The EDGE

How good are we at predicting the fate of someone with acute myeloid leukaemia?

E Estey and R P Gale

Leukemia 2017 31: 1255-1258; advance online publication, March 17, 2017; 10.1038/leu.2017.56

Review

The emerging roles of tumor-derived exosomes in hematological malignancies

M Boyiadzis and T L Whiteside

Leukemia 2017 31: 1259-1268; advance online publication, March 21, 2017; 10.1038/leu.2017.91

Original Articles

ACUTE MYELOID LEUKEMIA

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

C Dafflon, V J Craig, H Méreau, J Gräsel, B Schacher Engstler, G Hoffman, F Nigsch, S Gaulis, L Barys, M Ito, J Aguadé-Gorgorió, B Bornhauser, J-P Bourquin, A Proske, C Stork-Fux, M Murakami, W R Sellers, F Hofmann, J Schwaller and R Tiedt

Leukemia 2017 31: 1269-1277; advance online publication, November 14, 2016; 10.1038/leu.2016.327

Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;q22) acute myeloid leukemia

A-K Eisfeld, J Kohlschmidt, S Schwind, D Nicolet, J S Blachly, S Orwick, C Shah, M Bainazar, K W Kroll, C J Walker, A J Carroll, B L Powell, R M Stone, J E Kolitz, M R Baer, A de la Chapelle, K Mrózek, J C Byrd and C D Bloomfield

Leukemia 2017 31: 1278-1285; advance online publication, November 15, 2016; 10.1038/leu.2016.332

Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis

F Thol, S Klesse, L Köhler, R Gabdoulline, A Kloos, A Liebich, M Wichmann, A Chaturvedi, J Fabisch, V I Gaidzik, P Paschka, L Bullinger, G Bug, H Serve, G Göhring, B Schlegelberger, M Lübbert, H Kirchner, M Wattad, D Kraemer, B Hertenstein, G Heil, W Fiedler, J Krauter, R F Schlenk, K Döhner, H Döhner, A Ganser and M Heuser

Leukemia 2017 31: 1286-1295; advance online publication, November 24, 2016; 10.1038/leu.2016.345

p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status

A Quintás-Cardama, C Hu, A Qutub, Y H Qiu, X Zhang, S M Post, N Zhang, K Coombes and S M Kornblau

Leukemia 2017 31: 1296-1305; advance online publication, November 25, 2016; 10.1038/leu.2016.350

Impact of salvage regimens on response and overall survival in acute myeloid leukemia with induction failure

M Wattad, D Weber, K Döhner, J Krauter, V I Gaidzik, P Paschka, M Heuser, F Thol, T Kindler, M Lübbert, H R Salih, A Kündgen, H-A Horst, P Brossart, K Götze, D Nachbaur, C-H Köhne, M Ringhoffer, G Wulf, G Held, H Salwender, A Benner, A Ganser, H Döhner and R F Schlenk for the German-Austrian AMLSG

Leukemia 2017 31: 1306-1313; advance online publication, January 19, 2017; 10.1038/leu.2017.23

ACUTE LYMPHOBLASTIC LEUKEMIA

Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway

Y Shen, C S Park, K Suppipat, T-A Mistretta, M Puppi, T M Horton, K Rabin, N S Gray, J P P Meijerink and H D Lacorazza

Leukemia 2017 31: 1314-1324; advance online publication, November 22, 2016; 10.1038/leu.2016.339

ACUTE MYELOID LEUKEMIA

Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia

S E Karol, E Larsen, C Cheng, X Cao, W Yang, L B Ramsey, C A Fernandez, J R McCorkle, S W Paugh, R J Autry, E Lopez-Lopez, B Diouf, S Jeha, C-H Pui, E A Raetz, N J Winick, W L Carroll, S P Hunger, M L Loh, M Devidas, W E Evans, J J Yang and M V Relling

Leukemia 2017 31: 1325-1332; advance online publication, January 18, 2017; 10.1038/leu.2017.24

CHRONIC LYMPHOCYTIC LEUKEMIA

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib OPEN

J Yu, L Chen, B Cui, Christina Wu, M Y Choi, Y Chen, L Zhang, L Z Rassenti, G F Widhopf II and T J Kipps

Leukemia 2017 31: 1333-1339; advance online publication, December 1, 2016; 10.1038/leu.2016.368

Direct in vivo evidence for increased proliferation of CLL cells in lymph nodes compared to bone marrow and peripheral blood

T M Herndon, S-S Chen, N S Saba, J Valdez, C Emson, M Gatmaitan, X Tian, T E Hughes, C Sun, D C Arthur, M Stetler-Stevenson, C M Yuan, C U Niemann, G E Marti, G Aue, S Soto, M Z H Farooqui, S E M Herman, N Chiorazzi and A Wiestner

Leukemia 2017 31: 1340-1347; advance online publication, January 11, 2017; 10.1038/leu.2017.11

Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia

E J Murphy, D S Neuberg, L Z Rassenti, G Hayes, R Redd, C Emson, K Li, J R Brown, W G Wierda, S Turner, A W Greaves, C S Zent, J C Byrd, C McConnel, J Barrientos, N Kay, M K Hellerstein, N Chiorazzi, T J Kipps and K R Rai

Leukemia 2017 31: 1348-1354; advance online publication, January 24, 2017; 10.1038/leu.2017.34

LYMPHOMA

Genetic characterization of MYD88-mutated lymphoplasmacytic lymphoma in comparison with MYD88-mutated chronic lymphocytic leukemia

C Baer, F Dicker, W Kern, T Haferlach and C Haferlach

Leukemia 2017 31: 1355-1362; advance online publication, November 14, 2016; 10.1038/leu.2016.330

MULTIPLE MYELOMA, GAMMOPATHIES

IKZF1 expression is a prognostic marker in newly diagnosed standard-risk multiple myeloma treated with lenalidomide and intensive chemotherapy: a study of the German Myeloma Study Group (DSMM)

J Krönke, F Kuchenbauer, M Kull, V Teleanu, L Bullinger, D Bunjes, A Greiner, S Kolmus, S Köpff, M Schreder, L-O Mügge, C Straka, M Engelhardt, H Döhner, H Einsele, F Bassermann, R Bargou, S Knop and C Langer

Leukemia 2017 31: 1363-1367; advance online publication, December 26, 2016; 10.1038/leu.2016.384

Carfilzomib–dexamethasone vs bortezomib–dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR OPEN

W-J Chng, H Goldschmidt, M A Dimopoulos, P Moreau, D Joshua, A Palumbo, T Facon, H Ludwig, L Pour, R Niesvizky, A Oriol, L Rosiñol, A Suvorov, G Gaidano, T Pika, K Weisel, V Goranova-Marinova, H H Gillenwater, N Mohamed, S Feng, S Aggarwal and R Hájek

Leukemia 2017 31: 1368-1374; advance online publication, December 27, 2016; 10.1038/leu.2016.390

Impact of pretransplant induction therapy on autologous stem cell transplantation for patients with newly diagnosed POEMS syndrome

J Li, M-H Duan, C Wang, X-F Huang, W Zhang, X-X Cao, T-N Zhu, J-L Zhuang, B Han, H Cai, H-C Cai and D-B Zhou

Leukemia 2017 31: 1375-1381; advance online publication, January 19, 2017; 10.1038/leu.2017.27

MYELODYSPLASTIC SYNDROME

Loss of p300 accelerates MDS-associated leukemogenesis

G Cheng, F Liu, T Asai, F Lai, N Man, H Xu, S Chen, S Greenblatt, P-J Hamard, K Ando, X Chen, L Wang, C Martinez, M Tadi, L Wang, M Xu, F-C Yang, R Shiekhattar and S D Nimer

Leukemia 2017 31: 1382-1390; advance online publication, November 24, 2016; 10.1038/leu.2016.347

Comparison of clinical outcomes and prognostic utility of risk stratification tools in patients with therapy-related vs de novo myelodysplastic syndromes: a report on behalf of the MDS Clinical Research Consortium

A M Zeidan, N Al Ali, J Barnard, E Padron, J E Lancet, M A Sekeres, D P Steensma, A DeZern, G Roboz, E Jabbour, G Garcia-Manero, A List and R Komrokji

Leukemia 2017 31: 1391-1397; advance online publication, January 23, 2017; 10.1038/leu.2017.33

STEM CELL BIOLOGY

In vitro and in vivo assessment of direct effects of simulated solar and galactic cosmic radiation on human hematopoietic stem/progenitor cells

C Rodman, G Almeida-Porada, S K George, J Moon, S Soker, T Pardee, M Beaty, P Guida, S P Sajuthi, C D Langefeld, S J Walker, P F Wilson and C D Porada

Leukemia 2017 31: 1398-1407; advance online publication, November 24, 2016; 10.1038/leu.2016.344

STEM CELL TRANSPLANTATION

Outcomes of UCB transplantation are comparable in FLT3+ AML: results of CIBMTR, EUROCORD and EBMT collaborative analysis

C Ustun, F Giannotti, M-J Zhang, H-L Wang, C Brunstein, M Labopin, V Rocha, M de Lima, F Baron, B M Sandmaier, M Eapen, E Gluckman, A Nagler, D J Weisdorf and A Ruggeri

Leukemia 2017 31: 1408-1414; advance online publication, January 25, 2017; 10.1038/leu.2017.42

TRANSCRIPTIONAL CONTROL AND SIGNAL TRANSDUCTION, CELL CYCLE

Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

W Liu, W-M Yu, J Zhang, R J Chan, M L Loh, Z Zhang, K D Bunting and C-K Qu

Leukemia 2017 31: 1415-1422; advance online publication, November 14, 2016; 10.1038/leu.2016.326

