Nature Biotechnology Contents: Volume 35 pp 485 - 596

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Advertisement A*STAR Research - Highlighting the latest breakthroughs at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization   Recent Highlights Microchips: 10-dollar test detects tuberculosis in minutes | Spectral imaging: Getting the skinny on different shades of fat | Bioimaging: Animal development in action Download the A*STAR Research app now! TABLE OF CONTENTS June 2017 Volume 35, Issue 6 Editorial News Opinion and Comment Features News and Views Research Careers and Recruitment Advertisement In the middle of innovation, medicine, growth, and so much more, Destination Medical Center (DMC) is transforming Rochester, MN. DMC is a 20-year, $5.6 billion economic development plan. Together, DMC and Mayo Clinic are accelerating new advancements in life science research, medical technology, patient care, and education.  Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Big Data in Biology and Health (25-27 Sept 2017)  This conference will explore the opportunities and challenges of big data in biology, health and disease and provide a forum for scientists and clinicians from academia and industry to drive future research development in this area. Deadlines: Bursaries: 13 June / Abstracts: 27 June / Registration: 18 July   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement nature.com webcasts Nature presents an editorial webcast on: Rigorous data collection and analysis Date: Monday 19th June 2017 Time: 9AM PDT, 12PM EDT, 5PM BST, 6PM CEST Join experts in experimental design and analysis as they describe common pitfalls and how to avoid them. Register for FREE online Produced with support from: Gilson & sciNote   Advertisement REGENERATION 2017 Presented by: Ospedale San Raffaele | Nature The conference will feature sessions on regeneration in animal models, functional and dysfunctional regeneration in mammals, and new therapeutic approaches to regeneration. November 16-18, 2017 | Milan, Italy REGISTER NOW!   Editorial Top Patient-centered drug manufacture   p485 doi:10.1038/nbt.3901 Bedside production of protein drugs could help payers by lowering drug prices. It may ultimately lead to individualized treatments. News Top Industry 'road tests' new wave of immune checkpoints   pp487 - 488 Ken Garber doi:10.1038/nbt0617-487 Interest rekindles in drug cocktails that reprogram cells   pp489 - 490 Cormac Sheridan doi:10.1038/nbt0617-489 Verily chases a perfectly healthy human   p490 doi:10.1038/nbt0617-490 After Glybera's withdrawal, what's next for gene therapy?   pp491 - 492 Melanie Senior doi:10.1038/nbt0617-491 CAR-T death strikes Kite   p492 doi:10.1038/nbt0617-492 First deuterated drug approved   pp493 - 494 Charles Schmidt doi:10.1038/nbt0617-493 Eat a water bottle or two   p495 doi:10.1038/nbt0617-495a Around the world in a month   p495 doi:10.1038/nbt0617-495b News Feature Hanging on a thread   pp496 - 499 Laura DeFrancesco doi:10.1038/nbt.3894 Several companies are now banking on bioengineered silk to create a new generation of textiles and materials...and a necktie. Laura DeFrancesco investigates. Advertisement Bringing Edman Back to Life Shimadzu's protein sequencers provide reliable, sensitive N-terminal sequencing to researchers through automated Edman degradation. Software enables compliance with FDA 21 CFR Part 11 guidelines, while easy-to-use data analysis functions simplify operation, data processing and reporting. Learn more. Opinion and Comment Top Correspondence Alternative drug sensitivity metrics improve preclinical cancer pharmacogenomics   pp500 - 502 Marc Hafner, Mario Niepel and Peter K Sorger doi:10.1038/nbt.3882 The illusion of control in germline-engineering policy OPEN   pp502 - 506 Harald Konig doi:10.1038/nbt.3884 Commentary Making individualized drugs a reality   pp507 - 513 Huub Schellekens, Mohammed Aldosari, Herre Talsma and Enrico Mastrobattista doi:10.1038/nbt.3888 Magistral drug preparation offers a model to circumvent many of the technological, regulatory and financial challenges that prevent provision of the right drug at the right time to the right patient. Features Top Patents Patents as collateral for securitization   pp514 - 516 Nishad Deshpande and Asha Nagendra doi:10.1038/nbt.3891 Patents are important assets for biotech organizations, not only for protecting inventions but also as assets to raise monies. Recent patents in microbiomes and microbial genomics   p517 doi:10.1038/nbt.3905 Advertisement Nature Outlook: Food security Adequate access to food is a universal right, but eliminating all forms of malnutrition in a growing world is no small task. In the coming decades significant improvements in how we produce, distribute and consume food will be required.  