron system and reconstruct the evolution of these receptors in the Lepidoptera. | | | 05 June 2017 | doi: 10.1038/ncomms15709 | | |
| Rapid visualization of grain boundaries in monolayer MoS2 by multiphoton microscopy OPEN | | | Lasse Karvonen, Antti Säynätjoki, Mikko J. Huttunen, Anton Autere, Babak Amirsolaimani, Shisheng Li, Robert A. Norwood, Nasser Peyghambarian, Harri Lipsanen, Goki Eda, Khanh Kieu and Zhipei Sun | | | Atomically thin transition metal dichalcogenides can be grown on large scale using chemical vapour deposition which, however, determines presence of grain boundaries. Here, the authors report that third-harmonic generation imaging provides excellent sensitivity and fast speed for grain boundary visualization in MoS2. | | | 05 June 2017 | doi: 10.1038/ncomms15714 | | |
| Harnessing speckle for a sub-femtometre resolved broadband wavemeter and laser stabilization OPEN | | | Nikolaus Klaus Metzger, Roman Spesyvtsev, Graham D. Bruce, Bill Miller, Gareth T. Maker, Graeme Malcolm, Michael Mazilu and Kishan Dholakia | | | The complex speckle pattern produced by coherent multiple scattering contains information about the incident light field, which has recently been used for imaging. Metzger et al. use speckle to construct a wavemeter with sub-femtometre resolution which is subsequently used for laser stabilization. | | | 05 June 2017 | doi: 10.1038/ncomms15610 | | |
| Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish OPEN | | | Germán Reig, Mauricio Cerda, Néstor Sepúlveda, Daniela Flores, Victor Castañeda, Masazumi Tada, Steffen Härtel and Miguel L. Concha | | | The role of mechanical signals in early development are not fully understood. Here, the authors use the simplicity of early killifish embryos to show that tension arising from extra-embryonic epithelial expansion directs the spreading of mesenchymal-like embryonic cells during early morphogenesis. | | | 05 June 2017 | doi: 10.1038/ncomms15431 | | |
| Single-stage plasma-based correlated energy spread compensation for ultrahigh 6D brightness electron beams OPEN | | | G. G. Manahan, A. F. Habib, P. Scherkl, P. Delinikolas, A. Beaton, A. Knetsch, O. Karger, G. Wittig, T. Heinemann, Z. M. Sheng, J. R. Cary, D. L. Bruhwiler, J. B. Rosenzweig and B. Hidding | | | Controlling and improving electron beam parameters are crucial for their application in free electron laser and X-ray sources. Here the authors generate quality electron beams with reduced energy spread from plasma accelerators by using a tailored escort electron bunch with the main accelerating bunch. | | | 05 June 2017 | doi: 10.1038/ncomms15705 | | |
| Evidence for fungal and chemodenitrification based N2O flux from nitrogen impacted coastal sediments OPEN | | | Scott D. Wankel, Wiebke Ziebis, Carolyn Buchwald, Chawalit Charoenpong, Dirk de Beer, Jane Dentinger, Zhenjiang Xu and Karsten Zengler | | | Predicting nitrous oxide emissions (N2O) remains difficult due to the numerous N2O production pathways. Here, the authors use incubations simulating high nitrate inputs to show that, in intertidal sediments, increases in N2O flux are largely mediated by fungal denitrification and/or chemodenitrification. | | | 05 June 2017 | doi: 10.1038/ncomms15595 | | |
| Measuring finite-range phase coherence in an optical lattice using Talbot interferometry OPEN | | | Bodhaditya Santra, Christian Baals, Ralf Labouvie, Aranya B. Bhattacherjee, Axel Pelster and Herwig Ott | | | Quantum gas experiments are useful to study non-equilibrium many-body dynamics. Here, the authors demonstrate how the Talbot effect can be used to measure the spreading of phase coherence of ultracold atoms in an optical lattice. | | | 05 June 2017 | doi: 10.1038/ncomms15601 | | |
| The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells OPEN | | | Barbara Castella, Joanna Kopecka, Patrizia Sciancalepore, Giorgia Mandili, Myriam Foglietta, Nico Mitro, Donatella Caruso, Francesco Novelli, Chiara Riganti and Massimo Massaia | | | γδT cells are activated by phosphoantigens, and ABCA1 is involved in cholesterol transport. Here the authors link these ideas to show that ABCA1, apoA-I and BTN3A1 regulate extracellular phosphoantigen release by dendritic cells, and implicate ABCA1 in mevalonate-mediated activation of Vγ9Vδ2 T cells. | | | 05 June 2017 | doi: 10.1038/ncomms15663 | | |
| Pyrin-only protein 2 limits inflammation but improves protection against bacteria OPEN | | | Sivakumar Periasamy, Kristen A. Porter, Maninjay K. Atianand, Hongnga T. Le, Sarah Earley, Ellen B. Duffy, Matthew C. Haller, Heather Chin and Jonathan A. Harton | | | Pyrin-only proteins (POPs) are primate-specific negative regulators of inflammasome activation. Here the authors generate transgenic mice expressing POP2 under the control of the human promoter, and show that POP2 is important for balancing antibacterial inflammatory responses in vivo. | | | 05 June 2017 | doi: 10.1038/ncomms15564 | | |
| The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation OPEN | | | Rojo A. Ratsimandresy, Lan H. Chu, Sonal Khare, Lucia de Almeida, Anu Gangopadhyay, Mohanalaxmi Indramohan, Alexander V. Misharin, David R. Greaves, Harris Perlman, Andrea Dorfleutner and Christian Stehlik | | | Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering, respectively, with IκBα activation and NLRP3-ASC interaction. | | | 05 June 2017 | doi: 10.1038/ncomms15556 | | |