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis OPEN

M J Carter, K L Cox, S J Blakemore, A H Turaj, R J Oldham, L N Dahal, S Tannheimer, F Forconi, G Packham and M S Cragg

Leukemia 2017 31: 1423-1433; advance online publication, November 15, 2016; 10.1038/leu.2016.333

Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells

F Yan, N Shen, J X Pang, Y W Zhang, E Y Rao, A M Bode, A Al-Kali, D E Zhang, M R Litzow, B Li and S J Liu

Leukemia 2017 31: 1434-1442; advance online publication, November 25, 2016; 10.1038/leu.2016.349

Letters To The Editor

CBFβ-SMMHC regulates ribosomal gene transcription and alters ribosome biogenesis

G Cordonnier, A Mandoli, A Radhouane, G Hypolite, L Lhermitte, M Belhocine, V Asnafi, E Macintyre, J H A Martens, S Fumagalli and J Bond

Leukemia 2017 31: 1443-1446; advance online publication, February 15, 2017; 10.1038/leu.2017.53

Analytical and clinical validation of a novel in-house deep-sequencing method for minimal residual disease monitoring in a phase II trial for multiple myeloma OPEN

J Martinez-Lopez, B Sanchez-Vega, S Barrio, I Cuenca, Y Ruiz-Heredia, R Alonso, I Rapado, C Marin, M-T Cedena, B Paiva, N Puig, M-V Mateos, R Ayala, M-T Hernández, C Jimenez, L Rosiñol, R Martínez, A-I Teruel, N Gutiérrez, M-L Martin-Ramos, A Oriol, J Bargay, J Bladé, J San-Miguel, R Garcia-Sanz and J-J Lahuerta

Leukemia 2017 31: 1446-1449; advance online publication, February 17, 2017; 10.1038/leu.2017.58

Impact of treatment site on disparities in outcome among adolescent and young adults with Hodgkin lymphoma

J Wolfson, C-L Sun, L Wyatt, W Stock and S Bhatia

Leukemia 2017 31: 1450-1453; advance online publication, February 20, 2017; 10.1038/leu.2017.66

Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia

M Kobayashi, S Chen, Y Bai, C Yao, R Gao, X-J Sun, C Mu, T A Twiggs, Z-H Yu, H S Boswell, M C Yoder, R Kapur, J C Mulloy, Z-Y Zhang and Y Liu

Leukemia 2017 31: 1453-1457; advance online publication, February 21, 2017; 10.1038/leu.2017.67

Early death rates remain high in high-risk APL: update from the Swedish Acute Leukemia Registry 1997–2013

S Lehmann, S Deneberg, P Antunovic, Å Rangert-Derolf, H Garelius, V Lazarevic, K Myhr-Eriksson, L Möllgård, B Uggla, A Wahlin, L Wennström, M Höglund and G Juliusson

Leukemia 2017 31: 1457-1459; advance online publication, February 24, 2017; 10.1038/leu.2017.71

Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents OPEN

M Poganitsch-Korhonen, I Masliukaite, M Nurmio, P Lähteenmäki, M van Wely, A M M van Pelt, K Jahnukainen and J-B Stukenborg

Leukemia 2017 31: 1460-1463; advance online publication, March 8, 2017; 10.1038/leu.2017.76

Response-adapted consolidation with bortezomib after ASCT improves progression-free survival in newly diagnosed multiple myeloma

H Einsele, S Knop, M Vogel, J Müller, M Kropff, B Metzner, C Langer, H Sayer, W Jung, H A Dürk, H Salwender, H Wandt, F Bassermann, M Gramatzki, W Rösler, H-H Wolf, W Brugger, M Engelhardt, T Fischer, P Liebisch and C Straka

Leukemia 2017 31: 1463-1466; advance online publication, March 15, 2017; 10.1038/leu.2017.83

A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML

L M Kats, S J Vervoort, R Cole, A J Rogers, G P Gregory, E Vidacs, J Li, R Nagaraja, K E Yen and R W Johnstone

Leukemia 2017 31: 1466-1470; advance online publication, March 10, 2017; 10.1038/leu.2017.84

ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma

A Dzikiewicz-Krawczyk, K Kok, I Slezak-Prochazka, J-L Robertus, J Bruining, M M Tayari, B Rutgers, D de Jong, J Koerts, A Seitz, J Li, B Tillema, J E Guikema, I M Nolte, A Diepstra, L Visser, J Kluiver and A van den Berg

Leukemia 2017 31: 1470-1473; advance online publication, March 23, 2017; 10.1038/leu.2017.94

No evidence for microsatellite instability in acute myeloid leukemia

C J Walker, A-K Eisfeld, L K Genutis, M Bainazar, J Kohlschmidt, K Mrózek, A J Carroll, J E Kolitz, B L Powell, E S Wang, R M Stone, R Bundschuh, A de la Chapelle and C D Bloomfield

Leukemia 2017 31: 1474-1476; advance online publication, March 24, 2017; 10.1038/leu.2017.97