Access the Outlook free online for six months > Produced with support from:  Nestlé   News and Views Top Building the human inner ear in an organoid   pp518 - 520 Vidhya Munnamalai and Donna M Fekete doi:10.1038/nbt.3899 Inner ear organoids will facilitate disease studies and drug screening. See also: Research by Koehler et al. Manufacture of CAR-T cells in the body   pp520 - 521 Johanna Olweus doi:10.1038/nbt.3898 Engineered T cells for cancer therapy are produced in the mouse bloodstream, avoiding the need to harvest T cells and manipulate them ex vivo. Research Highlights   p521 doi:10.1038/nbt.3895 A spring collection of designer yeast chromosomes   p522 Katarzyna Marcinkiewicz doi:10.1038/nbt.3890 Biotechnology JOBS of the week Associate Professor / Assistant Professor in Biotechnology / Biochemistry / Cell Biology / Nutrition / Immunology / Microbiology The Hong Kong Polytechnic University (PolyU) Postdoctoral Research Fellow, Biomedical Imaging Genentech Research Director Rutgers University Postdoctoral fellowship on Translation in the shoot apical meristem Umea University, KBC /Umeå Plant Science Centre UPSC Faculty Recruitment in School of Life Science and Technology (SLST), ShanghaiTech University ShanghaiTech University More Science jobs from Biotechnology EVENT ICABT 2017 5th International Conference on Agriculture and Biotechnology (ICABT 2017) December 27, 2017 Tokyo, Japan More science events from Research Top Perspectives Open-source, community-driven microfluidics with Metafluidics OPEN   pp523 - 529 David S Kong, Todd A Thorsen, Jonathan Babb, Scott T Wick, Jeremy J Gam et al. doi:10.1038/nbt.3873 A community-led initiative will enable users to design, share, refine and innovate fluidic devices. The promise of organ and tissue preservation to transform medicine   pp530 - 542 Sebastian Giwa, Jedediah K Lewis, Luis Alvarez, Robert Langer, Alvin E Roth et al. doi:10.1038/nbt.3889 Articles Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene   pp543 - 550 Zhang-Hui Chen, Yan P Yu, Ze-Hua Zuo, Joel B Nelson, George K Michalopoulos et al. doi:10.1038/nbt.3843 Insertion of the sequence encoding herpes simplex virus 1 thymidine kinase at the breakpoints of fusion genes in cancer cells causes cell death and regression of mouse xenograft tumors. Single-cell topological RNA-seq analysis reveals insights into cellular differentiation and development   pp551 - 560 Abbas H Rizvi, Pablo G Camara, Elena K Kandror, Thomas J Roberts, Ira Schieren et al. doi:10.1038/nbt.3854 Analysis of RNA-seq data from individual developing mouse motor neuron cells with topological data analysis sheds light on crucial cell-fate decisions during neurogenesis. CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome   pp561 - 568 Tyler S Klann, Joshua B Black, Malathi Chellappan, Alexias Safi, Lingyun Song et al. doi:10.1038/nbt.3853 Regulatory elements for specific human genes are rapidly identified with CRISPR epigenome editing. Letters In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis   pp569 - 576 Jatin Roper, Tuomas Tammela, Naniye Malli Cetinbas, Adam Akkad, Ali Roghanian et al. doi:10.1038/nbt.3836 Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids. Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer   pp577 - 582 Kevin P O'Rourke, Evangelia Loizou, Geulah Livshits, Emma M Schatoff, Timour Baslan et al. doi:10.1038/nbt.3837 Genetically engineered colon organoids form tumors that undergo a stepwise progression toward metastatic disease after orthotopic transplantation. Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells   pp583 - 589 Karl R Koehler, Jing Nie, Emma Longworth-Mills, Xiao-Ping Liu, Jiyoon Lee et al. doi:10.1038/nbt.3840 Human pluripotent stem cells are differentiated into inner ear organoids containing cells similar to hair cells and sensory neurons. See also: News and Views by Munnamalai & Fekete Careers and Recruitment Top A synthetic biology approach to integrative high school STEM training   pp591 - 595 Sutherland Dube, Doug Orr, Brian Dempsey and Hans-Joachim Wieden doi:10.1038/nbt.3896 Synthetic biology-based group activities provide opportunities for integrative STEM training and literacy, while lowering barriers for high school students to become interested in science careers. People People   p596 doi:10.1038/nbt.3904 Advertisement Special offer! Recruit for less this summer!  10% discount on our Enhanced job posting package  20% discount on our Premium job posting package Be displayed alongside relevant content across nature.com reaching a potential audience of 10.8 million users.* Post a job now. * Publisher data 2016 Offer ends June 19, 2017   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. 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