| Universal fragment descriptors for predicting properties of inorganic crystals OPEN | | | Olexandr Isayev, Corey Oses, Cormac Toher, Eric Gossett, Stefano Curtarolo and Alexander Tropsha | | | Machine learning methods can be useful for materials discovery; however certain properties remain difficult to predict. Here, the authors present a universal machine learning approach for modelling the properties of inorganic crystals, which is validated for eight electronic and thermomechanical properties. | | | 05 June 2017 | doi: 10.1038/ncomms15679 | | |
| Control of morphology and formation of highly geometrically confined magnetic skyrmions OPEN | | | Chiming Jin, Zi-An Li, András Kovács, Jan Caron, Fengshan Zheng, Filipp N. Rybakov, Nikolai S. Kiselev, Haifeng Du, Stefan Blügel, Mingliang Tian, Yuheng Zhang, Michael Farle and Rafal E Dunin-Borkowski | | | Proposals for skyrmion-based high-density memory devices require an understanding of the formation and shape of skyrmions in confined geometries. Here, the authors use electron holography to image magnetic textures in FeGe nanostripes and explore the parameters governing skyrmion morphology. | | | 05 June 2017 | doi: 10.1038/ncomms15569 | | |
| Quasilinear quantum magnetoresistance in pressure-induced nonsymmorphic superconductor chromium arsenide OPEN | | | Q. Niu, W. C. Yu, K. Y. Yip, Z. L. Lim, H. Kotegawa, E. Matsuoka, H. Sugawara, H. Tou, Y. Yanase and Swee K. Goh | | | The electronic structure of the helimagnet CrAs is unusual due to its nonsymmorphic crystal symmetry. Here, the authors observe quasilinear magnetoresistance close to a pressure-driven superconducting transition, which may arise from the interaction of the band structure and magnetic fluctuations. | | | 05 June 2017 | doi: 10.1038/ncomms15358 | | |
| Synergistic cooperation promotes multicellular performance and unicellular free-rider persistence OPEN | | | William W Driscoll and Michael Travisano | | | Multicellularity can arise by cells aggregating or remaining connected after cell division. Here, Driscoll and Travisano show that both mechanisms operate in experimentally evolved strains of the yeast Kluyveromyces lactis, with transient aggregation facilitating the coexistence of unicellular and multicellular genotypes. | | | 05 June 2017 | doi: 10.1038/ncomms15707 | | |
| Cascaded spintronic logic with low-dimensional carbon OPEN | | | Joseph S. Friedman, Anuj Girdhar, Ryan M. Gelfand, Gokhan Memik, Hooman Mohseni, Allen Taflove, Bruce W. Wessels, Jean-Pierre Leburton and Alan V Sahakian | | | Spintronics, graphene, and carbon nanotubes are potential components of next-generation high performance computers. Here, the authors propose and theoretically evaluate a spintronic logic family composed solely of carbon materials with the potential for a 100 × improvement in energy efficiency. | | | 05 June 2017 | doi: 10.1038/ncomms15635 | | |
| Probing intermediates of the induction period prior to nucleation and growth of semiconductor quantum dots OPEN | | | Mingyang Liu, Kun Wang, Linxi Wang, Shuo Han, Hongsong Fan, Nelson Rowell, John A. Ripmeester, Romain Renoud, Fenggang Bian, Jianrong Zeng and Kui Yu | | | Growth of colloidal semiconductor quantum dots involves several stages, including an enigmatic induction period preceding nucleation. Here, the authors identify two distinct intermediates in the induction period, mapping their evolution from precursors all the way to either magic-size clusters or quantum dots. | | | 05 June 2017 | doi: 10.1038/ncomms15467 | | |
| Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory OPEN | | | Pierre-Yves Plaçais, Éloïse de Tredern, Lisa Scheunemann, Séverine Trannoy, Valérie Goguel, Kyung-An Han, Guillaume Isabel and Thomas Preat | | | Energy consumption in the brain is thought to respond to changes in neuronal activity, without informational role. Here the authors show that increased energy flux in the mushroom body, driven by a pair of input dopaminergic neurons, is a command for the formation of long-term memory in Drosophila. | | | 05 June 2017 | doi: 10.1038/ncomms15510 | | |
| Accurate prediction of X-ray pulse properties from a free-electron laser using machine learning OPEN | | | A. Sanchez-Gonzalez, P. Micaelli, C. Olivier, T. R. Barillot, M. Ilchen, A. A. Lutman, A. Marinelli, T. Maxwell, A. Achner, M. Agåker, N. Berrah, C. Bostedt, J. D. Bozek, J. Buck, P. H. Bucksbaum, S. Carron Montero, B. Cooper, J. P. Cryan, M. Dong, R. Feifel et al. | | | X-ray free-electron lasers, important light sources for materials research, suffer from shot-to-shot fluctuations that necessitate complex diagnostics. Here, the authors apply machine learning to accurately predict pulse properties, using parameters that can be acquired at high-repetition rates. | | | 05 June 2017 | doi: 10.1038/ncomms15461 | | |
| New Martian valley network volume estimate consistent with ancient ocean and warm and wet climate OPEN | | | Wei Luo, Xuezhi Cang and Alan D. Howard | | | To understand the early Martian climate, the volume of the global Martian valley network is required. Here, the authors use a black top hat transformation method and find that the minimum global valley network volume is 1.74 × 1,014 m3 with a minimum cumulative volume of water required of 6.86 × 1,017 m3. | | | 05 June 2017 | doi: 10.1038/ncomms15766 | | |
| Three-dimensional crossbar arrays of self-rectifying Si/SiO2/Si memristors OPEN | | | Can Li, Lili Han, Hao Jiang, Moon-Hyung Jang, Peng Lin, Qing Wu, Mark Barnell, J. Joshua Yang, Huolin L. Xin and Qiangfei Xia | | | Memristors are key structural units of complex memory and computing systems, yet most currently available memristors are based on materials that are not compatible with silicon technology. Here, the authors demonstrate a CMOS-compatible, self-rectifying memristor and arrays entirely based on p-Si/SiO2/n-Si. | | | 05 June 2017 | doi: 10.1038/ncomms15666 | | |
| IL-17-producing γδ T cells switch migratory patterns between resting and activated states OPEN | | | Duncan R. McKenzie, Ervin E. Kara, Cameron R. Bastow, Timona S. Tyllis, Kevin A. Fenix, Carly E. Gregor, Jasmine J. Wilson, Rachelle Babb, James C. Paton, Axel Kallies, Stephen L. Nutt, Anne Brüstle, Matthias Mack, Iain Comerford and Shaun R. McColl | | | IL-17-producing γδ T (γδT17) cells position in barrier tissues but also home to inflammatory sites. How this trafficking is regulated is unclear. Here the authors show that the dynamic expression of chemokine receptors CCR2 and CCR6 differentiates γδT17 cell trafficking patterns at homeostasis and in inflammatory scenarios. | | | 05 June 2017 | doi: 10.1038/ncomms15632 | | |
| A robot for high yield electrophysiology and morphology of single neurons in vivo OPEN | | | Lu Li, Benjamin Ouellette, William A. Stoy, Emma J. Garren, Tanya L. Daigle, Craig R. Forest, Christof Koch and Hongkui Zeng | | | Single-cell characterization and perturbation of neurons is critical for revealing the structure-function relationship of brain cells. Here the authors develop a robot that performs single-cell electroporation and extracellular electrophysiology and can be used for performing in vivo single-cell experiments in deep brain tissues optically difficult to access. | | | 01 June 2017 | doi: 10.1038/ncomms15604 | | |
| The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis OPEN | | | Cong Qiu, Yuewen Wang, Haige Zhao, Lingfeng Qin, Yanna Shi, Xiaolong Zhu, Lin Song, Xiaofei Zhou, Jian Chen, Hong Zhou, Haifeng Zhang, George Tellides, Wang Min and Luyang Yu | | | A major cause of transplanted organ failure is graft arteriosclerosis. Qiu et al. show that a key protease of post-translational SUMO modification, SENP1, is crucial for graft arteriosclerosis by regulating the activity of GATA2 transcription factor in the endothelium, and promoting endothelial inflammation and alloimmunity. | | | 01 June 2017 | doi: 10.1038/ncomms15426 | | |
| USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response OPEN | | | Yunhui Li, Kuntian Luo, Yujiao Yin, Chenming Wu, Min Deng, Lei Li, Yuping Chen, Somaira Nowsheen, Zhenkun Lou and Jian Yuan | | | RAP80 helps to recruit BRCA1 to double-strand breaks, facilitating DNA damage responses. Here the authors report that phosphorylated USP13 deubiquitinates RAP80 after DNA damage, prompting recruitment to the break site. | | | 01 June 2017 | doi: 10.1038/ncomms15752 | | |
| Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro OPEN | | | Andrew T. Lombardo, Shane R. Nelson, M. Yusuf Ali, Guy G. Kennedy, Kathleen M. Trybus, Sam Walcott and David M. Warshaw | | | Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage the actin tracks. | | | 01 June 2017 | doi: 10.1038/ncomms15692 | | |
| Tracing the oxygen isotope composition of the upper Earth’s atmosphere using cosmic spherules OPEN | | | Andreas Pack, Andres Höweling, Dominik C. Hezel, Maren T. Stefanak, Anne-Katrin Beck, Stefan T. M. Peters, Sukanya Sengupta, Daniel Herwartz and Luigi Folco | | | Oxygen contained within cosmic spherules is sourced from the atmosphere, making micrometeorites a possible archive for past atmospheric conditions. Here, Pack et al. compare the isotopic composition of oxygen in cosmic spherules from Antarctica with that of the troposphere, and validate the value of this archive. | | | 01 June 2017 | doi: 10.1038/ncomms15702 | | |
| Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4 OPEN | | | Nawal Maïssa, Valentina Covarelli, Sébastien Janel, Beatrice Durel, Nandi Simpson, Sandra C. Bernard, Liliana Pardo-Lopez, Haniaa Bouzinba-Ségard, Camille Faure, Mark G.H. Scott, Mathieu Coureuil, Philippe C. Morand, Frank Lafont, Xavier Nassif, Stefano Marullo and Sandrine Bourdoulous | | | Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells. | | | 01 June 2017 | doi: 10.1038/ncomms15764 | | |
| Large spin accumulation and crystallographic dependence of spin transport in single crystal gallium nitride nanowires OPEN | | | Tae-Eon Park, Youn Ho Park, Jong-Min Lee, Sung Wook Kim, Hee Gyum Park, Byoung-Chul Min, Hyung-jun Kim, Hyun Cheol Koo, Heon-Jin Choi, Suk Hee Han, Mark Johnson and Joonyeon Chang | | | Semiconductors are promising for high performance spintronics but the low functioning temperature hampers their applications. Here the authors achieve a strong room temperature modulation of spin-dependent resistance in GaN nanowires, which marks an important step towards practical spintronic devices. | | | 01 June 2017 | doi: 10.1038/ncomms15722 | | |
| Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits OPEN | | | Amrita Bhattacharyya, Kate M. Campbell, Shelly D. Kelly, Yvonne Roebbert, Stefan Weyer, Rizlan Bernier-Latmani and Thomas Borch | | | Crystalline uraninite is believed to be the dominant form in uranium deposits. Here, the authors find that non-crystalline U(IV) generated through biologically mediated U(VI) reduction is the predominant U(IV) species in ore deposits, implying that biogenic processes are more important than previously thought. | | | 01 June 2017 | doi: 10.1038/ncomms15538 | | |
| Polymorphism in a high-entropy alloy OPEN | | | Fei Zhang, Yuan Wu, Hongbo Lou, Zhidan Zeng, Vitali B. Prakapenka, Eran Greenberg, Yang Ren, Jinyuan Yan, John S. Okasinski, Xiongjun Liu, Yong Liu, Qiaoshi Zeng and Zhaoping Lu | | | Whether a polymorphic transition exists in high entropy alloys or not remains unclear since discovery of these alloys more than a decade ago. Here authors report an irreversible polymorphic transition from fcc to hcp in the prototype FeCoCrMnNi high entropy alloy and provide evidence for fcc phase being more stable than hcp phase only at high temperatures. | | | 01 June 2017 | doi: 10.1038/ncomms15687 | | |
| Ultrafast terahertz snapshots of excitonic Rydberg states and electronic coherence in an organometal halide perovskite OPEN | | | Liang Luo, Long Men, Zhaoyu Liu, Yaroslav Mudryk, Xin Zhao, Yongxin Yao, Joong M. Park, Ruth Shinar, Joseph Shinar, Kai-Ming Ho, Ilias E. Perakis, Javier Vela and Jigang Wang | | | The generation of bound electron and hole pairs—excitons—is a key process in photovoltaic technologies, yet it is challenging to follow their initial dynamics. Here, Luo et al. probe the Rydberg eigenstates that characterize the excitonic transport and coherent conversion in a perovskite material. | | | 01 June 2017 | doi: 10.1038/ncomms15565 | | |
| Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth OPEN | | | Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xian-Chao Zhang, Kai Zhou, Qing Liu, Hua Long, Ti-Wei Fu, Xiao-Ning Zhang, Mian-Fu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng et al. | | | Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in increased survival of tumour-bearing animals. | | | 01 June 2017 | doi: 10.1038/ncomms15080 | | |
| Ants regulate colony spatial organization using multiple chemical road-signs OPEN | | | Yael Heyman, Noam Shental, Alexander Brandis, Abraham Hefetz and Ofer Feinerman | | | While the organization of ants within their nest is key for colony function, it remains unknown how ants navigate this dark subterranean environment. Here, Heyman et al. use a series of behavioral tests, chemical analyses, and machine learning to identify chemical landmarks that ants use to distinguish between nest areas. | | | 01 June 2017 | doi: 10.1038/ncomms15414 | | |
| Experimental discrimination of ion stopping models near the Bragg peak in highly ionized matter OPEN | | | W. Cayzac, A. Frank, A. Ortner, V. Bagnoud, M. M. Basko, S. Bedacht, C. Bläser, A. Blažević, S. Busold, O. Deppert, J. Ding, M. Ehret, P. Fiala, S. Frydrych, D. O. Gericke, L. Hallo, J. Helfrich, D. Jahn, E. Kjartansson, A. Knetsch et al. | | | The energy loss of ions in plasma is a challenging issue in inertial confinement fusion and many theoretical models exist on ion-stopping power. Here, the authors use laser-generated plasma probed by accelerator-produced ions in experiments to discriminate various ion stopping models near the Bragg peak. | | | 01 June 2017 | doi: 10.1038/ncomms15693 | | |
| Direct and simultaneous observation of ultrafast electron and hole dynamics in germanium OPEN | | | Michael Zürch, Hung-Tzu Chang, Lauren J. Borja, Peter M. Kraus, Scott K. Cushing, Andrey Gandman, Christopher J. Kaplan, Myoung Hwan Oh, James S. Prell, David Prendergast, Chaitanya D. Pemmaraju, Daniel M. Neumark and Stephen R. Leone | | | Understanding excited carrier dynamics in semiconductors is central to the continued development of optoelectronic devices. Using extreme ultraviolet transient absorption spectroscopy, Zürch et al. directly and simultaneously observe ultrafast electron and hole dynamics in germanium thin films. | | | 01 June 2017 | doi: 10.1038/ncomms15734 | | |
| Fetal and postnatal metal dysregulation in autism OPEN | | | Manish Arora, Abraham Reichenberg, Charlotte Willfors, Christine Austin, Chris Gennings, Steve Berggren, Paul Lichtenstein, Henrik Anckarsäter, Kristiina Tammimies and Sven Bölte | | | The contribution of metal exposure to the etiology of ASD is unclear. Here the authors tested whether elemental dysregulation contributes to ASD risk by analysing tooth metal biomarkers from ASD discordant twins, and found significant differences in metal uptake between ASD cases and their control twin siblings, but only during certain developmental periods. | | | 01 June 2017 | doi: 10.1038/ncomms15493 | | |
| The microprotein Minion controls cell fusion and muscle formation OPEN | | | Qiao Zhang, Ajay A. Vashisht, Jason O’Rourke, Stéphane Y Corbel, Rita Moran, Angelica Romero, Loren Miraglia, Jia Zhang, Eric Durrant, Christian Schmedt, Srinath C. Sampath and Srihari C. Sampath | | | Cellular fusion is essential for skeletal muscle development. Here the authors identify Minion as a microprotein required for myoblast fusion and skeletal muscle formation, and show that co-expression of Minion and Myomaker is sufficient to induce cytoskeletal rearrangement and cell fusion even in non-muscle cells. | | | 01 June 2017 | doi: 10.1038/ncomms15664 | | |
| Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development OPEN | | | Malgorzata E. Quinn, Qingnian Goh, Mitsutoshi Kurosaka, Dilani G. Gamage, Michael J. Petrany, Vikram Prasad and Douglas P. Millay | | | Cellular fusion is fundamental for skeletal muscle development. Here the authors show that myomerger is expressed in myoblasts, is essential for myoblast fusion in mice, and in co-operation with myomaker confers fusogenic ability to non-fusogenic cells. | | | 01 June 2017 | doi: 10.1038/ncomms15665 | | |
| Quantum test of the equivalence principle for atoms in coherent superposition of internal energy states OPEN | | | G. Rosi, G. D’Amico, L. Cacciapuoti, F. Sorrentino, M. Prevedelli, M. Zych, Č. Brukner and G. M. Tino | | | Atom interferometers can be used in precision measurements and to test the fundamental laws of physics. Here the authors test the weak equivalence principle in the quantum regime with high sensitivity using a Bragg atom interferometer with rubidium atoms in their hyperfine states. | | | 01 June 2017 | doi: 10.1038/ncomms15529 | | |
| Evidence for a palaeo-subglacial lake on the Antarctic continental shelf OPEN | | | Gerhard Kuhn, Claus-Dieter Hillenbrand, Sabine Kasten, James A. Smith, Frank O. Nitsche, Thomas Frederichs, Steffen Wiers, Werner Ehrmann, Johann P. Klages and José M. Mogollón | | | While a number of subglacial lakes have been discovered beneath the modern Antarctic ice sheet, little is known regarding their prevalence during past glaciations. Here, Kuhn et al. present sedimentological evidence for an active palaeo-subglacial lake in Pine Island Bay during the last glaciation. | | | 01 June 2017 | doi: 10.1038/ncomms15591 | | |
| Detection of Zak phases and topological invariants in a chiral quantum walk of twisted photons OPEN | | | Filippo Cardano, Alessio D’Errico, Alexandre Dauphin, Maria Maffei, Bruno Piccirillo, Corrado de Lisio, Giulio De Filippis, Vittorio Cataudella, Enrico Santamato, Lorenzo Marrucci, Maciej Lewenstein and Pietro Massignan | | | The detection of topological invariants in the bulk remains challenging even in state-of-the-art experiments. Here, Cardano et al. propose a method to read-out the Zak phases and topological invariants in one-dimensional chiral systems and detect those in a photonic quantum walk of twisted photons. | | | 01 June 2017 | doi: 10.1038/ncomms15516 | | |
| Neuronal population coding of perceived and memorized visual features in the lateral prefrontal cortex OPEN | | | Diego Mendoza-Halliday and Julio C. Martinez-Trujillo | | | Neurons in the lateral prefrontal cortex are known to encode visual features as well as maintain them in working memory. Here the authors report that LPFC neurons encode both perceived and memorized visual features in diverse combinations and the population activity reliably decodes as well as differentiates between these two representations. | | | 01 June 2017 | doi: 10.1038/ncomms15471 | | |
| The sands of time run faster near the end OPEN | | | Juha Koivisto and Douglas J. Durian | | | Hourglasses measure time because the discharge rate of dry sand is constant. Here Koivisto et al. show that when such a system contains water there is a surge in discharge because the fluid drains faster than the grains, which might help us understand the transport of grains in silos. | | | 01 June 2017 | doi: 10.1038/ncomms15551 | | |
| One-Year stable perovskite solar cells by 2D/3D interface engineering OPEN | | | G. Grancini, C. Roldán-Carmona, I. Zimmermann, E. Mosconi, X. Lee, D. Martineau, S. Narbey, F. Oswald, F. De Angelis, M. Graetzel and Mohammad Khaja Nazeeruddin | | | Up-scaling represents a key challenge for photovoltaics based on metal halide perovskites. Using a composite of 2D and 3D perovskites in combination with a printable carbon black/graphite counter electrode; Grancini et al., report 11.2% efficient modules stable over 10,000 hours. | | | 01 June 2017 | doi: 10.1038/ncomms15684 | | |
| Biotransformation of p-xylene into terephthalic acid by engineered Escherichia coli OPEN | | | Zi Wei Luo and Sang Yup Lee | | | Terephthalic acid (TPA) is an important commodity chemical typically produced from the oxidation of fossil fuel-derived p-xylene (pX) at high temperature and pressure. Here the authors report an engineered Escherichia coli strain that can transform pX into TPA with a high conversion yield. | | | 31 May 2017 | doi: 10.1038/ncomms15689 | | |
| CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome OPEN | | | Ha Youn Shin, Chaochen Wang, Hye Kyung Lee, Kyung Hyun Yoo, Xianke Zeng, Tyler Kuhns, Chul Min Yang, Teresa Mohr, Chengyu Liu and Lothar Hennighausen | | | CRISPR/Cas9 gene editing has been used to generate mutations in several mouse genes. Here, the authors show that targeting events using single guide RNAs cause large deletions at 17 sites in the mouse genome, suggesting that careful genotyping is needed and sequential targeting may avoid such deletions. | | | 31 May 2017 | doi: 10.1038/ncomms15464 | | |
| Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification OPEN | | | Philip D. Dunne, Matthew Alderdice, Paul G. O'Reilly, Aideen C. Roddy, Amy M. B. McCorry, Susan Richman, Tim Maughan, Simon S. McDade, Patrick G. Johnston, Daniel B. Longley, Elaine Kay, Darragh G. McArt and Mark Lawler | | | Tumour expression profiling is currently used for prognostic and predictive purposes without taking into account the intra patient heterogeneity. Here the authors show that cancer cell specific signatures overcome the tumour heterogeneity effect and result in better classification of colorectal cancer patients. | | | 31 May 2017 | doi: 10.1038/ncomms15657 | | |
| Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease OPEN | | | Magali de Bruyn, Christine Breynaert, Ingrid Arijs, Gert De Hertogh, Karel Geboes, Greet Thijs, Gianluca Matteoli, Jialiang Hu, Jo Van Damme, Bernd Arnold, Marc Ferrante, Séverine Vermeire, Gert Van Assche and Ghislain Opdenakker | | | Metalloproteinase-9 has been suggested as therapeutic target to treat inflammatory bowel disease. Here de Bruyn et al. show that genetic and pharmacological inhibition of metalloproteinase-9 does not ameliorate inflammation and fibrosis in mice challenged with acute and chronic colitis protocols. | | | 31 May 2017 | doi: 10.1038/ncomms15384 | | |
| Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis OPEN | | | Yuqi Guo, Chengzhi Xie, Xiyan Li, Jian Yang, Tao Yu, Ruohan Zhang, Tianqing Zhang, Deepak Saxena, Michael Snyder, Yingjie Wu and Xin Li | | | Bone loss is common in patients with diabetes, but the underlying molecular and cellular mechanisms are unclear. Here the authors show high succinate levels in mice with type 2 diabetes and that succinate can signal through succinate receptor 1 on osteoclasts to induce bone resorption. | | | 31 May 2017 | doi: 10.1038/ncomms15621 | | |
| Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation OPEN | | | Nandhini Ponnuswamy, Maartje M. C. Bastings, Bhavik Nathwani, Ju Hee Ryu, Leo Y. T. Chou, Mathias Vinther, Weiwei Aileen Li, Frances M. Anastassacos, David J. Mooney and William M. Shih | | | The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents in in vivo applications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models. | | | 31 May 2017 | doi: 10.1038/ncomms15654 | | |
| Engineered clearing agents for the selective depletion of antigen-specific antibodies OPEN | | | Siva Charan Devanaboyina, Priyanka Khare, Dilip K. Challa, Raimund J. Ober and E. Sally Ward | | | The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn, to deplete MOG- and HER2-specific antibodies in mice. | | | 31 May 2017 | doi: 10.1038/ncomms15314 | | |
| Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer OPEN | | | Claudio Isella, Francesco Brundu, Sara E. Bellomo, Francesco Galimi, Eugenia Zanella, Roberta Porporato, Consalvo Petti, Alessandro Fiori, Francesca Orzan, Rebecca Senetta, Carla Boccaccio, Elisa Ficarra, Luigi Marchionni, Livio Trusolino, Enzo Medico and Andrea Bertotti | | | Stromal cells contribute to the gene expression profiles based on which colorectal cancer (CRC) molecular subtypes are classified. Here, patient-derived xenografts enable the authors to obtain cancer cell-specific transcriptomes by excluding transcripts from murine stromal cells, based on which they define CRC intrinsic subtypes (CRIS) and evaluate their prognostic and predictive potential. | | | 31 May 2017 | doi: 10.1038/ncomms15107 | | |
| Smooth 2D manifold extraction from 3D image stack OPEN | | | Asm Shihavuddin, Sreetama Basu, Elton Rexhepaj, Felipe Delestro, Nikita Menezes, Séverine M Sigoillot, Elaine Del Nery, Fekrije Selimi, Nathalie Spassky and Auguste Genovesio | | | Maximum Intensity Projection is a common tool to represent 3D biological imaging data in a 2D space, but it creates artefacts. Here the authors develop Smooth Manifold Extraction, an ImageJ/Fiji plugin, to preserve local spatial relationships when extracting the content of a 3D volume to a 2D space. | | | 31 May 2017 | doi: 10.1038/ncomms15554 | | |
| Beat frequency quartz-enhanced photoacoustic spectroscopy for fast and calibration-free continuous trace-gas monitoring OPEN | | | Hongpeng Wu, Lei Dong, Huadan Zheng, Yajun Yu, Weiguang Ma, Lei Zhang, Wangbao Yin, Liantuan Xiao, Suotang Jia and Frank K. Tittel | | | Quartz-enhanced photoacoustic spectroscopy is a sensitive gas detection method whereby radiation-induced sound waves from gas absorption are detected. Here, Wu et al. use the beat frequency between a modulated laser and a tuning fork resonance to increase sensitivity and avoid frequent calibrations. | | | 31 May 2017 | doi: 10.1038/ncomms15331 | | |
| Anapole nanolasers for mode-locking and ultrafast pulse generation OPEN | | | Juan S. Totero Gongora, Andrey E. Miroshnichenko, Yuri S. Kivshar and Andrea Fratalocchi | | | Here, the authors introduce the concept of nanocscale lasers based on a tightly confined anapole mode. Using first-principle calculations they show that the superposition of internal modes can generate radiation-less states that are scattering free, potentially overcoming the limitations of conventional nanolasers. | | | 31 May 2017 | doi: 10.1038/ncomms15535 | | |
| Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions OPEN | | | Manuel Hessenberger, Ralf M. Zerbes, Heike Rampelt, Séverine Kunz, Audrey H. Xavier, Bettina Purfürst, Hauke Lilie, Nikolaus Pfanner, Martin van der Laan and Oliver Daumke | | | The MICOS complex has an essential role in crista junction formation and mitochondrial inner membrane morphology. Here, the authors show that one of its components, Mic60, known to form contact sites between inner and outer membranes, also displays membrane-shaping activity. | | | 31 May 2017 | doi: 10.1038/ncomms15258 | | |
| Light-driven liquid metal nanotransformers for biomedical theranostics OPEN | | | Svetlana A. Chechetka, Yue Yu, Xu Zhen, Manojit Pramanik, Kanyi Pu and Eijiro Miyako | | | Liquid metals are excellent candidate materials for biomedicine, owing to their intriguing optical properties and chemical stability. Here, the authors design multifunctional theranostic liquid metal nanocapsules that, upon irradiation, generate heat and reactive oxygen species and change shape to release drugs. | | | 31 May 2017 | doi: 10.1038/ncomms15432 | | |
| Turbulence hierarchy in a random fibre laser OPEN | | | Iván R. Roa González, Bismarck C. Lima, Pablo I. R. Pincheira, Arthur A. Brum, Antônio M. S. Macêdo, Giovani L. Vasconcelos, Leonardo de S. Menezes, Ernesto P. Raposo, Anderson S. L. Gomes and Raman Kashyap | | | Random fibre lasers constitute a class of lasers where the optical feedback is provided by multiple scattering in a disordered system. Here, González et al. theoretically and experimentally study the statistical turbulence behaviour in relation to the lasing transition in such lasers. | | | 31 May 2017 | doi: 10.1038/ncomms15731 | | |
| Expression of CD226 is associated to but not required for NK cell education OPEN | | | Arnika K. Wagner, Nadir Kadri, Johanna Snäll, Petter Brodin, Susan Gilfillan, Marco Colonna, Günter Bernhardt, Petter Höglund, Klas Kärre and Benedict J. Chambers | | | CD226 is an activating receptor expressed in a co-varied manner with inhibitory receptors on natural killer (NK) cells, but whether CD226 is involved in NK cell education is unclear. Here the authors show that CD226 expression is plastic depending on the MHC environment and endows educated NK cells enhanced effector functions. | | | 31 May 2017 | doi: 10.1038/ncomms15627 | | |
| Giant electron-hole transport asymmetry in ultra-short quantum transistors OPEN | | | A. C. McRae, V. Tayari, J. M. Porter and A. R. Champagne | | | By utilizing electron-hole asymmetry in ultra-short single-walled carbon nanotube (SWCNT) transistors, McRae et al., develop ‘two-in-one’ SWCNT quantum devices that can switch from behaving as quantum-dot transistors for holes to quantum buses for electrons by changing the transistor’s gate voltage | | | 31 May 2017 | doi: 10.1038/ncomms15491 | | |
| A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks OPEN | | | Fabio Iannelli, Alessandro Galbiati, Ilaria Capozzo, Quan Nguyen, Brian Magnuson, Flavia Michelini, Giuseppina D’Alessandro, Matteo Cabrini, Marco Roncador, Sofia Francia, Nicola Crosetto, Mats Ljungman, Piero Carninci and Fabrizio d’Adda di Fagagna | | | DNA double strand breaks (DSBs) are among the most deleterious types of damage and there is strong evidence indicating a relationship between breaks and transcription. Here the authors provide a high-resolution, genome-wide map of induced DSBs and observe ATM-dependent transcriptional repression. | | | 31 May 2017 | doi: 10.1038/ncomms15656 | | |
| HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells OPEN | | | Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins and Robert J. Binder | | | Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasmacytoid dendritic cell expression of neuropilin-1, thus functionally supporting interaction with Treg cells. | | | 31 May 2017 | doi: 10.1038/ncomms15648 | | |
| WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy OPEN | | | Daniela Bakula, Amelie J. Müller, Theresia Zuleger, Zsuzsanna Takacs, Mirita Franz-Wachtel, Ann-Katrin Thost, Daniel Brigger, Mario P. Tschan, Tancred Frickey, Horst Robenek, Boris Macek and Tassula Proikas-Cezanne | | | During autophagy, AMPK and mTOR associate with ULK1 and regulate phosphatidylinositol 3-phosphate (PtdIns3P) production that mediates autophagosome formation via WIPI proteins. Here the authors show WIPI3 and WIPI4 have a scaffolding function upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes. | | | 31 May 2017 | doi: 10.1038/ncomms15637 | | |
| IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression OPEN | | | Chenhui Wang, Cun-Jin Zhang, Bradley N. Martin, Katarzyna Bulek, Zizhen Kang, Junjie Zhao, Guanglin Bian, Julie A. Carman, Ji Gao, Ashok Dongre, Haibo Xue, Stephen D. Miller, Youcun Qian, Dolores Hambardzumyan, Tom Hamilton, Richard M. Ransohoff and Xiaoxia Li | | | NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory response. | | | 31 May 2017 | doi: 10.1038/ncomms15508 | | |
| Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging OPEN | | | Mengmeng Liu, Qian Li, Le Liang, Jiang Li, Kun Wang, Jiajun Li, Min Lv, Nan Chen, Haiyun Song, Joon Lee, Jiye Shi, Lihua Wang, Ratnesh Lal and Chunhai Fan | | | The interaction of nanoparticles intracellularly has been investigated widely but the mechanisms of such interactions are not fully understood. Here, the authors utilize a semi-quantitative technique to assess the intracellular transportation and clustering potential of nanoparticles in real-time. | | | 31 May 2017 | doi: 10.1038/ncomms15646 | | |
| Bacterial RadA is a DnaB-type helicase interacting with RecA to promote bidirectional D-loop extension OPEN | | | Léa Marie, Chiara Rapisarda, Violette Morales, Mathieu Bergé, Thomas Perry, Anne-Lise Soulet, Clémence Gruget, Han Remaut, Rémi Fronzes and Patrice Polard | | | Bacterial homologous recombination involves the actions of RadA and RecA to promote single-stranded DNA integration. Here the authors report the structure of RadA from Streptococcus pneumoniae and demonstrate that it acts as a hexameric DnaB-type helicase. | | | 31 May 2017 | doi: 10.1038/ncomms15638 | | |
| Metabolic network analysis reveals microbial community interactions in anammox granules OPEN | | | Christopher E. Lawson, Sha Wu, Ananda S. Bhattacharjee, Joshua J. Hamilton, Katherine D. McMahon, Ramesh Goel and Daniel R. Noguera | | | The use of anammox microbiomes to treat wastewater is an escalating biotechnology, yet the functional role heterotrophic bacteria play in these systems remains poorly understood. Here, Lawson et al. use metagenomics and metatranscriptomics to reveal that heterotrophs degrade free peptides, while recycling nitrate to nitrite. | | | 31 May 2017 | doi: 10.1038/ncomms15416 | | |
| Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions OPEN | | | Antje Sucker, Fang Zhao, Natalia Pieper, Christina Heeke, Raffaela Maltaner, Nadine Stadtler, Birgit Real, Nicola Bielefeld, Sebastian Howe, Benjamin Weide, Ralf Gutzmer, Jochen Utikal, Carmen Loquai, Helen Gogas, Ludger Klein-Hitpass, Michael Zeschnigk, Astrid M. Westendorf, Mirko Trilling, Susanne Horn, Bastian Schilling et al. | | | IFNγ secretion by CD8+ T cells is critical for immunotherapy efficacy. In this study, the authors show that melanoma patients can become resistant to immunotherapy by acquiring chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2. | | | 31 May 2017 | doi: 10.1038/ncomms15440 | | |
| End-Triassic mass extinction started by intrusive CAMP activity OPEN | | | J.H.F.L. Davies, A. Marzoli, H. Bertrand, N. Youbi, M. Ernesto and U. Schaltegger | | | The cause of the end-Triassic extinction remains controversial. Here, the authors present U-Pb age data showing that magmatic activity occurred 100 kyr before the earliest known eruptions, which links to changes in climate and biotic records indicating the importance of understanding the intrusive record. | | | 31 May 2017 | doi: 10.1038/ncomms15596 | | |
| Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data OPEN | | | Subarna Sinha, Daniel Thomas, Steven Chan, Yang Gao, Diede Brunen, Damoun Torabi, Andreas Reinisch, David Hernandez, Andy Chan, Erinn B. Rankin, Rene Bernards, Ravindra Majeti and David L. Dill | | | There are no robust methods for systematically identifying mutation-specific synthetic lethal (SL) partners in cancer. Here, the authors develop a computational algorithm that uses pan-cancer data to detect mutation-andcancer-specific SL partners and they validate a novel SL interaction between mutant IDH and loss of ACACA in leukaemia. | | | 31 May 2017 | doi: 10.1038/ncomms15580 | | |
| Hot excited state management for long-lived blue phosphorescent organic light-emitting diodes OPEN | | | Jaesang Lee, Changyeong Jeong, Thilini Batagoda, Caleb Coburn, Mark E. Thompson and Stephen R. Forrest | | | Large-scale commercialization of organic light-emitting diodes is impeded by the short operational lifetime of blue emitting materials. Lee et al. show a strategy to manage the energy dissipation on molecular dissociation using dopants with high triplet exciton energy that improves device stability. | | | 31 May 2017 | doi: 10.1038/ncomms15566 | | |
| Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing OPEN | | | Rutger C. C. Hengeveld, Martijn J. M. Vromans, Mathijs Vleugel, Michael A. Hadders and Susanne M. A. Lens | | | Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on bi-oriented chromosomes and allows mitotic checkpoint silencing. | | | 31 May 2017 | doi: 10.1038/ncomms15542 | | |
| Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect OPEN | | | Liguo Jiang, Siqin Cao, Peter Pak-Hang Cheung, Xiaoyan Zheng, Chris Wai Tung Leung, Qian Peng, Zhigang Shuai, Ben Zhong Tang, Shuhuai Yao and Xuhui Huang | | | Hydrophobic interactions occur between nonpolar molecules in water and their experimental quantification can help the understanding of biological self-assembly. Here Jiang et al. examine the kinetics and thermodynamics of hydrophobic aggregation in a bulk environment and characterize its cooperativity. | | | 31 May 2017 | doi: 10.1038/ncomms15639 | | | | | | | | | | | | | Latest Corrigenda | | | | |
| | | | | Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes OPEN | | | Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour and Richard A. Young | | | 01 June 2017 | doi: 10.1038/ncomms15797 | | | | | | | | | | Latest Erratum | | | | | | Erratum: Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations OPEN | | | David Brown, Dominiek Smeets, Borbála Székely, Denis Larsimont, A. Marcell Szász, Pierre-Yves Adnet, Françoise Rothé, Ghizlane Rouas, Zsófia I Nagy, Zsófia Faragó, Anna-Mária Tőkés, Magdolna Dank, Gyöngyvér Szentmártoni, Nóra Udvarhelyi, Gabriele Zoppoli, Lajos Pusztai, Martine Piccart, Janina Kulka, Diether Lambrechts, Christos Sotiriou et al. | | | 06 June 2017 | doi: 10.1038/ncomms15759 | | | | | | | |
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